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Born in 1940 in rural Minas Gerais State, Marques migrated to S\u00e3o Paulo with her husband in 1958 where they settled in its southern periphery. Marques was an early leader of the mothers' clubs (clubes de m\u00e3es), groups of women organized through the Catholic Church. In 1973, Odete Marques helped write an open letter from the mothers' clubs to Brazil's military dictator, Em\u00edlio M\u00e9dici, protesting high food prices and cost of living. That letter, addressed from the \"mothers of the periphery,\" triggered a regime crackdown on popular organizing but also gave rise to the largest popular movement of the dictatorship era, the Cost of Living Movement (Movimento do Custo de Vida). In this movement and others up to the present, Marques advocated for the rights of working people and women. Her poem, Veteranas (2001) or Veterans, narrates the rise of the mothers' clubs amid the dictatorship and her bittersweet memories of those years. Like much poetry in another language, meaning can be difficult to translate: even the title when rendered into English loses Marques's purposeful use of the feminine \"a\" to refer to her female comrades. Still, the poem translated below offers a unique glimpse into one leading activist's memories of women's organizing in the periphery during the dictatorship. The line \"we left our houses in search of addresses\" evokes the precarious title to their land that many rural migrants held in the periphery. Indeed, the millions of migrants to the periphery in those years found it completely devoid of basic urban infrastructure and essential state services, a fact which Marques documents in detailed fashion. But after recounting the unfinished work of her comrades, Marques chooses to end her account of these years by evoking the poem's title, \"We are the veterans (veteranas) that confronted the dictatorship.\" To hear Odete Marques read her poem, click the audio clip below the following English translation. Collection: \"Songs of Revolution\" Special Exhibit. Audio: Odete Maria Ant\u00f4nia Marques, interview with Daniel McDonald, February 23, 2018, S\u00e3o Paulo, Brazil. English Translation by Daniel McDonald It was in the 1970s that it all began. We left our homes in search of addresses. We needed to research for the struggle to begin. Everything here was awful, no electricity, no water, no sewers no daycares, no schools, no health clinics. The need was vast, children in the street [exposed] to the sun, the rain, the moon. We began to rise, youths, women, and men in the hope of changing our country for the better. We suffered repression and from much doubt. For our group, the sacrifice was great. The terror of our comrades, fearing our imprisonment. There was even separation, but within our hearts the hope was great [for] we had much faith. With each victory, joy exploded in our assemblies, in our celebrations, in our prayers. God the father we thanked for our courage and stubbornness and for our unity. And now, so much time has passed and the struggle continues. She who the struggle embraced cannot falter. We embraced the party and we made it grow. Our children already have children and yet nothing is set in stone. We are the veterans that fought the dictatorship. And here in our country, we fight with love, trying to make happy the working people."], "mods_abstract_ssim": ["A gifted poet and singer, Odete Marques became an important grassroots leader in S\u00e3o Paulo's southern urban periphery during Brazil's military dictatorship (1964-1985). Born in 1940 in rural Minas Gerais State, Marques migrated to S\u00e3o Paulo with her husband in 1958 where they settled in its southern periphery. Marques was an early leader of the mothers' clubs (clubes de m\u00e3es), groups of women organized through the Catholic Church. In 1973, Odete Marques helped write an open letter from the mothers' clubs to Brazil's military dictator, Em\u00edlio M\u00e9dici, protesting high food prices and cost of living. That letter, addressed from the \"mothers of the periphery,\" triggered a regime crackdown on popular organizing but also gave rise to the largest popular movement of the dictatorship era, the Cost of Living Movement (Movimento do Custo de Vida). In this movement and others up to the present, Marques advocated for the rights of working people and women. Her poem, Veteranas (2001) or Veterans, narrates the rise of the mothers' clubs amid the dictatorship and her bittersweet memories of those years. Like much poetry in another language, meaning can be difficult to translate: even the title when rendered into English loses Marques's purposeful use of the feminine \"a\" to refer to her female comrades. Still, the poem translated below offers a unique glimpse into one leading activist's memories of women's organizing in the periphery during the dictatorship. The line \"we left our houses in search of addresses\" evokes the precarious title to their land that many rural migrants held in the periphery. Indeed, the millions of migrants to the periphery in those years found it completely devoid of basic urban infrastructure and essential state services, a fact which Marques documents in detailed fashion. 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Vaporization associated with impacting comets and asteroids controls much of the geophysical and compositional evolution of planetary systems. A sampling of planetary science problems traceable to impact vaporization phenomena include: generation and deposition of nanophase iron within lunar soil rims, the Moon-forming impact, the accretionary histories of the icy satellites, erosion of the early Martian atmosphere, target degassing consequences for the terrestrial biosphere from catastrophic impacts, and impact delivery of organics or volatiles to planetary surfaces. Numerical methods to constrain impact vaporization have made enormous strides over the past two decades, perhaps catalyzed (in part) by the fortuitous 1994 impact of Jupiter by Comet Shoemaker-Levy 9. Such planetary-scale impact \"experiments\" provide rare glimpses of the remarkable, high-energy vapor plumes released during impact events. Accurate modeling of impact-generated vapor, however, relies heavily upon the availability of robust equations of state and constitutive relations for the target and projectile materials of interest. Continued work to constrain the behavior of geologic materials at high temperatures and pressures, coupled with accelerating parallel computing capabilities, has opened up a new frontier of planetary-scale impact vaporization problems, as evidenced by recent, vigorous work on the Moon-forming impact. While numerical methods are powerful and necessary for considering planetary-magnitude events, experimental strategies to characterize impact vaporization remain critical for testing the roles of various impactor and target material models. Furthermore, modeling of oblique impacts remains relatively difficult and computationally expensive; certain experimentally resolved trends, including enhanced vaporization at lower incidence angles, are not yet captured numerically. Nature favors oblique impacts: the impact angle probability distribution peaks at 45 degrees. Hence, a comprehensive approach to impact vaporization problems will consider impacts beyond the frequently modeled 90 degree case. Here we employ a hybrid approach: both experimental and numerical methods provide complementary insights to impact vaporization phenomena. A wide range of planetary science problems are considered, but all are intimately tied to the way in which planetary surfaces and impactors vaporize."], "mods_abstract_ssim": ["Upon hypervelocity impact, projectile and target materials are frequently shocked to pressures and temperatures sufficient to induce complete vaporization. Vaporization associated with impacting comets and asteroids controls much of the geophysical and compositional evolution of planetary systems. A sampling of planetary science problems traceable to impact vaporization phenomena include: generation and deposition of nanophase iron within lunar soil rims, the Moon-forming impact, the accretionary histories of the icy satellites, erosion of the early Martian atmosphere, target degassing consequences for the terrestrial biosphere from catastrophic impacts, and impact delivery of organics or volatiles to planetary surfaces. Numerical methods to constrain impact vaporization have made enormous strides over the past two decades, perhaps catalyzed (in part) by the fortuitous 1994 impact of Jupiter by Comet Shoemaker-Levy 9. Such planetary-scale impact \"experiments\" provide rare glimpses of the remarkable, high-energy vapor plumes released during impact events. Accurate modeling of impact-generated vapor, however, relies heavily upon the availability of robust equations of state and constitutive relations for the target and projectile materials of interest. Continued work to constrain the behavior of geologic materials at high temperatures and pressures, coupled with accelerating parallel computing capabilities, has opened up a new frontier of planetary-scale impact vaporization problems, as evidenced by recent, vigorous work on the Moon-forming impact. While numerical methods are powerful and necessary for considering planetary-magnitude events, experimental strategies to characterize impact vaporization remain critical for testing the roles of various impactor and target material models. Furthermore, modeling of oblique impacts remains relatively difficult and computationally expensive; certain experimentally resolved trends, including enhanced vaporization at lower incidence angles, are not yet captured numerically. Nature favors oblique impacts: the impact angle probability distribution peaks at 45 degrees. Hence, a comprehensive approach to impact vaporization problems will consider impacts beyond the frequently modeled 90 degree case. Here we employ a hybrid approach: both experimental and numerical methods provide complementary insights to impact vaporization phenomena. A wide range of planetary science problems are considered, but all are intimately tied to the way in which planetary surfaces and impactors vaporize."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z08050Z0", "mods_id": "etd1350", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Syal, Megan B.", "Schultz, Peter", "Barr, Amy", "Pieters, Carle", "Mustard, John", "Meech, Karen", "Brown University. Geological Sciences"], "mods_role_ssim": ["creator", "Director", "Reader", "sponsor"], "mods_role_creator_ssim": ["Syal, Megan B."], "mods_name_nonplace_ssim": ["Syal, Megan B.", "Schultz, Peter", "Barr, Amy", "Pieters, Carle", "Mustard, John", "Meech, Karen", "Brown University. Geological Sciences"], "creator": ["Syal, Megan B."], "creator_string": ["Syal, Megan B."], "contributor_display": ["Syal, Megan B. (creator)", "Schultz, Peter (Director)", "Barr, Amy (Reader)", "Pieters, Carle (Reader)", "Mustard, John (Reader)", "Meech, Karen (Reader)", "Brown University. Geological Sciences (sponsor)"], "mods_role_director_ssim": ["Schultz, Peter"], "contributor": ["Schultz, Peter", "Barr, Amy", "Pieters, Carle", "Mustard, John", "Meech, Karen", "Brown University. Geological Sciences"], "contributor_string": ["Schultz, Peter", "Barr, Amy", "Pieters, Carle", "Mustard, John", "Meech, Karen", "Brown University. 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Geological Sciences"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xiv, 232 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "subject": ["Moon"], "mods_geographic_ssim": ["Moon"], "keyword": ["Impact Crater", "Vaporization", "Asteroid", "Comet", "Planetary science"], "mods_subject_ssim": ["Impact Crater", "Vaporization", "Asteroid", "Comet", "Planetary science"], "mods_subject_fast_ssim": ["Planetary science"], "mods_subject_joined_ssim": ["Impact Crater", "Vaporization", "Asteroid", "Comet", "Planetary science", "Moon"], "mods_subject_joined_fast_ssim": ["Planetary science", "Moon"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["Impact Vaporization: Experimental and Numerical Insights"], "mods_title_full_primary_tsi": "Impact Vaporization: Experimental and Numerical Insights", "primary_title": "Impact Vaporization: Experimental and Numerical Insights", "primary_title_txt_en_split": "Impact Vaporization: Experimental and Numerical Insights", "resource_type_ssi": "dissertations", "timestamp": "2021-11-23T11:47:31.263Z", "title_si": "Impact Vaporization: Experimental and Numerical Insights"}, {"pid": "bdr:386316", "fed_created_dsi": "2014-10-16T14:31:12.531Z", "object_created_dsi": "2014-10-16T14:31:12.531Z", "fed_last_modified_dsi": "2021-11-23T11:47:33.531Z", "object_last_modified_dsi": "2021-11-23T11:47:33.531Z", "storage_location_ssi": "ocfl", "datastreams_ssi": "{\"rightsMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 1103, \"checksum\": \"211b5c5b126abf23452930c732f50446b943584379c58f3dc29d353a7c450015854813ae68c4af6c57f3d9d291000be4552b3a41f1acb9517a0633ceb5355e6f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2018-07-06T16:49:56.346000Z\"}, \"EXTRACTED_TEXT\": {\"mimeType\": \"text/plain\", \"size\": 393009, \"checksum\": \"22128157e65315fdcb8bd12896ad8425e1734ce0b201eee801a011c8104336f3d9d150f3faeecd5e5e7640cb58a6a717e75bb10614ee091cb3d1f8f49fc9aa2f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-07-29T16:34:30.200000Z\"}, \"irMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 471, \"checksum\": \"5468cdf89bf462f3cb8b980fb28386d49a1c114a696f90590e6b15ee7d5631e09dc59ec3d0c544fe416910d0e0599cf559adbdac90f95d5d8e72cca46be09f7f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:31:12.531000Z\"}, \"DC\": {\"mimeType\": \"application/octet-stream\", \"size\": 339, \"checksum\": \"8dc05efbc15b3b11f89bc28263d2c6fe094d3bfbe8f327eac43caadbccd580e61aa5b744ae4b784774e8657f6ae562598637e2173e5da048c033467eff8c2084\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:31:12.531000Z\"}, \"RELS-INT\": {\"mimeType\": \"text/xml\", \"size\": 544, \"checksum\": \"8fb332990834a3b75629541d2c0e6b0b1e9d2e91b975ed183bb7d462d2ba550b3de5dbbbba71141ab6c56a58423928ee74986857407df5f33d395362ae2ec8be\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-07-29T16:34:30.325000Z\"}, \"MODS\": {\"mimeType\": \"text/xml\", \"size\": 6790, \"checksum\": \"b22381fcde47ae6d5cff13035f3660f2e14a71b4e1d226ee9490a671e3847724e320393c77347296f13fca60fee465efb7a2aae7328d5b1993da235737f13183\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-08-09T14:53:52.013319Z\"}, \"RELS-EXT\": {\"mimeType\": \"text/xml\", \"size\": 736, \"checksum\": \"e35cb747f4dfc03a9dd15e9df1fee352f41d770257b663a6993dafd5e8771c2e6985f46dfd92b87e7cfee8d5f35351c55495c33c8bc185bf2006c4d9ce289f3c\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-11-23T11:47:33.531168Z\"}, \"PDF\": {\"mimeType\": \"application/pdf\", \"size\": 15294524, \"checksum\": \"e8e75db464857826ac6d77cb7279fffda767e9dc763e741fa98010f3b07208692d09829abfb0f6e99f091839dac99eaf7eacf84811e3cc9d885fa16083f3225b\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:31:12.531000Z\"}, \"thumbnail\": {\"mimeType\": \"application/octet-stream\", \"size\": 2300, \"checksum\": \"e931c08bba2fac501f711065619e6b0c0772109edb85dcd5fc8f452733a1043159b8f287206fc9df2bc1c7eb7992c709f162e5f75eece5ed14a173e0a1781dbf\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2015-07-28T13:40:52.915000Z\"}}", "fed_object_size_lsi": 15699816, "object_size_lsi": 15699816, "rel_content_models_ssim": ["commonMetadata", "pdf"], "rel_object_type_ssi": "pdf", "object_type": "pdf", "rel_is_member_of_collection_ssim": ["bdr:2rdc7d9g"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "rel_embargo_years_ssim": ["2016"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [315], "ir_collection_name": ["Biology and Medicine", "Pathobiology", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["Neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as Neutrophil Extracellular Traps (NETs). The receptor:ligand interactions and intracellular signaling mechanisms responsible for elaborating NETs were determined for the response to Candida albicans. Since the host response of extravasated neutrophils to mycotic infections within tissues necessitates contact with ECM, this study also identified a novel and significant regulatory role for the ubiquitous matrix component fibronectin (Fn) in NET release. We report that recognition of purified fungal pathogen-associated molecular pattern \u03b2-glucan by human neutrophils causes rapid (\u2264 30 mins) homotypic aggregation and NET release by a mechanism that requires Fn. Alone, immobilized \u03b2-glucan induces reactive oxygen species (ROS) production but not NET release, whereas in the context of Fn, ROS production is suppressed and NETs are extruded. NET release to Fn + \u03b2-glucan is robust, accounting for 17.2 \u00b1 3.4% of total DNA in the cell population. Release is dependent on \u03b2-glucan recognition by CR3 (CD11b/CD18), but not Dectin-1, or ROS. The process of NET release included filling of intracellular vesicles with nuclear material that was eventually extruded. We identify a role for ERK in homotypic aggregation and NET release. NET formation to C. albicans hyphae was also found to depend on \u03b2-glucan recognition by CR3, require Fn and ERK but not ROS, and results in hyphal destruction. We report a new regulatory mechanism of NETosis in which the extracellular matrix is a key component of the rapid anti-fungal response. We also report that neonatal neutrophils formed aggregates and released NETs rapidly and independent of ROS production. Providing additional evidence of the ROS independent mechanism of aggregation and NET release, neutrophils from Chronic Granulomatous Disease (CGD) patients formed large homotypic aggregates and released NETs to \u03b2-glucan and Fn. Therefore, the susceptibility of these immunocompromised populations to fungal infections may not be due to an inherent inability of neutrophils to aggregate and produce NETs in response to the fungal PAMP \u03b2-glucan. Ultimately, we hope innovative therapeutic approaches can mediate a regulatory balance in immunocompromised patients to improve health outcomes."], "mods_abstract_ssim": ["Neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as Neutrophil Extracellular Traps (NETs). The receptor:ligand interactions and intracellular signaling mechanisms responsible for elaborating NETs were determined for the response to Candida albicans. Since the host response of extravasated neutrophils to mycotic infections within tissues necessitates contact with ECM, this study also identified a novel and significant regulatory role for the ubiquitous matrix component fibronectin (Fn) in NET release. We report that recognition of purified fungal pathogen-associated molecular pattern \u03b2-glucan by human neutrophils causes rapid (\u2264 30 mins) homotypic aggregation and NET release by a mechanism that requires Fn. Alone, immobilized \u03b2-glucan induces reactive oxygen species (ROS) production but not NET release, whereas in the context of Fn, ROS production is suppressed and NETs are extruded. NET release to Fn + \u03b2-glucan is robust, accounting for 17.2 \u00b1 3.4% of total DNA in the cell population. Release is dependent on \u03b2-glucan recognition by CR3 (CD11b/CD18), but not Dectin-1, or ROS. The process of NET release included filling of intracellular vesicles with nuclear material that was eventually extruded. We identify a role for ERK in homotypic aggregation and NET release. NET formation to C. albicans hyphae was also found to depend on \u03b2-glucan recognition by CR3, require Fn and ERK but not ROS, and results in hyphal destruction. We report a new regulatory mechanism of NETosis in which the extracellular matrix is a key component of the rapid anti-fungal response. We also report that neonatal neutrophils formed aggregates and released NETs rapidly and independent of ROS production. Providing additional evidence of the ROS independent mechanism of aggregation and NET release, neutrophils from Chronic Granulomatous Disease (CGD) patients formed large homotypic aggregates and released NETs to \u03b2-glucan and Fn. Therefore, the susceptibility of these immunocompromised populations to fungal infections may not be due to an inherent inability of neutrophils to aggregate and produce NETs in response to the fungal PAMP \u03b2-glucan. Ultimately, we hope innovative therapeutic approaches can mediate a regulatory balance in immunocompromised patients to improve health outcomes."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0VQ312H", "mods_id": "etd1353", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Byrd, Angel Shree'", "Reichner, Jonathan", "Gruppuso, Philip", "Sanders, Jennifer", "Frackelton, A. Raymond", "Salomon, Arthur", "Brown University. BIOMED: Pathobiology"], "mods_role_ssim": ["creator", "Director", "Reader", "sponsor"], "mods_role_creator_ssim": ["Byrd, Angel Shree'"], "mods_name_nonplace_ssim": ["Byrd, Angel Shree'", "Reichner, Jonathan", "Gruppuso, Philip", "Sanders, Jennifer", "Frackelton, A. Raymond", "Salomon, Arthur", "Brown University. BIOMED: Pathobiology"], "creator": ["Byrd, Angel Shree'"], "creator_string": ["Byrd, Angel Shree'"], "contributor_display": ["Byrd, Angel Shree' (creator)", "Reichner, Jonathan (Director)", "Gruppuso, Philip (Reader)", "Sanders, Jennifer (Reader)", "Frackelton, A. Raymond (Reader)", "Salomon, Arthur (Reader)", "Brown University. BIOMED: Pathobiology (sponsor)"], "mods_role_director_ssim": ["Reichner, Jonathan"], "contributor": ["Reichner, Jonathan", "Gruppuso, Philip", "Sanders, Jennifer", "Frackelton, A. Raymond", "Salomon, Arthur", "Brown University. 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BIOMED: Pathobiology"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xlix, 237 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["NEONATES", "CGD", "MYELOPOEISIS", "ECM", "and NETS", "Newborn infants", "Phagocytes", "Granulocytes", "Colegio de Me\u0301xico"], "mods_subject_ssim": ["NEONATES", "CGD", "MYELOPOEISIS", "ECM", "and NETS", "Newborn infants", "Phagocytes", "Granulocytes", "Colegio de Me\u0301xico"], "mods_subject_fast_ssim": ["Newborn infants", "Phagocytes", "Granulocytes", "Colegio de Me\u0301xico"], "mods_subject_joined_ssim": ["NEONATES", "CGD", "MYELOPOEISIS", "ECM", "and NETS", "Newborn infants", "Phagocytes", "Granulocytes", "Colegio de Me\u0301xico"], "mods_subject_joined_fast_ssim": ["Newborn infants", "Phagocytes", "Granulocytes", "Colegio de Me\u0301xico"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["Abstract of, \u201cRegulation of Human Neutrophil Functions by the Integrin, CR3 \u2013 An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation\u201d by Angel S. Byrd, Ph.D., Brown University, May 2014"], "mods_title_full_primary_tsi": "Abstract of, \u201cRegulation of Human Neutrophil Functions by the Integrin, CR3 \u2013 An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation\u201d by Angel S. Byrd, Ph.D., Brown University, May 2014", "primary_title": "Abstract of, \u201cRegulation of Human Neutrophil Functions by the Integrin, CR3 \u2013 An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation\u201d by Angel S. Byrd, Ph.D., Brown University, May 2014", "primary_title_txt_en_split": "Abstract of, \u201cRegulation of Human Neutrophil Functions by the Integrin, CR3 \u2013 An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation\u201d by Angel S. Byrd, Ph.D., Brown University, May 2014", "resource_type_ssi": "dissertations", "timestamp": "2021-11-23T11:47:34.564Z", "title_si": "Abstract of, \u201cRegulation of Human Neutrophil Functions by the Integrin, CR3 \u2013 An Extracellular Matrix-Based Mechanism of Rapid Neutrophil Extracellular Trap Formation\u201d by Angel S. 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I address this question by generating millennial- and orbital-scale leaf wax hydrogen isotope (\u03b42Hwax) records spanning a climate gradient in East Asia. Orbital-scale isotope-enabled transient climate model data demonstrate that temperature has a significant impact on orbital-scale precipitation isotopes throughout China. I use independent molecular temperature records to remove the effect of temperature from \u03b42Hwax, yielding records that reflect source area and transport history, two factors related to atmospheric circulation. These records suggest that the mechanisms that influence orbital-scale circulation differ by region. In southern China, circulation is controlled by Northern Hemisphere insolation with a minor influence of ice volume. In central China, circulation is more strongly influenced by ice volume due to proximity to the mid-latitude westerly winds, the strength of which is tightly linked to Northern Hemisphere ice volume. These results highlight the importance of considering temperature and regionally variable precipitation seasonality and source dynamics when interpreting East Asian precipitation isotope records. A 32,000 year-long core from Lake Qinghai provides an opportunity to study the interaction of westerly and monsoon air masses on the northeastern Tibetan Plateau. I use \u03b42Hwax to distinguish between isotopically distinct source areas, and leaf wax carbon isotopes to reconstruct plant ecosystem changes. The cold, arid glacial period was dominated by westerly precipitation and by cold-adapted C3 plants. During the Lateglacial and early Holocene, higher summer insolation caused monsoon circulation to reach the northeastern Tibetan Plateau. The resulting warm, wet summers allowed warm-adapted C4 plants to thrive in this region. Millennial-scale cool, arid events superimposed on the deglacial warming and wetting were likely forced by North Atlantic freshwater pulses. 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I use \u03b42Hwax to distinguish between isotopically distinct source areas, and leaf wax carbon isotopes to reconstruct plant ecosystem changes. The cold, arid glacial period was dominated by westerly precipitation and by cold-adapted C3 plants. During the Lateglacial and early Holocene, higher summer insolation caused monsoon circulation to reach the northeastern Tibetan Plateau. The resulting warm, wet summers allowed warm-adapted C4 plants to thrive in this region. Millennial-scale cool, arid events superimposed on the deglacial warming and wetting were likely forced by North Atlantic freshwater pulses. This suite of temperature and stable isotope paleoclimate records in East Asia enhances our understanding of climate and ecosystem dynamics on a range of time scales. 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The assembly of mitochondrial enzyme complexes that produce the majority of cellular energy require the coordinated expression and translation of both mitochondrial and nuclear encoded proteins. The joint genetic architecture of this system complicates the basis of mitochondrial diseases, and mutations in both mtDNA- and nuclear-encoded genes have been implicated in mitochondrial dysfunction. Previously, in a set of mitochondrial-nuclear introgression strains we characterized a dual genome epistasis in which a naturally occurring mutation in the D. simulans simw501 mtDNA interacts with a mutation in the nuclear encoded mitochondrial localized tyrosyl-tRNA synthetase from D. melanogaster. Each SNP alone does not have a large fitness effect, but when co-expressed a suite of deleterious phenotypes are seen. Here we show that the incompatible mitochondrial-nuclear combination results in locomotor defects, reduced mitochondrial respiratory capacity, decreased OXPHOS enzyme activity, and sever alterations in mitochondrial morphology. Transgenic rescue strains containing nuclear variants of the tyrosyl-tRNA synthetase are sufficient to rescue many of the deleterious phenotypes identified when paired with the simw501 mtDNA. This study provides a mitochondrial-nuclear introgression model that can be effectively used to dissect the molecular basis of mitochondrial diseases and provide insight into the joint genetic architecture of mitochondrial function and translation."], "mods_abstract_ssim": ["Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes that produce the majority of cellular energy require the coordinated expression and translation of both mitochondrial and nuclear encoded proteins. The joint genetic architecture of this system complicates the basis of mitochondrial diseases, and mutations in both mtDNA- and nuclear-encoded genes have been implicated in mitochondrial dysfunction. Previously, in a set of mitochondrial-nuclear introgression strains we characterized a dual genome epistasis in which a naturally occurring mutation in the D. simulans simw501 mtDNA interacts with a mutation in the nuclear encoded mitochondrial localized tyrosyl-tRNA synthetase from D. melanogaster. Each SNP alone does not have a large fitness effect, but when co-expressed a suite of deleterious phenotypes are seen. Here we show that the incompatible mitochondrial-nuclear combination results in locomotor defects, reduced mitochondrial respiratory capacity, decreased OXPHOS enzyme activity, and sever alterations in mitochondrial morphology. Transgenic rescue strains containing nuclear variants of the tyrosyl-tRNA synthetase are sufficient to rescue many of the deleterious phenotypes identified when paired with the simw501 mtDNA. 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In this dissertation, a new measure of expected house price appreciation is developed based on variation in household level tenure choice decisions. I provide evidence of the role that shifts in expectations played in the U.S. housing boom and bust of 1996-2011, and exploit cross-sectional variation in expectations to investigate the determinants of household forecasts of house price appreciation. Metropolitan area level expectations are found to be related to fundamental demand drivers, housing supply elasticity, and historical price appreciation trends. I next turn to the question of the extent to which anticipated capital gains from housing are a direct driver of the price to rent relationship. A quasi-experimental setting in which supply elasticities are altered across towns in Massachusetts is brought to bear on this question in conjunction with the novel measure of expected house price appreciation. A two-stage least squares approach demonstrates that OLS estimates of the capitalization of expectations into house prices were significantly downward biased, and that a one to one relationship is largely supported. Finally, I exploit the changes in the urban landscape wrought by this period of rapid construction to answer the question of how tightly firms must cluster to receive the benefits of agglomeration. The magnitude of productivity differences driven by variation in the within city density of economic activity are estimated using both wage and output data. Results demonstrate that proximity of firms in the central business district, rather than the overall presence of a sector in the broader metropolitan area, drive estimated agglomeration effects."], "mods_abstract_ssim": ["Changing expectations of future house price growth are thought to play an important role in housing boom and bust cycles, but investigating such hypotheses is difficult as expectations are not directly observable. In this dissertation, a new measure of expected house price appreciation is developed based on variation in household level tenure choice decisions. I provide evidence of the role that shifts in expectations played in the U.S. housing boom and bust of 1996-2011, and exploit cross-sectional variation in expectations to investigate the determinants of household forecasts of house price appreciation. Metropolitan area level expectations are found to be related to fundamental demand drivers, housing supply elasticity, and historical price appreciation trends. I next turn to the question of the extent to which anticipated capital gains from housing are a direct driver of the price to rent relationship. A quasi-experimental setting in which supply elasticities are altered across towns in Massachusetts is brought to bear on this question in conjunction with the novel measure of expected house price appreciation. A two-stage least squares approach demonstrates that OLS estimates of the capitalization of expectations into house prices were significantly downward biased, and that a one to one relationship is largely supported. Finally, I exploit the changes in the urban landscape wrought by this period of rapid construction to answer the question of how tightly firms must cluster to receive the benefits of agglomeration. The magnitude of productivity differences driven by variation in the within city density of economic activity are estimated using both wage and output data. Results demonstrate that proximity of firms in the central business district, rather than the overall presence of a sector in the broader metropolitan area, drive estimated agglomeration effects."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z01G0JNB", "mods_id": "etd1343", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Suher, Michael Banks", "Baum-Snow, Nathaniel", "Henderson, John", "Eggertsson, Gauti", "Brown University. 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Such users can send probe traffic to develop inferences about the network's present state, yet they cannot directly contact the control-plane for answers because of security or privacy concerns. In addition to reading the control-plane's state, modern applications have increasing need to write configuration state as well. These applications, running in home, campus, and datacenter networks, know what they need from the network, yet cannot convey such intentions to the control-plane. This dissertation introduces participatory networking, a novel platform for delegating read and write authority from a network's administrators to end users, or applications and devices acting on their behalf. Users can then work with the network, rather than around it, to achieve better performance, security, or predictable behavior. Our platform's design addresses the two key challenges: how to safely decompose control and visibility of the network, and how to resolve conflicts between untrusted users and across requests, while maintaining baseline levels of fairness and security. We present a prototype implementation of participatory networking, structured as an API and controller for OpenFlow-based software-defined networks (SDNs). We call our controller PANE, and demonstrate its usefulness by experiments with four real applications (Ekiga, SSHGuard, ZooKeeper, and Hadoop), and its practicality through microbenchmarks. Furthermore, we develop a mechanical proof for a key portion of PANE, the first for an SDN controller. Unfortunately, network administrators interested in using SDN controllers such as PANE to manage the network face the herculean challenge of migrating existing policy to the new platform. To lessen this challenge, this dissertation introduces Exodus, the first tool for directly translating existing network configurations in languages such as Cisco IOS and Linux iptables to SDN controller software. These controllers are written in Flowlog, a novel, rule-based, tierless language for SDNs we significantly enhance for Exodus. Automatic migration of existing configurations into SDN controllers has exposed several limitations in both today's languages for SDN programming, and OpenFlow itself. This dissertation explores these limits, and provides guidance on SDN migration and necessary switch features."], "mods_abstract_ssim": ["In today's networks, non-administrative users have little interaction with a network's control-plane. Such users can send probe traffic to develop inferences about the network's present state, yet they cannot directly contact the control-plane for answers because of security or privacy concerns. 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We present a prototype implementation of participatory networking, structured as an API and controller for OpenFlow-based software-defined networks (SDNs). We call our controller PANE, and demonstrate its usefulness by experiments with four real applications (Ekiga, SSHGuard, ZooKeeper, and Hadoop), and its practicality through microbenchmarks. Furthermore, we develop a mechanical proof for a key portion of PANE, the first for an SDN controller. Unfortunately, network administrators interested in using SDN controllers such as PANE to manage the network face the herculean challenge of migrating existing policy to the new platform. To lessen this challenge, this dissertation introduces Exodus, the first tool for directly translating existing network configurations in languages such as Cisco IOS and Linux iptables to SDN controller software. These controllers are written in Flowlog, a novel, rule-based, tierless language for SDNs we significantly enhance for Exodus. 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In order to evaluate the sources and chemistry of NOx, models often compare to observed NO3- concentrations, but many questions remain about the balance of NOx sources. The isotopes of NO3- provide more information than concentration alone, potentially allowing for a quantitative measure of the influence of NOx sources on NO3- deposition. Ice core records of NO3- preserved in snow may provide a record of past NOx, however, NO3- is reversibly deposited to snow and interpretation over time requires understanding NO3- preservation. The preservation of NO3- in snow at Summit, Greenland was investigated by measurement of NO3- concentration and isotopic composition at high temporal-resolution in surface snow. A strong, linear relationship was found between the oxygen isotopes of NO3- that cannot be explained in the presence of significant post-depositional alteration of NO3-. Additionally, a suite of atmospheric constituents was measured and none show correlation with the isotopes or concentration of NO3- in the snow, indicating that the NO3- is regionally, rather than locally, derived. When the nitrogen isotopes of NO3- are compared to the oxygen isotopes, the data show a mixing of three isotopically distinct NO3- sources characterized best as: 1) influenced by the stratosphere, 2) derived from mid-latitude sources and 3) local anthropogenic pollution from the field station. Using the nitrogen isotopes of NO3- to quantitatively distinguish these sources is difficult, however, until a better inventory of the nitrogen isotopes of NOx from various emissions sources exists. To that end, a new method was developed to collect NOx for isotopic evaluation. This method is the first NOx isotopic method to be tested in the laboratory for consistency under a variety of conditions. 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line, an external sensory system composed of a network of hair cells arranged along the skin of fishes and aquatic amphibians, plays an important role in orientation and navigation in the aquatic environment. 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Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["The rapid advance proton exchange membrane fuel cell technology demand highly efficient platinum based nanoscale electrocatalysts for fuel cell reactions. In this dissertation, monodisperse nanoparticles were successfully synthesized using organic solution phase synthesis methods. Not only the particle size, shape and composition were precisely controlled, but also the electronic properties of the surface atoms were finely tuned to reach the optimal catalytic performance. Moreover, Pt single crystals and sputtered thin films provide a unique insight into the structure-function relationship of the complex nanoparticle surfaces. First, pure Pt nanoparticles were used as a model catalyst to explore the best surface cleaning method for nanoparticle activation. The particle size and shape effects on oxygen reduction reaction (ORR) at fuel cell cathode were studied to optimize particle activity and stability in the ORR condition. Pt alloy nanoparticles and nanowires with Pt skin layer structure were produced with enhanced ORR activity. To minimize the Pt use, core/shell structured Au/PtM (M=Fe, Co, Cu\u2026.) nanoparticles were designed and synthesized. These core/shell nanocatalysts demonstrated tunable activities with much enhanced stability. Furthermore, Pt3Sn nanoparticles were also developed as catalyst at anode to catalyze methanol oxidation reaction (MOR). They exhibited enhanced CO tolerance and were promising next generation anode catalyst for MOR."], "mods_abstract_ssim": ["The rapid advance proton exchange membrane fuel cell technology demand highly efficient platinum based nanoscale electrocatalysts for fuel cell reactions. In this dissertation, monodisperse nanoparticles were successfully synthesized using organic solution phase synthesis methods. Not only the particle size, shape and composition were precisely controlled, but also the electronic properties of the surface atoms were finely tuned to reach the optimal catalytic performance. Moreover, Pt single crystals and sputtered thin films provide a unique insight into the structure-function relationship of the complex nanoparticle surfaces. First, pure Pt nanoparticles were used as a model catalyst to explore the best surface cleaning method for nanoparticle activation. The particle size and shape effects on oxygen reduction reaction (ORR) at fuel cell cathode were studied to optimize particle activity and stability in the ORR condition. Pt alloy nanoparticles and nanowires with Pt skin layer structure were produced with enhanced ORR activity. To minimize the Pt use, core/shell structured Au/PtM (M=Fe, Co, Cu\u2026.) nanoparticles were designed and synthesized. These core/shell nanocatalysts demonstrated tunable activities with much enhanced stability. Furthermore, Pt3Sn nanoparticles were also developed as catalyst at anode to catalyze methanol oxidation reaction (MOR). They exhibited enhanced CO tolerance and were promising next generation anode catalyst for MOR."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z089146C", "mods_id": "etd1284", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Li, Dongguo", "Shouheng, Sun", "Wesley, Bernskoetter", "Lai-Sheng, Wang", "Brown University. 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Chemistry"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xxiv, 209 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["oxygen reduction reaction", "Catalysis", "Platinum", "Fuel cells", "Electrochemistry"], "mods_subject_ssim": ["oxygen reduction reaction", "Catalysis", "Platinum", "Fuel cells", "Electrochemistry"], "mods_subject_fast_ssim": ["Catalysis", "Platinum", "Fuel cells", "Electrochemistry"], "mods_subject_joined_ssim": ["oxygen reduction reaction", "Catalysis", "Platinum", "Fuel cells", "Electrochemistry"], "mods_subject_joined_fast_ssim": ["Catalysis", "Platinum", "Fuel cells", "Electrochemistry"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["Platinum Based Electrocatalysts for Proton Exchange Membrane Fuel Cells"], "mods_title_full_primary_tsi": "Platinum Based Electrocatalysts for Proton Exchange Membrane Fuel Cells", "primary_title": "Platinum Based 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"_display_public_bsi": true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["Stimulation of estrogen receptor (ER)-negative human breast cancer cells with 17\u03b2-estradiol (E2\u03b2) results in fibronectin (FN) matrix assembly and transactivation of the epidermal growth factor receptor (EGFR) via the G protein-coupled estrogen receptor (GPER). This mechanism of action results in the recruitment of FN-engaged integrin \u03b15\u03b21 to fibrillar adhesions and the formation of integrin \u03b15\u03b21-Shc adaptor protein complexes. Here, we show that GPER stimulation of murine 4T1 or human SKBR3 breast cancer cells promotes the formation of focal adhesions, actin stress fibers, and results in increased cellular adhesion and haptotaxis on FN, but not collagen. These actions are also induced by the xenoestrogen, bisphenol A, and the ER antagonist, ICI 182, 780, but not the inactive stereoisomer, 17\u03b1-estradiol (E2\u03b1). In addition, we show that GPER stimulation of breast cancer cells allows for FN-dependent, anchorage-independent growth and FN fibril formation in hanging drop assays, indicating that these GPER-mediated actions occur independently of adhesion to solid substrata. Furthermore, stable expression of Shc mutant Y317F lacking its primary tyrosyl phosphorylation site disrupts E2\u03b2-induced focal adhesion and actin stress fiber formation, and abolishes E2\u03b2-enhanced haptotaxis on FN and anchorage-dependent growth. We also show that overexpression of a phosphatase, PTPN12, known to interact with Shc inhibits focal adhesion and FN fibril formation, adhesion and haptotaxis on FN, and anchorage independent growth. Moreover, PTPN12 knockdown positively influences these events associated with cellular survival. Collectively, these data demonstrate that E2\u03b2 action via GPER enhances cellular adhesivity and FN matrix assembly and allows for anchorage-independent growth, cellular events that may allow for cellular survival and tumor progression."], "mods_abstract_ssim": ["Stimulation of estrogen receptor (ER)-negative human breast cancer cells with 17\u03b2-estradiol (E2\u03b2) results in fibronectin (FN) matrix assembly and transactivation of the epidermal growth factor receptor (EGFR) via the G protein-coupled estrogen receptor (GPER). This mechanism of action results in the recruitment of FN-engaged integrin \u03b15\u03b21 to fibrillar adhesions and the formation of integrin \u03b15\u03b21-Shc adaptor protein complexes. Here, we show that GPER stimulation of murine 4T1 or human SKBR3 breast cancer cells promotes the formation of focal adhesions, actin stress fibers, and results in increased cellular adhesion and haptotaxis on FN, but not collagen. These actions are also induced by the xenoestrogen, bisphenol A, and the ER antagonist, ICI 182, 780, but not the inactive stereoisomer, 17\u03b1-estradiol (E2\u03b1). In addition, we show that GPER stimulation of breast cancer cells allows for FN-dependent, anchorage-independent growth and FN fibril formation in hanging drop assays, indicating that these GPER-mediated actions occur independently of adhesion to solid substrata. Furthermore, stable expression of Shc mutant Y317F lacking its primary tyrosyl phosphorylation site disrupts E2\u03b2-induced focal adhesion and actin stress fiber formation, and abolishes E2\u03b2-enhanced haptotaxis on FN and anchorage-dependent growth. We also show that overexpression of a phosphatase, PTPN12, known to interact with Shc inhibits focal adhesion and FN fibril formation, adhesion and haptotaxis on FN, and anchorage independent growth. Moreover, PTPN12 knockdown positively influences these events associated with cellular survival. Collectively, these data demonstrate that E2\u03b2 action via GPER enhances cellular adhesivity and FN matrix assembly and allows for anchorage-independent growth, cellular events that may allow for cellular survival and tumor progression."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z03J3BB8", "mods_id": "etd1293", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Magruder, Hilary", "Filardo, Edward", "Reichner, Jonathan", "Freiman, Richard", "Yang, Wentian", "Prossnitz, Eric", "Brown University. 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BIOMED: Pathobiology"], "mods_role_reader_ssim": ["Reichner, Jonathan", "Freiman, Richard", "Yang, Wentian", "Prossnitz, Eric"], "mods_role_sponsor_ssim": ["Brown University. BIOMED: Pathobiology"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xix, 207 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["estrogen receptor (ER)", "fibronectin (FN)", "G protein-coupled Estrogen Receptor (GPER)", "breast cancer", "Estrogen", "Breast--Cancer"], "mods_subject_ssim": ["estrogen receptor (ER)", "fibronectin (FN)", "G protein-coupled Estrogen Receptor (GPER)", "breast cancer", "Estrogen", "Breast--Cancer"], "mods_subject_fast_ssim": ["Estrogen", "Breast--Cancer"], "mods_subject_joined_ssim": ["estrogen receptor (ER)", "fibronectin (FN)", "G protein-coupled Estrogen Receptor (GPER)", "breast cancer", "Estrogen", "Breast--Cancer"], "mods_subject_joined_fast_ssim": ["Estrogen", "Breast--Cancer"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["Signaling Effectors Required for G Protein-Coupled Estrogen Receptor-, GPER, Induced Events Associated with Breast Cancer 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These enzymes must complete their required task and coordinate with one another to faithfully repair DNA. Deficiencies and incorrect coordination of BER enzymes has been linked to development of several cancers and neurological disorders. Repair of an 8-oxo-7,8-dihydroguanine (8oxoG) lesion within the CAG trinucleotide repeat tract of the huntingtin gene by BER, is implicated in expansion of the repeat tract leading to Huntington\u2019s disease (HD). In this work, we employ transient-state and steady-state kinetic techniques to provide insight into the molecular mechanisms and substrate specificity of BER enzymes to better understand the disorders that arise due to incorrect repair. Moreover, we center our work on examining kinetics of BER enzymes on CAG repeat containing DNA to provide insight into the molecular mechanism of repeat expansion seen in HD. Through examination of kinetics of removal of an 8oxoG lesion by the DNA glycosylase oxoguanine glycosylase 1 (OGG1) from CAG repeat and non-repetitive sequences, and of coordination of OGG1 with APE1, we revealed that BER is initiated by OGG1 and coordinated with APE1 on CAG repeat sequences as well as on non-repetitive sequences. We further examined kinetics of APE1 cleaving DNA on authentic DNA substrates, and commonly used DNA analogs. Kinetics revealed APE1 incises DNA at rate \u2265 700 s-1, making APE1 one of the faster BER enzymes. We observed differences in the rate of APE1 incision on authentic DNA substrate, compared to commonly used analogs. Finally, we examined kinetics of pol \u03b2 incorporating single and multiple nucleotides on CAG repeat and non-repetitive DNA sequences. While we observed similar kinetics for pol \u03b2 single-nucleotide incorporation on CAG repeat and non-repetitive sequences, we observed difference in multinucleotide incorporation on CAG repeat versus non-repetitive sequences. The experiments performed here expand our understanding of the action of several BER enzymes, and provide further insight into the molecular mechanism of CAG repeat expansion seen in HD."], "mods_abstract_ssim": ["The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase \u03b2 (pol \u03b2) and a DNA ligase, and is responsible for repairing single nucleobase and AP site lesions. These enzymes must complete their required task and coordinate with one another to faithfully repair DNA. Deficiencies and incorrect coordination of BER enzymes has been linked to development of several cancers and neurological disorders. Repair of an 8-oxo-7,8-dihydroguanine (8oxoG) lesion within the CAG trinucleotide repeat tract of the huntingtin gene by BER, is implicated in expansion of the repeat tract leading to Huntington\u2019s disease (HD). In this work, we employ transient-state and steady-state kinetic techniques to provide insight into the molecular mechanisms and substrate specificity of BER enzymes to better understand the disorders that arise due to incorrect repair. Moreover, we center our work on examining kinetics of BER enzymes on CAG repeat containing DNA to provide insight into the molecular mechanism of repeat expansion seen in HD. Through examination of kinetics of removal of an 8oxoG lesion by the DNA glycosylase oxoguanine glycosylase 1 (OGG1) from CAG repeat and non-repetitive sequences, and of coordination of OGG1 with APE1, we revealed that BER is initiated by OGG1 and coordinated with APE1 on CAG repeat sequences as well as on non-repetitive sequences. We further examined kinetics of APE1 cleaving DNA on authentic DNA substrates, and commonly used DNA analogs. Kinetics revealed APE1 incises DNA at rate \u2265 700 s-1, making APE1 one of the faster BER enzymes. We observed differences in the rate of APE1 incision on authentic DNA substrate, compared to commonly used analogs. Finally, we examined kinetics of pol \u03b2 incorporating single and multiple nucleotides on CAG repeat and non-repetitive DNA sequences. While we observed similar kinetics for pol \u03b2 single-nucleotide incorporation on CAG repeat and non-repetitive sequences, we observed difference in multinucleotide incorporation on CAG repeat versus non-repetitive sequences. The experiments performed here expand our understanding of the action of several BER enzymes, and provide further insight into the molecular mechanism of CAG repeat expansion seen in HD."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0KH0KPH", "mods_id": "etd1298", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Schermerhorn, Kelly", "Delaney, Sarah", "Cane, David", "Basu, Amit", "Brown University. 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It has been observed that people believe they understand causal workings in more detail than they actually do. Despite the fact that our knowledge of causal systems is often skeletal in nature, we oftentimes remain capable of successfully navigating the complex systems for which we lack detailed, mechanistic knowledge. To explain this phenomenon, it is proposed that people employ the domain-matching heuristic. Over time, we learn and refine the associations by which different kinds of causes lead to different kinds of effects, in accord with how similar we believe their supposed mechanisms are. By matching the mechanism domains between specific causes and effects, we are able to dramatically reduce our search space during various types of causal reasoning, as in these cases our attention is focused on likely relations. A clustering study reveals three domains of causal mechanisms in the space of artifacts: the mechanical, the chemical, and the electromagnetic. In a series of experiments, these domains are evaluated in the context of causal attribution, prediction, believability judgment, and subjective understanding. The findings show that mechanism domains offer a unified and economical representation that can predict human performance across a variety of tasks. The domain-matching heuristic offers a way of thinking about causality that does not require theoretical knowledge; instead, it relies upon a set of abstract representations that reflect the true nature of underlying mechanisms."], "mods_abstract_ssim": ["This thesis introduces mechanism domains as a cognitive representation underlying causal reasoning. It has been observed that people believe they understand causal workings in more detail than they actually do. Despite the fact that our knowledge of causal systems is often skeletal in nature, we oftentimes remain capable of successfully navigating the complex systems for which we lack detailed, mechanistic knowledge. To explain this phenomenon, it is proposed that people employ the domain-matching heuristic. Over time, we learn and refine the associations by which different kinds of causes lead to different kinds of effects, in accord with how similar we believe their supposed mechanisms are. By matching the mechanism domains between specific causes and effects, we are able to dramatically reduce our search space during various types of causal reasoning, as in these cases our attention is focused on likely relations. A clustering study reveals three domains of causal mechanisms in the space of artifacts: the mechanical, the chemical, and the electromagnetic. In a series of experiments, these domains are evaluated in the context of causal attribution, prediction, believability judgment, and subjective understanding. The findings show that mechanism domains offer a unified and economical representation that can predict human performance across a variety of tasks. The domain-matching heuristic offers a way of thinking about causality that does not require theoretical knowledge; instead, it relies upon a set of abstract representations that reflect the true nature of underlying mechanisms."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0HQ3X8V", "mods_id": "etd1282", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Goldin, Gideon", "Sloman, Steven", "Krueger, Joachim", "Austerweil, Joseph", "Brown University. 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Unfortunately, natural stimuli lack any clear parameterization, and therefore many of those experiments are difficult to control, analyze, and interpret. This led investigators to interpret their results using abstract and general theories that lack quantitative predictions. Moreover, these interpretations are sometimes inconsistent with predictions from perceptual categorization models, since it is unclear how these models can be applied to natural stimuli. In this thesis we bridge the gap between categorization models and natural scenes categorization experiments, and show that rapid visual categorization results are a simple outcome of discriminability between two categories. Towards this, we derive a simple measure of natural scene discriminability using a decision boundary, learned over a rudimentary visual representation. We then measure the difficulty of classifying an individual image, by measuring its distance to the decision boundary. Empirical distributions of discriminability values are used to predict human accuracy and reaction times across tasks and stimuli sets. We then extend the model to predict full reaction time distributions. Using a combination of simulations and psychophysics experiments, we validate the model assumptions, show that it is consistent with a large set of published results, and predict novel categorization effects. Our work greatly improves on the current status in several aspects: First, the theory generates quantitative and testable predictions of human's speed and accuracy in natural scene categorization tasks, both at the single image level and the category level; second, it allows to control and design experiments based on measurable visual information; third, it provides a simple, elegant, and intuitive interpretation of novel and existing results based on discriminability between targets and distractors."], "mods_abstract_ssim": ["In the last couple of decades, categorization experiments using natural images have started to unravel the way our brain represents and categorizes visual information. Unfortunately, natural stimuli lack any clear parameterization, and therefore many of those experiments are difficult to control, analyze, and interpret. This led investigators to interpret their results using abstract and general theories that lack quantitative predictions. Moreover, these interpretations are sometimes inconsistent with predictions from perceptual categorization models, since it is unclear how these models can be applied to natural stimuli. In this thesis we bridge the gap between categorization models and natural scenes categorization experiments, and show that rapid visual categorization results are a simple outcome of discriminability between two categories. Towards this, we derive a simple measure of natural scene discriminability using a decision boundary, learned over a rudimentary visual representation. We then measure the difficulty of classifying an individual image, by measuring its distance to the decision boundary. Empirical distributions of discriminability values are used to predict human accuracy and reaction times across tasks and stimuli sets. We then extend the model to predict full reaction time distributions. Using a combination of simulations and psychophysics experiments, we validate the model assumptions, show that it is consistent with a large set of published results, and predict novel categorization effects. 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Such nanoscale materials are highly nonlinear and thus have different energy profiles in different atomic configurations. Therefore, failure of GBs under straining is highly cooperative and process-dependent in nano-granular materials. To ascertain the strength and toughness of GBs, accurate and quantitative assessments of GB field descriptions with atomic features are required. Two new means of establishing connections between global loadings to nanoscale GB traction distributions are developed: the interior and exterior field projection methods of GBs for computation and experiment respectively. Three mechanisms of Cu symmetric tilt GB deformation are introduced through the GB field projection methods. First, symmetric atomic rearrangement reduces concentrated compression of the GB tractions due to the ease of intergranular incompatibility. Second, asymmetric atomic rearrangement or dislocation emission decreases the concentrated tension leading GB opening and triggers the shear traction fluctuations as a new strain energy reservoir. Thus the GB separation toughness is enhanced. Third, Pb impurities at the GBs maintain the tension peaks of normal traction fluctuations and then retard the traction transformation. Hence, the GB becomes brittle. In addition to the GB field projection methods, we introduce an invention of an experimental instrument \u2013 atomic lattice interferometer, which can give us sub-angstrom scale resolution of deformation measurement. The corresponding calibration experiments were implemented on highly ordered pyrolytic graphite (HOPG), and the atomic-scale strain fields of a crinkle structure in HOPG were successfully measured. The measurement results show that the crinkle ridge line has a highly concentrated surface curvature involving localized atomic-scale deformations. With the help of simulation-assisted data analyses, the experimental data reveal that the typical width, the kink angle and the minimum radius of the ridge as 1.76 nm, 6.2\u00b0 and 8.51 nm, respectively. In summary, this thesis develops novel scientific computational projection methods and experimental metrology instrument for investigating unexplored global physical phenomena of materials associated with minute and localized atomic deformation at nanometer scales."], "mods_abstract_ssim": ["The aim of this thesis is to investigate how grain boundary (GB) strength and separation mechanisms affect strength and ductility of nanocrystalline materials. Such nanoscale materials are highly nonlinear and thus have different energy profiles in different atomic configurations. Therefore, failure of GBs under straining is highly cooperative and process-dependent in nano-granular materials. To ascertain the strength and toughness of GBs, accurate and quantitative assessments of GB field descriptions with atomic features are required. Two new means of establishing connections between global loadings to nanoscale GB traction distributions are developed: the interior and exterior field projection methods of GBs for computation and experiment respectively. Three mechanisms of Cu symmetric tilt GB deformation are introduced through the GB field projection methods. First, symmetric atomic rearrangement reduces concentrated compression of the GB tractions due to the ease of intergranular incompatibility. Second, asymmetric atomic rearrangement or dislocation emission decreases the concentrated tension leading GB opening and triggers the shear traction fluctuations as a new strain energy reservoir. Thus the GB separation toughness is enhanced. Third, Pb impurities at the GBs maintain the tension peaks of normal traction fluctuations and then retard the traction transformation. Hence, the GB becomes brittle. In addition to the GB field projection methods, we introduce an invention of an experimental instrument \u2013 atomic lattice interferometer, which can give us sub-angstrom scale resolution of deformation measurement. The corresponding calibration experiments were implemented on highly ordered pyrolytic graphite (HOPG), and the atomic-scale strain fields of a crinkle structure in HOPG were successfully measured. The measurement results show that the crinkle ridge line has a highly concentrated surface curvature involving localized atomic-scale deformations. With the help of simulation-assisted data analyses, the experimental data reveal that the typical width, the kink angle and the minimum radius of the ridge as 1.76 nm, 6.2\u00b0 and 8.51 nm, respectively. In summary, this thesis develops novel scientific computational projection methods and experimental metrology instrument for investigating unexplored global physical phenomena of materials associated with minute and localized atomic deformation at nanometer scales."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0794320", "mods_id": "etd1292", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Wang, Chien-Kai", "Kim, Kyung-Suk", "Gao, Huajian", "Kumar, Sharvan", "Brown University. 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Yet Peruvians themselves remain skeptical of this success. They argue that help fails to reach the truly needy and that official reports to the contrary are statistical \u201cmake up\u201d designed to obscure Peru\u2019s corrupt and impoverished reality. Based on 14 months of comparative and multi-sited ethnographic research, I track this discord from the offices of policy designers in Lima and into the homes of Peruvians making their lives on the urban periphery. I argue that as \u201cextreme poverty\u201d is mediated by official reports and popular imagery, it is also domesticated; on the one hand identified, quantified and controlled, but also increasingly understood and experienced through domestic space and intimate relations. At the level of the household, however, politics and bureaucratic documents intertwine with kinship, sexual morality, and violence to produce new indeterminacies and marginalize non-normative family forms, particularly female-headed households. In analyzing this phenomenon, I explore the coproduction of knowledge and skepticism, how efforts to create governable societies feed illicit markets, the real-life flexibility and fragility of ostensibly rigid family structures, and the permeable boundaries between politics and kinship. This research makes original contributions to anthropological understandings of urban poverty in Latin America, the human dimensions of documentation and emerging constellations of citizenship and exclusion in the margins of the state."], "mods_abstract_ssim": ["According to the numbers, Peru\u2019s economy is growing rapidly with poverty rates declining apace. Yet Peruvians themselves remain skeptical of this success. They argue that help fails to reach the truly needy and that official reports to the contrary are statistical \u201cmake up\u201d designed to obscure Peru\u2019s corrupt and impoverished reality. Based on 14 months of comparative and multi-sited ethnographic research, I track this discord from the offices of policy designers in Lima and into the homes of Peruvians making their lives on the urban periphery. I argue that as \u201cextreme poverty\u201d is mediated by official reports and popular imagery, it is also domesticated; on the one hand identified, quantified and controlled, but also increasingly understood and experienced through domestic space and intimate relations. At the level of the household, however, politics and bureaucratic documents intertwine with kinship, sexual morality, and violence to produce new indeterminacies and marginalize non-normative family forms, particularly female-headed households. In analyzing this phenomenon, I explore the coproduction of knowledge and skepticism, how efforts to create governable societies feed illicit markets, the real-life flexibility and fragility of ostensibly rigid family structures, and the permeable boundaries between politics and kinship. This research makes original contributions to anthropological understandings of urban poverty in Latin America, the human dimensions of documentation and emerging constellations of citizenship and exclusion in the margins of the state."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0N58JR6", "mods_id": "etd1347", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Skrabut, Kristin J", "Warren, Kay", "Smith, Daniel", "Leinaweaver, Jessaca", "Seligmann, Linda", "Brown University. 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It does so by developing an argument at two levels: (1) at the city level, I take Mexico City as an extreme case (Gerring 2007) of late democratization in Latin America (Myers 2002; Davis and Alvarado 2004) as well as a negative case for citizen participation engaging the state when compared with S\u00e3o Paulo, the other most important global and mega-city in the region (Houtzager et al 2005); (2) and at the neighborhood level I take the two oldest and most iconic sections of the central part of Mexico City as local cases. At the level of the city, I argue that Mexico City has been transitioning from a corporatist urban regime (Stone 1989) - similar to the national corporatist regime in place since the 1930s to the 1990s - to what I call a \u201cpragmatic\u201d urban regime - which began to form with the election of leftist party Partido de la Revoluci\u00f3n Democr\u00e1tica (Party of Democratic Revolution or PRD) in 1997 and combines strong pro-poor and pro-capital tendencies. At the level of the local cases, an interesting paradox emerges: Centro Hist\u00f3rico (the poorest and worst served of my cases) is advancing more rapidly than Roma Condesa (the neighborhood with better infrastructure and living conditions) in its urban renovation efforts and an increasing number of residents are participating in defining and implementing those efforts while the opposite is true in Roma Condesa. The presence of a state institution that serves as facilitator of consensus and \u201cinstitutional catalyst\u201d (Bhatta 2006) in Centro Hist\u00f3rico has been the key difference between the two cases. 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Although these electronic transactions provide efficiency and convenience, they usually overlook the privacy of the users. This thesis studies privacy-enhancing technologies in order to get the best of both worlds: all the benefits of electronic transactions but without sacrificing user privacy. Using efficient cryptographic tools such as digital signatures, zero-knowledge proof systems and encryption schemes, we propose secure protocols that protect user privacy and at the same time are practical. Anonymous credential systems allow users to obtain and demonstrate possession of digital credentials in order to authenticate themselves in a privacy-preserving manner. We first show impossibility results on proving the security of one of the most well-known anonymous credential systems, the one due to Stefan Brands, that is currently being implemented by Microsoft under their credential management project, U-prove. 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Here I used leaf optical properties to study the seasonality of plant physiology, and how it is controlled by environmental factors. I started with using digital repeat photography to estimate the budburst date of trees in New England. I up-scaled a species-level phenology model to the New England area, and I reconstructed and predicted the changes of budburst dates. The budburst date in New England advanced 6.64 days from 1960 to 2010, and it will continue to advance 8~22 days by 2100 given different emission scenarios. I then used weekly sampled leaf traits including chlorophyll concentration to interpret the data from digital repeat photography, and I found a temporal mismatch between greenness index and chlorophyll concentration, while in the fall, redness index was a good indicator of vegetation senescence. I further used vegetation spectroscopy to successfully capture the seasonal variability of leaf traits. In the end, I developed a system in the first time to continuously measure solar-induced fluorescence (SIF) over a temperate deciduous forest. I proved strong correlation between SIF and vegetation photosynthesis, and absorbed photosynthetically active radiation. In summary, I used remote sensing and modeling to understand the seasonality of plant physiology and its environmental drivers. Remote sensing can provide spatially explicit estimates of properties which are related to key ecological processes, while the mechanistic understandings of how environmental factors control these processes can help to understand how terrestrial ecosystem will respond to climate change."], "mods_abstract_ssim": ["One of the ubiquitous impacts of climate change on the terrestrial ecosystem is the shifting plant phenology, which is the periodic events in the life cycle of plants, and the related changes of vegetation physiology such as photosynthesis. Here I used leaf optical properties to study the seasonality of plant physiology, and how it is controlled by environmental factors. I started with using digital repeat photography to estimate the budburst date of trees in New England. I up-scaled a species-level phenology model to the New England area, and I reconstructed and predicted the changes of budburst dates. The budburst date in New England advanced 6.64 days from 1960 to 2010, and it will continue to advance 8~22 days by 2100 given different emission scenarios. I then used weekly sampled leaf traits including chlorophyll concentration to interpret the data from digital repeat photography, and I found a temporal mismatch between greenness index and chlorophyll concentration, while in the fall, redness index was a good indicator of vegetation senescence. I further used vegetation spectroscopy to successfully capture the seasonal variability of leaf traits. In the end, I developed a system in the first time to continuously measure solar-induced fluorescence (SIF) over a temperate deciduous forest. I proved strong correlation between SIF and vegetation photosynthesis, and absorbed photosynthetically active radiation. In summary, I used remote sensing and modeling to understand the seasonality of plant physiology and its environmental drivers. Remote sensing can provide spatially explicit estimates of properties which are related to key ecological processes, while the mechanistic understandings of how environmental factors control these processes can help to understand how terrestrial ecosystem will respond to climate change."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z05719C2", "mods_id": "etd1342", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Yang, Xi", "Mustard, John", "Tang, Jianwu", "Lee, Jung-Eun", "Hastings, Meredith", "Berry, Joseph", "Brown University. 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Scholars have often imagined the social environment for these texts to be a communal in some measure, with authors writing narratives about Jesus that mirror the social and theological interests of their communities or \u201cchurches.\u201d I challenge that this approach stems from the mistaken premise that the cohesive and widespread social movement painted by the gospel writers was a historical reality. I demonstrate that accepting early Christianity\u2019s own myth of origins has resulted in an extremely idiosyncratic approach to early Christian sources when compared with allied studies of ancient literature. By contrast, I establish that ancient Mediterranean authors tended to write within a competitive field of elite cultural producers, creating narratives that more or less conformed to established genres. Rather than attempt to read the gospels and Q under the related assumptions that they reveal cohesive communities and preserve strands of authentic material about Jesus, I situate them more coherently within a wider field of Greco-Roman literature as an example of \u201csubversive biography,\u201d in which a marginal figure is forced to succeed through the use of his wits and wonderworking skills. This study also demonstrates the extent to which Romanticism continues to exact a strong influence on the field of early Christian Studies. I argue that the gospels and Q have been analyzed in twentieth and twenty-first century thought with an uncritical German Romantic communitarian framework that has imposed anachronistic, Romantic ideas of an implicit Volk (people, nation) or inspirational Geist (spirit) onto the text. This is a critique of current scholarship that has application not only in Christian thought, but also other religious traditions and texts studied within the academy."], "mods_abstract_ssim": ["This dissertation offers a reevaluation of the Synoptic gospels (Matthew, Mark and Luke) and a hypothetical document thought to be common to Matthew and Luke, known as Q (Quelle). Scholars have often imagined the social environment for these texts to be a communal in some measure, with authors writing narratives about Jesus that mirror the social and theological interests of their communities or \u201cchurches.\u201d I challenge that this approach stems from the mistaken premise that the cohesive and widespread social movement painted by the gospel writers was a historical reality. I demonstrate that accepting early Christianity\u2019s own myth of origins has resulted in an extremely idiosyncratic approach to early Christian sources when compared with allied studies of ancient literature. By contrast, I establish that ancient Mediterranean authors tended to write within a competitive field of elite cultural producers, creating narratives that more or less conformed to established genres. Rather than attempt to read the gospels and Q under the related assumptions that they reveal cohesive communities and preserve strands of authentic material about Jesus, I situate them more coherently within a wider field of Greco-Roman literature as an example of \u201csubversive biography,\u201d in which a marginal figure is forced to succeed through the use of his wits and wonderworking skills. This study also demonstrates the extent to which Romanticism continues to exact a strong influence on the field of early Christian Studies. I argue that the gospels and Q have been analyzed in twentieth and twenty-first century thought with an uncritical German Romantic communitarian framework that has imposed anachronistic, Romantic ideas of an implicit Volk (people, nation) or inspirational Geist (spirit) onto the text. This is a critique of current scholarship that has application not only in Christian thought, but also other religious traditions and texts studied within the academy."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0JD4V4T", "mods_id": "etd1339", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Walsh, Robyn", "Stowers, Stanley", "Kraemer, Ross", "Konstan, David", "Brown University. 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The partitioning of trace elements into these minerals is fundamental to understanding of the magmatic and subsolidus processes in the Earth and other planetary bodies. In Chapters 1, 2, 3, and 6, I present a new generation of lattice strain models for rare earth elements (REEs) partitioning between mantle minerals (clinopyroxene, orthopyroxene, garnet, olivine, and plagioclase) and basaltic melts that were calibrated against experimentally determined partitioning data. Application of these models to mantle melting and magma fractionation processes demonstrate: (1) temperature, pressure and mineral composition dominate REE partitioning between mantle minerals and basaltic melts; (2) the competing effects of temperature and composition lead to constant REE partition coefficients in pyroxene during adiabatic mantle melting; (3) the combining effects of temperature and composition result in significant variations in mineral-melt REE partition coefficients during solidification of a large magma body. In Chapter 4, I have developed generalized models for REE partitioning between coexisting mantle minerals. These models reveal that subsolidus re-equilibration can significantly redistribute REEs among minerals in peridotites. Without proper correction for subsolidus re-equilibration, the extents of melting for abyssal peridotites based on REE abundances in clinopyroxene can be significantly over-estimated. In Chapters 5 and 6, I present two new thermobarometers, a REE-in-garnet-clinopyroxene thermobarometer, and a REE-in-plagioclase-clinopyroxene thermometer, for mafic and ultramafic rocks. These thermobarometers are based on the temperature and pressure dependent REE partitioning between two coexisting minerals. The REE-based thermobarometers are unique because they can fully make use of all REEs as a group to constrain robust temperatures and pressures simultaneously. Due to the slower diffusion rates of REEs in minerals, the REE-based thermometers generally record higher closure temperatures than major element-based thermometers for samples that experienced cooling, but provide former equilibrium temperatures for samples that underwent heating. The REE-based thermobarometers can shed new light on thermal evolutions of mafic and ultramafic rocks from different tectonic environments."], "mods_abstract_ssim": ["Olivine, orthopyroxene, clinopyroxene, garnet and plagioclase are major rock-forming minerals in the Earth mantle and other planetary bodies. The partitioning of trace elements into these minerals is fundamental to understanding of the magmatic and subsolidus processes in the Earth and other planetary bodies. In Chapters 1, 2, 3, and 6, I present a new generation of lattice strain models for rare earth elements (REEs) partitioning between mantle minerals (clinopyroxene, orthopyroxene, garnet, olivine, and plagioclase) and basaltic melts that were calibrated against experimentally determined partitioning data. Application of these models to mantle melting and magma fractionation processes demonstrate: (1) temperature, pressure and mineral composition dominate REE partitioning between mantle minerals and basaltic melts; (2) the competing effects of temperature and composition lead to constant REE partition coefficients in pyroxene during adiabatic mantle melting; (3) the combining effects of temperature and composition result in significant variations in mineral-melt REE partition coefficients during solidification of a large magma body. In Chapter 4, I have developed generalized models for REE partitioning between coexisting mantle minerals. These models reveal that subsolidus re-equilibration can significantly redistribute REEs among minerals in peridotites. Without proper correction for subsolidus re-equilibration, the extents of melting for abyssal peridotites based on REE abundances in clinopyroxene can be significantly over-estimated. In Chapters 5 and 6, I present two new thermobarometers, a REE-in-garnet-clinopyroxene thermobarometer, and a REE-in-plagioclase-clinopyroxene thermometer, for mafic and ultramafic rocks. These thermobarometers are based on the temperature and pressure dependent REE partitioning between two coexisting minerals. The REE-based thermobarometers are unique because they can fully make use of all REEs as a group to constrain robust temperatures and pressures simultaneously. Due to the slower diffusion rates of REEs in minerals, the REE-based thermometers generally record higher closure temperatures than major element-based thermometers for samples that experienced cooling, but provide former equilibrium temperatures for samples that underwent heating. The REE-based thermobarometers can shed new light on thermal evolutions of mafic and ultramafic rocks from different tectonic environments."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0DN43DG", "mods_id": "etd1340", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Sun, Chenguang", "Liang, Yan", "Cooper, Reid", "Parmentier, E.", "Saal, Alberto", "Watson, E.", "Parman, Stephen", "Brown University. 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"rel_is_member_of_collection_ssim": ["bdr:n9pjv5jn"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "rel_embargo_years_ssim": ["2016"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [281], "ir_collection_name": ["Anthropology", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["This dissertation explores the intersections of class relations, social mobility, and bodily self-care. In recent years, yoga has become increasingly accessible to Mexicans through state-sponsored initiatives executed in city spaces, low-income neighborhoods, and government institutes. My study of yoga\u2019s production, promotion, and practice in these spaces and among diverse social sectors in Mexico City provides a window onto how Mexicans are maneuvering class boundaries, and are also being maneuvered by them. Twenty-four months of ethnographic research revealed an underlying tension between the ways yoga practitioners idealize social sameness and how they aspire for bodily (personal, social, national) transformation. It is in this space of tension where, I argue, class divisions are being challenged and reinforced, revealing both the likelihoods and limits of mobility in urban Mexico. Yoga\u2019s promise for union affects Mexicans\u2019 interactions with each other, impacts people\u2019s expectations of themselves and others, and sometimes shifts life possibilities and impossibilities. It provides some people new credentials, labor options, and social status, and expands networks of mutual assistance. While the potential for mobility that yoga granted some Mexicans was remarkable, it involved new challenges, too; for some, in terms of its upkeep and, for others, its concealment. Here, mobility may be characterized by transition and instability, yet it is experienced as a relational transformation, one that offers Mexicans a kind of mobility I call constrained potential. Prospects for social mobility among working-class practitioners, for example, may be limited, but their modes of relating to others complicate our readings of class to allow for a richer analysis of how it is experienced. In this way, my analysis demonstrates that modalities of self-care feel empowering to practitioners at the same time that they offer a stark look at how structural differences in Mexico are being obscured by state-sponsored discourses of self-care. The practice of yoga is therefore both a reaction to rising inequalities (unequal chances to live \u201cthe good life\u201d in Mexico), and emblematic of them, too: of the inability to secure work with stable pay or access affordable, quality health care."], "mods_abstract_ssim": ["This dissertation explores the intersections of class relations, social mobility, and bodily self-care. In recent years, yoga has become increasingly accessible to Mexicans through state-sponsored initiatives executed in city spaces, low-income neighborhoods, and government institutes. My study of yoga\u2019s production, promotion, and practice in these spaces and among diverse social sectors in Mexico City provides a window onto how Mexicans are maneuvering class boundaries, and are also being maneuvered by them. Twenty-four months of ethnographic research revealed an underlying tension between the ways yoga practitioners idealize social sameness and how they aspire for bodily (personal, social, national) transformation. It is in this space of tension where, I argue, class divisions are being challenged and reinforced, revealing both the likelihoods and limits of mobility in urban Mexico. Yoga\u2019s promise for union affects Mexicans\u2019 interactions with each other, impacts people\u2019s expectations of themselves and others, and sometimes shifts life possibilities and impossibilities. It provides some people new credentials, labor options, and social status, and expands networks of mutual assistance. While the potential for mobility that yoga granted some Mexicans was remarkable, it involved new challenges, too; for some, in terms of its upkeep and, for others, its concealment. Here, mobility may be characterized by transition and instability, yet it is experienced as a relational transformation, one that offers Mexicans a kind of mobility I call constrained potential. Prospects for social mobility among working-class practitioners, for example, may be limited, but their modes of relating to others complicate our readings of class to allow for a richer analysis of how it is experienced. In this way, my analysis demonstrates that modalities of self-care feel empowering to practitioners at the same time that they offer a stark look at how structural differences in Mexico are being obscured by state-sponsored discourses of self-care. The practice of yoga is therefore both a reaction to rising inequalities (unequal chances to live \u201cthe good life\u201d in Mexico), and emblematic of them, too: of the inability to secure work with stable pay or access affordable, quality health care."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0M61HMC", "mods_id": "etd1356", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Maldonado, Andrea", "Smith, Daniel", "Gutmann, Matthew", "Warren, Kay", "G\u00e1lvez, Alyshia", "Brown University. 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This dissertation reveals that MqsR also has exclusive properties. Using a combination of X-ray crystallography, NMR, and other biophysical and biochemical techniques, it is shown that unlike all other protein TA systems, the MqsR-MqsA complex cannot bind DNA. Instead, MqsR functions as a de-repressor, further promoting multidrug tolerance through its ability to disrupt MqsA-mediated repression of persistence-related genes. In addition, the mechanism of mRNA cleavage and the molecular basis of MqsA neutralization of MqsR activity are elucidated; these studies reveal that, unlike other toxins, MqsR does not require a histidine or the ribosome for activity. Finally, a novel \u2018Type V\u2019 TA system, GhoT-GhoS, is revealed for the first time and this TA system is activated by MqsR, the first time one TA system has been shown to regulate a second. 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This phenotypic state is characterized by the expression of \u2018toxin:antitoxin\u2019 (TA) gene pairs, with the toxin mqsR being the most highly upregulated gene in E. coli persisters [13, 14]. During normal cell growth, MqsR and its antitoxin, MqsA, form a non-toxic complex. However, during stress, MqsA is degraded allowing MqsR to induce growth arrest via mRNA cleavage. We previously reported that the mqsRA TA pair is unique because of the unusual features of MqsA. This dissertation reveals that MqsR also has exclusive properties. Using a combination of X-ray crystallography, NMR, and other biophysical and biochemical techniques, it is shown that unlike all other protein TA systems, the MqsR-MqsA complex cannot bind DNA. Instead, MqsR functions as a de-repressor, further promoting multidrug tolerance through its ability to disrupt MqsA-mediated repression of persistence-related genes. 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The findings from the case studies also demonstrate that takeovers can positively and negatively affect other aspects of political empowerment, including substantive representation on the school board and the ability for local communities to influence school policies and control district resources. The results of this research suggest that the impact of centralization depends on the level of empowerment a community has at the time of the takeover."], "mods_abstract_ssim": ["Racial minorities have had an ambiguous history with state intervention. At times, the state has prevented racial minorities from achieving political power and at other times, it has helped in the process of political empowerment. However, theories of Black and Latino political empowerment often treat the role of the state as peripheral or ignore it all together. Similarly, theories of centralization often ignore the historically complicated experiences racial minorities have had with state intervention. This dissertation examines the effects of state intervention on Black and Latino political empowerment by focusing on state takeovers of local school districts. Since the 1980s, states have increasingly relied on takeovers to address issues with underperforming school districts. Yet, in addition to serving as learning institutions, school districts also serve as important local political institutions. Therefore, state takeovers of local school districts have political implications. Furthermore, nearly 80 percent of takeovers occur in districts where Blacks and Latinos represent the majority of the student population. The findings from this dissertation research demonstrate that the effects of state takeovers are complex. Using an original dataset of all state takeovers and relying on case studies of Newark, Paterson, and Union City, New Jersey, this dissertation shows that at times state takeovers can advance Black and Latino political empowerment. I find that state takeovers have a positive effect on Black and Latino descriptive representation on the school board in localities where their respective groups have low levels of political power at the time of the takeover. Conversely, this study finds that state takeovers of local school districts negatively affect groups that are politically empowered at the time of the takeover. The findings from the case studies also demonstrate that takeovers can positively and negatively affect other aspects of political empowerment, including substantive representation on the school board and the ability for local communities to influence school policies and control district resources. 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The negative dimension of human-god interaction has, however, gone understudied in past analyses of Greek religion, which have focused largely on propitiatory actions such as sacrifice and dedication. Most treatments of religious transgression, moreover, have not differentiated among the various actions labeled \u201cimpious (asebes)\u201d within Greek religious culture. Such an approach prevents us from understanding how ancient Greeks thought, wrote, and acted differently when an action, such as looting a temple, directly wronged a god, and when an action, such as abusing one\u2019s parents, may merely have elicited the gods\u2019 disapproval. This dissertation, which studies religious transgression in Greek prose and epigraphical sources from the fifth through second centuries BCE, argues that among the actions that may be construed as \u201cimpious\u201d within Greek religious culture, we can distinguish as qualitatively different actions that directly and personally harm a god: they uniquely involve the abuse of something that directly pertains to a god \u2013 for example, a sacred (hieron) object or an oath \u2013 and require punishment from or on behalf of the wronged divinity. Making this distinction allows us to understand more precisely the ideology of religious transgression in Greek religious culture and its significance within social and political life. Chapters One and Two define direct wrongs against the gods and the retribution that follows them as a type of negative reciprocal interaction between mortals and gods; this negative reciprocity, moreover, stands in parallel opposition to positive reciprocal interactions with the gods that involve, for example, sacrifice and dedication. Chapters Three and Four examine the relevance of direct wrongs against the gods to communal life and how remembered wrongs against the gods could be used to shape perceived communal identity. I emphasize throughout that ancient Greek descriptions of religious transgression must be approached as essentially subjective narratives that operate within the ideological bounds of Greek religious discourse yet are also shaped by a host of non-religious factors such as rhetorical interests and political biases."], "mods_abstract_ssim": ["Ancient Greeks regarded their gods as beings with whom they could interact in either helpful or harmful ways. The negative dimension of human-god interaction has, however, gone understudied in past analyses of Greek religion, which have focused largely on propitiatory actions such as sacrifice and dedication. Most treatments of religious transgression, moreover, have not differentiated among the various actions labeled \u201cimpious (asebes)\u201d within Greek religious culture. Such an approach prevents us from understanding how ancient Greeks thought, wrote, and acted differently when an action, such as looting a temple, directly wronged a god, and when an action, such as abusing one\u2019s parents, may merely have elicited the gods\u2019 disapproval. This dissertation, which studies religious transgression in Greek prose and epigraphical sources from the fifth through second centuries BCE, argues that among the actions that may be construed as \u201cimpious\u201d within Greek religious culture, we can distinguish as qualitatively different actions that directly and personally harm a god: they uniquely involve the abuse of something that directly pertains to a god \u2013 for example, a sacred (hieron) object or an oath \u2013 and require punishment from or on behalf of the wronged divinity. Making this distinction allows us to understand more precisely the ideology of religious transgression in Greek religious culture and its significance within social and political life. Chapters One and Two define direct wrongs against the gods and the retribution that follows them as a type of negative reciprocal interaction between mortals and gods; this negative reciprocity, moreover, stands in parallel opposition to positive reciprocal interactions with the gods that involve, for example, sacrifice and dedication. Chapters Three and Four examine the relevance of direct wrongs against the gods to communal life and how remembered wrongs against the gods could be used to shape perceived communal identity. I emphasize throughout that ancient Greek descriptions of religious transgression must be approached as essentially subjective narratives that operate within the ideological bounds of Greek religious discourse yet are also shaped by a host of non-religious factors such as rhetorical interests and political biases."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0ZK5F2S", "mods_id": "etd1327", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["McDonald, Joseph M", "Scafuro, Adele", "Boedeker, Deborah", "Mignone, Lisa", "Sacks, Kenneth", "Brown University. 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How domains of co-regulation are established in vivo remains poorly understood. X-chromosome dosage compensation system provides an excellent model for studying coordinate gene regulation because all of the active genes along the length of a whole chromosome are precisely co-regulated. Both Drosophila and mammals coordinately increase expression of genes on the male X-chromosome to equalize expression with autosomes and the female two X-chromosomes. Drosophila dosage compensation is mediated by the Male-Specific Lethal (MSL) ribonucleoprotein complex, which is expressed only in males and specifically identifies the X-chromosome. MSL complex is recruited to the X-chromosome via 21-bp MSL Recognition Elements (MRE) that contain a highly conserved 8-bp core. MREs are two-fold enriched on the X-chromosome but this enrichment alone cannot explain the complete X-specificity of MSL complex. Furthermore, it was unknown how MRE motifs are identified by MSL complex, because none of the known components of MSL specifically recognize MREs. Using a genetic screen, we identified a previously unstudied protein called CLAMP (Chromatin Linked Adaptor for MSL Proteins) that provides the previously unknown link between MSL complex and X-chromosome. CLAMP is a seven C2H2 zinc finger protein with a glutamine-rich domain, similar to other highly conserved transcriptional activators. Using chromatin immunoprecipitation (ChIP), custom protein binding microarrays (PBMs), structure-function analysis, Electrophorectic Mobility Shift Assays (EMSAs), and RNA immunoprecipitation (RIP), we determined the following: 1) CLAMP directly binds MREs; 2) CLAMP has an in vivo association with the non-coding roX (RNA on X) of MSL complex, and 3) CLAMP\u2019s glutamine-rich domain is critical for MSL recruitment. It was previously known that MSL complex requires the entire GA-repeat containing 21-bp MRE for recruitment although only the 8-bp core is highly conserved. We determined that increasing the number of GA repeats increases CLAMP binding and the X-chromosome has higher number of GA-repeats than autosomes. Together, our data supports a model in which increasing GA-repeats facilitates increased CLAMP binding, thereby promoting X-chromosome identification."], "mods_abstract_ssim": ["Coordinate gene regulation is critical to promote normal development and prevent disease. How domains of co-regulation are established in vivo remains poorly understood. X-chromosome dosage compensation system provides an excellent model for studying coordinate gene regulation because all of the active genes along the length of a whole chromosome are precisely co-regulated. Both Drosophila and mammals coordinately increase expression of genes on the male X-chromosome to equalize expression with autosomes and the female two X-chromosomes. Drosophila dosage compensation is mediated by the Male-Specific Lethal (MSL) ribonucleoprotein complex, which is expressed only in males and specifically identifies the X-chromosome. MSL complex is recruited to the X-chromosome via 21-bp MSL Recognition Elements (MRE) that contain a highly conserved 8-bp core. MREs are two-fold enriched on the X-chromosome but this enrichment alone cannot explain the complete X-specificity of MSL complex. Furthermore, it was unknown how MRE motifs are identified by MSL complex, because none of the known components of MSL specifically recognize MREs. Using a genetic screen, we identified a previously unstudied protein called CLAMP (Chromatin Linked Adaptor for MSL Proteins) that provides the previously unknown link between MSL complex and X-chromosome. CLAMP is a seven C2H2 zinc finger protein with a glutamine-rich domain, similar to other highly conserved transcriptional activators. Using chromatin immunoprecipitation (ChIP), custom protein binding microarrays (PBMs), structure-function analysis, Electrophorectic Mobility Shift Assays (EMSAs), and RNA immunoprecipitation (RIP), we determined the following: 1) CLAMP directly binds MREs; 2) CLAMP has an in vivo association with the non-coding roX (RNA on X) of MSL complex, and 3) CLAMP\u2019s glutamine-rich domain is critical for MSL recruitment. It was previously known that MSL complex requires the entire GA-repeat containing 21-bp MRE for recruitment although only the 8-bp core is highly conserved. We determined that increasing the number of GA repeats increases CLAMP binding and the X-chromosome has higher number of GA-repeats than autosomes. Together, our data supports a model in which increasing GA-repeats facilitates increased CLAMP binding, thereby promoting X-chromosome identification."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0TX3CQX", "mods_id": "etd1328", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Chery , Jessica", "Larschan, Erica", "Freiman, Richard", "Delong, Alison", "Bender, Judith", "Buratowski, Stephen", "Brown University. 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Intitulado \u201c\u00c0 Procura de Uma Na\u00e7\u00e3o: Os Processos de Forma\u00e7\u00e3o da Identidade Nacional na Prosa Angolana\u201d, este projecto vai al\u00e9m da categoriza\u00e7\u00e3o dicot\u00f3mica da perspectiva ut\u00f3pica versus dist\u00f3pica frequentemente usada na esquematiza\u00e7\u00e3o da literatura angolana de forma a repensar o papel que a literatura desempenha nos processos de forma\u00e7\u00e3o da na\u00e7\u00e3o angolana. Em particular, este projecto analisa detalhadamente a forma como as obras de tr\u00eas autores da mesma gera\u00e7\u00e3o, com altos n\u00edveis de engajamento pol\u00edtico e liter\u00e1rio dentro do quadro pol\u00edtico do MPLA (Movimento Popular para a Liberta\u00e7\u00e3o de Angola) participam na constru\u00e7\u00e3o do projecto pol\u00edtico nacional e problematizam a forma\u00e7\u00e3o de uma identidade colectiva, prestando especial aten\u00e7\u00e3o a quest\u00f5es de g\u00e9nero, ra\u00e7a, l\u00edngua vis-\u00e0-vis o projecto ideol\u00f3gico do movimento nacionalista pelo qual os tr\u00eas escritores lutaram e no qual se integraram."], "mods_abstract_ssim": ["O estudo realizado nesta disserta\u00e7\u00e3o debru\u00e7a-se sobre a rela\u00e7\u00e3o incontest\u00e1vel entre o escritor e o militante pol\u00edtico no contexto revolucion\u00e1rio africano, por via do caso angolano, prestando-se a uma an\u00e1lise das qualidades transformativas da literatura, como for\u00e7a de consciencializa\u00e7\u00e3o pol\u00edtica e cultural, por um lado, e como ve\u00edculo para a projec\u00e7\u00e3o da na\u00e7\u00e3o, por outro. Intitulado \u201c\u00c0 Procura de Uma Na\u00e7\u00e3o: Os Processos de Forma\u00e7\u00e3o da Identidade Nacional na Prosa Angolana\u201d, este projecto vai al\u00e9m da categoriza\u00e7\u00e3o dicot\u00f3mica da perspectiva ut\u00f3pica versus dist\u00f3pica frequentemente usada na esquematiza\u00e7\u00e3o da literatura angolana de forma a repensar o papel que a literatura desempenha nos processos de forma\u00e7\u00e3o da na\u00e7\u00e3o angolana. 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In order to resolve these two issues, we sequenced and assembled de novo transcriptomes of twenty species of echinoderms from all five extant classes of echinoderms. With these data, we constructed a phylogenetic tree that is well-supported; using multiple phylogenetic methods and sampling depths. Using these results, we were then able to test evolutionary transitions that have occurred in echinoderms, including fertilization, early development, and germ line determination. Echinodermata will continue to be a valuable resource in many fields of scientific study and the data from this body of work will greatly facilitate that research through the availability of DNA and RNA sequences and a robust phylogenetic tree."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0639N3K", "mods_id": "etd1333", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Reich, Adrian", "Wessel, Gary", "Dunn, Casey", "Johnson, Mark", "Mowry, Kimberly", "Cameron, Andrew", "Brown University. 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BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xx, 314 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["Echinoderms", "transcriptome", "Echinodermata", "Developmental biology", "Phylogeny"], "mods_subject_ssim": ["Echinoderms", "transcriptome", "Echinodermata", "Developmental biology", "Phylogeny"], "mods_subject_fast_ssim": ["Echinodermata", "Developmental biology", "Phylogeny"], "mods_subject_joined_ssim": ["Echinoderms", "transcriptome", "Echinodermata", "Developmental biology", "Phylogeny"], "mods_subject_joined_fast_ssim": ["Echinodermata", "Developmental biology", "Phylogeny"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["Evolutionary transitions within Echinodermata"], "mods_title_full_primary_tsi": "Evolutionary transitions within Echinodermata", "primary_title": "Evolutionary transitions within Echinodermata", "primary_title_txt_en_split": "Evolutionary transitions within Echinodermata", "resource_type_ssi": "dissertations", "timestamp": "2021-11-23T11:47:10.996Z", "title_si": "Evolutionary transitions within Echinodermata"}, {"pid": "bdr:386299", "fed_created_dsi": "2014-10-16T14:30:15.066Z", "object_created_dsi": "2014-10-16T14:30:15.066Z", "fed_last_modified_dsi": "2021-11-23T11:47:11.095Z", "object_last_modified_dsi": "2021-11-23T11:47:11.095Z", "storage_location_ssi": "ocfl", "datastreams_ssi": "{\"EXTRACTED_TEXT\": {\"mimeType\": \"text/plain\", \"size\": 454331, \"checksum\": \"0084521aa88a10614b2f4ab84d2f6bf7b091eb74627d5c7b635d12defc96bb4cc7cea2258ed4fbf9846ae73e37bc03e8c062a5d4599f8af88e4ef9adf9a654dd\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-07-29T16:33:41.504000Z\"}, \"DC\": {\"mimeType\": \"application/octet-stream\", \"size\": 339, \"checksum\": \"1928837f4dc3e5ec56134d7be9d5d1cbf6d79d65781f64665b7a95b99fd745eba68df35c8e20d7c22d5cea44d0dd27a45a7d5ea06092232fb9c931fa6bd4e00c\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:30:15.066000Z\"}, \"rightsMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 1103, \"checksum\": \"211b5c5b126abf23452930c732f50446b943584379c58f3dc29d353a7c450015854813ae68c4af6c57f3d9d291000be4552b3a41f1acb9517a0633ceb5355e6f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2018-07-06T16:49:32.435000Z\"}, \"RELS-INT\": {\"mimeType\": \"text/xml\", \"size\": 544, \"checksum\": \"394029f044d39d19c9a854ca33310022b531c11c25a0851ba3384ceda712e16c9066c53500c1842dab9e1993c16f75b2d65292865a55ac923cfde8f6a3f3bdc0\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-07-29T16:33:41.635000Z\"}, \"thumbnail\": {\"mimeType\": \"application/octet-stream\", \"size\": 1642, \"checksum\": \"5eb020a943da80a4c42636fdd4418254698e44fb96c75b7f2746777ae47ca1e1d81d09d1d5d54559b6e171d12b234535e279f9912471536dd87ff328fbe01d4b\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2015-12-05T05:01:31.918000Z\"}, \"irMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 471, \"checksum\": \"6644c1b679e088c35d5d60fbf7c055df80e21a2d50881cecc7dadbf945347f775d473e053f81ad443e21b9f24f02145ae8b54fa2f434a52f29c1b27ae2b36a7c\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:30:15.066000Z\"}, \"RELS-EXT\": {\"mimeType\": \"text/xml\", \"size\": 736, \"checksum\": \"6d5ca15124571dbf8cf11acfbe05c7d317c5ff1552eb9f9326a2a658e8c4f8984290a3347c779e3198c2be1ca9289c15225a1879f9da1fe081f176b8eb874375\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-11-23T11:47:11.095620Z\"}, \"MODS\": {\"mimeType\": \"text/xml\", \"size\": 5358, \"checksum\": \"9894602d3e4a5cdce4b356724fe18774174463c0e3f63c050a283cf8f363b2e203cc330ac74ca363912a65c87b3214df0c397f76acf56ae608db2e6e853dbd4f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-08-09T15:14:41.353690Z\"}, \"PDF\": {\"mimeType\": \"application/pdf\", \"size\": 982047, \"checksum\": \"c172877b2ff8030202ade12bb3f4710a20555e8c72ba6f7e20ddd0ac8854e995140f9da33ea0a15fde53e08c902416f73a8163e97e5a40a4a6d65a57b30301c2\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:30:15.066000Z\"}}", "fed_object_size_lsi": 1446571, "object_size_lsi": 1446571, "rel_content_models_ssim": ["pdf", "commonMetadata"], "rel_object_type_ssi": "pdf", "object_type": "pdf", "rel_is_member_of_collection_ssim": ["bdr:eefs25en"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "rel_embargo_years_ssim": ["2016"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [357], "ir_collection_name": ["Political Science", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["This dissertation investigates the thought of Mill and Nietzsche in order to consider the relationship between democracy and human flourishing. Chapters One and Two argue that Mill is an ambivalent democrat because different dimensions of democracy corrupt and cultivate different components of human flourishing; while democratic society corrupts individuality, structured democratic political participation cultivates the moral and intellectual virtues. Chapter Three examines Nietzsche\u2019s critique of democracy as corroding human flourishing, conceptualized as creativity, which is rooted in an individual\u2019s self-conception as radically unique. While Nietzsche was an egalitarian in his view that all individuals as radically unique and therefore capable of creativity, he still rejected democracy because radical uniqueness is at odds with democratic equality. In Chapter Four, I argue that Mill and Nietzsche ultimately diverge in their conclusions about democracy because of their different notions of individuality and creativity, respectively; while Mill is committed to normative commitments that ought to constrain certain expressions of individuality, Nietzsche lacks such commitments. Moreover, these normative commitments also provide the basis of democracy in Mill\u2019s thought, while their absence explains why Nietzsche ultimately rejects democracy. In conclusion, I argue that while Mill and Nietzsche are right to be concerned with absence of individual authority at the heart of individuality and creativity, their arguments fall short. Specifically, I argue that Mill is wrong to think that democracy is somehow unique as a regime type in encouraging conformity and discouraging individuality because he overlooks the source of conformity that existed under hierarchical society\u2014that is, in classes. Democratic society may have its own unique ways of producing conformity, but it is not unique in the fact that it produces conformity. In addition, I argue that Nietzsche\u2019s view that radical uniqueness and democratic equality are incompatible is compelling. However, I argue that it is precisely because we not radically unique\u2014but rather, unique and common\u2014that democracy is a desirable way to order our politics."], "mods_abstract_ssim": ["This dissertation investigates the thought of Mill and Nietzsche in order to consider the relationship between democracy and human flourishing. Chapters One and Two argue that Mill is an ambivalent democrat because different dimensions of democracy corrupt and cultivate different components of human flourishing; while democratic society corrupts individuality, structured democratic political participation cultivates the moral and intellectual virtues. Chapter Three examines Nietzsche\u2019s critique of democracy as corroding human flourishing, conceptualized as creativity, which is rooted in an individual\u2019s self-conception as radically unique. While Nietzsche was an egalitarian in his view that all individuals as radically unique and therefore capable of creativity, he still rejected democracy because radical uniqueness is at odds with democratic equality. In Chapter Four, I argue that Mill and Nietzsche ultimately diverge in their conclusions about democracy because of their different notions of individuality and creativity, respectively; while Mill is committed to normative commitments that ought to constrain certain expressions of individuality, Nietzsche lacks such commitments. Moreover, these normative commitments also provide the basis of democracy in Mill\u2019s thought, while their absence explains why Nietzsche ultimately rejects democracy. In conclusion, I argue that while Mill and Nietzsche are right to be concerned with absence of individual authority at the heart of individuality and creativity, their arguments fall short. Specifically, I argue that Mill is wrong to think that democracy is somehow unique as a regime type in encouraging conformity and discouraging individuality because he overlooks the source of conformity that existed under hierarchical society\u2014that is, in classes. Democratic society may have its own unique ways of producing conformity, but it is not unique in the fact that it produces conformity. In addition, I argue that Nietzsche\u2019s view that radical uniqueness and democratic equality are incompatible is compelling. However, I argue that it is precisely because we not radically unique\u2014but rather, unique and common\u2014that democracy is a desirable way to order our politics."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z02B8WD9", "mods_id": "etd1335", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Ikuta, Jennie Choi", "Krause, Sharon", "Larmore, Charles", "Gourevitch, Alexander", "Brown University. 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I account for the ways in which this trope has increasingly come to be practiced and understood in postwar America in terms of ethical and epistemological processes of becoming rather than teleological conceptions of formal mastery. The mutable senses of poetic ambition, commitment, survival, endurance, and evolution articulated in the poetry of William Carlos Williams, Robert Duncan, Adrienne Rich, and Yusef Komunyakaa signal a sustained reappraisal of the bifurcated and oversimplified narratives of secularization still inscribed within histories of literary modernity. By examining these poets\u2019 formal experiments with the personal epic, open-field poetics, infinite seriality, polyvocality, hybrid prosodies, and rhetorical address, I articulate the complex resonance between modernist poetry\u2019s aesthetic and cultural afterlives and postmodern modes of religiosity. I show that the process of vocation in postwar American poetry has radicalized various pragmatist conceptions of religious and artistic experience\u2014conceptions according to which sacred and secular domains of artistic practice are reciprocally entangled and mutually co-productive of a late modern ethos of pluralistic engagement."], "mods_abstract_ssim": ["Making a Living Poetry investigates modern and contemporary American poetry\u2019s reworking of the religious and romantic valences of a vocation in order to resist and reform the technocratic logic of the professional career. I account for the ways in which this trope has increasingly come to be practiced and understood in postwar America in terms of ethical and epistemological processes of becoming rather than teleological conceptions of formal mastery. The mutable senses of poetic ambition, commitment, survival, endurance, and evolution articulated in the poetry of William Carlos Williams, Robert Duncan, Adrienne Rich, and Yusef Komunyakaa signal a sustained reappraisal of the bifurcated and oversimplified narratives of secularization still inscribed within histories of literary modernity. By examining these poets\u2019 formal experiments with the personal epic, open-field poetics, infinite seriality, polyvocality, hybrid prosodies, and rhetorical address, I articulate the complex resonance between modernist poetry\u2019s aesthetic and cultural afterlives and postmodern modes of religiosity. I show that the process of vocation in postwar American poetry has radicalized various pragmatist conceptions of religious and artistic experience\u2014conceptions according to which sacred and secular domains of artistic practice are reciprocally entangled and mutually co-productive of a late modern ethos of pluralistic engagement."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0FN14JV", "mods_id": "etd1331", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Neilson, Jeffrey P", "Gould, Philip", "Herrnstein Smith, Barbara", "Nabers, Deak", "Shoptaw, John", "Brown University. 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Contrary to the common assumption that they are hidden and invisible, this dissertation argues that secrets must always be exposed to be constituted as secrets, making secrecy a powerful narrative strategy deployed in different ways by authors of the French novella. Drawing upon source material such as courtly treatises by Dominique Bouhours and Baldassare Castiglione, perspective treatises and paintings such as Hans Holbein the Younger's The Ambassadors (1533), emblem books by Andrea Alciato and Gilles Corrozet, and libertine philosophical treatises by authors like Pierre Charron, each chapter begins with the establishment of a different theoretical and conceptual framework of secrecy, which is then used to analyze specific passages from each author of the corpus. This dissertation has uncovered an \"iconography of secrecy,\" a repository of visual and literary tropes, that novella authors in the early modern period could access and manipulate, thus pushing the genre into new narrative territory. Chapter One argues that the representation of secrecy heightens the dramatic atmosphere in Marguerite de Navarre's retelling of a medieval tragedy, La Chastelaine de Vergi, by placing characters in triangulated power relationships that pivot around difficult ethical situations created by ambiguities inherent in courtly codes. Chapter Two argues that in the 32nd Novella of the Heptam\u00e9ron, Marguerite de Navarre is experimenting with a form of literary anamorphosis akin to visual anamorphosis, an artistic technique inextricable from the dynamics of secrecy. Chapter Three explores the relationship between secrecy, emblems, and emblematic narration in Le printemps by Jacques Yver. Chapter Four explores the role secrecy plays in both libertine philosophy and the emerging nouvelle classique in two novella collections by Charles Sorel. Chapter Five comes full-circle by returning to the relationship between secrecy and court culture in the emerging nouvelle historique in Madame de Lafayette's La Princesse de Cl\u00e8ves."], "mods_abstract_ssim": ["Through a Glass Darkly: Secrecy in the Sixteenth- and Seventeenth-Century French Novella explores secrecy's role in the development of the literary genre of the French novella from 1559 to 1678. Contrary to the common assumption that they are hidden and invisible, this dissertation argues that secrets must always be exposed to be constituted as secrets, making secrecy a powerful narrative strategy deployed in different ways by authors of the French novella. Drawing upon source material such as courtly treatises by Dominique Bouhours and Baldassare Castiglione, perspective treatises and paintings such as Hans Holbein the Younger's The Ambassadors (1533), emblem books by Andrea Alciato and Gilles Corrozet, and libertine philosophical treatises by authors like Pierre Charron, each chapter begins with the establishment of a different theoretical and conceptual framework of secrecy, which is then used to analyze specific passages from each author of the corpus. This dissertation has uncovered an \"iconography of secrecy,\" a repository of visual and literary tropes, that novella authors in the early modern period could access and manipulate, thus pushing the genre into new narrative territory. Chapter One argues that the representation of secrecy heightens the dramatic atmosphere in Marguerite de Navarre's retelling of a medieval tragedy, La Chastelaine de Vergi, by placing characters in triangulated power relationships that pivot around difficult ethical situations created by ambiguities inherent in courtly codes. Chapter Two argues that in the 32nd Novella of the Heptam\u00e9ron, Marguerite de Navarre is experimenting with a form of literary anamorphosis akin to visual anamorphosis, an artistic technique inextricable from the dynamics of secrecy. Chapter Three explores the relationship between secrecy, emblems, and emblematic narration in Le printemps by Jacques Yver. Chapter Four explores the role secrecy plays in both libertine philosophy and the emerging nouvelle classique in two novella collections by Charles Sorel. 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true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["A wealth of astrophysical evidence confirms that 26% of the energy density of the universe is comprised of a mysterious, non-baryonic, dark matter. A leading candidate for dark matter is the Weakly Interacting Massive Particle (WIMP) that is suggested both by the relic abundance of dark matter, and extensions to the standard model of particle physics. WIMPs interact with baryonic matter only through gravity and the weak nuclear force. The Large Underground Xenon (LUX) dark matter experiment aims to detect WIMPs through this weak interaction. LUX is a 370 kg two-phase (liquid/gas) xenon time projection chamber designed to detect nuclear recoils from interactions with WIMPs. Particle interactions in LUX are observed by 122 photomultiplier tubes (PMTs). Signals from these PMTs are processed by custom-built analog electronics. The data acquisition system (DAQ) is composed of commercial digitizers with firmware customized for the LUX experiment. The LUX DAQ is optimized to provide a high rate and a large dynamic range during precision calibrations involving radioactive sources, while also delivering a low threshold for maximum sensitivity. The LUX detector is housed in a 300 tonne water tank on the 4850 ft level of the Sanford Underground Research Facility, in Lead, SD. The first WIMP search results are based on 85.3 live-days of data-taking. This non-blind analysis yields 160 events in the WIMP search energy range in a 118kg fiducial volume. A profile likelihood analysis of this data supports the background-only hypothesis, producing the highest constraint on the WIMP-nucleon interaction cross-section to date. The minimum 90% C.L. upper limit is 7.6x10^-46 cm2 for a WIMP mass of 33 GeV/c2. In particular this run has strongly ruled out hints of signal in the low-mass regime between 6 and 20 GeV/c2 recently suggested by several direct detection experiments. LUX will continue to undergo engineering and calibrations runs to improve detector sensitivity. The subsequent 300 live-day blinded WIMP search will extend the WIMP limit of LUX by a factor of x5 above a mass of 20 GeV/c2."], "mods_abstract_ssim": ["A wealth of astrophysical evidence confirms that 26% of the energy density of the universe is comprised of a mysterious, non-baryonic, dark matter. A leading candidate for dark matter is the Weakly Interacting Massive Particle (WIMP) that is suggested both by the relic abundance of dark matter, and extensions to the standard model of particle physics. WIMPs interact with baryonic matter only through gravity and the weak nuclear force. The Large Underground Xenon (LUX) dark matter experiment aims to detect WIMPs through this weak interaction. LUX is a 370 kg two-phase (liquid/gas) xenon time projection chamber designed to detect nuclear recoils from interactions with WIMPs. Particle interactions in LUX are observed by 122 photomultiplier tubes (PMTs). Signals from these PMTs are processed by custom-built analog electronics. The data acquisition system (DAQ) is composed of commercial digitizers with firmware customized for the LUX experiment. The LUX DAQ is optimized to provide a high rate and a large dynamic range during precision calibrations involving radioactive sources, while also delivering a low threshold for maximum sensitivity. The LUX detector is housed in a 300 tonne water tank on the 4850 ft level of the Sanford Underground Research Facility, in Lead, SD. The first WIMP search results are based on 85.3 live-days of data-taking. This non-blind analysis yields 160 events in the WIMP search energy range in a 118kg fiducial volume. A profile likelihood analysis of this data supports the background-only hypothesis, producing the highest constraint on the WIMP-nucleon interaction cross-section to date. The minimum 90% C.L. upper limit is 7.6x10^-46 cm2 for a WIMP mass of 33 GeV/c2. In particular this run has strongly ruled out hints of signal in the low-mass regime between 6 and 20 GeV/c2 recently suggested by several direct detection experiments. LUX will continue to undergo engineering and calibrations runs to improve detector sensitivity. The subsequent 300 live-day blinded WIMP search will extend the WIMP limit of LUX by a factor of x5 above a mass of 20 GeV/c2."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0BV7DZZ", "mods_id": "etd1324", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Chapman, Jeremy J", "Gaitskell, Richard", "Narain, Meenakshi", "Tucker, Greg", "Brown University. 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Scott Fitzgerald, Gertrude Stein, Richard Wright, Graham Greene, and Christopher Isherwood. While recent literary criticism has tended to focus on communal forms ranging from the nation-state to the black diaspora, each of these forms still retains a commitment to communal essentialism. Countering this tradition, I argue that the literature of late modernism strives to depict relations that don\u2019t draw on the romance of community. Moreover, I suggest that such intimacies transpire through various non-linguistic media such as noise, signals, and silence. The first chapter provides a framework for reading noise by turning to the archives of communication theory and scientific opinion polling. I argue that Fitzgerald\u2019s novel, Tender is the Night, frames noise as the locus of public desire but refuses to convert these desires into language. In Chapter Two, I consider Greene\u2019s The Quiet American, a novel often read as allegorizing America\u2019s intervention in Vietnam. 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Along with consumption poverty, this study measures poverty of access to basic services faced by migrants in urban destinations. The analyses are presented at two levels: (1) an all-India comparison of migrants\u2019 household consumption poverty (relative to non-migrants) in million plus versus smaller cities, and (2) a case study of India\u2019s capital Delhi examining migrants\u2019 consumption poverty and their neighborhood level access to water and sanitation provision (relative to non-migrants). The results demonstrate that India\u2019s urbanization, while accompanied by economic growth, is failing to translate into the success of rural migrants in Indian cities. Overall, migrants are economically worse off than non-migrants in urban areas, with economic inequality being more pronounced in million plus cities, compared their medium and small sized counterparts. 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Although this study does not empirically examine the mechanisms responsible for challenges faced by migrants in their urban transition, it systematically lays out the social and institutional arrangements that have affected migrants\u2019 urban experiences in India since 1990s economic liberalization reforms. The discussion emphasizes that the question of migrant exclusion in Indian cities is inherently a socio-political one, and contributes to a more nuanced understanding of the prospects of Indian urbanization as well as social inequality in the urban context."], "mods_abstract_ssim": ["My dissertation places rural-urban migrants at the center of an exploration of urban inequality by examining their success as urban residents in India. Along with consumption poverty, this study measures poverty of access to basic services faced by migrants in urban destinations. The analyses are presented at two levels: (1) an all-India comparison of migrants\u2019 household consumption poverty (relative to non-migrants) in million plus versus smaller cities, and (2) a case study of India\u2019s capital Delhi examining migrants\u2019 consumption poverty and their neighborhood level access to water and sanitation provision (relative to non-migrants). The results demonstrate that India\u2019s urbanization, while accompanied by economic growth, is failing to translate into the success of rural migrants in Indian cities. Overall, migrants are economically worse off than non-migrants in urban areas, with economic inequality being more pronounced in million plus cities, compared their medium and small sized counterparts. In Delhi, rural-urban migrants are found to be severely lagging behind in their access to basic services, net of socio-demographic characteristics. Inequality in access to services for migrants is almost twice as high as their gap in economic wellbeing relative to non-migrants. My dissertation is one of the few studies examining rural-urban migrants\u2019 poverty across different sized Indian cities, and the only one using data collected within the last decade to the best of my knowledge. It is additionally the first quantitative study to employ spatial indicators of access to services using the Delhi GIS, further combining it with unique geo-referenced survey data to examine migrant poverty beyond economic indicators. Although this study does not empirically examine the mechanisms responsible for challenges faced by migrants in their urban transition, it systematically lays out the social and institutional arrangements that have affected migrants\u2019 urban experiences in India since 1990s economic liberalization reforms. 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Li ion batteries (LIBs) have been the most important portable power source for consumer electronics and show great promise for vehicle electrification. However, to meet the advanced energy goals required in next-generation vehicular applications, new materials with ultra-high lithium capacities need to be investigated. The study of the bulk and interfacial properties of these new-type electrodes, and especially of their change upon lithiation, is a fundamentally significant and challenging topic in designing heterogeneous nano-structured electrodes for LIBs. This issue becomes more intriguing for silicon (Si) and tin (Sn) electrodes, whose ultrahigh capacity is accompanied by large volumetric expansion and mechanical stresses, having a pivotal impact on the LIBs' performance. Though numerous experiments have been performed to address these issues and trace these changes, in many cases these experimental studies can only report properties that are averaged over time or space, while the local and detailed information of the structure remains buried. Clearly the role of computational studies in acquiring a profound understanding of these mechanisms is critical. Computer simulations at the atomic level, able to provide a unique insight into these changes, can significantly enhance our ability to understand the fundamental interactions between Li ions and the host electrode during Li insertion. Therefore, they can provide a foundation for developing quantitative models for electrode failure and for subsequent development of flaw-tolerant architectures. In this thesis we quantitatively study the lithiation procedure in C, Si and Sn electrodes from first-principles calculations based on density functional theory (DFT) and ab-initio molecular dynamics (AIMD) and study a wide range of different systems and architectures, including surfaces, interfaces and bulk nano-materials. We discuss an assortment of computational aspects related to Li insertion in various types of active host materials, such as bulk Sn, Si/Cu and amorphous Si/C interfaces and introduce the detailed atomistic picture of the lithiation properties and processes from first-principles simulations."], "mods_abstract_ssim": ["Energy storage is a crucial aspect of integrating renewable energy sources in power grids, portable electronic devices and vehicle applications, making the development of efficient batteries a high technological challenge. Li ion batteries (LIBs) have been the most important portable power source for consumer electronics and show great promise for vehicle electrification. However, to meet the advanced energy goals required in next-generation vehicular applications, new materials with ultra-high lithium capacities need to be investigated. The study of the bulk and interfacial properties of these new-type electrodes, and especially of their change upon lithiation, is a fundamentally significant and challenging topic in designing heterogeneous nano-structured electrodes for LIBs. This issue becomes more intriguing for silicon (Si) and tin (Sn) electrodes, whose ultrahigh capacity is accompanied by large volumetric expansion and mechanical stresses, having a pivotal impact on the LIBs' performance. Though numerous experiments have been performed to address these issues and trace these changes, in many cases these experimental studies can only report properties that are averaged over time or space, while the local and detailed information of the structure remains buried. Clearly the role of computational studies in acquiring a profound understanding of these mechanisms is critical. Computer simulations at the atomic level, able to provide a unique insight into these changes, can significantly enhance our ability to understand the fundamental interactions between Li ions and the host electrode during Li insertion. Therefore, they can provide a foundation for developing quantitative models for electrode failure and for subsequent development of flaw-tolerant architectures. In this thesis we quantitatively study the lithiation procedure in C, Si and Sn electrodes from first-principles calculations based on density functional theory (DFT) and ab-initio molecular dynamics (AIMD) and study a wide range of different systems and architectures, including surfaces, interfaces and bulk nano-materials. We discuss an assortment of computational aspects related to Li insertion in various types of active host materials, such as bulk Sn, Si/Cu and amorphous Si/C interfaces and introduce the detailed atomistic picture of the lithiation properties and processes from first-principles simulations."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z09W0CT4", "mods_id": "etd1332", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Stournara, Maria Eleftheria", "Shenoy, Vivek", "Gao, Huajian", "Chason, Eric", "Qi, Yue", "Brown University. 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"_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["The nanocrystals (NCs) dispersed in solution are promising ink materials for solution-process because they can be readily deposited on substrates in thin films by self-assembly with the solvent drying. As a well-studied transparent conductive oxide, indium tin oxide (ITO) is a good material choice to study solution-processed transparent electrode. Sputtered ITO thin films exhibit the transparency higher than 85% in visible spectral range and the resistivity of 10-4 \u03a9\u2022cm order. Here, we present the synthesis of indium tin oxide (ITO) NCs and the optoelectronic properties of their assemblies. By controlling the reaction condition, we synthesized monodisperse 11 nm nanospheres and 14 nm nanocubes by the thermal decomposition of In(acac)3 and Sn(acac)2Cl2 in an organic solvent. As-synthesized ITO NCs are stably dispersed in organic solutions such as hexane, toluene, and chloroform. The uniform assemblies of ITO nanospheres and nanocubes were made by spin-coating or dip-coating. The thickness of these assemblies is readily tuned from 30 to 200 nm by the concentration of ITO NC solution. After annealing at 300 \u00b0C, these assemblies exhibited the transparency over 85% in visible spectral range and Rs of 133 \u03a9/sq and resistivity of 2.6 \u00d7 10-3 \u03a9\u2022cm, which meet the requirements to be used as electrodes in resistive touch panels, capacitive touch panels and LCD pixels. This high optoelectronic performance is attributed to both monodispersed ITO NCs and uniform, densely-packed assembly of the NCs. Via exchange spring between hard and soft phase magnets, composite magnet can store higher magnetic energy than single component magnet can do. For optimum exchange spring, soft phase magnets must be in nanometer scale, and they should be mixed homogeneously in hard-phase matrix. Binary assembly of soft and hard magnetic NCs is a promising method to build exchange spring system. Here, we studied fct-FePt and SmCo5 as hard-phase magnets and application of protection materials to keep the structure of magnetic NCs from high temperature annealing for the homogenous mixture."], "mods_abstract_ssim": ["The nanocrystals (NCs) dispersed in solution are promising ink materials for solution-process because they can be readily deposited on substrates in thin films by self-assembly with the solvent drying. As a well-studied transparent conductive oxide, indium tin oxide (ITO) is a good material choice to study solution-processed transparent electrode. Sputtered ITO thin films exhibit the transparency higher than 85% in visible spectral range and the resistivity of 10-4 \u03a9\u2022cm order. Here, we present the synthesis of indium tin oxide (ITO) NCs and the optoelectronic properties of their assemblies. By controlling the reaction condition, we synthesized monodisperse 11 nm nanospheres and 14 nm nanocubes by the thermal decomposition of In(acac)3 and Sn(acac)2Cl2 in an organic solvent. As-synthesized ITO NCs are stably dispersed in organic solutions such as hexane, toluene, and chloroform. The uniform assemblies of ITO nanospheres and nanocubes were made by spin-coating or dip-coating. The thickness of these assemblies is readily tuned from 30 to 200 nm by the concentration of ITO NC solution. After annealing at 300 \u00b0C, these assemblies exhibited the transparency over 85% in visible spectral range and Rs of 133 \u03a9/sq and resistivity of 2.6 \u00d7 10-3 \u03a9\u2022cm, which meet the requirements to be used as electrodes in resistive touch panels, capacitive touch panels and LCD pixels. This high optoelectronic performance is attributed to both monodispersed ITO NCs and uniform, densely-packed assembly of the NCs. Via exchange spring between hard and soft phase magnets, composite magnet can store higher magnetic energy than single component magnet can do. For optimum exchange spring, soft phase magnets must be in nanometer scale, and they should be mixed homogeneously in hard-phase matrix. Binary assembly of soft and hard magnetic NCs is a promising method to build exchange spring system. Here, we studied fct-FePt and SmCo5 as hard-phase magnets and application of protection materials to keep the structure of magnetic NCs from high temperature annealing for the homogenous mixture."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0Q52N0X", "mods_id": "etd1329", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Lee, Jonghun", "Sun, Shouheng", "Palmore, G. 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Secreted ligands initiate BMP signaling by binding to a quadripartite receptor complex consisting of two type I and two type II receptor kinases. The type I receptor kinase, which is activated by the type II receptor in the signaling complex, phosphorylates R-Smad transcription factors to elicit cellular responses via target gene regulation. The existence of multiple BMP receptors raises the possibility that different combinations of receptors can affect signaling output of receptor complexes. This concept is supported by studies in cell culture, zebrafish, and Drosophila indicating that type I receptor permutations within a complex can dramatically impact signaling activity. Although it has been suggested that type I receptors influence each other\u2019s activity, the precise mechanism is unknown. In Drosophila, two type I receptors, Tkv and Sax, and two type II receptors, Punt and Wit, transduce signals initiated by the BMP ligands Dpp, Gbb, and Scw. The interplay between these components is essential in a variety of developmental contexts. During wing development, a dual function has been ascribed to Sax where it can facilitate or antagonize signaling. Genetic characterization of this behavior led to a model in which Sax mediates signaling in a complex with Tkv, but inhibits BMP signals when paired with another Sax receptor. From experiments described here, we have identified protein subdomains that determine type I receptor signaling activity. These regions are important in type II receptor-mediated activation of type I receptor kinases and dimerization of type I receptors. In a Drosophila model for the bone disease fibrodysplasia ossificans progressiva (FOP), we have demonstrated that the constitutive activity of the FOP mutant receptor ALK2[R206H] is type II receptor-dependent, further underscoring the importance of the type II receptor. 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This concept is supported by studies in cell culture, zebrafish, and Drosophila indicating that type I receptor permutations within a complex can dramatically impact signaling activity. Although it has been suggested that type I receptors influence each other\u2019s activity, the precise mechanism is unknown. In Drosophila, two type I receptors, Tkv and Sax, and two type II receptors, Punt and Wit, transduce signals initiated by the BMP ligands Dpp, Gbb, and Scw. The interplay between these components is essential in a variety of developmental contexts. During wing development, a dual function has been ascribed to Sax where it can facilitate or antagonize signaling. Genetic characterization of this behavior led to a model in which Sax mediates signaling in a complex with Tkv, but inhibits BMP signals when paired with another Sax receptor. From experiments described here, we have identified protein subdomains that determine type I receptor signaling activity. These regions are important in type II receptor-mediated activation of type I receptor kinases and dimerization of type I receptors. In a Drosophila model for the bone disease fibrodysplasia ossificans progressiva (FOP), we have demonstrated that the constitutive activity of the FOP mutant receptor ALK2[R206H] is type II receptor-dependent, further underscoring the importance of the type II receptor. We propose that Sax:Sax dimers inhibit signaling by adopting a configuration that is incompatible for activation by type II receptors. 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Residential patterns of the six major Asian groups (Chinese, Indians, Filipinos, Japanese, Koreans, and Vietnamese) over the period from 1970 to 2010 offer the empirical ground for testing the theories of spatial assimilation, place stratification, and ethnic preferences. Data from the aggregate census tabulation tables and the individual sample files allow the analyses of trends in residential segregation, the formation and development of local ethnic neighborhoods, and the locational attainment at the individual level. The findings reveal an increasing intermingling of Asian groups and the persistent self-segregation of most Asian groups over time. Individual location attainment models report that foreign-born status, English-language proficiency, educational attainment, self-employment, and homeownership are found to be significantly associated with the probability of living in co-ethnic neighborhoods. Yet, these effects vary across groups. Contrary to the interpretation of the standard assimilation model, household income is found to be positively associated with the propensity of living in co-ethnic neighborhoods. The results show that in addition to assimilating with whites, Asian members have alternative options."], "mods_abstract_ssim": ["The dissertation examines competing theories that explain national origin variations in residential assimilation of Asian Americans in the United States with a particular attention to the effects of ethnicity and socioeconomic status. Residential patterns of the six major Asian groups (Chinese, Indians, Filipinos, Japanese, Koreans, and Vietnamese) over the period from 1970 to 2010 offer the empirical ground for testing the theories of spatial assimilation, place stratification, and ethnic preferences. Data from the aggregate census tabulation tables and the individual sample files allow the analyses of trends in residential segregation, the formation and development of local ethnic neighborhoods, and the locational attainment at the individual level. The findings reveal an increasing intermingling of Asian groups and the persistent self-segregation of most Asian groups over time. Individual location attainment models report that foreign-born status, English-language proficiency, educational attainment, self-employment, and homeownership are found to be significantly associated with the probability of living in co-ethnic neighborhoods. Yet, these effects vary across groups. Contrary to the interpretation of the standard assimilation model, household income is found to be positively associated with the propensity of living in co-ethnic neighborhoods. The results show that in addition to assimilating with whites, Asian members have alternative options."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0251GH9", "mods_id": "etd1172", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Zhang, Weiwei", "Logan, John", "White, Michael", "Itzigsohn, Jos\u00e9", "Lindstrom, David", "Pacewicz, Josh", "Brown University. 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The LUX detector inner fiducial region is the lowest measured background particle detector in the world at keV energies, with background rates at the level of 1E-3 counts/keV/kg/day. Low background rates are essential for identifying WIMP interactions in the detector, which occur with frequencies <1/kg/(5 years). LUX completed its first low-background science run at the Sanford Underground Research Facility in August 2013. WIMP search results are reported from an 85 live day analysis. The experiment places the tightest constraint on WIMP spin-independent interaction cross-sections to date. Results from LUX also exclude several potential dark matter signal claims from other direct detection experiments, for WIMP masses in the range 6-15 GeV. The LUX result is the product of low detector background rates and high photon signal collection efficiency. Analysis of the first WIMP search data has provided direct characterization of low-energy backgrounds in LUX. Measured background rates were found to be in agreement with expectations based on models of detector material radioactivity. The data also provides the first measurements of intrinsic radioactive contaminants in the detector, including short-lived cosmogenic Xe radioisotopes. I will describe the LUX background model, detailing work which was used in the design and early performance projections of the LUX detector, as well as background measurements which constrain and support the model."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0057D9F", "mods_id": "etd1190", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Malling, David Charles", "Gaitskell, Richard", "Savvas, Koushiappas", "Cutts, David", "Brown University. 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"deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [313], "ir_collection_name": ["Biology and Medicine", "Molecular Pharmacology, Physiology, and Biotechnology", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["Aspartyl-asparaginyl-\u03b2-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). AAH expression is stimulated by insulin and insulin-like growth factor-1 (IGF-1) signaling networks. Insulin/IGF-1 signaling is over-activated in HCCs, but inhibited by ethanol exposure, partly due to aberrant ceramide accumulation. AAH promotes cell adhesion, migration, and invasion partly through the hydroxylation of Notch-1 and Jagged-1 and attendant activation of Notch signaling. Insulin/IGF-1 signaling networks regulate AAH at the transcriptional, as well as the post-translational levels. More specifically, AAH may be post-translationally regulated by phosphorylation since inhibition of glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) increases AAH protein and migration, while GSK-3\u03b2 overexpression yields the opposite effects. Correspondingly, sub-sequence analysis of AAH protein demonstrated a number of potential phosphorylation sites corresponding to GSK-3\u03b2, as well as protein kinase A (PKA), protein kinase C (PKC), and casein kinase 2 (CK2). To investigate the regulation of AAH in the liver, liver tissue or liver slice cultures from Long Evans rats were exposed to ethanol and a ceramide inhibitor or insulin sensitizing treatments to examine the effects on insulin/IGF-1, AAH, and Notch signaling activation. Human hepatoma-derived Huh7 cells served to characterize the effects of IGF-1 stimulation on AAH protein and the post-translational regulation of AAH by phosphorylation, using chemical inhibitors of GSK-3\u03b2, PKA, PKC, or CK2, or using AAH mutants lacking individual phosphorylation sites. The findings demonstrated that inhibition of ceramide synthesis restored ethanol-impaired insulin/IGF-1 signaling, expression of AAH and Notch signaling proteins in the liver. Furthermore, IGF-1 signaling promoted AAH expression and subcellular trafficking with consequences on the activation of Notch signaling. Lastly, the findings suggest AAH protein is post-translationally regulated by phosphorylation at multiple sites, possibly through priming mechanisms of phosphorylation. The investigations shed light on the regulation of AAH protein expression and function as it relates to the activation of Notch signaling and its dysregulation in HCC and ALD."], "mods_abstract_ssim": ["Aspartyl-asparaginyl-\u03b2-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). AAH expression is stimulated by insulin and insulin-like growth factor-1 (IGF-1) signaling networks. Insulin/IGF-1 signaling is over-activated in HCCs, but inhibited by ethanol exposure, partly due to aberrant ceramide accumulation. AAH promotes cell adhesion, migration, and invasion partly through the hydroxylation of Notch-1 and Jagged-1 and attendant activation of Notch signaling. Insulin/IGF-1 signaling networks regulate AAH at the transcriptional, as well as the post-translational levels. More specifically, AAH may be post-translationally regulated by phosphorylation since inhibition of glycogen synthase kinase-3\u03b2 (GSK-3\u03b2) increases AAH protein and migration, while GSK-3\u03b2 overexpression yields the opposite effects. Correspondingly, sub-sequence analysis of AAH protein demonstrated a number of potential phosphorylation sites corresponding to GSK-3\u03b2, as well as protein kinase A (PKA), protein kinase C (PKC), and casein kinase 2 (CK2). To investigate the regulation of AAH in the liver, liver tissue or liver slice cultures from Long Evans rats were exposed to ethanol and a ceramide inhibitor or insulin sensitizing treatments to examine the effects on insulin/IGF-1, AAH, and Notch signaling activation. Human hepatoma-derived Huh7 cells served to characterize the effects of IGF-1 stimulation on AAH protein and the post-translational regulation of AAH by phosphorylation, using chemical inhibitors of GSK-3\u03b2, PKA, PKC, or CK2, or using AAH mutants lacking individual phosphorylation sites. The findings demonstrated that inhibition of ceramide synthesis restored ethanol-impaired insulin/IGF-1 signaling, expression of AAH and Notch signaling proteins in the liver. Furthermore, IGF-1 signaling promoted AAH expression and subcellular trafficking with consequences on the activation of Notch signaling. Lastly, the findings suggest AAH protein is post-translationally regulated by phosphorylation at multiple sites, possibly through priming mechanisms of phosphorylation. The investigations shed light on the regulation of AAH protein expression and function as it relates to the activation of Notch signaling and its dysregulation in HCC and ALD."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0VH5M5K", "mods_id": "etd1191", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Lizarazo, Diana", "de la Monte, Suzanne", "Wands, Jack", "Salomon, Arthur", "Harnett, Karen", "Britt, Deborah", "Brown University. 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Dingeldein, Ph.D., Brown University, May 2014 Inhabitants of the ancient Mediterranean operated with robust notions of moral development, promoting various ideas about the goals, mechanisms, and stages involved in humans\u2019 cultivation of virtue. Among those concerned with articulating theories about moral progress stands the apostle Paul. Attempting to form communities of Christ followers in the lands surrounding the Mediterranean Sea during the first century CE, Paul describes in a series of letters preserved in the New Testament a program of moral development for non-Jews who desire to inherit immortality from the God of Israel. In this dissertation I reconstruct and historically contextualize Paul\u2019s program of moral development for non-Jews by means of a detailed, critical comparison with the systems of moral progress espoused by ancient Mediterranean philosophers. The prevailing scholarly approach to the study of Paul\u2019s letters maintains that Paul neither conceives of Christ followers as participating in virtue acquisition nor differentiates among Christ followers with respect to their moral abilities. Moreover, studies of specific aspects of Paul\u2019s program of moral development often compare Paul\u2019s thought exclusively with \u201cHellenistic Jewish\u201d philosophy, rather than with ancient Mediterranean philosophy more broadly. In this dissertation I argue that this standard approach is untenable: it fails to take seriously evidence derived from Paul\u2019s own letters, and to securely locate Paul within his historical context. I argue that Paul\u2019s program of moral development cannot be fully understood without recourse to ancient Mediterranean philosophy and that Paul\u2019s thought aligns best with Middle Platonic understandings of moral progress. I also use my reconstruction of Paul\u2019s program of moral development to overturn the standard interpretation of 1 Cor 2:6-3:4, arguing that Paul describes in this passage a hierarchical schema of moral differentiation into which he categorizes Christ followers. Ultimately, by reconstructing and historically situating Paul\u2019s program of moral development in this manner, I aim to elucidate some of the ways in which Paul\u2019s vision of non-Jewish Christ followers\u2019 moral development would have been recognizable to Paul\u2019s audiences in the first century CE."], "mods_abstract_ssim": ["Abstract of \u201cGaining Virtue, Gaining Christ: Moral Development in the Letters of Paul,\u201d by Laura B. Dingeldein, Ph.D., Brown University, May 2014 Inhabitants of the ancient Mediterranean operated with robust notions of moral development, promoting various ideas about the goals, mechanisms, and stages involved in humans\u2019 cultivation of virtue. Among those concerned with articulating theories about moral progress stands the apostle Paul. Attempting to form communities of Christ followers in the lands surrounding the Mediterranean Sea during the first century CE, Paul describes in a series of letters preserved in the New Testament a program of moral development for non-Jews who desire to inherit immortality from the God of Israel. In this dissertation I reconstruct and historically contextualize Paul\u2019s program of moral development for non-Jews by means of a detailed, critical comparison with the systems of moral progress espoused by ancient Mediterranean philosophers. The prevailing scholarly approach to the study of Paul\u2019s letters maintains that Paul neither conceives of Christ followers as participating in virtue acquisition nor differentiates among Christ followers with respect to their moral abilities. Moreover, studies of specific aspects of Paul\u2019s program of moral development often compare Paul\u2019s thought exclusively with \u201cHellenistic Jewish\u201d philosophy, rather than with ancient Mediterranean philosophy more broadly. In this dissertation I argue that this standard approach is untenable: it fails to take seriously evidence derived from Paul\u2019s own letters, and to securely locate Paul within his historical context. I argue that Paul\u2019s program of moral development cannot be fully understood without recourse to ancient Mediterranean philosophy and that Paul\u2019s thought aligns best with Middle Platonic understandings of moral progress. I also use my reconstruction of Paul\u2019s program of moral development to overturn the standard interpretation of 1 Cor 2:6-3:4, arguing that Paul describes in this passage a hierarchical schema of moral differentiation into which he categorizes Christ followers. Ultimately, by reconstructing and historically situating Paul\u2019s program of moral development in this manner, I aim to elucidate some of the ways in which Paul\u2019s vision of non-Jewish Christ followers\u2019 moral development would have been recognizable to Paul\u2019s audiences in the first century CE."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0DZ06NF", "mods_id": "etd1271", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Dingeldein, Laura Beth", "Stowers, Stanley", "Kraemer, Ross", "Harvey, Susan", "Brown University. 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Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["This thesis presents experimental measurements and modeling of multi-scale collective behaviors characteristics of hierarchical interfaces in lithium-ion batteries (LIBs) during cycling. Two interfacial mechanisms are introduced: One is in-plane sliding between lithiated electrodes (a-SiLix) and current collectors (Cu). The other is normal contact between the internal interfaces of pouch battery cells. To estimate the interfacial properties at a-SiLix//Cu interfaces, a new apparatus, named \u201cSelf-Adjusting Liquid Linnik Interferometer (SALLI)\u201d, has been invented to perform in situ whole field deformation measurements with \u00b5m resolution in lateral direction and nm resolution in out-of-plane direction. Our result clearly demonstrates Li segregation at the interface initially which leads to 200 \u00b5m shrinkage of the Si film in the first cycle due to relaxation of residual tensile stress. A mechanical model system, plate bending distribution sensor (PBDS), which incorporates substrate bending and interfacial sliding in its calibration has been developed. By bridging the deformation estimated from PBDS and that measured from the SALLI experiment, the interfacial properties are extracted quantitatively. The critical energy release rate is estimated as 0.075 J/m2 and 0.34 J/m2 for the receding and growing shear crack fronts respectively. A remarkable discovery is that the interfacial shear strength of the actively segregating lithium at the interface is measured only 1.15 kPa. It is due electro-chemically active lithium-ion segregation process that allows slip processes of hopping through a series of meta-stable atomic configurations. Finally, two sets of in situ experiments have been performed and a mechanical model has been developed to explain the internal contact mechanism and its relationship with interface bubble-gas evolution. Through these techniques, the degradation mechanism of the pouch cells are explained. It shows that applying 4\u20135 psi prestressed pressure to the cell can better control the bubble-gas formation and increase the electrode contact area. Therefore, the battery life is efficiently elongated. It is hoped that the thesis work can contribute to optimal design of battery cells and maximize cell capacity and life of LIBs."], "mods_abstract_ssim": ["This thesis presents experimental measurements and modeling of multi-scale collective behaviors characteristics of hierarchical interfaces in lithium-ion batteries (LIBs) during cycling. Two interfacial mechanisms are introduced: One is in-plane sliding between lithiated electrodes (a-SiLix) and current collectors (Cu). The other is normal contact between the internal interfaces of pouch battery cells. To estimate the interfacial properties at a-SiLix//Cu interfaces, a new apparatus, named \u201cSelf-Adjusting Liquid Linnik Interferometer (SALLI)\u201d, has been invented to perform in situ whole field deformation measurements with \u00b5m resolution in lateral direction and nm resolution in out-of-plane direction. Our result clearly demonstrates Li segregation at the interface initially which leads to 200 \u00b5m shrinkage of the Si film in the first cycle due to relaxation of residual tensile stress. A mechanical model system, plate bending distribution sensor (PBDS), which incorporates substrate bending and interfacial sliding in its calibration has been developed. By bridging the deformation estimated from PBDS and that measured from the SALLI experiment, the interfacial properties are extracted quantitatively. The critical energy release rate is estimated as 0.075 J/m2 and 0.34 J/m2 for the receding and growing shear crack fronts respectively. A remarkable discovery is that the interfacial shear strength of the actively segregating lithium at the interface is measured only 1.15 kPa. It is due electro-chemically active lithium-ion segregation process that allows slip processes of hopping through a series of meta-stable atomic configurations. Finally, two sets of in situ experiments have been performed and a mechanical model has been developed to explain the internal contact mechanism and its relationship with interface bubble-gas evolution. Through these techniques, the degradation mechanism of the pouch cells are explained. It shows that applying 4\u20135 psi prestressed pressure to the cell can better control the bubble-gas formation and increase the electrode contact area. Therefore, the battery life is efficiently elongated. It is hoped that the thesis work can contribute to optimal design of battery cells and maximize cell capacity and life of LIBs."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0959FXG", "mods_id": "etd1272", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Wu, Hsiao-Mei", "Kim, Kyung-Suk", "Guduru, Pradeep R.", "Sheldon, Brian W.", "Brown University. 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The gonadal-enriched TFIID subunit TAF4B is required for murine fertility and mediates estrogen-induced proliferation of ovarian granulosa cells. These results prompted the hypothesis that TAF4B is part of an ovarian estrogen signaling pathway. Furthermore, the fact that ovarian tumors rely on deregulation of the same growth and apoptotic signaling pathways that regulate folliculogenesis suggested that TAF4B may also affect ovarian tumorigenesis. To determine whether TAF4B is involved in ovarian estrogen response, I first tested whether Taf4b is itself estrogen responsive. Indeed, Taf4b mRNA and TAF4B protein were upregulated in normal mouse ovaries and mouse ovarian tumors exposed to exogenous estrogens. This response occurred primarily via ER\u03b2; however, ER\u03b1 could maintain Taf4b levels in ER\u03b2\u2019s absence. Bioinformatic promoter analysis allowed the identification of a putative estrogen response element in the Taf4b promoter. The significance of these results was explored by comparing estrogen-dependent transcriptional responses in Taf4b-knockout versus wildtype ovaries. Microarray analysis revealed a small number of genes differing in their response to estrogen in the absence of TAF4B. Together with the estrogen responsiveness of TAF4B, these results illustrate the involvement of TAF4B in ovarian estrogen response. To complement this genome-wide approach, ovarian tumor development was examined in Taf4b-knockout and wildtype mice. Preliminary data suggest that Taf4b-knockout mice can develop tumors; however, background strain effects of the Taf4b mouse line precluded determining the effect of TAF4B on estrogen-induced changes in tumor onset and survival. In addition to TAF4B, I show that other TFIID subunits, especially TAF2, are amplified or upregulated in many high-grade serous ovarian cancers. A cell-based assay was established to identify TAF inhibitors that could potentially be used to disrupt TFIID in human ovarian cancer. Together, the results presented demonstrate that TAFs should be examined more closely for their specific roles in ovarian cancer and for how their deregulation can be targeted in future therapeutics."], "mods_abstract_ssim": ["Historically, the TFIID complex has been viewed as part of the general transcriptional apparatus; however, recent studies demonstrate that it is flexible in its constituents and has tissue-specific functions. The gonadal-enriched TFIID subunit TAF4B is required for murine fertility and mediates estrogen-induced proliferation of ovarian granulosa cells. These results prompted the hypothesis that TAF4B is part of an ovarian estrogen signaling pathway. 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["bdr:eefs25en"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "rel_embargo_years_ssim": ["2016"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [357], "ir_collection_name": ["Political Science", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["In this thesis I study the individual consequences of state-led repression for the case of the Chilean military dictatorship. The main questions are: how did repression influence individual\u2019s political preferences and political participation? And to what extent was this inter-generationally transmitted to their children? I conduct my analysis within a model which sees people\u2019s preferences as being formed by socialization as part of their identity. I develop three hypotheses: i) While the political preferences of repressed subjects would tend not to change they would disengage from political life, participating less in any way which risked further repression.; ii) Those who belonged to radical parties and were students in 1973, and were repressed, would experience a greater challenge to their identity and could react by taking actions to reconfirm that identity. and iii) a): I would expect that basic average effects on political behavior participation to be transmitted to the children. and b): given the persistence of fear, the impact of having a parent repressed would be to shift the political preferences of children to the right. I test these hypotheses using a unique dataset I collected in Chile in 2012. I surveyed subjects who experienced repression and built a matching group with very similar socio-economic characteristics that did not experience repression. Since there is a clear selection into the repressed group, I use a difference in differences strategy where I compare the outcome of the repressed relative to the non-repressed before and after repression took place. From these estimations, I find several robust results: In Chapter 2, I find that as a consequence of repression the participation of these subjects fell relatively to the non-repressed. In Chapter 3, I find evidence that repression has differential effects depending on people\u2019s identities and how they react to challenges to it. In Chapter 4, I find that children of the repressed replicate the behavior of the parents and the fear of repression persisted shifting the children\u2019s political preferences\u2019 to the right."], "mods_abstract_ssim": ["In this thesis I study the individual consequences of state-led repression for the case of the Chilean military dictatorship. The main questions are: how did repression influence individual\u2019s political preferences and political participation? And to what extent was this inter-generationally transmitted to their children? I conduct my analysis within a model which sees people\u2019s preferences as being formed by socialization as part of their identity. I develop three hypotheses: i) While the political preferences of repressed subjects would tend not to change they would disengage from political life, participating less in any way which risked further repression.; ii) Those who belonged to radical parties and were students in 1973, and were repressed, would experience a greater challenge to their identity and could react by taking actions to reconfirm that identity. and iii) a): I would expect that basic average effects on political behavior participation to be transmitted to the children. and b): given the persistence of fear, the impact of having a parent repressed would be to shift the political preferences of children to the right. I test these hypotheses using a unique dataset I collected in Chile in 2012. I surveyed subjects who experienced repression and built a matching group with very similar socio-economic characteristics that did not experience repression. Since there is a clear selection into the repressed group, I use a difference in differences strategy where I compare the outcome of the repressed relative to the non-repressed before and after repression took place. From these estimations, I find several robust results: In Chapter 2, I find that as a consequence of repression the participation of these subjects fell relatively to the non-repressed. In Chapter 3, I find evidence that repression has differential effects depending on people\u2019s identities and how they react to challenges to it. In Chapter 4, I find that children of the repressed replicate the behavior of the parents and the fear of repression persisted shifting the children\u2019s political preferences\u2019 to the right."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0X065FM", "mods_id": "etd1278", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Bautista, Maria Angelica", "Cammett, Melani", "Weitz-Shappiro, Rebecca", "Jones Luong, Pauline", "Brown University. 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Rapid adaptive camouflage is particularly interesting because it allows us to examine the visual perception of prey animals that must quickly alter their body pattern (color, brightness, scale), posture, locomotion and/or texture to hide amidst their surroundings. This work also informs our understanding of the visual systems of predators, animals that must break camouflage to identify their next potential meal. Coleoid cephalopods are particularly good models for this work because they must achieve crypsis against predators with diverse visual systems (diving sea birds, marine mammals, teleost fish, elasmobranchs, and other cephalopods). Here, I focused on one aspect of cuttlefish and octopus changeable camouflage: texture and edge modulation via three-dimensional skin papillae. The ability to extend and retract papillae allows these animals to produce complicated edges for camouflage without the cost of increased swimming drag. Previous work showed that papilla extension is mediated by visual information, yet the biomechanics of these structures had never been examined in detail. First, I used a variety of histological techniques to examine details of the functional morphology of one type of papilla in the cuttlefish Sepia officinalis. I followed this study with a comparative analysis of nine types of papillae of different shapes, sizes, complexity and locations on the body using six species of octopus and cuttlefish. Finally, I examined the adaptive camouflage capabilities of a different model, the slender filefish Monacanthus tuckeri, a Caribbean reef fish with three-dimensional skin projections (dermal flaps) and the ability to rapidly change its color and pattern. The detection of an object\u2019s true edge (i.e., outline) promotes recognition by a viewer, and prey animals have evolved a variety of ways to disguise their true edges. 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Here, I focused on one aspect of cuttlefish and octopus changeable camouflage: texture and edge modulation via three-dimensional skin papillae. The ability to extend and retract papillae allows these animals to produce complicated edges for camouflage without the cost of increased swimming drag. Previous work showed that papilla extension is mediated by visual information, yet the biomechanics of these structures had never been examined in detail. First, I used a variety of histological techniques to examine details of the functional morphology of one type of papilla in the cuttlefish Sepia officinalis. I followed this study with a comparative analysis of nine types of papillae of different shapes, sizes, complexity and locations on the body using six species of octopus and cuttlefish. Finally, I examined the adaptive camouflage capabilities of a different model, the slender filefish Monacanthus tuckeri, a Caribbean reef fish with three-dimensional skin projections (dermal flaps) and the ability to rapidly change its color and pattern. The detection of an object\u2019s true edge (i.e., outline) promotes recognition by a viewer, and prey animals have evolved a variety of ways to disguise their true edges. 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Particles evolve as exchangeable jump Markov processes, where finite collections of particles are allowed to change their state simultaneously. Such models arise naturally in statistical physics, queueing systems and communication networks literatures. In the first part of the thesis, we establish a large deviation principle for the empirical measure process for the interacting particle systems. The approach is based on a variational representation for functionals of a Poisson random measure. Under an appropriate communication condition, we also prove a locally uniform large deviation principle. The main novelty is that more than one particle is allowed to change its state simultaneously, and so a standard approach to the proof based on change of measure is not possible. Along the way, we establish an LDP for jump Markov processes on the simplex, whose rates decay to zero as they approach the boundary of the domain. This result may be of independent interest. In the second part of the thesis, we focus on the mean field interacting particle systems that only admit single particle jumps. Under the assumption that there exists a unique stationary measure, we construct a Markov chain approximation of the quasipotential function associated with the equilibrium. This is the first example of the Markov chain approximation for problems with non-quadratic running cost (but still convex in the control), which may also have singularities near the boundary."], "mods_abstract_ssim": ["We study a general class of mean field interacting particle systems with a finite state space. Particles evolve as exchangeable jump Markov processes, where finite collections of particles are allowed to change their state simultaneously. Such models arise naturally in statistical physics, queueing systems and communication networks literatures. In the first part of the thesis, we establish a large deviation principle for the empirical measure process for the interacting particle systems. The approach is based on a variational representation for functionals of a Poisson random measure. Under an appropriate communication condition, we also prove a locally uniform large deviation principle. The main novelty is that more than one particle is allowed to change its state simultaneously, and so a standard approach to the proof based on change of measure is not possible. Along the way, we establish an LDP for jump Markov processes on the simplex, whose rates decay to zero as they approach the boundary of the domain. This result may be of independent interest. In the second part of the thesis, we focus on the mean field interacting particle systems that only admit single particle jumps. Under the assumption that there exists a unique stationary measure, we construct a Markov chain approximation of the quasipotential function associated with the equilibrium. This is the first example of the Markov chain approximation for problems with non-quadratic running cost (but still convex in the control), which may also have singularities near the boundary."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0NG4P0K", "mods_id": "etd1280", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Wu, Wei", "Dupuis, Paul", "Ramanan, Kavita", "Fleming, Wendell", "Brown University. 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By exploiting the special structure of planar graphs, it is often possible to design algorithms that are faster or give better results than their counterparts for general graphs. We present an efficient polynomial-time approximation scheme for the Steiner forest problem in planar graphs, a bicriteria polynomial-time approximation scheme for the ball cover problem in planar graphs, a linear-time algorithm for multiple-source shortest paths problem (MSSP) in planar graphs with integer weights that are small on average, and algorithms that use MSSP to compute closeness and betweenness centrality in planar graphs. We report on our implementation of the latter."], "mods_abstract_ssim": ["Many optimization problems involving graphs naturally feature road networks, grids, or other large planar graphs. By exploiting the special structure of planar graphs, it is often possible to design algorithms that are faster or give better results than their counterparts for general graphs. 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We report on our implementation of the latter."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0S75DQW", "mods_id": "etd1279", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Eisenstat, David Elliot", "Mathieu, Claire", "Klein, Philip", "Werneck, Renato", "Brown University. 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This dissertation focuses on the development of four biosensors that utilize electrochemical and optical transducers to detect vitamin D and glucose, all of which may be modified to detect other biochemical analytes. Nano-structured materials (e.g. DNA, proteins and nano-grooves/slits) were used together with molecular biology and surface chemistry to create signal transducers that can be miniaturized and integrated with microfluidic devices to yield novel biosensing platforms that could result in faster diagnostics of disease and the consequential improvement in health care. Briefly, the first sensor studied the electrochemical properties of CYP27B1 immobilized in a surfactant film on an edge-plane graphite electrode. Cyclic voltammetry revealed a mid-point potential of \u2013180 +/- 5 mV (vs. Ag/AgCl) and the rate of heterogeneous electron transfer was 3.5 +/- 0.6 s<sup>-1</sup>. The lipid film was found to perturb the structural integrity of CYP27B1 and thus, the catalytic conversion of 25(OH)D<sub>3</sub> to 1\u03b1,25(OH)<sub>2</sub>D<sub>3</sub> was not observed. The second sensor detects the electrochemical impedance change upon the binding of 1\u03b1,25(OH)<sub>2</sub>D<sub>3</sub> to a vitamin D receptor embedded in a lipid film on a gold electrode. The response time of the modified electrodes is <10 min with a detection limit of 52 nM. The third sensor consists of a DNA biocircuit that encodes for a bacterial sensor protein that can be expressed and triggered to produce a dose-dependent fluorescent response in the presence of 1\u03b1,25(OH)<sub>2</sub>D<sub>3</sub>. Different parameters including receptor length, induction conditions, and the addition of pelB sequence were investigated to optimize the expression of an active sensor protein into the soluble fraction. The final sensor studied is a groove-slit-groove plasmonic interferometer designed, fabricated and characterized for real-time monitoring of glucose. The detection limit for glucose in aqueous solutions is 5.5 \u00b5M with a sensitivity of 105,000 %/RIU. To address the issue of selectivity, the plasmonic interferometer was coupled to a dye assay, which enabled specific detection of glucose in a complex mixture of salts and small molecules (i.e., artificial saliva) and an 8.5-fold increase in sensitivity."], "mods_abstract_ssim": ["Over the past few decades, remarkable progress has been made in the development of analytical biosensors for use in medical diagnostics. This dissertation focuses on the development of four biosensors that utilize electrochemical and optical transducers to detect vitamin D and glucose, all of which may be modified to detect other biochemical analytes. Nano-structured materials (e.g. DNA, proteins and nano-grooves/slits) were used together with molecular biology and surface chemistry to create signal transducers that can be miniaturized and integrated with microfluidic devices to yield novel biosensing platforms that could result in faster diagnostics of disease and the consequential improvement in health care. Briefly, the first sensor studied the electrochemical properties of CYP27B1 immobilized in a surfactant film on an edge-plane graphite electrode. Cyclic voltammetry revealed a mid-point potential of \u2013180 +/- 5 mV (vs. Ag/AgCl) and the rate of heterogeneous electron transfer was 3.5 +/- 0.6 s<sup>-1</sup>. The lipid film was found to perturb the structural integrity of CYP27B1 and thus, the catalytic conversion of 25(OH)D<sub>3</sub> to 1\u03b1,25(OH)<sub>2</sub>D<sub>3</sub> was not observed. The second sensor detects the electrochemical impedance change upon the binding of 1\u03b1,25(OH)<sub>2</sub>D<sub>3</sub> to a vitamin D receptor embedded in a lipid film on a gold electrode. The response time of the modified electrodes is <10 min with a detection limit of 52 nM. The third sensor consists of a DNA biocircuit that encodes for a bacterial sensor protein that can be expressed and triggered to produce a dose-dependent fluorescent response in the presence of 1\u03b1,25(OH)<sub>2</sub>D<sub>3</sub>. Different parameters including receptor length, induction conditions, and the addition of pelB sequence were investigated to optimize the expression of an active sensor protein into the soluble fraction. The final sensor studied is a groove-slit-groove plasmonic interferometer designed, fabricated and characterized for real-time monitoring of glucose. The detection limit for glucose in aqueous solutions is 5.5 \u00b5M with a sensitivity of 105,000 %/RIU. To address the issue of selectivity, the plasmonic interferometer was coupled to a dye assay, which enabled specific detection of glucose in a complex mixture of salts and small molecules (i.e., artificial saliva) and an 8.5-fold increase in sensitivity."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0BR8QH6", "mods_id": "etd580", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Siu, Vince Shing-Wing", "Palmore, Tayhas", "Pacifici, Domenico", "Tripathi, Anubhav", "Wessel, Gary", "MacDonald, John", "Brown University. 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By 2 years, very preterm/low birthweight children tend to have smaller vocabularies and use less complex grammatical structures than do their full-term counterparts. Yet, little is known about whether variations in skills in preverbal stages of development predict later delays. Reduced vocabularies, however, suggest that preterm children have difficulty with word-learning, which depends on receptive language abilities developed early in life. The present longitudinal study addresses this premise in two parts. First, it compares infant sound-structure sensitivities (i.e., preferences for trochaic versus iambic lexical stress at 4 and 6 months and for high versus low phonotactic probabilities at 6 and 9 months) and toddler word form representations (i.e., detection of mispronunciations at 19 months and speed and accuracy of word recognition at 26 months) in full-term and preterm English-learning subjects using the video Head-Turn Preference Procedure (v-HPP) and the Intermodal Preferential Looking Paradigm (IPLP), respectively. Second, this study explores the predictive value of sound-structure sensitivities and word form representations on language outcomes at 14.5 and 26 months using structural equation modeling (SEM). The effects of gestational age (GA), cognitive skill (i.e., MVRS Score), and maternal education (MaEd) on measures of receptive language skills and language outcomes are also examined using covariance analyses. V-HPP and IPLP results indicate that, compared to their full-term counterparts, preterm participants show atypical sound-structure sensitivities and word form representations. Specifically, preterm infants have opposite preference patterns for lexical stress and phonotactic probabilities than full-term infants. Furthermore, preterm toddlers are not as sensitive to mispronunciations and do not always use context cues as efficiently during word recognition tasks as full-term toddlers. Despite these differences in infant and toddler receptive language abilities, SEM analyses show that neither sound-structure sensitivities nor word form representations are linked to language outcomes, even though sound-structure sensitivities are highly predictive of word form representations. Lastly, GA and MaEd significantly co-vary with sound-structure sensitivities, and MVRS Score with language outcomes."], "mods_abstract_ssim": ["Preterm children are at risk for language delays and deficits. By 2 years, very preterm/low birthweight children tend to have smaller vocabularies and use less complex grammatical structures than do their full-term counterparts. Yet, little is known about whether variations in skills in preverbal stages of development predict later delays. Reduced vocabularies, however, suggest that preterm children have difficulty with word-learning, which depends on receptive language abilities developed early in life. The present longitudinal study addresses this premise in two parts. First, it compares infant sound-structure sensitivities (i.e., preferences for trochaic versus iambic lexical stress at 4 and 6 months and for high versus low phonotactic probabilities at 6 and 9 months) and toddler word form representations (i.e., detection of mispronunciations at 19 months and speed and accuracy of word recognition at 26 months) in full-term and preterm English-learning subjects using the video Head-Turn Preference Procedure (v-HPP) and the Intermodal Preferential Looking Paradigm (IPLP), respectively. Second, this study explores the predictive value of sound-structure sensitivities and word form representations on language outcomes at 14.5 and 26 months using structural equation modeling (SEM). The effects of gestational age (GA), cognitive skill (i.e., MVRS Score), and maternal education (MaEd) on measures of receptive language skills and language outcomes are also examined using covariance analyses. V-HPP and IPLP results indicate that, compared to their full-term counterparts, preterm participants show atypical sound-structure sensitivities and word form representations. Specifically, preterm infants have opposite preference patterns for lexical stress and phonotactic probabilities than full-term infants. Furthermore, preterm toddlers are not as sensitive to mispronunciations and do not always use context cues as efficiently during word recognition tasks as full-term toddlers. Despite these differences in infant and toddler receptive language abilities, SEM analyses show that neither sound-structure sensitivities nor word form representations are linked to language outcomes, even though sound-structure sensitivities are highly predictive of word form representations. 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These objectives were created so that ABC-transporters, here specifically P-glycoprotein, could be studied in a 3D environment that more closely replicates the in vivo environment to further define their role in the complex processes of multi-drug resistance and drug absorption, distribution, metabolism, excretion, and toxicity (ADME-Tox). 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Hofmann, Ph.D., Brown University, May 2014 The gene Myc encodes a transcription factor that is expressed in most cell types, and it regulates the expression of at least 15% of known genes in diverse pathways. The MYC protein promotes proliferation, and its overexpression is a frequent cause of a wide variety of cancers. Though the expression of Myc is unaffected by age in mice, many of the processes that it regulates have been implicated in aging. To investigate the effect of Myc expression on aging, we generated mice with one copy of Myc knocked out (Myc+/\u2013 mice). These mice are 20% smaller than Myc+/+ (wild-type) mice, but breed normally and appear healthy. The central finding of this investigation is that the median lifespan of Myc+/\u2013 mice was 15.1% greater than Myc+/+. Myc+/\u2013 also had reduced prevalence and grade of the most common neoplastic diseases, although their longevity extension is only partially attributable to this cancer resistance. 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Though the expression of Myc is unaffected by age in mice, many of the processes that it regulates have been implicated in aging. To investigate the effect of Myc expression on aging, we generated mice with one copy of Myc knocked out (Myc+/\u2013 mice). These mice are 20% smaller than Myc+/+ (wild-type) mice, but breed normally and appear healthy. The central finding of this investigation is that the median lifespan of Myc+/\u2013 mice was 15.1% greater than Myc+/+. Myc+/\u2013 also had reduced prevalence and grade of the most common neoplastic diseases, although their longevity extension is only partially attributable to this cancer resistance. Many pathologic effects of aging were attenuated in Myc+/\u2013 mice, including osteoporosis, loss of motor coordination, immunosenescence, and cardiac fibrosis. 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This process helps establish the rapid and efficient communication pathways that integrate the neural systems responsible for higher order cognitive functioning. Using a novel, quantitative magnetic resonance imaging (MRI) technique, this dissertation examines the maturation of myelinated white matter in typically developing infants and toddlers. In particular, cross-sectional and longitudinal studies were conducted to measure and characterize the normative patterns of myelination. Non-linear changes were noted throughout the brain, with regional variation in the timing and magnitude of development. This developmental trajectory was found to follow a sigmoidal pattern and models of these growth patterns were developed and statistically examined, thus characterizing normative myelination and establishing a strong foundation for future studies of typical and atypical brain development. Developmental differences between males and females; and in children genetically predisposed to late-onset Alzheimer's disease were additionally investigated. Rates of development between males and females were found to differ across the brain, while carriers of the apolipoprotein E $\\varepsilon$4 allele were found to have dissimilar developmental trajectories than non-carriers. Finally, relationships between cognitive function and brain structure were examined. Myelination patterns were observed to strongly correlate with evolving alterations of gross motor, receptive language, and visual reception abilities; while changes in expressive language and fine motor functioning were found to vary with developmental stage. This thesis substanitally contributes to a growing body of literature that is focused on understanding the highly dynamic and nonlinear mechanisms that support normative brain development. Studies of early development are essential in order to 1. 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Non-linear changes were noted throughout the brain, with regional variation in the timing and magnitude of development. This developmental trajectory was found to follow a sigmoidal pattern and models of these growth patterns were developed and statistically examined, thus characterizing normative myelination and establishing a strong foundation for future studies of typical and atypical brain development. Developmental differences between males and females; and in children genetically predisposed to late-onset Alzheimer's disease were additionally investigated. Rates of development between males and females were found to differ across the brain, while carriers of the apolipoprotein E $\\varepsilon$4 allele were found to have dissimilar developmental trajectories than non-carriers. Finally, relationships between cognitive function and brain structure were examined. 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In particular, the FQH liquid at filling factor 5/2 was proposed to host Majorana bound state (MBS) with exotic non-Abelian statistics. A collection of MBSs can span a topological Hilbert space, in which each many-particle state is topologically distinct, depending on the historical trajectories of all the MBSs in the system. Logic operations in quantum computation can be encoded in the linear transformations in topological Hilbert space and in principle be protected against local defects and perturbations, which are topologically trivial and cannot induce transitions between different many-particle states. Despite such intriguing theoretical picture, experiments probing the nature of the 5/2 FQH liquid are controversial. In this dissertation, we provide an explanation of two seemingly contradicting experiments in the 5/2 FQH liquid, by exploring the role of electrostatic interaction closely related to the geometries of the devices. We also construct several new 5/2 FQH states, by making use of the particle-hole symmetry in FQH systems, to account for a recent experiment observing upstream neutral edge transport in the 5/2 FQH liquid, which ruled out most of the existing theories. In addition to the new particle-hole states, we propose another topological description of the 5/2 FQH liquid which reconciles all existing transport experiments. Later, we turn our attention to the MBSs in superconductor systems. We study the approaches to minimizing the decoherence of a Majorana-fermion-based qbit due to its interaction with environment, based on a full classification of the fermionic zero modes in a system of interacting Majorana fermions."], "mods_abstract_ssim": ["Fractional quantum Hall (FQH) liquids are interesting two-dimensional electron systems that possess quasiparticle excitations with fractional charges, obeying quantum statistics different from those of bosons and fermions. In particular, the FQH liquid at filling factor 5/2 was proposed to host Majorana bound state (MBS) with exotic non-Abelian statistics. A collection of MBSs can span a topological Hilbert space, in which each many-particle state is topologically distinct, depending on the historical trajectories of all the MBSs in the system. Logic operations in quantum computation can be encoded in the linear transformations in topological Hilbert space and in principle be protected against local defects and perturbations, which are topologically trivial and cannot induce transitions between different many-particle states. Despite such intriguing theoretical picture, experiments probing the nature of the 5/2 FQH liquid are controversial. In this dissertation, we provide an explanation of two seemingly contradicting experiments in the 5/2 FQH liquid, by exploring the role of electrostatic interaction closely related to the geometries of the devices. We also construct several new 5/2 FQH states, by making use of the particle-hole symmetry in FQH systems, to account for a recent experiment observing upstream neutral edge transport in the 5/2 FQH liquid, which ruled out most of the existing theories. In addition to the new particle-hole states, we propose another topological description of the 5/2 FQH liquid which reconciles all existing transport experiments. Later, we turn our attention to the MBSs in superconductor systems. 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If the function is discontinuous, the truncated spectral series has large oscillations near the jump, and the overshoot does not decay as the number of terms in the truncated series increases. There is therefore no convergence in the maximum norm, and convergence in smooth regions away from the discontinuity is also slow. This behavior is the so-called Gibbs phenomenon. In history, many researchers have worked on overcoming the Gibbs phenomenon and recovering the accuracy from truncated spectral series, and developed widely used methods, such as filters and Gegenbauer reconstructions. In this thesis, we develop the techniques to handle functions which are analytic in the open interval but have unbounded derivative singularities at end points, resulting in recovering exponential accuracy from the first N Fourier coefficients or standard collocation point values of such functions. 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This detection is significant because it enables robust mineralogic investigations of the Moon\u2019s most ancient, primary crust, which is dominated by plagioclase. This thesis is directed at (1) determining what information can be extracted from spectra of plagioclase-bearing materials in terms of mineral composition and abundance, and (2) applying these lessons to interpretation of new spectroscopic data at two case study locations on the Moon. The fist goal is accomplished through detailed spectroscopic investigations of well-characterized plagioclase and plagioclase-dominated materials in a laboratory setting. In Chapter 1, we begin with an analysis of plagioclase and anorthosite samples from a diversity of origins: terrestrial, lunar, and synthetic. In Chapter 2, we explore the variations in bulk spectral properties that arise from systematic percent-level changes in the minor mafic component in analog anorthosite materials. From these two laboratory-based chapters, we find that the plagioclase absorption is repeatable for a range of different sample compositions and geologic histories. Furthermore, the addition of small amounts of different mafic components enables estimation of mineral abundances in the bulk sample rather than simply erasing the plagioclase feature. In Chapter 3, we analyze nearly 800 anorthosite exposures across the ~1000 km diameter Orientale basin and find that most occurrences are exceedingly pure, containing >95%, and often >98%, plagioclase. A similar investigation at the smaller (~200 km diameter) Tsiolkovskiy crater in Chapter 4 shows much more variability in the anorthosite purity over relatively small (hundred-meter) spatial scales. 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This thesis is directed at (1) determining what information can be extracted from spectra of plagioclase-bearing materials in terms of mineral composition and abundance, and (2) applying these lessons to interpretation of new spectroscopic data at two case study locations on the Moon. The fist goal is accomplished through detailed spectroscopic investigations of well-characterized plagioclase and plagioclase-dominated materials in a laboratory setting. In Chapter 1, we begin with an analysis of plagioclase and anorthosite samples from a diversity of origins: terrestrial, lunar, and synthetic. In Chapter 2, we explore the variations in bulk spectral properties that arise from systematic percent-level changes in the minor mafic component in analog anorthosite materials. From these two laboratory-based chapters, we find that the plagioclase absorption is repeatable for a range of different sample compositions and geologic histories. Furthermore, the addition of small amounts of different mafic components enables estimation of mineral abundances in the bulk sample rather than simply erasing the plagioclase feature. In Chapter 3, we analyze nearly 800 anorthosite exposures across the ~1000 km diameter Orientale basin and find that most occurrences are exceedingly pure, containing >95%, and often >98%, plagioclase. A similar investigation at the smaller (~200 km diameter) Tsiolkovskiy crater in Chapter 4 shows much more variability in the anorthosite purity over relatively small (hundred-meter) spatial scales. The contrast between the anorthositic exposures at these two locations, coupled with the laboratory data that enable estimation of their mineral make-up, suggests that the structure of the Moon\u2019s anorthositic crust, which has often been considered generically \u201cplagioclase-rich\u201d, contains vertical and/or lateral heterogeneity that is quantifiable using new remote sensing data. 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These systems achieve this by storing databases in a cluster of shared-nothing, main memory partitions. This partitioning enables them to eschew much of the legacy, disk-oriented architecture that slows down traditional systems, such as heavy-weight concurrency control algorithms, thereby allowing for the efficient execution of single-partition transactions. But many applications cannot be partitioned such that all of their transactions execute in this manner; these multi-partition transactions require expensive coordination that inhibits performance. In this dissertation, we study the problem of scalable transaction execution for modern on-line transaction processing (OLTP) applications. We present the design of H-Store, a distributed, main memory DBMS that is optimized for short-lived, write-heavy transactional workloads. We then present domain-specific applications of optimization and machine learning techniques to improve the performance of fast database systems like H-Store. Our first contribution is an approach for automatically generating a database design for an OLTP application that both minimizes both the amount of cross-node communication and skew in the cluster. We then present a Markov model-based approach for automatically selecting which optimizations to enable at run time for new transaction requests based on their most likely behavior. Finally, we present a method for using these models to schedule speculative transactions and queries whenever a DBMS stalls because of a multi-partition transaction. All together, these allow enable H-Store to support transactional workloads that are beyond what single-node systems can handle."], "mods_abstract_ssim": ["An emerging class of distributed database management systems (DBMS) seek to provide high-performance transaction processing for data-intensive applications while maintaining strong consistency guarantees. These systems achieve this by storing databases in a cluster of shared-nothing, main memory partitions. This partitioning enables them to eschew much of the legacy, disk-oriented architecture that slows down traditional systems, such as heavy-weight concurrency control algorithms, thereby allowing for the efficient execution of single-partition transactions. But many applications cannot be partitioned such that all of their transactions execute in this manner; these multi-partition transactions require expensive coordination that inhibits performance. In this dissertation, we study the problem of scalable transaction execution for modern on-line transaction processing (OLTP) applications. We present the design of H-Store, a distributed, main memory DBMS that is optimized for short-lived, write-heavy transactional workloads. We then present domain-specific applications of optimization and machine learning techniques to improve the performance of fast database systems like H-Store. Our first contribution is an approach for automatically generating a database design for an OLTP application that both minimizes both the amount of cross-node communication and skew in the cluster. We then present a Markov model-based approach for automatically selecting which optimizations to enable at run time for new transaction requests based on their most likely behavior. Finally, we present a method for using these models to schedule speculative transactions and queries whenever a DBMS stalls because of a multi-partition transaction. 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Additionally, we have discovered remarkably potent acyldepsipeptide (ADEP) antibacterial agents that target bacterial proteolysis. Because of their distinct mechanism of action, ADEPs are toxic to bacteria that have become resistant to clinically used antibiotics. Our medicinal chemistry optimization of the ADEPs has led to the discovery of some of the most potent antibacterial agents ever reported and we have shown that they are effective in mouse models of bacterial infection. It is our hope that continued development of these anti-infective drug strategies will lead to clinically useful small molecule therapeutics."], "mods_abstract_ssim": ["Infectious diseases are the 2nd leading cause of death worldwide and pose a global health problem that requires constant effort towards the discovery of new anti-infective drugs. One driver for anti-infective drug development is the inevitable emergence of drug resistant pathogens, which are no longer susceptible to traditional therapeutic strategies. Another driver is that the absence of therapeutic agents that are effective against troublesome infective agents. Given these challenges, development programs for new anti-infective small-molecule therapeutics are often directed towards the identification and validation of new drug targets. This thesis discusses the development of drug leads with targets that are not yet exploited by clinically used small molecule therapeutics. We have discovered dihydroquinazolinones (DHQs) that modulate host retrograde trafficking. By targeting a host cellular factor, these small molecules exhibit a broad therapeutic scope. Infection by human polyomavirus and papillomavirus, as well as intoxication by deadly toxins such as ricin and Shiga-like toxins are inhibited by these remarkable compounds. Additionally, we have discovered remarkably potent acyldepsipeptide (ADEP) antibacterial agents that target bacterial proteolysis. Because of their distinct mechanism of action, ADEPs are toxic to bacteria that have become resistant to clinically used antibiotics. Our medicinal chemistry optimization of the ADEPs has led to the discovery of some of the most potent antibacterial agents ever reported and we have shown that they are effective in mouse models of bacterial infection. 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Common mental disorders take a heavy toll on sufferers both directly, in terms of high medical costs; and indirectly, in terms of reduced labor supply and decreased mental health status. In addition, there is a high rate of unmet need for mental health services among sufferers of mental disorders. To address these issues, policymakers require a strong understanding of: 1) the scope of the societal costs attributable to mental disorders, and 2) the expected benefits of expanding access to mental health services through health policy. In the first two chapters, I use a quasi-experimental design and nationally representative data to examine the impact of U.S. state mental health parity laws on labor outcomes in the adult population and mental health service utilization outcomes in the child population from 1988 and 2008. Our findings suggest that among privately insured adults, labor outcomes were largely unaffected by the passage of strong parity laws, but adults who suffered from likely depression saw a significant increase in their odds of being employed. Within the population of privately insured children, the passage of mental health parity laws led to a significant increase in the odds of children seeing a mental health provider and receiving insurance coverage for the visit. Strikingly, there was also a dramatic increase in the odds that children took a prescription medication for a behavioral or mental problem when a strong parity law was passed. Taken together, these findings suggest that employers did not pass the costs of complying with mental health parity laws onto their employees and these laws were specifically active in increasing access to certain services. In the third chapter, I studied the individual, household and societal lost income associated with mental disorders using a nationally representative epidemiological dataset from Chile. My results suggest that anxiety disorders are associated with the greatest disease burden in terms of lost income, and this \u201cincome gap\u201d is particularly pronounced at both the personal and household level among male sufferers."], "mods_abstract_ssim": ["The prevalence of mental illness has been rising rapidly in the United States and abroad in the last two decades. Common mental disorders take a heavy toll on sufferers both directly, in terms of high medical costs; and indirectly, in terms of reduced labor supply and decreased mental health status. In addition, there is a high rate of unmet need for mental health services among sufferers of mental disorders. To address these issues, policymakers require a strong understanding of: 1) the scope of the societal costs attributable to mental disorders, and 2) the expected benefits of expanding access to mental health services through health policy. In the first two chapters, I use a quasi-experimental design and nationally representative data to examine the impact of U.S. state mental health parity laws on labor outcomes in the adult population and mental health service utilization outcomes in the child population from 1988 and 2008. Our findings suggest that among privately insured adults, labor outcomes were largely unaffected by the passage of strong parity laws, but adults who suffered from likely depression saw a significant increase in their odds of being employed. Within the population of privately insured children, the passage of mental health parity laws led to a significant increase in the odds of children seeing a mental health provider and receiving insurance coverage for the visit. Strikingly, there was also a dramatic increase in the odds that children took a prescription medication for a behavioral or mental problem when a strong parity law was passed. Taken together, these findings suggest that employers did not pass the costs of complying with mental health parity laws onto their employees and these laws were specifically active in increasing access to certain services. In the third chapter, I studied the individual, household and societal lost income associated with mental disorders using a nationally representative epidemiological dataset from Chile. 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Chapter I examines empirically the role of historical political centralization on the likelihood of contemporary civil conflict in Sub-Saharan Africa. It constructs an original measure of long-run exposure to statehood. It then exploits variation in this new measure along with geo-referenced conflict data to document a robust negative relationship between long-run exposure to statehood and contemporary conflict. Chapter 1 argues that regions with long histories of statehood are better equipped with mechanisms to preserve order. It presents two pieces of evidence consistent with this hypothesis. First, regions with long historical exposure to statehood are less prone to experience conflict when hit by a negative economic shock. Second, Chapter 1 also provides evidence that long historical statehood experience is linked to people's positive attitudes toward state institutions and traditional leaders. Chapter 2 examines the effect of malaria on economic development in Africa over the very long run. Using data on the prevalence of the mutation that causes sickle cell disease it measures the impact of malaria on mortality in pre-colonial Africa. The presented estimate suggests that in the more afflicted regions, malaria lowered the probability of surviving to adulthood by about ten percentage points. Following both a model-based and statistically-based approach, Chapter 2 does not find evidence that the impact of malaria would have been very significant for pre-colonial development. Chapter 3 provides a valuable input for the analysis of future gun policies in the US. Particularly, Chapter 3 exploits monthly data constructed from futures markets on presidential election outcomes and a novel proxy for firearm purchases, to analyze how the demand for guns responded to the likelihood of Barack Obama being elected in 2008. The existence of a large Obama effect on the demand for guns is documented, being this political effect larger than the effect associated to the worsening economic conditions. Furthermore, Chapter 3 presents empirical evidence consistent with the hypotheses that the unprecedented increase in the demand for guns was partially driven by both a fear of a future Obama gun-control policy and racial prejudice."], "mods_abstract_ssim": ["This dissertation is composed of three chapters on comparative development and political economy. Chapter I examines empirically the role of historical political centralization on the likelihood of contemporary civil conflict in Sub-Saharan Africa. It constructs an original measure of long-run exposure to statehood. It then exploits variation in this new measure along with geo-referenced conflict data to document a robust negative relationship between long-run exposure to statehood and contemporary conflict. 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In other words, the epistemological potential of genre\u2014its ability to mediate between the individual subject and the vast, unrepresentable totalities that transcend her\u2014is in decline, overwhelmed by the radical, traumatic transformations in human experience that define our present. The dissertation is divided in two parts. In the first part I outline a diagnosis of the current state of affairs in contemporary genre cinema by focusing on the recent mutations of two of the most epistemologically charged genres\u2014namely, the fantastic and the detective story. In chapter one I discuss how the emergence of a \u201cdisenchanted fantastic\u201d thematizes in unprecedented ways the relationship between magic, science, and spectacle. In chapter two I analyze the impasse of the hermeneutic process of detection that characterizes specific instances of the \u201cserial-killer movie\u201d sub-genre. 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In other words, the epistemological potential of genre\u2014its ability to mediate between the individual subject and the vast, unrepresentable totalities that transcend her\u2014is in decline, overwhelmed by the radical, traumatic transformations in human experience that define our present. The dissertation is divided in two parts. In the first part I outline a diagnosis of the current state of affairs in contemporary genre cinema by focusing on the recent mutations of two of the most epistemologically charged genres\u2014namely, the fantastic and the detective story. In chapter one I discuss how the emergence of a \u201cdisenchanted fantastic\u201d thematizes in unprecedented ways the relationship between magic, science, and spectacle. In chapter two I analyze the impasse of the hermeneutic process of detection that characterizes specific instances of the \u201cserial-killer movie\u201d sub-genre. 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For a prime l, we construct an infinite class of cyclic degree l extensions of the field of lth roots unity that have infinite class field tower and are only ramified at l and two additional primes. As an application, we consider the case l=3 and construct an S_3 extension of the rationals with infinite class field tower that is only ramified at 3 primes, giving an example of a \"small\" field with infinite class field tower. Motivated by the class field tower problem, we next study the behavior of the root discriminant in a solvable number field extension. In particular, we use class field theory to show that for any fixed number field K, there are only finitely many extensions of K of a given solvable length and bounded root discriminant. This theorem should be viewed in light of the fact that all fields in a class field tower have the same root discriminant. In the next part of the thesis, we analyze the possibilities for the fields cut out by a solvable three-dimensional representation of the absolute Galois group of the rationals that is ramified at a single finite prime. In doing so, we give bounds for the number of such representations with given Artin conductor. This work is motivated by similar results in the case of two-dimensional Galois representations, where Langlands-type techniques are available. We then continue our study of Galois representations in the context of torsion points on abelian varieties over number fields. We prove several facts about the image of the representation of Galois acting on the l-torsion points of an abelian variety subject to certain constraints. Lastly, we study a variant of Noether's problem in Galois theory. Building on work of Lenstra, we give an upper bound for the degree of irrationality of the fields whose rationality is the question of Noether's problem."], "mods_abstract_ssim": ["We begin by investigating the class field tower problem for Kummer extensions of cyclotomic fields. For a prime l, we construct an infinite class of cyclic degree l extensions of the field of lth roots unity that have infinite class field tower and are only ramified at l and two additional primes. As an application, we consider the case l=3 and construct an S_3 extension of the rationals with infinite class field tower that is only ramified at 3 primes, giving an example of a \"small\" field with infinite class field tower. Motivated by the class field tower problem, we next study the behavior of the root discriminant in a solvable number field extension. In particular, we use class field theory to show that for any fixed number field K, there are only finitely many extensions of K of a given solvable length and bounded root discriminant. This theorem should be viewed in light of the fact that all fields in a class field tower have the same root discriminant. In the next part of the thesis, we analyze the possibilities for the fields cut out by a solvable three-dimensional representation of the absolute Galois group of the rationals that is ramified at a single finite prime. In doing so, we give bounds for the number of such representations with given Artin conductor. This work is motivated by similar results in the case of two-dimensional Galois representations, where Langlands-type techniques are available. We then continue our study of Galois representations in the context of torsion points on abelian varieties over number fields. We prove several facts about the image of the representation of Galois acting on the l-torsion points of an abelian variety subject to certain constraints. Lastly, we study a variant of Noether's problem in Galois theory. Building on work of Lenstra, we give an upper bound for the degree of irrationality of the fields whose rationality is the question of Noether's problem."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z04M92WD", "mods_id": "etd1249", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Leshin, Jonah", "Silverman, Joseph", "Rosen, Michael", "Lichtenbaum, Stephen", "Brown University. 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However, I prove that every robust mechanism admits the existence of an ex post equilibrium, and, if the ex post best response property is satisfied in the mechanism, every interim equilibrium must be an ex post equilibrium. For this result, it is not sufficient to consider only payoff type spaces. Full robust implementation guarantees the existence of such a good mechanism. In Chapter 4, I study the assignment games of Shapley and Shubik (1972) under uncertainty at the ex ante stage. With symmetric uncertainty, the Shapley-Shubik equivalence of core and competitive equilibrium allocations breaks down. I show that the ex ante core contains strictly the set of Arrow-Debreu equilibrium allocations. However, one replica suffices to restore equivalence. Without the assumption of indispensability of wealth, the failure of equivalence is more severe. 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In Chapter 3, I explore the robustness of full robust implementation in terms of robustness of equilibria. I illustrate an example in which a mechanism fully robustly implements a social choice function, but there exists an interim equilibrium that is not an ex post equilibrium. However, I prove that every robust mechanism admits the existence of an ex post equilibrium, and, if the ex post best response property is satisfied in the mechanism, every interim equilibrium must be an ex post equilibrium. For this result, it is not sufficient to consider only payoff type spaces. Full robust implementation guarantees the existence of such a good mechanism. In Chapter 4, I study the assignment games of Shapley and Shubik (1972) under uncertainty at the ex ante stage. With symmetric uncertainty, the Shapley-Shubik equivalence of core and competitive equilibrium allocations breaks down. I show that the ex ante core contains strictly the set of Arrow-Debreu equilibrium allocations. 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"_display_public_bsi": true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["Seismic anisotropy in olivine and orthopyroxene mineral crystals enables us to infer first-order flow characteristics in the asthenospheric mantle and the preserved tectonic history in the lithospheric mantle of continental plates. This work focuses on the observed seismic anisotropy within both the lithospheric and asthenospheric mantle in the southern South American subduction zone, the southeastern United States, and the Hindu Kush-Pamir region. Because these three study areas represent different tectonic environments, their patterns and sources of seismic anisotropy are diverse. Chapter 1 is devoted to the observation, modeling, and interpretation of local S and teleseismic SK(K)S shear-wave splitting results in the southern South American subduction zone. We theorize that the observed shear-wave splitting in the asthenospheric mantle indicates a combination of flow through a slab gap, the presence of the flat Pampean slab segment, and rollback of the subducting Nazca slab. In Chapter 2, we examine the effects of those flow drivers on asthenospheric mantle flow using a subduction zone laboratory tank model. With this apparatus, we can replicate some of the flow patterns discussed in Chapter 1, including the strong pull of mantle wedge material towards the shallowly-dipping slab, analogous to the Pampean flat slab segment. In Chapter 3, we use Pn phases from regional earthquakes in the southeastern United States to constrain lateral variation and azimuthal anisotropy in uppermost mantle P-wave velocities. In particular, mantle P-wave velocities are significantly lower beneath the Blue Ridge Mountains, suggesting that mantle structure may contribute to supporting the higher elevations. We also measure azimuthal anisotropy in this region in Chapter 4, but here, we use S-waves to measure SK(K)S shear-wave splitting. Because of the close station spacing and the density of shear-wave splitting data, we are able to define distinct lithospheric mantle anisotropy signatures that vary between accreted terranes. Lastly, in Chapter 5, we conduct a shear-wave splitting study in the Hindu Kush-Pamir region, where the SK(K)S splitting is primarily sampling asthenospheric mantle flow induced by absolute plate motion of the Eurasian Plate. The shallow upper plate mantle, as sampled by local S waves, is not strongly anisotropic."], "mods_abstract_ssim": ["Seismic anisotropy in olivine and orthopyroxene mineral crystals enables us to infer first-order flow characteristics in the asthenospheric mantle and the preserved tectonic history in the lithospheric mantle of continental plates. This work focuses on the observed seismic anisotropy within both the lithospheric and asthenospheric mantle in the southern South American subduction zone, the southeastern United States, and the Hindu Kush-Pamir region. Because these three study areas represent different tectonic environments, their patterns and sources of seismic anisotropy are diverse. Chapter 1 is devoted to the observation, modeling, and interpretation of local S and teleseismic SK(K)S shear-wave splitting results in the southern South American subduction zone. We theorize that the observed shear-wave splitting in the asthenospheric mantle indicates a combination of flow through a slab gap, the presence of the flat Pampean slab segment, and rollback of the subducting Nazca slab. In Chapter 2, we examine the effects of those flow drivers on asthenospheric mantle flow using a subduction zone laboratory tank model. With this apparatus, we can replicate some of the flow patterns discussed in Chapter 1, including the strong pull of mantle wedge material towards the shallowly-dipping slab, analogous to the Pampean flat slab segment. In Chapter 3, we use Pn phases from regional earthquakes in the southeastern United States to constrain lateral variation and azimuthal anisotropy in uppermost mantle P-wave velocities. In particular, mantle P-wave velocities are significantly lower beneath the Blue Ridge Mountains, suggesting that mantle structure may contribute to supporting the higher elevations. We also measure azimuthal anisotropy in this region in Chapter 4, but here, we use S-waves to measure SK(K)S shear-wave splitting. Because of the close station spacing and the density of shear-wave splitting data, we are able to define distinct lithospheric mantle anisotropy signatures that vary between accreted terranes. Lastly, in Chapter 5, we conduct a shear-wave splitting study in the Hindu Kush-Pamir region, where the SK(K)S splitting is primarily sampling asthenospheric mantle flow induced by absolute plate motion of the Eurasian Plate. The shallow upper plate mantle, as sampled by local S waves, is not strongly anisotropic."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z08C9TMR", "mods_id": "etd1248", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["MacDougall, Julia", "Fischer, Karen", "Forsyth, Donald", "Parman, Stephen", "Parmentier, Edgar", "Kincaid, Chris", "Brown University. 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Our analysis revealed over 70 enhancers that direct expression in the embryo, larvae, and adult. A subset of these cis-acting elements regulate expression during neurogenesis, and we determined that several enhancers are active in embryonic and larval neuroblasts (NBs). We also found a collinear relationship between two sets of functionally-related enhancers (denoted as nub-46, nub-49b, pdm2-34, and pdm2-37a). Specifically, the nub-46 and nub-49b share similar function, structure, and genomic position as pdm2-34 and pdm2-37a, respectively. Given these observations, we reasoned that they were most likely part of the pdm gene duplication event. In addition, our analysis of a subgroup of neural pdm enhancers revealed that they contain Suppressor of Hairless, Grainy head, and/or basic helix loop helix transcriptional factor (TF) DNA-binding sites. For this reason, we performed a genome-wide search for other neural enhancers that are made up of these TF DNA-binding motifs. In sum, we identified four matching enhancers (denoted as dl-32, dl-37, N-25, Su(H)-6) that are adjacent to Notch signaling pathway genes. Further, we developed a novel algorithm called BLND (Building Logic from enhancer Nested Data) that searches for functionally-related enhancers based on conserved sequence elements. BLND utilizes enhancer information stored in cisPatterns, a web database application that showcases enhancer data from our studies. We used BLND to identify enhancers that are functionally-similar to nub-49b and pdm2-37a, two larval NB enhancers enriched for CA and GA dinucleotide repeat elements and located immediately 5\u2019 to the transcriptional start sites (TSS) of nub and pdm-2 short transcripts, respectively. BLND analysis revealed three enhancers (denoted as ase-10, cas-5, and pros-9b) that direct expression in larval NBs, are enriched for CA and GA repeats, and are immediately proximal to TSS of neural genes including asense (ase), castor (cas) and prospero (pros)."], "mods_abstract_ssim": ["In this thesis, we identified and functionally characterized cis-regulatory enhancers in and around two Drosophila paralogs, nubbin (nub) and POU domain 2 (pdm-2) (collectively known as pdm). Our analysis revealed over 70 enhancers that direct expression in the embryo, larvae, and adult. A subset of these cis-acting elements regulate expression during neurogenesis, and we determined that several enhancers are active in embryonic and larval neuroblasts (NBs). We also found a collinear relationship between two sets of functionally-related enhancers (denoted as nub-46, nub-49b, pdm2-34, and pdm2-37a). Specifically, the nub-46 and nub-49b share similar function, structure, and genomic position as pdm2-34 and pdm2-37a, respectively. Given these observations, we reasoned that they were most likely part of the pdm gene duplication event. In addition, our analysis of a subgroup of neural pdm enhancers revealed that they contain Suppressor of Hairless, Grainy head, and/or basic helix loop helix transcriptional factor (TF) DNA-binding sites. For this reason, we performed a genome-wide search for other neural enhancers that are made up of these TF DNA-binding motifs. In sum, we identified four matching enhancers (denoted as dl-32, dl-37, N-25, Su(H)-6) that are adjacent to Notch signaling pathway genes. Further, we developed a novel algorithm called BLND (Building Logic from enhancer Nested Data) that searches for functionally-related enhancers based on conserved sequence elements. BLND utilizes enhancer information stored in cisPatterns, a web database application that showcases enhancer data from our studies. We used BLND to identify enhancers that are functionally-similar to nub-49b and pdm2-37a, two larval NB enhancers enriched for CA and GA dinucleotide repeat elements and located immediately 5\u2019 to the transcriptional start sites (TSS) of nub and pdm-2 short transcripts, respectively. BLND analysis revealed three enhancers (denoted as ase-10, cas-5, and pros-9b) that direct expression in larval NBs, are enriched for CA and GA repeats, and are immediately proximal to TSS of neural genes including asense (ase), castor (cas) and prospero (pros)."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0RF5SCQ", "mods_id": "etd1252", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Ross, Jermaine L", "Odenwald, Ward", "Hart, Anne", "Lee, Chi-Hon", "Hursh, Deborah", "Brown University. 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We may decompose not only functions in this space but also quantities such as shifted convolution sums, or Kloosterman sum zeta functions. In this thesis we list some applications of spectral expansions to analytic number theory. We find a subconvexity bound for L-functions of half integral weight modular forms twisted by Dirichlet characters. This is done by obtaining a meromorphic continuation for the Dirichlet series encoding shifted convolution sums of Fourier coefficients of half integer weight modular forms, which in turn is given by a spectral expansion. A key step in the meromorphic continuation of the Dirichlet series involves an estimation of a triple inner product. Another application is obtaining upper bounds for sup-norms of half integer weight modular forms of high level. The main technique is amplifiying a particular term in the spectral expansion of a half-integer weight automorphic kernel using Hecke operators. In either application we use the amplification mehtod of Duke Friedlander and Iwaniec. The shifted convolution sum Dirichlet series converges in some right half plane, and its spectral expansion converges in a non-overlapping left half plane. Another related instance of such a phenomenon is encountered in the spectral expansion of an opposite sign Kloosterman sum zeta function. Kloosterman sums of opposite sign case show up in the Fourier expansion of the Poincare series that is employed to get the shifted convolution Dirichlet series. We obtain the zeta function's meromorphic continuation and a spectral expansion."], "mods_abstract_ssim": ["The spectrum of the hyperbolic Laplacian decomposes the space of square integrable functions on the hyperbolic plane invariant under a discrete subgroup of isometries. We may decompose not only functions in this space but also quantities such as shifted convolution sums, or Kloosterman sum zeta functions. In this thesis we list some applications of spectral expansions to analytic number theory. We find a subconvexity bound for L-functions of half integral weight modular forms twisted by Dirichlet characters. This is done by obtaining a meromorphic continuation for the Dirichlet series encoding shifted convolution sums of Fourier coefficients of half integer weight modular forms, which in turn is given by a spectral expansion. A key step in the meromorphic continuation of the Dirichlet series involves an estimation of a triple inner product. Another application is obtaining upper bounds for sup-norms of half integer weight modular forms of high level. The main technique is amplifiying a particular term in the spectral expansion of a half-integer weight automorphic kernel using Hecke operators. In either application we use the amplification mehtod of Duke Friedlander and Iwaniec. The shifted convolution sum Dirichlet series converges in some right half plane, and its spectral expansion converges in a non-overlapping left half plane. Another related instance of such a phenomenon is encountered in the spectral expansion of an opposite sign Kloosterman sum zeta function. Kloosterman sums of opposite sign case show up in the Fourier expansion of the Poincare series that is employed to get the shifted convolution Dirichlet series. We obtain the zeta function's meromorphic continuation and a spectral expansion."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0W37TPQ", "mods_id": "etd1251", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Kiral, Eren Mehmet", "Hoffstein, Jeffrey", "Min, Lee", "Michael, Rosen", "Brown University. 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However, most of these results focus on one chosen aspect of the L-function. This thesis aims to break convexity in two aspects at the same time, improving upon known results by Blomer-Harcos, Michel-Venkatesh, Munshi and Han Wu in the case of holomorphic cusp forms. For f a primitive holomorphic cusp form of even weight k at least 4, square-free level N, this thesis proves a new hybrid subconvexity bound for L-function associated to f on the critical line twisted by a Dirichlet character whose conductor is relatively prime to the level. The main tools used are amplication and a shifted convolution sum of two variables defined and analyzed in a recent paper of Ho\ufb06ein and Hulse."], "mods_abstract_ssim": ["Throughout the years, there have been many subconvexity results of L-functions. However, most of these results focus on one chosen aspect of the L-function. This thesis aims to break convexity in two aspects at the same time, improving upon known results by Blomer-Harcos, Michel-Venkatesh, Munshi and Han Wu in the case of holomorphic cusp forms. For f a primitive holomorphic cusp form of even weight k at least 4, square-free level N, this thesis proves a new hybrid subconvexity bound for L-function associated to f on the critical line twisted by a Dirichlet character whose conductor is relatively prime to the level. The main tools used are amplication and a shifted convolution sum of two variables defined and analyzed in a recent paper of Ho\ufb06ein and Hulse."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0D50KB1", "mods_id": "etd1247", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Kuan, Chan Ieong", "Hoffstein, Jeffrey", "Lee, Min", "Rosen, Michael", "Brown University. 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Frederick, Ph.D., Brown University, May 2014 Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a subset of unique photoreceptors in the vertebrate retina that mediate a number of physiologic responses to light such as circadian entrainment, melatonin release, and the pupillary light reflex. They are characterized by a depolarizing light response that is sluggish in the absence of synaptic influence and a slow recovery in the dark. The distinctive photoreceptive properties exhibited by ipRGCs are attributed to the activity of the G-protein coupled receptor (GPCR) melanopsin, which is endogenously expressed in these cells. Although many details of melanopsin signaling have been established, little has been presented regarding termination of the pathway. This study is an examination of the termination of the phototransduction cascade initiated by the melanopsin. Whole cell patch recordings made on HEK293 cells expressing C-terminally truncated mouse melanopsin revealed photocurrents that failed to terminate. Likewise, a mouse melanopsin protein whose putative phosphorylation sites were neutralized by alanine substitution also generated persistent photoresponses that did not recover. Reverse transcriptase polymerase chain reaction (RT-PCR) done on single melanopsin positive rat retinal ganglion cells revealed the presence of both \u03b2 arrestin -1 and -2 transcripts. Immunohistochemical staining on mouse and rat vertical sections confirmed the expression of both \u03b2 arrestin protein isoforms in melanopsin immunopositive retinal ganglion cells while excluding the presence of rod and cone arrestin. The termination of phototransduction at the GPCR level typically occurs when the C-terminal tail of the photopigment is phosphorylated and subsequently bound by an isoform of arrestin. The data collected here suggests a canonical mechanism of C-terminal tail regulation and the involvement of an isoform of \u03b2 arrestin in the melanopsin signaling pathway."], "mods_abstract_ssim": ["Abstract of Mechanisms of Melanopsin Photoresponse Termination: Biochemical Analysis of the Intrinsically Photosensitive Retinal Ganglion Cell Photopigment, by Courtney E. Frederick, Ph.D., Brown University, May 2014 Intrinsically photosensitive retinal ganglion cells (ipRGCs) are a subset of unique photoreceptors in the vertebrate retina that mediate a number of physiologic responses to light such as circadian entrainment, melatonin release, and the pupillary light reflex. They are characterized by a depolarizing light response that is sluggish in the absence of synaptic influence and a slow recovery in the dark. The distinctive photoreceptive properties exhibited by ipRGCs are attributed to the activity of the G-protein coupled receptor (GPCR) melanopsin, which is endogenously expressed in these cells. Although many details of melanopsin signaling have been established, little has been presented regarding termination of the pathway. This study is an examination of the termination of the phototransduction cascade initiated by the melanopsin. Whole cell patch recordings made on HEK293 cells expressing C-terminally truncated mouse melanopsin revealed photocurrents that failed to terminate. Likewise, a mouse melanopsin protein whose putative phosphorylation sites were neutralized by alanine substitution also generated persistent photoresponses that did not recover. Reverse transcriptase polymerase chain reaction (RT-PCR) done on single melanopsin positive rat retinal ganglion cells revealed the presence of both \u03b2 arrestin -1 and -2 transcripts. Immunohistochemical staining on mouse and rat vertical sections confirmed the expression of both \u03b2 arrestin protein isoforms in melanopsin immunopositive retinal ganglion cells while excluding the presence of rod and cone arrestin. The termination of phototransduction at the GPCR level typically occurs when the C-terminal tail of the photopigment is phosphorylated and subsequently bound by an isoform of arrestin. The data collected here suggests a canonical mechanism of C-terminal tail regulation and the involvement of an isoform of \u03b2 arrestin in the melanopsin signaling pathway."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2013"], "mods_dateAll_ssim": ["2013"], "copyrightDate_year_ssim": ["2013"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2013"], "copyrightDate": "2013-01-01T00:00:00Z", "date_dsi": "2013-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0N014WN", "mods_id": "etd1185", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Frederick, Courtney", "BERSON, DAVID", "ZIMMERMAN, ANITA", "MARSHALL, JOHN", "BARNEA, GILAD", "WESSEL, GARY", "Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology"], "mods_role_ssim": ["creator", "Director", "Reader", "sponsor"], "mods_role_creator_ssim": ["Frederick, Courtney"], "mods_name_nonplace_ssim": ["Frederick, Courtney", "BERSON, DAVID", "ZIMMERMAN, ANITA", "MARSHALL, JOHN", "BARNEA, GILAD", "WESSEL, GARY", "Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology"], "creator": ["Frederick, Courtney"], "creator_string": ["Frederick, Courtney"], "contributor_display": ["Frederick, Courtney (creator)", "BERSON, DAVID (Director)", "ZIMMERMAN, ANITA (Reader)", "MARSHALL, JOHN (Reader)", "BARNEA, GILAD (Reader)", "WESSEL, GARY (Reader)", "Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)"], "mods_role_director_ssim": ["BERSON, DAVID"], "contributor": ["BERSON, DAVID", "ZIMMERMAN, ANITA", "MARSHALL, JOHN", "BARNEA, GILAD", "WESSEL, GARY", "Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology"], "contributor_string": ["BERSON, DAVID", "ZIMMERMAN, ANITA", "MARSHALL, JOHN", "BARNEA, GILAD", "WESSEL, GARY", "Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology"], "mods_role_reader_ssim": ["ZIMMERMAN, ANITA", "MARSHALL, JOHN", "BARNEA, GILAD", "WESSEL, GARY"], "mods_role_sponsor_ssim": ["Brown University. 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The association between DNA methylation and adiposity was also investigated; adipose tissue DNA methylation patterns were associated with adiposity, whereas no association was observed in blood. In conclusion, results from this dissertation research suggest that multiple risk factors contribute collectively to CVD development. In addition, exposures early in life may contribute to adulthood CVD risk, and epigenetic mechanisms may be involved."], "mods_abstract_ssim": ["Cardiovascular disease (CVD) is complex and chronic in nature, resulting over time from multiple factors. First, CVD rarely develops due to the presence of a single risk factor in isolation; rather, multiple risk factors contribute to disease independently, cumulatively, and interactively. Furthermore, risk for CVD begins early in life, with growing evidence that exposures acting as early as the fetal period may have an impact on CVD that manifests in adulthood. 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A particular biological mechanism of interest is the programming and regulation of gene expression through the epigenetic mechanism of DNA methylation. Accordingly, the impact of prenatally-assessed socioeconomic position on adulthood DNA methylation patterns was investigated among men and women from the LEAP study. Prenatal socioeconomic position was associated with adulthood adipose tissue DNA methylation patterns in women and not men, while no associations was seen with blood tissue DNA Methylation. The association between DNA methylation and adiposity was also investigated; adipose tissue DNA methylation patterns were associated with adiposity, whereas no association was observed in blood. In conclusion, results from this dissertation research suggest that multiple risk factors contribute collectively to CVD development. 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The project looks to canonical works in nineteenth-century American literature, art and science to track how the capture of animals (literal and figural) defined the emergent nation. This dissertation locates a shift in the representation of animals when hunting fell out of common practice in the United States at the turn of the nineteenth century. From James Fenimore Cooper\u2019s The Leatherstocking Tales to Louis Agassiz\u2019s Natural History of the United States, John James Audubon\u2019s Birds of America to Eadweard Muybridge\u2019s Animals in Motion, the century witnessed a shift in literary, scientific, and artistic treatments of \u201cthe animal.\u201d In this brave new age of mechanical objectivity, the animal progressively came to be seen not merely through apparatuses of capture (i.e. the lens of the camera or the eye of the microscope) but as essentially captured \u2013 effectively naturalizing their mechanized decontextualization from \u201cnature.\u201d This captured animal would find potent expression in Jakob von Uexk\u00fcll\u2019s concept of Umwelt, thereby gaining acceptance within various twentieth and twenty-first-century philosophies. Such works include those of Heidegger, Merleau-Ponty, Deleuze and Guattari, and Agamben, which along with those of Benjamin and Derrida, make up the philosophical archive of this project. The ambition of this dissertation is to examine how this conception of the animal as essentially captured came to be so widely accepted and relayed in American representational practices. Tracking a cultural and epistemological turn from a logic of the hunt to one of capture, I recover hunting as the repressed substrate of the modern regime of capture that would emphasize procedure over process, apprehension over pursuit."], "mods_abstract_ssim": ["The dissertation examines forms of cultural production that assimilated capture as an epistemological model in the modern period. The project looks to canonical works in nineteenth-century American literature, art and science to track how the capture of animals (literal and figural) defined the emergent nation. This dissertation locates a shift in the representation of animals when hunting fell out of common practice in the United States at the turn of the nineteenth century. From James Fenimore Cooper\u2019s The Leatherstocking Tales to Louis Agassiz\u2019s Natural History of the United States, John James Audubon\u2019s Birds of America to Eadweard Muybridge\u2019s Animals in Motion, the century witnessed a shift in literary, scientific, and artistic treatments of \u201cthe animal.\u201d In this brave new age of mechanical objectivity, the animal progressively came to be seen not merely through apparatuses of capture (i.e. the lens of the camera or the eye of the microscope) but as essentially captured \u2013 effectively naturalizing their mechanized decontextualization from \u201cnature.\u201d This captured animal would find potent expression in Jakob von Uexk\u00fcll\u2019s concept of Umwelt, thereby gaining acceptance within various twentieth and twenty-first-century philosophies. Such works include those of Heidegger, Merleau-Ponty, Deleuze and Guattari, and Agamben, which along with those of Benjamin and Derrida, make up the philosophical archive of this project. The ambition of this dissertation is to examine how this conception of the animal as essentially captured came to be so widely accepted and relayed in American representational practices. 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This transition took place from the early 1920s till the 1970s largely through the emigration of local non-Muslim population that overlapped with the immigration of local Muslims from rural areas. Although the emigration of non-Muslims was a common experience in Istanbul and Alexandria, lived experiences of these populations who were excluded from the national space in Turkey and Egypt differed significantly. This dissertation explains these differences by exploring the ways in which non-Muslims in Istanbul and Alexandria perceived and experienced belonging during the unfolding of national projects in Turkey and Egypt. Based on newspaper reviews and oral history interviews collected through 15 months of historical and ethnographic research, the dissertation argues that struggles and contestations within the state apparatus over the meaning of the nation took place within a limited range of political action that forged state-society relations. State, nation and community as the primary sources of belonging ambiguously coalesced and diverged within this range shaping individuals\u2019 perceptions and experiences of belonging. These perceptions and experiences contributed to the formation of cultural repertoires of belonging that individuals who fell outside of national boundaries deployed in their encounters with their fellow citizens and the state. The dissertation demonstrates this theoretical claim through a comparison of the ways in which two post-Ottoman national projects, Turkey and Egypt, deployed religion in ways to consolidate and weaken boundaries of the nation, on one hand, and confessional community boundaries, on the other hand. Accordingly, non-Muslims in Istanbul felt left in an ambiguous zone between individual citizenship and confessional membership. State policies that dissolved the communal realm as a primary basis of social organization rendered confessional communities symbolic\u2014one exception was in the 1950s. On the other hand, the communal realm was an important source of belonging for Non-Muslims in Alexandria especially when they lacked formal citizenship status, as it was the case with some non-Coptic and non-Muslim groups."], "mods_abstract_ssim": ["Istanbul and Alexandria, two of the most important port cities of the Ottoman Empire, experienced a gradual transition from religious diversity to homogenization during the unfolding of national projects in Turkey and Egypt, respectively. This transition took place from the early 1920s till the 1970s largely through the emigration of local non-Muslim population that overlapped with the immigration of local Muslims from rural areas. Although the emigration of non-Muslims was a common experience in Istanbul and Alexandria, lived experiences of these populations who were excluded from the national space in Turkey and Egypt differed significantly. This dissertation explains these differences by exploring the ways in which non-Muslims in Istanbul and Alexandria perceived and experienced belonging during the unfolding of national projects in Turkey and Egypt. Based on newspaper reviews and oral history interviews collected through 15 months of historical and ethnographic research, the dissertation argues that struggles and contestations within the state apparatus over the meaning of the nation took place within a limited range of political action that forged state-society relations. State, nation and community as the primary sources of belonging ambiguously coalesced and diverged within this range shaping individuals\u2019 perceptions and experiences of belonging. These perceptions and experiences contributed to the formation of cultural repertoires of belonging that individuals who fell outside of national boundaries deployed in their encounters with their fellow citizens and the state. The dissertation demonstrates this theoretical claim through a comparison of the ways in which two post-Ottoman national projects, Turkey and Egypt, deployed religion in ways to consolidate and weaken boundaries of the nation, on one hand, and confessional community boundaries, on the other hand. Accordingly, non-Muslims in Istanbul felt left in an ambiguous zone between individual citizenship and confessional membership. State policies that dissolved the communal realm as a primary basis of social organization rendered confessional communities symbolic\u2014one exception was in the 1950s. 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A range of microstructures that resulted in different static mechanical properties in a family of Ni-containing steels was generated by modifying heat treatments for a given steel composition (10% Ni-0.1%C) and by modifying the steel composition in terms of Ni content (2.5%, 3.5%, 4.5%, 6.5% and 10%) as well as C (0.1% and 0.03%) content. The loss in strength from C decrease in the lower Ni versions was offset by adding Cu to produce precipitation hardening from the nanosize Cu precipitates. The influence of microstructure on the dynamic properties of these steels was studied through a combination of careful documentation of the initial microstructure, mechanical testing using the Kolsky compression bar set-up, and detailed post-deformation microstructure characterization. The dynamic deformation behavior of a steel with the composition 0.09%C-10.0%Ni-1.2%Mo-0.6%Mn-0.5%Cr-0.1%V (wt.%) was first examined in two different tempers. In the first case, the microstructure consisted of heavily dislocated martensite laths with a fine distribution of MC carbides. This microstructure was highly prone to shear localization in the strain rate regime 2 x 10 3 s -1 to 4 x 10 3 s -1 . The resulting adiabatic shear band, approximately 15 \u03bcm wide, consisted of submicron equiaxed grains composed of a mixture of fcc and bcc phases thought to be austenite and ferrite/martensite.In the second case, the tempered microstructure consisted of martensite laths although the dislocation density appeared lower; in addition to coarse MC carbides, M 2 C carbides and austenite islands were noted. At comparable strain rates, the steel was more resistant to localization and a well-developed shear band was not obtained; incorporating a notch in the specimen however facilitated the formation of a shear band. The microstructure within the band was again composed of equiaxed grains but diffraction patterns did not show the presence of the fcc phase, implying its transformation during deformation to bcc ferrite/martensite. This phase transformation of austenite to martensite may be responsible for the enhanced resistance to shear localization. This finding was followed by a methodical study to evaluate the role of precipitated austenite content, composition and size distribution on xvi discouraging shear localization. M\u00f6ssbauer spectroscopy was used to determine austenite content in the heat-treated steels. Results confirmed that when the austenite content was in excess of 5 volume percent, shear localization could be postponed. For similar volume fractions that showed enhancements in shear localization resistance, tempering at a lower temperature resulted in less of a loss in static strength while displaying enhanced ballistic resistance. When lower levels of Ni were incorporated in the alloy, for example 2.5% Ni or 3.5% Ni instead of 10% Ni, the shear localization resistance improved but the improvement came at the expense of static strength. This study has shown that it is possible to develop a microstructure that provides a high static strength while maintaining acceptable levels of ballistic resistance; the improvement is thought to come from a martensite transformation of precipitated austenite, the transformation being triggered by deformation."], "mods_abstract_ssim": ["This thesis documents a study of the high strain rate deformation behavior of Ni-containing steels of interest to the U.S. Navy for ship structures. A range of microstructures that resulted in different static mechanical properties in a family of Ni-containing steels was generated by modifying heat treatments for a given steel composition (10% Ni-0.1%C) and by modifying the steel composition in terms of Ni content (2.5%, 3.5%, 4.5%, 6.5% and 10%) as well as C (0.1% and 0.03%) content. The loss in strength from C decrease in the lower Ni versions was offset by adding Cu to produce precipitation hardening from the nanosize Cu precipitates. The influence of microstructure on the dynamic properties of these steels was studied through a combination of careful documentation of the initial microstructure, mechanical testing using the Kolsky compression bar set-up, and detailed post-deformation microstructure characterization. The dynamic deformation behavior of a steel with the composition 0.09%C-10.0%Ni-1.2%Mo-0.6%Mn-0.5%Cr-0.1%V (wt.%) was first examined in two different tempers. In the first case, the microstructure consisted of heavily dislocated martensite laths with a fine distribution of MC carbides. This microstructure was highly prone to shear localization in the strain rate regime 2 x 10 3 s -1 to 4 x 10 3 s -1 . The resulting adiabatic shear band, approximately 15 \u03bcm wide, consisted of submicron equiaxed grains composed of a mixture of fcc and bcc phases thought to be austenite and ferrite/martensite.In the second case, the tempered microstructure consisted of martensite laths although the dislocation density appeared lower; in addition to coarse MC carbides, M 2 C carbides and austenite islands were noted. At comparable strain rates, the steel was more resistant to localization and a well-developed shear band was not obtained; incorporating a notch in the specimen however facilitated the formation of a shear band. The microstructure within the band was again composed of equiaxed grains but diffraction patterns did not show the presence of the fcc phase, implying its transformation during deformation to bcc ferrite/martensite. This phase transformation of austenite to martensite may be responsible for the enhanced resistance to shear localization. This finding was followed by a methodical study to evaluate the role of precipitated austenite content, composition and size distribution on xvi discouraging shear localization. M\u00f6ssbauer spectroscopy was used to determine austenite content in the heat-treated steels. Results confirmed that when the austenite content was in excess of 5 volume percent, shear localization could be postponed. For similar volume fractions that showed enhancements in shear localization resistance, tempering at a lower temperature resulted in less of a loss in static strength while displaying enhanced ballistic resistance. When lower levels of Ni were incorporated in the alloy, for example 2.5% Ni or 3.5% Ni instead of 10% Ni, the shear localization resistance improved but the improvement came at the expense of static strength. 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By generating substrates inspired by the features and dimensions of SC, we find that SC processes are optimal for guidance and SC somas are sufficient for guidance. We also find that neurite response to these bioinspired materials was time-dependent. Next, we wanted to investigate the functional and behavioral effects of substrate stiffness on SCs. For these studies we cultured SCs on polyacrylamide (PA) substrates with varying stiffnesses and find that substrate stiffness can regulate SC phenotype as well as the magnitude of the interactions with the underlying material, possibly by cytoskeletal regulation, distribution and re-arrangement. To examine the added effect of biochemical guidance cues on substrate stiffness, we cultured SCs on PA substrates micropatterned with laminin (LN). In the presence of LN stripes, SCs exhibit a migrating phenotype different than the one observed on flat materials uniformly coated with LN. 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The present experiments selectively destabilized three geometric properties of the environment during learning, specifically Euclidean metric structure, neighborhoods, or the place graph. In the learning phase, separate groups of participants walked in one of four virtual hedge mazes: (1) The Control Maze preserved all three properties. (2) Elastic Maze I preserved the place graph while destabilizing Euclidean and neighborhood structure, by stretching paths during learning so that a target could occupy two different metric locations in different neighborhoods. This maze provided metric (via path integration) but not visual information about neighborhood boundary relations. (3) Elastic Maze II added visual information for neighborhood boundaries, by having stretched paths visibly intersect paths they crossed during learning. (4) The Swap Maze preserved neighborhoods while destabilizing Euclidean and graph structure by swapping pairs of targets within a neighborhood during learning. In the test phase, spatial learning was probed by asking participants to perform one of three navigational tasks: (a) metric shortcut task, designed to assess Euclidean spatial knowledge, (b) neighborhood shortcut task, to assess knowledge of neighborhoods, (c) route task, to assess graph knowledge. This design aimed to test several specific predictions: (H1) if spatial knowledge is primarily Euclidean, then performance on all tasks should deteriorate when metric structure is destabilized during learning; (H2) if spatial knowledge is primarily topological, performance should reflect the place graph when metric and neighborhood structure are destabilized, and (H3) if navigators acquire whatever geometric properties remain stable during learning, performance should reflect the stable structure in each maze. The results are inconsistent with the Euclidean and Stability hypotheses, but support the Topological hypothesis. Metric performance is highly unreliable and neighborhood knowledge can suffer even when neighborhoods are stable. In contrast, the place graph is successfully learned in all environments, with over 96% accuracy. Spatial knowledge appears to be primarily topological, and is consistent with a labeled graph that incorporates approximate local distance and angle information."], "mods_abstract_ssim": ["This dissertation critically examined the structure of human spatial knowledge by testing three general hypotheses: the Euclidean, Topological, and Stability Hypotheses. The present experiments selectively destabilized three geometric properties of the environment during learning, specifically Euclidean metric structure, neighborhoods, or the place graph. In the learning phase, separate groups of participants walked in one of four virtual hedge mazes: (1) The Control Maze preserved all three properties. (2) Elastic Maze I preserved the place graph while destabilizing Euclidean and neighborhood structure, by stretching paths during learning so that a target could occupy two different metric locations in different neighborhoods. This maze provided metric (via path integration) but not visual information about neighborhood boundary relations. (3) Elastic Maze II added visual information for neighborhood boundaries, by having stretched paths visibly intersect paths they crossed during learning. (4) The Swap Maze preserved neighborhoods while destabilizing Euclidean and graph structure by swapping pairs of targets within a neighborhood during learning. In the test phase, spatial learning was probed by asking participants to perform one of three navigational tasks: (a) metric shortcut task, designed to assess Euclidean spatial knowledge, (b) neighborhood shortcut task, to assess knowledge of neighborhoods, (c) route task, to assess graph knowledge. This design aimed to test several specific predictions: (H1) if spatial knowledge is primarily Euclidean, then performance on all tasks should deteriorate when metric structure is destabilized during learning; (H2) if spatial knowledge is primarily topological, performance should reflect the place graph when metric and neighborhood structure are destabilized, and (H3) if navigators acquire whatever geometric properties remain stable during learning, performance should reflect the stable structure in each maze. The results are inconsistent with the Euclidean and Stability hypotheses, but support the Topological hypothesis. Metric performance is highly unreliable and neighborhood knowledge can suffer even when neighborhoods are stable. In contrast, the place graph is successfully learned in all environments, with over 96% accuracy. Spatial knowledge appears to be primarily topological, and is consistent with a labeled graph that incorporates approximate local distance and angle information."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0WD3XXP", "mods_id": "etd1183", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Ericson, Jonathan D", "Warren, William", "Domini, Fulvio", "Burwell, Rebecca", "Brown University. 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Functions of the left ventrolateral prefrontal cortex (VLPFC) help us access, shape, and act upon remembered information or potential memory targets in a manner consistent with current behavioral goals. It has long been hypothesized that VLPFC cognitive control mechanisms achieve this by biasing ongoing neural activity in other brain areas. However, the extrinsic functional and anatomical pathways involved in these putative interactions are to date, largely underspecified. The experiments described in this dissertation attempt to address this important gap in the literature of the cognitive control of memory. In Chapter 1, models of memory will be introduced briefly as will the core concepts of the cognitive control of memory and a concise review of the relevant anatomy. Chapter 2 describes a source memory experiment used to both: 1) identify and isolate regions of VLPFC and other memory areas involved in control-dependent memory access, and, 2) to study the functional networks that might support regional interactions. In Chapter 3, we discuss a human anatomical tractography study in which high angular resolution diffusion-weighted imaging was used to compare and contrast the anatomical connectivity fingerprint of the three main subdivisions of VLPFC. Finally, in Chapter 4 an experiment that specifically isolates post-retrieval control will be reviewed. Together, the work summarized in this thesis suggests that two distinct, functionally heterogeneous pathways are leveraged by VLPFC during the cognitive control of retrieval."], "mods_abstract_ssim": ["Abstract of \u201cFunctional and Anatomical Pathways Supporting the Cognitive Control of Memory Retrieval\u201d by Jennifer Barredo, Brown University, May 2014. Functions of the left ventrolateral prefrontal cortex (VLPFC) help us access, shape, and act upon remembered information or potential memory targets in a manner consistent with current behavioral goals. It has long been hypothesized that VLPFC cognitive control mechanisms achieve this by biasing ongoing neural activity in other brain areas. However, the extrinsic functional and anatomical pathways involved in these putative interactions are to date, largely underspecified. The experiments described in this dissertation attempt to address this important gap in the literature of the cognitive control of memory. In Chapter 1, models of memory will be introduced briefly as will the core concepts of the cognitive control of memory and a concise review of the relevant anatomy. Chapter 2 describes a source memory experiment used to both: 1) identify and isolate regions of VLPFC and other memory areas involved in control-dependent memory access, and, 2) to study the functional networks that might support regional interactions. In Chapter 3, we discuss a human anatomical tractography study in which high angular resolution diffusion-weighted imaging was used to compare and contrast the anatomical connectivity fingerprint of the three main subdivisions of VLPFC. Finally, in Chapter 4 an experiment that specifically isolates post-retrieval control will be reviewed. Together, the work summarized in this thesis suggests that two distinct, functionally heterogeneous pathways are leveraged by VLPFC during the cognitive control of retrieval."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0J67F95", "mods_id": "etd1176", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Barredo, Jennifer", "Badre, David", "Sheinberg, David", "Burwell, Rebecca", "Eichenbaum, Howard", "Brown University. 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"rel_is_member_of_collection_ssim": ["bdr:89h4xzck"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [351], "ir_collection_name": ["Neuroscience", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["Auditory and visual information interact in the brain to produce a wide variety of behavioral and cognitive phenomena, however much is unknown about the mechanisms of these interactions. In this thesis I investigate functional networks determined by neural electromagnetic signals in order to investigate dynamic cortical communication present during audiovisual interactions. The goal of this research is to not only outline the contributions of various functional links between brain regions during different types of audiovisual interactions, but additionally to investigate what types of electromagnetic relationships are present between communicating areas. I find that correlations of beta power directly illustrate connectivity between auditory and visual areas during audiovisual integration. Specifically, co-fluctuations of beta power are seen between R-V4/V5 and R-auditory cortex when tracking an audiovisual object. Additional investigations of beta-power functional networks during audiovisual searching show an indirect audiovisual integrative route, bridging auditory and visual cortex through a fronto-parietal network. Further, these connections varied with task performance and strategy as well as showed changes over training. The strength of the fronto-parietal network links are positively correlated with the speed at which subjects performed their audiovisual search. Large changes over training were in low level visual cortex during searching, indicating that as an audiovisual search becomes more trained, lower level cortices become more involved. Fronto-parietal connections, as well as auditory and visual cortical links to the fronto-parietal network were correlated with how much subjects used auditory information to drive their visual search, indicating a top-down, task-driven audiovisual integrative route. We conclude these findings not only implicate differential functional network pathways underlying audiovisual tracking and searching, but further indicate that beta power correlations are a robust measure of cortical communication with direct behavioral relevance, not limited to auditory and visual areas."], "mods_abstract_ssim": ["Auditory and visual information interact in the brain to produce a wide variety of behavioral and cognitive phenomena, however much is unknown about the mechanisms of these interactions. In this thesis I investigate functional networks determined by neural electromagnetic signals in order to investigate dynamic cortical communication present during audiovisual interactions. The goal of this research is to not only outline the contributions of various functional links between brain regions during different types of audiovisual interactions, but additionally to investigate what types of electromagnetic relationships are present between communicating areas. I find that correlations of beta power directly illustrate connectivity between auditory and visual areas during audiovisual integration. Specifically, co-fluctuations of beta power are seen between R-V4/V5 and R-auditory cortex when tracking an audiovisual object. Additional investigations of beta-power functional networks during audiovisual searching show an indirect audiovisual integrative route, bridging auditory and visual cortex through a fronto-parietal network. Further, these connections varied with task performance and strategy as well as showed changes over training. The strength of the fronto-parietal network links are positively correlated with the speed at which subjects performed their audiovisual search. Large changes over training were in low level visual cortex during searching, indicating that as an audiovisual search becomes more trained, lower level cortices become more involved. Fronto-parietal connections, as well as auditory and visual cortical links to the fronto-parietal network were correlated with how much subjects used auditory information to drive their visual search, indicating a top-down, task-driven audiovisual integrative route. 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"rel_is_member_of_collection_ssim": ["bdr:gfb24rk4"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "rel_embargo_years_ssim": ["2016", "2018", "2020"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [333], "ir_collection_name": ["French Studies", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["Abstract of \u201cThe Unruly Body or \u2018the New Normal\u2019: Renaissance Pathology and the Literary Imagination,\u201d by Yuri Kondratiev, Ph.D, Brown University, May 2014 Conceived at the intersection between history of medicine and literature in 16th century France, this dissertation focuses on pathology, whose influence and importance in literary, philosophical, cultural, and scientific context of the Renaissance have not been given due critical attention. I adapt an epistemological approach in exploring unsymmetrical, anamorphic and unruly corporeal shapes as a source of imagination and an aesthetic principle, which underlie both literary pursuits and scientific endeavors. As a literary critic and a historian of science, I adapt an interdisciplinary perspective that bridges sciences and arts to show the viability of the literary perspective as I establish a close interdependence between the medical realm and the literary imagination, while examining major medical and literary corpora - including Jean Fernel\u2019s Pathologiae Libri and De Abdtitis Rerum Causis, Ambroise Par\u00e9\u2019s Monstres et prodiges, Montaigne\u2019s Essais, and Rabelais\u2019 oeuvre. The result is two-fold \u2013 first, it led to the conceptualization of unruly bodies as an idiosyncratic object of Renaissance pathology ensuing from the \u201cprise de conscience\u201d over varietas and inconstantia of nature. Second, unruly bodies are an effect of pathology as a scientific endeavor of naturalizing, normalizing, and rationalizing the nature and causes of corporeal deviations. While pathology seems to falls short of circumscribing diverse pathological phenomena to a specific source in both literary and medical contexts, the body as its object remains pervious, unstable, and above all open to the outside world, thus allowing to conceive of the Renaissance as a transitional period, which anticipates and precedes the Cartesian Cogito as well as what Foucault described as the clinical and abnormal body in his Naissance de la clinique and les Anormaux respectively. This interdisciplinary study thus unveils unruly body as a part of the dynamic relationship between the normal and pathological phenomena and an aesthetic principle situated in the context of the transition from natural philosophy, humoral doctrine, and demonic pathology towards ontological, localizing, and psychosomatic conceptions of disease."], "mods_abstract_ssim": ["Abstract of \u201cThe Unruly Body or \u2018the New Normal\u2019: Renaissance Pathology and the Literary Imagination,\u201d by Yuri Kondratiev, Ph.D, Brown University, May 2014 Conceived at the intersection between history of medicine and literature in 16th century France, this dissertation focuses on pathology, whose influence and importance in literary, philosophical, cultural, and scientific context of the Renaissance have not been given due critical attention. I adapt an epistemological approach in exploring unsymmetrical, anamorphic and unruly corporeal shapes as a source of imagination and an aesthetic principle, which underlie both literary pursuits and scientific endeavors. As a literary critic and a historian of science, I adapt an interdisciplinary perspective that bridges sciences and arts to show the viability of the literary perspective as I establish a close interdependence between the medical realm and the literary imagination, while examining major medical and literary corpora - including Jean Fernel\u2019s Pathologiae Libri and De Abdtitis Rerum Causis, Ambroise Par\u00e9\u2019s Monstres et prodiges, Montaigne\u2019s Essais, and Rabelais\u2019 oeuvre. The result is two-fold \u2013 first, it led to the conceptualization of unruly bodies as an idiosyncratic object of Renaissance pathology ensuing from the \u201cprise de conscience\u201d over varietas and inconstantia of nature. Second, unruly bodies are an effect of pathology as a scientific endeavor of naturalizing, normalizing, and rationalizing the nature and causes of corporeal deviations. While pathology seems to falls short of circumscribing diverse pathological phenomena to a specific source in both literary and medical contexts, the body as its object remains pervious, unstable, and above all open to the outside world, thus allowing to conceive of the Renaissance as a transitional period, which anticipates and precedes the Cartesian Cogito as well as what Foucault described as the clinical and abnormal body in his Naissance de la clinique and les Anormaux respectively. This interdisciplinary study thus unveils unruly body as a part of the dynamic relationship between the normal and pathological phenomena and an aesthetic principle situated in the context of the transition from natural philosophy, humoral doctrine, and demonic pathology towards ontological, localizing, and psychosomatic conceptions of disease."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0V1234Z", "mods_id": "etd1295", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Kondratiev, Yuri", "Krause, Virginia", "Saint-Amand, Pierre", "Cook, Harold", "Brown University. 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Security is conventionally viewed as the state\u2019s quintessential and exclusive domain. Centralization, bureaucratization, and nationalization of coercion are deemed necessary for modernization and modern state making. Yet, modern states often incorporate a variety of nonstate partners into their repertoire of coercion. This dissertation examines why states \u201coutsource\u201d violence by creating irregular military units manned by domestic nonstate actors \u2013 individuals with no prior professional ties to the state. Furthermore, the dissertation addresses the variation in the type of domestic nonstate actor states use in violent conflict. It shows that the creation and use of irregular military units is a product of target density, the spatial distribution of the military target across population and territory, and the state\u2019s military capacity. These findings contrast with the conventional wisdom that weakness leads states to outsource violence. Building a new theory of state outsourcing of violence, this dissertation employs the method of controlled comparison to systematically analyze \u201cmost similar\u201d military operations Pakistan and India undertook between the years 1965 and 2003. The implications of the theory are then explored with out-of-sample cases drawn from Russia and Turkey. The original data used in this dissertation come from two years of extensive cross-national archival and field research. Over 150 interviews were conducted with acting and former state and military officials, including ambassadors and foreign secretaries, generals, soldiers and army officers, intelligence officials, bureaucrats, local journalists, regional experts, human rights activists, witnesses and victims of violence, and former militants. 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Yet, modern states often incorporate a variety of nonstate partners into their repertoire of coercion. This dissertation examines why states \u201coutsource\u201d violence by creating irregular military units manned by domestic nonstate actors \u2013 individuals with no prior professional ties to the state. Furthermore, the dissertation addresses the variation in the type of domestic nonstate actor states use in violent conflict. It shows that the creation and use of irregular military units is a product of target density, the spatial distribution of the military target across population and territory, and the state\u2019s military capacity. These findings contrast with the conventional wisdom that weakness leads states to outsource violence. Building a new theory of state outsourcing of violence, this dissertation employs the method of controlled comparison to systematically analyze \u201cmost similar\u201d military operations Pakistan and India undertook between the years 1965 and 2003. The implications of the theory are then explored with out-of-sample cases drawn from Russia and Turkey. The original data used in this dissertation come from two years of extensive cross-national archival and field research. Over 150 interviews were conducted with acting and former state and military officials, including ambassadors and foreign secretaries, generals, soldiers and army officers, intelligence officials, bureaucrats, local journalists, regional experts, human rights activists, witnesses and victims of violence, and former militants. 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In Drosophila, dosage compensation is mediated by the Male Specific Lethal (MSL) complex, which increases transcript levels of X-linked genes in males approximately two-fold to equalize expression levels with the two X chromosomes in females as well as with autosomes. It is thought that the MSL complex identifies the X chromosome in multiple steps. First, the roX loci are though to be targeted which encode the two non-coding RNA components of complex. Next, in a sequence dependent step, a series of high affinity sites containing cis-acting GA-rich MSL Recognition Elements (MRE) are targeted. Finally, sequence-independent spreading of the MSL complex occurs along the X chromosome through the recognition of specific histone modifications association with active transcription. Recently, we identified a previously unstudied zinc finger protein, Chromatin-linked adaptor for MSL proteins (CLAMP), as a key regulator of Drosophila dosage compensation. CLAMP is able to directly target MRE sequences and is enriched at MSL high affinity sites on the X chromosome including the roX loci. Enrichment of CLAMP at the roX loci could identify them as \u201cseed sites\u201d for MSL recruitment that initiates the X-identification cascade. CLAMP is found at the promoters of many active genes in male and female cells, is an essential protein in both males and females and is therefore not a sex-specific factor. To investigate CLAMP as a genome wide transcription factor, we analyzed a fly line containing a P-element insertion and performed mRNA-seq in male and female cells. Using the P-element insertion fly line, we uncovered a new role for CLAMP in development where decreased CLAMP levels caused sever viability and motor defects in male and females with males being very sensitive to the loss of CLAMP. Using mRNA-seq, we found CLAMP regulating genes involved in neuromuscular development. Understanding how the non-sex specific function and the dosage compensation function of CLAMP is integrated is critical in understanding how dosage compensation evolved in Drosophila"], "mods_abstract_ssim": ["Dosage compensation in Drosophila is a valuable model for studying how transcription complexes are targeted throughout the genome because all of the genes along the length of a single chromosome are identified for co-regulation. In Drosophila, dosage compensation is mediated by the Male Specific Lethal (MSL) complex, which increases transcript levels of X-linked genes in males approximately two-fold to equalize expression levels with the two X chromosomes in females as well as with autosomes. It is thought that the MSL complex identifies the X chromosome in multiple steps. First, the roX loci are though to be targeted which encode the two non-coding RNA components of complex. Next, in a sequence dependent step, a series of high affinity sites containing cis-acting GA-rich MSL Recognition Elements (MRE) are targeted. Finally, sequence-independent spreading of the MSL complex occurs along the X chromosome through the recognition of specific histone modifications association with active transcription. Recently, we identified a previously unstudied zinc finger protein, Chromatin-linked adaptor for MSL proteins (CLAMP), as a key regulator of Drosophila dosage compensation. CLAMP is able to directly target MRE sequences and is enriched at MSL high affinity sites on the X chromosome including the roX loci. Enrichment of CLAMP at the roX loci could identify them as \u201cseed sites\u201d for MSL recruitment that initiates the X-identification cascade. CLAMP is found at the promoters of many active genes in male and female cells, is an essential protein in both males and females and is therefore not a sex-specific factor. To investigate CLAMP as a genome wide transcription factor, we analyzed a fly line containing a P-element insertion and performed mRNA-seq in male and female cells. Using the P-element insertion fly line, we uncovered a new role for CLAMP in development where decreased CLAMP levels caused sever viability and motor defects in male and females with males being very sensitive to the loss of CLAMP. Using mRNA-seq, we found CLAMP regulating genes involved in neuromuscular development. 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Paleoceanography is the discipline of reconstructing past climates using physical and chemical clues left behind in marine sediments. Estuaries provide an attractive opportunity to reconstruct paleo-environments because they often contain thick sequences of sediment that have accumulated much faster than in the open ocean, and are transition zones between marine and fresh waters, thus their sediments concurrently capture both terrestrial and marine responses to environmental change at high temporal resolution. Herein, I discuss results based on the application of a suite of geochemical proxies to the sediment record of Narragansett Bay, a high-salinity estuary located in RI, USA, towards the reconstruction of sea surface temperature and watershed soil and nutrient mobilization. Highlights include: 1) the verification that sedimentary Uk\u201937 Index accurately reflects mean annual sea surface temperature in Narragansett Bay to within \u00b10.3\u00b0C, 2) the determination that water-column Uk\u201937 over four annual cycles was within 1.1\u00b0C of instrumental mean (12.7\u00b0C) during the same period despite interesting seasonal deviations between Uk\u201937 and water temperature , 3) the development of a 1500 year-long record of sea surface temperature for Narragansett Bay showing structure consistent with the Medieval Climate Anomaly, the Little Ice Age, and modern global warming, and the reconstruction of the effects of land-use change on sediment and nutrient delivery in Narragansett Bay."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z00K26WT", "mods_id": "etd1319", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Salacup, Jeffrey M", "Herbert, Timothy", "Prell, Warren", "Huang, Yongsong", "Parman, Stephen", "Hastings, Meredith", "Cronin, Thomas", "Brown University. 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Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["Ancient volcanic deposits on terrestrial planetary bodies preserve a record of the early stages of planetary evolution, revealing important information about both the interior evolution and the surface modification history of planetary bodies. The work presented in this dissertation has mapped ancient volcanic deposits on the Moon (cryptomaria) and Mercury (intercrater plains) and measured their physical characteristics using remote orbital datasets to understand better the distribution and flux of volcanic materials onto these planetary surfaces. Initially, the character of how volcanic flows fill cratered terrain was modeled using high-resolution topography data in three different geologic settings in order to develop criteria for identifying the distribution and thickness of ancient volcanic deposits. Areal extents and map patterns can be used to predict volcanic deposit thicknesses. These expected morphologies for volcanic deposits and the latest available lunar datasets were used to establish the criteria necessary to distinguish cryptomaria from basin ejecta deposits. Eighteen cryptomaria regions were identified; all cluster on the nearside, with the largest deposits associated with impact basins. After identification, the mineralogy and composition of cryptomaria were measured to determine if these deposits are actually composed of mare basalts. Mineralogic modeling was combined with elemental analyses to assess which of the early igneous rocks could comprise the cryptomaria. The results of mineralogic modeling and compositional analyses of thorium and iron abundances indicate that the mapped cryptomaria are mare basalts. On Mercury, the origin of the intercrater plains was investigated to determine the role of volcanism during the planet\u2019s early history. Ten areas of intercrater plains were evaluated to re-characterize the unit and produce a geologic map covering ~20% of the surface. Analysis of the stratigraphic relationships and evaluation of the basin impact ejecta origin led to the conclusion that the intercrater plains are formed by volcanic processes. Then, the importance of basin ejecta on Mercury was evaluated by analyzing the plains around Rembrandt basin. Evaluation of the ages, color properties, and distribution of the circum-Rembrandt plains indicate that the low albedo exterior plains are dominantly impact melt produced during the basin-formation event."], "mods_abstract_ssim": ["Ancient volcanic deposits on terrestrial planetary bodies preserve a record of the early stages of planetary evolution, revealing important information about both the interior evolution and the surface modification history of planetary bodies. The work presented in this dissertation has mapped ancient volcanic deposits on the Moon (cryptomaria) and Mercury (intercrater plains) and measured their physical characteristics using remote orbital datasets to understand better the distribution and flux of volcanic materials onto these planetary surfaces. Initially, the character of how volcanic flows fill cratered terrain was modeled using high-resolution topography data in three different geologic settings in order to develop criteria for identifying the distribution and thickness of ancient volcanic deposits. Areal extents and map patterns can be used to predict volcanic deposit thicknesses. These expected morphologies for volcanic deposits and the latest available lunar datasets were used to establish the criteria necessary to distinguish cryptomaria from basin ejecta deposits. Eighteen cryptomaria regions were identified; all cluster on the nearside, with the largest deposits associated with impact basins. After identification, the mineralogy and composition of cryptomaria were measured to determine if these deposits are actually composed of mare basalts. Mineralogic modeling was combined with elemental analyses to assess which of the early igneous rocks could comprise the cryptomaria. The results of mineralogic modeling and compositional analyses of thorium and iron abundances indicate that the mapped cryptomaria are mare basalts. On Mercury, the origin of the intercrater plains was investigated to determine the role of volcanism during the planet\u2019s early history. Ten areas of intercrater plains were evaluated to re-characterize the unit and produce a geologic map covering ~20% of the surface. Analysis of the stratigraphic relationships and evaluation of the basin impact ejecta origin led to the conclusion that the intercrater plains are formed by volcanic processes. Then, the importance of basin ejecta on Mercury was evaluated by analyzing the plains around Rembrandt basin. Evaluation of the ages, color properties, and distribution of the circum-Rembrandt plains indicate that the low albedo exterior plains are dominantly impact melt produced during the basin-formation event."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0CV4G3R", "mods_id": "etd1315", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Whitten, Jennifer", "Head, James", "Hess, Paul", "Pieters, Carle", "Saal, Alberto", "Blewett, David", "Brown University. 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"_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["In recent years, there has been great interest in fluid-structure interaction (FSI) problems due to their relevance in structural engineering and biomedical applications. However, several difficulties have hindered the development of partitioned FSI algorithms in large-scale simulations: the relatively small values of the mass ratio between the arterial wall and the blood causes instabilities in solvers; the arterial wall responses are very complicated therefore difficult to be described by classical structural models; accurate simulations in patient-specific geometries require large CPU time; and so on. To resolve these difficulties, design and analysis of efficient and stable numerical schemes for structure solver, fluid solver, and FSI procedure are considered in this thesis, with contributions on: developing and accelerating the spectral element method structure solvers for linear elastic, hyperelastic and viscoelastic models; validating the spectral element method fluid solver in image-based computational biofluid mechanics; stabilizing the partitioned fluid-structure interaction procedure and resolving the added-mass effect; developing and employing fractional PDEs solvers to model the complex biomechanical viscoelastic properties of patient-specific arteries. Specifically, on the structure side firstly a mixed formulation for nearly incompressible nonlinear elasticity is investigated, which has superior accuracy and efficiency compared with the displacement-only formulation. Moreover, a semi-local solver is developed for spectral element discretization of the linear elasticity equations, from which we obtain good scalability in large scale parallel computing. To better capture the complex biomechanical viscoelastic properties of soft tissue in arteries, the governing equations for structure are extended to fractional viscoelasticity models, and their sensitivities to the patient-specific parameters are numerically investigated. On the fluid side, the spectral element method solver is validated by comparing the simulation results with clinical angiographic images and with numerical solutions from other research groups. Lastly, two new schemes for FSI are designed to stabilize and accelerate the communications between fluid and structure solvers, with analysis for choosing the optimal coefficients provided. To validate the analysis, the FSI framework is applied to patient-specific aneurysms and also to deepwater offshore risers covered with fairings, hence demonstrating the general applicability of the methodology."], "mods_abstract_ssim": ["In recent years, there has been great interest in fluid-structure interaction (FSI) problems due to their relevance in structural engineering and biomedical applications. However, several difficulties have hindered the development of partitioned FSI algorithms in large-scale simulations: the relatively small values of the mass ratio between the arterial wall and the blood causes instabilities in solvers; the arterial wall responses are very complicated therefore difficult to be described by classical structural models; accurate simulations in patient-specific geometries require large CPU time; and so on. To resolve these difficulties, design and analysis of efficient and stable numerical schemes for structure solver, fluid solver, and FSI procedure are considered in this thesis, with contributions on: developing and accelerating the spectral element method structure solvers for linear elastic, hyperelastic and viscoelastic models; validating the spectral element method fluid solver in image-based computational biofluid mechanics; stabilizing the partitioned fluid-structure interaction procedure and resolving the added-mass effect; developing and employing fractional PDEs solvers to model the complex biomechanical viscoelastic properties of patient-specific arteries. Specifically, on the structure side firstly a mixed formulation for nearly incompressible nonlinear elasticity is investigated, which has superior accuracy and efficiency compared with the displacement-only formulation. Moreover, a semi-local solver is developed for spectral element discretization of the linear elasticity equations, from which we obtain good scalability in large scale parallel computing. To better capture the complex biomechanical viscoelastic properties of soft tissue in arteries, the governing equations for structure are extended to fractional viscoelasticity models, and their sensitivities to the patient-specific parameters are numerically investigated. On the fluid side, the spectral element method solver is validated by comparing the simulation results with clinical angiographic images and with numerical solutions from other research groups. Lastly, two new schemes for FSI are designed to stabilize and accelerate the communications between fluid and structure solvers, with analysis for choosing the optimal coefficients provided. 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and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["Volatile elements (C, H, F, S, and Cl) have a profound impact on the evolution and differentiation of planetary bodies and their atmospheres. Therefore, constraining the concentration and flux of volatiles within magmatic systems is vital to our understanding of various geologic processes (e.g., magma ascent, degassing, elemental partitioning, mantle metasomatism, and hydrothermal alteration) that play fundamental roles in the evolution of a planetary body. Studying volatile abundances and their behavior also provides valuable information regarding the origin of Earth\u2019s volatiles, a topic that is still highly debated. In this dissertation, I present work that contributes results needed to address these outstanding questions, particularly those considering carbon and hydrogen dissolved in melts under reduced conditions and sulfur in melts derived from Earth\u2019s upper mantle. Our experiments on lunar volcanic glasses show that carbon speciation is a function of oxygen fugacity and controls carbon solubility in basaltic melts. By studying the natural Apollo 15 and 17 lunar glasses, we confirm that most of the hydrogen is dissolved as hydroxyl and molecular water. We can use this solubility and speciation data for dissolved carbon and hydrogen to better understand the degassing process in lunar melts. Most of the carbon will degas first as CO before any water is partitioned into the gas phase. Water degasses much later in the eruption process, resulting in information used to constrain a common origin for the Earth and Moon\u2019s volatiles. We also empirically determine sulfur degassing in submarine oceanic basalts by using a S/Dy ratio. Sulfur degassing is found to correlate with the fraction water in the gas phase, which has implications for monitoring volcanic activity and the subsequent impact on the global climate. Results from this dissertation will help further our understanding of how volatiles affect various magmatic processes as well as how volatiles contribute to the exosphere during volcanic eruptions and the effects on the climate of Earth and other planetary bodies."], "mods_abstract_ssim": ["Volatile elements (C, H, F, S, and Cl) have a profound impact on the evolution and differentiation of planetary bodies and their atmospheres. Therefore, constraining the concentration and flux of volatiles within magmatic systems is vital to our understanding of various geologic processes (e.g., magma ascent, degassing, elemental partitioning, mantle metasomatism, and hydrothermal alteration) that play fundamental roles in the evolution of a planetary body. Studying volatile abundances and their behavior also provides valuable information regarding the origin of Earth\u2019s volatiles, a topic that is still highly debated. In this dissertation, I present work that contributes results needed to address these outstanding questions, particularly those considering carbon and hydrogen dissolved in melts under reduced conditions and sulfur in melts derived from Earth\u2019s upper mantle. Our experiments on lunar volcanic glasses show that carbon speciation is a function of oxygen fugacity and controls carbon solubility in basaltic melts. By studying the natural Apollo 15 and 17 lunar glasses, we confirm that most of the hydrogen is dissolved as hydroxyl and molecular water. We can use this solubility and speciation data for dissolved carbon and hydrogen to better understand the degassing process in lunar melts. Most of the carbon will degas first as CO before any water is partitioned into the gas phase. Water degasses much later in the eruption process, resulting in information used to constrain a common origin for the Earth and Moon\u2019s volatiles. We also empirically determine sulfur degassing in submarine oceanic basalts by using a S/Dy ratio. Sulfur degassing is found to correlate with the fraction water in the gas phase, which has implications for monitoring volcanic activity and the subsequent impact on the global climate. Results from this dissertation will help further our understanding of how volatiles affect various magmatic processes as well as how volatiles contribute to the exosphere during volcanic eruptions and the effects on the climate of Earth and other planetary bodies."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0HM56T2", "mods_id": "etd1314", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Wetzel, Diane", "Saal, Alberto", "Rutherford, Malcolm", "Cooper, Reid", "Parmentier, E. 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However, the fact that users no longer have physical possession of their data raises new challenges in terms of data privacy. Storing the data in encrypted form is a key component in maintaining privacy against the storage provider. However, encryption alone is not enough since information may be leaked through the pattern in which users access the data. In this thesis, we describe algorithms that allow \\emph{data-oblivious} access to remotely stored data. That is, access patterns of such algorithms depend only on the size of the outsourced data and algorithm input, but not their content. Hence, such algorithms reveal nothing about the data they are processing. We start by describing a general method that obliviously simulates user requests to outsourced data of size n and adds O(\\log n) overhead in the average case, succeeding with very high probability. This method assumes a private workspace of size O(n^{\\epsilon}) on the user side, for any given fixed positive constant \\epsilon, and does not maintain a state between data requests. We then show how to deamortize our method to achieve O(\\log n) overhead in the worst case. Our deamortization technique is general and can be applied to several existing oblivious simulations. The next oblivious simulation technique presented in this thesis improves over the O(\\log n) solution and demonstrates an interplay between system parameters such as latency, bandwidth, and the size of the user's private memory. We show that if a user exchanges messages of size O(n^{1/c} \\log n) with the storage provider, for some constant c>=2, and has access to private memory of the same size, then our method can achieve O(1) access overhead in the worst case with very high probability. Finally, we study application-specific access patterns and look at how to make them oblivious without using the general oblivious simulation methods mentioned above. In particular, we show how one can access and perform a computation in an oblivious fashion on an externally stored graph. We also show that a number of classic graph drawing algorithms can be efficiently implemented in this framework while maintaining user privacy."], "mods_abstract_ssim": ["Cloud storage has emerged as the next generation of data storage where users can remotely store their data and leave its management to a third party, e.g., Amazon S3, Google Drive or Microsoft Azure. However, the fact that users no longer have physical possession of their data raises new challenges in terms of data privacy. Storing the data in encrypted form is a key component in maintaining privacy against the storage provider. However, encryption alone is not enough since information may be leaked through the pattern in which users access the data. In this thesis, we describe algorithms that allow \\emph{data-oblivious} access to remotely stored data. That is, access patterns of such algorithms depend only on the size of the outsourced data and algorithm input, but not their content. Hence, such algorithms reveal nothing about the data they are processing. We start by describing a general method that obliviously simulates user requests to outsourced data of size n and adds O(\\log n) overhead in the average case, succeeding with very high probability. This method assumes a private workspace of size O(n^{\\epsilon}) on the user side, for any given fixed positive constant \\epsilon, and does not maintain a state between data requests. We then show how to deamortize our method to achieve O(\\log n) overhead in the worst case. 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"_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["Abstract of \"Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics\" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis and therapy, holds great promise for successful cancer therapy. It allows simultaneous monitoring of distribution, localization/release of a chemotherapy drug, and therapeutic response. Gold (Au) and iron oxide (Fe3O4) nanoparticles (NPs) have been extensively studied for the theranostic applications due to their distinguished optical/magnetic properties, their biocompatibility, and their modifiable surface chemistry. In one study, I synthesized dumbbell-like Au-Fe3O4 NPs, which are both magnetically and optically active, and functionalized them with doxorubicin (DOX, a powerful cancer therapeutic drug) on the Au side via a pH sensitive Schiff-base bond and MUC1 antibody on Fe3O4 side for breast cancer targeting (MUC1-antigen is over-expressed in 95% of breast cancer cells). The efficacies of these theranostic NPs for targeting and therapy were evaluated both in vitro and in vivo. Our data show that the theranostic NPs target breast cancer cells and release DOX in low pH lysosomes to inhibit tumor growth. They are superior to the pure therapeutic drug. I studied iron oxide (Fe3O4) nanoparticles (NPs) which are FDA approved as contrast agents in Magnetic Resonance Imaging (MRI). I synthesized, functionalized the Fe3O4 NPs with pH low insertion peptide (pHLIP) and studied their targeting ability to the cancer cells utilizing extracellular low pH environment of tumor. I also studied an alternative approach for cancer therapy without using any conventional drugs. In this study, I synthesized FeAu alloy NPs and tested their controlled Fe-release in low pH environment. FeAu alloy NPs possesses plasmonic property that can be combined with theraperutic to monitor the therapeutic response. I noticed that the release Fe(0) can catalyze H2O2 decomposition into hydroxyl radical, one of the known reactive oxygen species (ROS). The overproduction of ROS causes rapid oxidation of biomolecules, leading to cell apoptosis. My preliminary tests showed that FeAu NPs are cytotoxic to cancer cells and can be used as a new generation of therapeutic drug."], "mods_abstract_ssim": ["Abstract of \"Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics\" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis and therapy, holds great promise for successful cancer therapy. It allows simultaneous monitoring of distribution, localization/release of a chemotherapy drug, and therapeutic response. Gold (Au) and iron oxide (Fe3O4) nanoparticles (NPs) have been extensively studied for the theranostic applications due to their distinguished optical/magnetic properties, their biocompatibility, and their modifiable surface chemistry. In one study, I synthesized dumbbell-like Au-Fe3O4 NPs, which are both magnetically and optically active, and functionalized them with doxorubicin (DOX, a powerful cancer therapeutic drug) on the Au side via a pH sensitive Schiff-base bond and MUC1 antibody on Fe3O4 side for breast cancer targeting (MUC1-antigen is over-expressed in 95% of breast cancer cells). The efficacies of these theranostic NPs for targeting and therapy were evaluated both in vitro and in vivo. Our data show that the theranostic NPs target breast cancer cells and release DOX in low pH lysosomes to inhibit tumor growth. They are superior to the pure therapeutic drug. I studied iron oxide (Fe3O4) nanoparticles (NPs) which are FDA approved as contrast agents in Magnetic Resonance Imaging (MRI). I synthesized, functionalized the Fe3O4 NPs with pH low insertion peptide (pHLIP) and studied their targeting ability to the cancer cells utilizing extracellular low pH environment of tumor. I also studied an alternative approach for cancer therapy without using any conventional drugs. In this study, I synthesized FeAu alloy NPs and tested their controlled Fe-release in low pH environment. FeAu alloy NPs possesses plasmonic property that can be combined with theraperutic to monitor the therapeutic response. I noticed that the release Fe(0) can catalyze H2O2 decomposition into hydroxyl radical, one of the known reactive oxygen species (ROS). The overproduction of ROS causes rapid oxidation of biomolecules, leading to cell apoptosis. My preliminary tests showed that FeAu NPs are cytotoxic to cancer cells and can be used as a new generation of therapeutic drug."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0R49P4R", "mods_id": "etd1321", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Sigdel, Aruna", "Sun, Shouheng", "Basu, Amit", "Hurt, Robert", "Brown University. 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"_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["A new hybrid methodology for the stochastic partial differential equations (SPDEs) is developed based on the dynamically-orthogonal (DO) and bi-orthogonal (BO) expansions; both approaches are an extension of the Karhunen-Loeve (KL) expansion. The original KL expansion provides a low-dimensional representation for square integrable random processes since it is optimal in the mean square sense. The solution to SPDEs is represented in a way that it follows the characteristics of KL expansion on-the-fly at any given time. To this end, both the spatial and stochastic basis in the representation are time-dependent unlike the traditional methods such as polynomial chaos (PC), where only one of them is time-dependent. In order to overcome the redundancy the DO imposes the dynamical constraints on the spatial basis while the BO imposes the static constraints on the spatial and stochastic basis. We examine the relation of the BO and DO and prove theoretically and illustrate numerically their equivalence, in the sense that one method is an exact reformulation of the other by deriving an invertible and linear transformation matrix governed by a matrix differential equation that connects the BO and the DO. We also examine the pathology of the BO that occurs when there is an eigenvalue crossing leading to the numerical instability. On the other hand we observe that the DO suffers numerically when there is a high condition number of the covariance matrix for the stochastic basis. To this end, we propose a unified hybrid framework of the two methods by utilizing an invertible and linear transformation between them. We also present an adaptive algorithm to add or remove modes to better capture the transient behavior. Several numerical examples, linear and nonlinear, are presented to illustrate the DO and BO methods, their equivalence, and adaptive strategies. It is also shown numerically that two methods converge exponentially fast with respect to the number of modes giving the same levels of accuracy, which is comparable with the PC method but with substantially smaller computational cost compared to stochastic collocation, especially when the involved parametric space is high-dimensional."], "mods_abstract_ssim": ["A new hybrid methodology for the stochastic partial differential equations (SPDEs) is developed based on the dynamically-orthogonal (DO) and bi-orthogonal (BO) expansions; both approaches are an extension of the Karhunen-Loeve (KL) expansion. The original KL expansion provides a low-dimensional representation for square integrable random processes since it is optimal in the mean square sense. The solution to SPDEs is represented in a way that it follows the characteristics of KL expansion on-the-fly at any given time. To this end, both the spatial and stochastic basis in the representation are time-dependent unlike the traditional methods such as polynomial chaos (PC), where only one of them is time-dependent. In order to overcome the redundancy the DO imposes the dynamical constraints on the spatial basis while the BO imposes the static constraints on the spatial and stochastic basis. We examine the relation of the BO and DO and prove theoretically and illustrate numerically their equivalence, in the sense that one method is an exact reformulation of the other by deriving an invertible and linear transformation matrix governed by a matrix differential equation that connects the BO and the DO. We also examine the pathology of the BO that occurs when there is an eigenvalue crossing leading to the numerical instability. On the other hand we observe that the DO suffers numerically when there is a high condition number of the covariance matrix for the stochastic basis. To this end, we propose a unified hybrid framework of the two methods by utilizing an invertible and linear transformation between them. We also present an adaptive algorithm to add or remove modes to better capture the transient behavior. Several numerical examples, linear and nonlinear, are presented to illustrate the DO and BO methods, their equivalence, and adaptive strategies. It is also shown numerically that two methods converge exponentially fast with respect to the number of modes giving the same levels of accuracy, which is comparable with the PC method but with substantially smaller computational cost compared to stochastic collocation, especially when the involved parametric space is high-dimensional."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0VT1QF0", "mods_id": "etd1320", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Choi, Minseok", "Karniadakis, George", "Rozovsky, Boris", "Themistoklis, Sapsis", "Brown University. Applied Mathematics"], "mods_role_ssim": ["creator", "Director", "Reader", "sponsor"], "mods_role_creator_ssim": ["Choi, Minseok"], "mods_name_nonplace_ssim": ["Choi, Minseok", "Karniadakis, George", "Rozovsky, Boris", "Themistoklis, Sapsis", "Brown University. Applied Mathematics"], "creator": ["Choi, Minseok"], "creator_string": ["Choi, Minseok"], "contributor_display": ["Choi, Minseok (creator)", "Karniadakis, George (Director)", "Rozovsky, Boris (Reader)", "Themistoklis, Sapsis (Reader)", "Brown University. Applied Mathematics (sponsor)"], "mods_role_director_ssim": ["Karniadakis, George"], "contributor": ["Karniadakis, George", "Rozovsky, Boris", "Themistoklis, Sapsis", "Brown University. Applied Mathematics"], "contributor_string": ["Karniadakis, George", "Rozovsky, Boris", "Themistoklis, Sapsis", "Brown University. Applied Mathematics"], "mods_role_reader_ssim": ["Rozovsky, Boris", "Themistoklis, Sapsis"], "mods_role_sponsor_ssim": ["Brown University. 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"_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["It has been proposed that a hidden conformal symmetry governs the dynamics of low frequency scattering in a general Kerr black hole background, enabling a possibility of realizing the physical bulk scattering amplitudes within a conformal field theory (CFT). We investigate this correspondence by mapping higher order corrections to the massless wave equations in a Kerr background to an expansion within the CFT in terms of higher dimension operators. We find that in the low frequency regime the exact Kerr background softly breaks the conformal symmetry and the scaling dimensions of these operators run with frequency. We further extend this analysis by constructing a family of vector fields that generate local symmetries in the solution space of low frequency massless field perturbations in the general Kerr geometry. This yields a one-parameter family of SL(2R)xSL(2,R) algebras. We identify limits in which the SL(2R)xSL(2,R) algebra contracts to an SL(2,R) symmetry of the Schwarzschild background. We note that for a particular value of the free parameter, the symmetry algebra generates the quasinormal mode spectrum of a Kerr black hole in the large damping limit, suggesting a connection between the hidden conformal symmetry and a fundamental CFT underlying the quantum Kerr black hole. Finally, we consider finite frequencies. We determine how the exact mode functions decompose into representations of the SL(2R)xSL(2,R) symmetry group. This extends earlier results on the low frequency limit of the massless scalar case to finite frequencies and general spin. As an application, we numerically determine the parameters of the representations that appear in quasinormal modes. These results represent a first step to formulating a more precise mapping to a holographic dual conformal field theory for generic black holes."], "mods_abstract_ssim": ["It has been proposed that a hidden conformal symmetry governs the dynamics of low frequency scattering in a general Kerr black hole background, enabling a possibility of realizing the physical bulk scattering amplitudes within a conformal field theory (CFT). We investigate this correspondence by mapping higher order corrections to the massless wave equations in a Kerr background to an expansion within the CFT in terms of higher dimension operators. We find that in the low frequency regime the exact Kerr background softly breaks the conformal symmetry and the scaling dimensions of these operators run with frequency. We further extend this analysis by constructing a family of vector fields that generate local symmetries in the solution space of low frequency massless field perturbations in the general Kerr geometry. This yields a one-parameter family of SL(2R)xSL(2,R) algebras. We identify limits in which the SL(2R)xSL(2,R) algebra contracts to an SL(2,R) symmetry of the Schwarzschild background. We note that for a particular value of the free parameter, the symmetry algebra generates the quasinormal mode spectrum of a Kerr black hole in the large damping limit, suggesting a connection between the hidden conformal symmetry and a fundamental CFT underlying the quantum Kerr black hole. Finally, we consider finite frequencies. We determine how the exact mode functions decompose into representations of the SL(2R)xSL(2,R) symmetry group. This extends earlier results on the low frequency limit of the massless scalar case to finite frequencies and general spin. As an application, we numerically determine the parameters of the representations that appear in quasinormal modes. These results represent a first step to formulating a more precise mapping to a holographic dual conformal field theory for generic black holes."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0SN079P", "mods_id": "etd1174", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Skanata, Antun", "Lowe, David", "Jevicki, Antal", "Spradlin, Marcus", "Brown University. 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Physics"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xiii, 97 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["Conformal field theory", "AdS/CFT", "Kerr black holes"], "mods_subject_ssim": ["Conformal field theory", "AdS/CFT", "Kerr black holes"], "mods_subject_fast_ssim": ["Kerr black holes"], "mods_subject_joined_ssim": ["Conformal field theory", "AdS/CFT", "Kerr black holes"], "mods_subject_joined_fast_ssim": ["Kerr black holes"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["The Hidden Kerr/CFT Conjecture"], "mods_title_full_primary_tsi": "The Hidden Kerr/CFT Conjecture", "primary_title": "The Hidden Kerr/CFT Conjecture", "primary_title_txt_en_split": "The Hidden Kerr/CFT Conjecture", "resource_type_ssi": "dissertations", "timestamp": "2021-11-23T11:44:05.683Z", "title_si": "The Hidden Kerr/CFT Conjecture"}, {"pid": "bdr:386145", "fed_created_dsi": "2014-10-16T14:20:55.472Z", "object_created_dsi": "2014-10-16T14:20:55.472Z", "fed_last_modified_dsi": "2021-11-23T11:43:53.226Z", "object_last_modified_dsi": "2021-11-23T11:43:53.226Z", "storage_location_ssi": "ocfl", "datastreams_ssi": "{\"RELS-EXT\": {\"mimeType\": \"text/xml\", \"size\": 736, \"checksum\": \"0bf517454a65bbfbfd988e3d63babf98ea75006c85540711cf28d2133be36ffb7dfb5943d725e2c884b30267ae3e68e23ed95c7fe502b234ad73bf7f3c733dc0\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-11-23T11:43:53.226402Z\"}, \"rightsMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 1103, \"checksum\": \"211b5c5b126abf23452930c732f50446b943584379c58f3dc29d353a7c450015854813ae68c4af6c57f3d9d291000be4552b3a41f1acb9517a0633ceb5355e6f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2018-07-06T16:50:29.260000Z\"}, \"irMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 471, \"checksum\": \"5b4292f3521c919fd61e3df06aa4fdcbebb94718091ac75d2a2096a402ca324487ddacdd34d128228772837f71b210c251d4a55e0e72882d50e0a21396db2b7f\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:20:55.472000Z\"}, \"RELS-INT\": {\"mimeType\": \"text/xml\", \"size\": 544, \"checksum\": \"5b472357ddd5b27819bee2358213f4c17fdc6896dc5bf6beae5650684d3fb2f9f1b5216663770449fec222b2b138fa939f7971b6a1330bf17810891318c0b771\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-07-29T15:57:29.829000Z\"}, \"PDF\": {\"mimeType\": \"application/pdf\", \"size\": 6409402, \"checksum\": \"618fd555df1767f1a06db3cec8c8574eb1756ef45ca52a50d6a8746a6979e8b6517022a03755f3520343b9cc0b94c670e7e2389fd176be1911f137bd3d0ab71d\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:20:55.472000Z\"}, \"EXTRACTED_TEXT\": {\"mimeType\": \"text/plain\", \"size\": 298281, \"checksum\": \"b005d2bc7ff2197e20d304304d3b5de314167c6c39d751252b0418ba42e4f9d5847e4c92bfa4721cd2714ab1f9757ecec2438f4a9d02417c39b0cc4cef9b09ab\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-07-29T15:57:29.717000Z\"}, \"thumbnail\": {\"mimeType\": \"application/octet-stream\", \"size\": 2841, \"checksum\": \"c9df41bf75ea2971720d53a72a729243393e1a3cd3cff1e6fffca1d93daf4fe8450d40a182cfe53fdb02736e3748199f7ed8f4c9fe7f1aba85060daca63832a9\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2015-12-08T03:30:41.439000Z\"}, \"MODS\": {\"mimeType\": \"text/xml\", \"size\": 5757, \"checksum\": \"ce6ef19e8cf331f44122a860b3087aae8b1313c15b0b5b836f84029b7b4e7649703ebdf08b62216d9d1f43ff7a5d085f796e60076e3019b896da093672a38c3c\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-08-09T14:53:48.627418Z\"}, \"DC\": {\"mimeType\": \"application/octet-stream\", \"size\": 339, \"checksum\": \"da640c40efb5060c5734c2fc6b127d6235675f6863351b6a2acf984079bc6b94a0713ad72e82f0fb182acb3d5d1fcef82613ecd56794c77d6e1728acb3091912\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-10-16T14:20:55.472000Z\"}}", "fed_object_size_lsi": 6719474, "object_size_lsi": 6719474, "rel_content_models_ssim": ["pdf", "commonMetadata"], "rel_object_type_ssi": "pdf", "object_type": "pdf", "rel_is_member_of_collection_ssim": ["bdr:bgx4t88z"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "rel_embargo_years_ssim": ["2016"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [311], "ir_collection_name": ["Biology and Medicine", "Molecular Biology, Cell Biology, and Biochemistry", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite the conservation of this process across various eukaryotes, mechanisms responsible for gamete fusion have not been elucidated in any system. In flowering plants, two gamete fusion events are required to produce a seed, a product that is essential for both propagation of plant species and agriculture. In this system, two immotile sperm cells are delivered to the site of gamete fusion by a tip-growing cell called a pollen tube. Once the pollen tube bursts and releases the sperm cells, one fuses with the egg cell giving rise to the embryo, and the other fuses with the central cell, giving rise to the endosperm that provides nutrients to the developing embryo. If only one pollen tube targets each ovule, only the two required sperm for fertilization are deposited and additional pollen tubes are repelled. This regulation prevents too many sperm from being delivered to the site of fusion, an event that can lead to multiple sperm cells fusing with a single egg cell and detrimental developmental defects. An experimental inroad into the process of gamete fusion and sperm delivery is HAP2, a sperm-specific gene required for gamete fusion in several diverged species including the flowering plant Arabidopsis. Here, it is demonstrated using live-cell imaging that when hap2 mutant sperm incapable of gamete fusion are delivered, additional pollen tubes are attracted at a high rate in an effort to deposit functional sperm, an event rarely seen in wild type. This observation shows that flowering plants have coupled successful gamete fusion with sperm cell delivery to enhance reproductive success by ensuring that every ovule receives functional sperm. In addition, we show that HAP2 is sufficient to rescue fusion in na\u00efve Arabidopsis sperm cells that are unable to fuse with either the egg cell or the central cell. Using a forward genetic screen we also identified several novel candidate genes expressed in both male and female cells that might interact with HAP2 to mediate fusion."], "mods_abstract_ssim": ["In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite the conservation of this process across various eukaryotes, mechanisms responsible for gamete fusion have not been elucidated in any system. In flowering plants, two gamete fusion events are required to produce a seed, a product that is essential for both propagation of plant species and agriculture. In this system, two immotile sperm cells are delivered to the site of gamete fusion by a tip-growing cell called a pollen tube. Once the pollen tube bursts and releases the sperm cells, one fuses with the egg cell giving rise to the embryo, and the other fuses with the central cell, giving rise to the endosperm that provides nutrients to the developing embryo. If only one pollen tube targets each ovule, only the two required sperm for fertilization are deposited and additional pollen tubes are repelled. This regulation prevents too many sperm from being delivered to the site of fusion, an event that can lead to multiple sperm cells fusing with a single egg cell and detrimental developmental defects. An experimental inroad into the process of gamete fusion and sperm delivery is HAP2, a sperm-specific gene required for gamete fusion in several diverged species including the flowering plant Arabidopsis. Here, it is demonstrated using live-cell imaging that when hap2 mutant sperm incapable of gamete fusion are delivered, additional pollen tubes are attracted at a high rate in an effort to deposit functional sperm, an event rarely seen in wild type. This observation shows that flowering plants have coupled successful gamete fusion with sperm cell delivery to enhance reproductive success by ensuring that every ovule receives functional sperm. In addition, we show that HAP2 is sufficient to rescue fusion in na\u00efve Arabidopsis sperm cells that are unable to fuse with either the egg cell or the central cell. Using a forward genetic screen we also identified several novel candidate genes expressed in both male and female cells that might interact with HAP2 to mediate fusion."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0ZC816P", "mods_id": "etd1164", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Beale, Kristin M", "Johnson, Mark", "Palanivelu, Ravi", "Bender, Judith", "Page, Rebecca", "Wessel, Gary", "Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "mods_role_ssim": ["creator", "Director", "Reader", "sponsor"], "mods_role_creator_ssim": ["Beale, Kristin M"], "mods_name_nonplace_ssim": ["Beale, Kristin M", "Johnson, Mark", "Palanivelu, Ravi", "Bender, Judith", "Page, Rebecca", "Wessel, Gary", "Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "creator": ["Beale, Kristin M"], "creator_string": ["Beale, Kristin M"], "contributor_display": ["Beale, Kristin M (creator)", "Johnson, Mark (Director)", "Palanivelu, Ravi (Reader)", "Bender, Judith (Reader)", "Page, Rebecca (Reader)", "Wessel, Gary (Reader)", "Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)"], "mods_role_director_ssim": ["Johnson, Mark"], "contributor": ["Johnson, Mark", "Palanivelu, Ravi", "Bender, Judith", "Page, Rebecca", "Wessel, Gary", "Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "contributor_string": ["Johnson, Mark", "Palanivelu, Ravi", "Bender, Judith", "Page, Rebecca", "Wessel, Gary", "Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "mods_role_reader_ssim": ["Palanivelu, Ravi", "Bender, Judith", "Page, Rebecca", "Wessel, Gary"], "mods_role_sponsor_ssim": ["Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["20, 167 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["Gamete fusion", "plant reproduction", "polyspermy", "polytubey", "Plants--Reproduction"], "mods_subject_ssim": ["Gamete fusion", "plant reproduction", "polyspermy", "polytubey", "Plants--Reproduction"], "mods_subject_fast_ssim": ["Plants--Reproduction"], "mods_subject_joined_ssim": ["Gamete fusion", "plant reproduction", "polyspermy", "polytubey", "Plants--Reproduction"], "mods_subject_joined_fast_ssim": ["Plants--Reproduction"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["Coupling Gamete Fusion with Sperm Cell Delivery Maximizes Reproductive Success in Flowering Plants"], "mods_title_full_primary_tsi": "Coupling Gamete Fusion with Sperm Cell Delivery Maximizes Reproductive Success in Flowering Plants", 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"Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["The fate of nitrate (NO3-) in marine sediments depends on a balance of microbially mediated processes that remove or recycle available nitrogen (N), i.e. denitrification and anammox (anaerobic ammonium oxidation) versus DNRA (dissimilatory NO3- reduction to ammonium). If these processes respond differently to ecosystem shifts such as climate warming and changes in substrate availability, environmental change could alter the balance of N availability. Relationships between these processes and environmental factors were assessed for New England estuarine and continental shelf sediments at multiple temporal and spatial scales. Potential rates of denitrification and anammox were measured for five sites over two years. Denitrification varied among sites and seasons, and variation was related to organic matter and temperature. In contrast, anammox varied among sites but not seasons, and variation was related to organic matter and pore water NO3-. To explore direct effects of warming, temperature dependence was reviewed for biogeochemical processes, with a focus on N cycling. In a separate study, temperature dependence was measured for denitrification and anammox at an estuarine and a continental shelf site, and thermal optima and activation energies were found to be comparable between processes, and consistent between sites and among seasons. To further examine effects of warming and carbon, a 12-week microcosm experiment with continental shelf sediments was conducted at ambient winter (4\u00b0C) and warmer summer (17\u00b0C) temperatures, with and without regular carbon additions comparable to in situ C deposition rates. Both treatments increased sediment remineralization as inferred by diffusive O2 fluxes, and decreased NO3- influx. Potential rate measurements showed that warming increased both denitrification and DNRA, whereas carbon addition further increased DNRA, which likely competed with denitrification and caused the shift from NO3- influx to efflux. Thus DNRA may be an important, previously overlooked process in shelf sediments, and environmental change could shift the role of sediments from N removal to N recycling through an unexpected link of DNRA and nitrification."], "mods_abstract_ssim": ["The fate of nitrate (NO3-) in marine sediments depends on a balance of microbially mediated processes that remove or recycle available nitrogen (N), i.e. denitrification and anammox (anaerobic ammonium oxidation) versus DNRA (dissimilatory NO3- reduction to ammonium). If these processes respond differently to ecosystem shifts such as climate warming and changes in substrate availability, environmental change could alter the balance of N availability. Relationships between these processes and environmental factors were assessed for New England estuarine and continental shelf sediments at multiple temporal and spatial scales. Potential rates of denitrification and anammox were measured for five sites over two years. Denitrification varied among sites and seasons, and variation was related to organic matter and temperature. In contrast, anammox varied among sites but not seasons, and variation was related to organic matter and pore water NO3-. To explore direct effects of warming, temperature dependence was reviewed for biogeochemical processes, with a focus on N cycling. In a separate study, temperature dependence was measured for denitrification and anammox at an estuarine and a continental shelf site, and thermal optima and activation energies were found to be comparable between processes, and consistent between sites and among seasons. To further examine effects of warming and carbon, a 12-week microcosm experiment with continental shelf sediments was conducted at ambient winter (4\u00b0C) and warmer summer (17\u00b0C) temperatures, with and without regular carbon additions comparable to in situ C deposition rates. Both treatments increased sediment remineralization as inferred by diffusive O2 fluxes, and decreased NO3- influx. Potential rate measurements showed that warming increased both denitrification and DNRA, whereas carbon addition further increased DNRA, which likely competed with denitrification and caused the shift from NO3- influx to efflux. Thus DNRA may be an important, previously overlooked process in shelf sediments, and environmental change could shift the role of sediments from N removal to N recycling through an unexpected link of DNRA and nitrification."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z09P300W", "mods_id": "etd1170", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Brin, Lindsay Devon", "Rich, Jeremy", "Giblin, Anne", "Leslie, Heather", "Porder, Stephen", "Brown University. 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elected office \u2013 from 3,743 in 1996 to 5,740 in 2010. Latinos now hold considerable influence in cities such as San Antonio and Los Angeles and growing influence in other cities across the country. Latinos\u2019 electoral success signifies the rapidly changing climate of urban America and poses a new chapter in the history of racial and ethnic politics for American cities, which experienced previous waves of Italians, Irish, African Americans and others before. The focus of my dissertation is on the following research question: Under what conditions do local Latino elected officials act as a voice and advocate for Latino communities? Central to this question, I ask: do local Latino elected officials view themselves as representatives of a identifiable or unified Latino community? What do they, as leaders, view as their role in representing their ethnic community? If Latinos are understood to be a diverse community with weak ties, how does Latino leadership vary in urban areas nationwide? What local factors influence their leaders' ideas on representation? To address these questions, I combine original quantitative and qualitative research. The dissertation relies on surveys of local Latino elected officials\u2019 backgrounds, contexts, beliefs, and actions and qualitative data from case studies in Providence, Rhode Island and Hartford, Connecticut. The dissertation demonstrates that like other city leaders, Latino elected officials\u2019 capacity to lead is embedded in a web of institutional, economic, and political constraints, which are particularly complex at the local level. My research suggests that Latinos choose their leadership style based on personality, political instincts, and electoral circumstances. I find that ethnicity can play a role in their leadership behavior, but not all local Latino elected officials emerge as what we traditionally consider to be ethnic leaders."], "mods_abstract_ssim": ["Abstract of Latino Leadership in City Hall, by Emily Farris, Ph.D., Brown University, May 2014 In recent years, there has been a large increase in the total number of Latinos serving in elected office \u2013 from 3,743 in 1996 to 5,740 in 2010. Latinos now hold considerable influence in cities such as San Antonio and Los Angeles and growing influence in other cities across the country. Latinos\u2019 electoral success signifies the rapidly changing climate of urban America and poses a new chapter in the history of racial and ethnic politics for American cities, which experienced previous waves of Italians, Irish, African Americans and others before. The focus of my dissertation is on the following research question: Under what conditions do local Latino elected officials act as a voice and advocate for Latino communities? Central to this question, I ask: do local Latino elected officials view themselves as representatives of a identifiable or unified Latino community? What do they, as leaders, view as their role in representing their ethnic community? If Latinos are understood to be a diverse community with weak ties, how does Latino leadership vary in urban areas nationwide? What local factors influence their leaders' ideas on representation? To address these questions, I combine original quantitative and qualitative research. The dissertation relies on surveys of local Latino elected officials\u2019 backgrounds, contexts, beliefs, and actions and qualitative data from case studies in Providence, Rhode Island and Hartford, Connecticut. The dissertation demonstrates that like other city leaders, Latino elected officials\u2019 capacity to lead is embedded in a web of institutional, economic, and political constraints, which are particularly complex at the local level. My research suggests that Latinos choose their leadership style based on personality, political instincts, and electoral circumstances. I find that ethnicity can play a role in their leadership behavior, but not all local Latino elected officials emerge as what we traditionally consider to be ethnic leaders."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0M32T45", "mods_id": "etd1159", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Farris, Emily", "Orr, Marion", "Morone, James", "Wong, Kenneth", "Brown University. 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First, the interaction of proteins with surfactant molecules was studied to address some of the fundamental issues in microchip electrophoresis such as simultaneous quantification and detection. This work was followed by developing a rapid method for detection and quantification of proteins by electrophoresis and immunodepletion techniques. In order to quantify the effect of surfactant adsorption on electrokinetic flow, electroosmotic mobility measurements were performed at the solid-liquid interface of plastic microcapillaries(poly methylmethacrylate, PMMA). In addition, the electrokinetic effects with respect to electroporation of the cell wall were applied to develop an effective technique for inhibition of gram-negative bacteria(E.Coli). 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For a successful design of an optimum microfluidic device, these interactions need to be precisely quantified and controlled. This thesis focuses on studying the interfacial and electrokinetic interactions in micro-geometries, with the goal of designing an optimal platform for separation and detection of biomolecules. First, the interaction of proteins with surfactant molecules was studied to address some of the fundamental issues in microchip electrophoresis such as simultaneous quantification and detection. This work was followed by developing a rapid method for detection and quantification of proteins by electrophoresis and immunodepletion techniques. In order to quantify the effect of surfactant adsorption on electrokinetic flow, electroosmotic mobility measurements were performed at the solid-liquid interface of plastic microcapillaries(poly methylmethacrylate, PMMA). In addition, the electrokinetic effects with respect to electroporation of the cell wall were applied to develop an effective technique for inhibition of gram-negative bacteria(E.Coli). Finally, the dispersion of a semi-infinite suspension of particles was investigated in a capillary, in order to study the effects of hydrodynamic interactions and capillary confinement on the diffusive behavior of the particles."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2013"], "mods_dateAll_ssim": ["2013"], "copyrightDate_year_ssim": ["2013"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2013"], "copyrightDate": "2013-01-01T00:00:00Z", "date_dsi": "2013-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0TM78FH", "mods_id": "etd1165", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Azadi, Glareh", "Tripathi, Anubhav", "Hurt, Robert", "Hoffman-Kim, Diane", "Wessel, Gary", "Maxey, Martin", "Brown University. 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We present evidence that this structure is similar to a labeled graph: a network of topological connections between places, labeled with local metric information. In contrast to route knowledge, we find that the most frequent routes and detours to target locations had not been traveled during learning. Contrary to purely topological knowledge, participants typically traveled the shortest metric distance to a target, rather than topologically equivalent but longer paths. The results are consistent with the proposal that people learn a labeled graph of their environment."], "mods_abstract_ssim": ["We investigate the structure of spatial knowledge that spontaneously develops during free exploration of a novel environment. We present evidence that this structure is similar to a labeled graph: a network of topological connections between places, labeled with local metric information. In contrast to route knowledge, we find that the most frequent routes and detours to target locations had not been traveled during learning. Contrary to purely topological knowledge, participants typically traveled the shortest metric distance to a target, rather than topologically equivalent but longer paths. 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The novel that inspired him to launch his Garden City Movement was the 1888 international bestseller Looking Backward 2000-1887 by Edward Bellamy. This study is designed to confront the ironic fact that Looking Backward is, in fact, rather light on architectural and urban content, by tracing the history of architectural and urban planning thought in the utopian novels that preceded Bellamy\u2019s work, and in many ways informed it. Victorian utopian discourse on the future of the city was transnational, arguably beginning in France, thanks in part to the legacies of Saint-Simon and Fourier, and reaching a fevered pitch in 1860s Paris, when Haussmann\u2019s transformation of that city erased any doubt that modern technology had the power to alter large, complex, existing cities. 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The novel that inspired him to launch his Garden City Movement was the 1888 international bestseller Looking Backward 2000-1887 by Edward Bellamy. This study is designed to confront the ironic fact that Looking Backward is, in fact, rather light on architectural and urban content, by tracing the history of architectural and urban planning thought in the utopian novels that preceded Bellamy\u2019s work, and in many ways informed it. Victorian utopian discourse on the future of the city was transnational, arguably beginning in France, thanks in part to the legacies of Saint-Simon and Fourier, and reaching a fevered pitch in 1860s Paris, when Haussmann\u2019s transformation of that city erased any doubt that modern technology had the power to alter large, complex, existing cities. After considering the utopian and dystopian reception of Haussmann\u2019s urban schemes, this study turns to 1870s Britain, where the utopian novel exploded in popularity and acquired a sense of true political urgency throughout an intense but exciting decade of labor unrest, urban growth, sanitation reform, and profound developments in housing design. This study then finally turns to the United States, where longstanding ambivalence about the industrial city had for some time been propelling growth in suburbia. 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In 1852, a photography journal queried: \u201cWhy is it that Americans do not add to their reputation as inventors as well as manipulators in the art?\u201d But in the United States over the latter half of the century, manipulation gradually came to be reframed as invention. This dissertation considers individual and institutional efforts to manage the development and circulation of photographs and photographic ideas in the United States between 1839 and 1884, and contends that American legal conditions both influenced and were influenced by photographic conceptions to a degree not previously acknowledged. Historians tend to describe photographic innovations as motivated by a drive for reproducibility, but in the United States legal developments contributed to efforts to curtail photographic reproduction. This project attends to early reluctance to adopt techniques of photographic replication as well as ownership claims that sought to restrict duplication of chemical and formal compositions. Looking to New York portrait studios and publications as an important nexus for studying American practices, I argue that deeper understanding of the business of photography offers greater insight into its visual forms. The first chapter examines why negative-positive photography was unable to find commercial footing in New York despite its popularity in Europe, arguing that the city\u2019s culture of counterfeiting made photographic reproducibility suspect. The second chapter explores how changing patent regulations impacted perceptions of photographic invention, and redefined photographic ideas as individual intellectual property rather than shared experimental activity. The third chapter studies how the production and circulation of photographic portraits complicated attempts at copyright regulation. Painted backdrops and elaborate poses were increasingly used to secure legal and commercial protections, developments detailed in the fourth chapter. The epilogue demonstrates the extent to which photographic portraiture and legal debates continue to be mutually informed. Nineteenth-century precedents established the real and rhetorical manipulations that remain crucial in efforts to stake claim to photographic portraits and processes."], "mods_abstract_ssim": ["Ownership of photographic depictions was as contentious in the nineteenth century as it is today. In 1852, a photography journal queried: \u201cWhy is it that Americans do not add to their reputation as inventors as well as manipulators in the art?\u201d But in the United States over the latter half of the century, manipulation gradually came to be reframed as invention. This dissertation considers individual and institutional efforts to manage the development and circulation of photographs and photographic ideas in the United States between 1839 and 1884, and contends that American legal conditions both influenced and were influenced by photographic conceptions to a degree not previously acknowledged. Historians tend to describe photographic innovations as motivated by a drive for reproducibility, but in the United States legal developments contributed to efforts to curtail photographic reproduction. This project attends to early reluctance to adopt techniques of photographic replication as well as ownership claims that sought to restrict duplication of chemical and formal compositions. Looking to New York portrait studios and publications as an important nexus for studying American practices, I argue that deeper understanding of the business of photography offers greater insight into its visual forms. 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I explore this question as it relates to issues regarding hypothetical and actual consent, and propose a new form of politics for our engagements with each other. Rawls attempts to ground his two principles as a freestanding political conception. I argue that he does not persuasively ground the difference principle once we take seriously the suggestion that other liberal conceptions might come to contend for the basis of a more or less wide overlapping consensus. Rawls runs into a motivation problem around those principles that threatens the reciprocity he hopes they would generate. Habermas challenges Rawls on this point and argues instead for a discourse ethics that would ground motivation around our shared terms directly in the \u2018embers of radical democracy.\u2019 I argue that Habermas assumes too much about the capacity for objective and noncoerced discourse. Yet, I suggest that we might redeem the role for reason-giving in politics by transfiguring the \u2018truthfulness\u2019 condition of validity to include a role for distorted reasons. To better resolve questions about consent and justice I examine the efforts of an environmental group in Kansas that makes gains against climate change by taking beliefs seriously as starting points in their politics. They practice a principled micropolitics that does justice to citizens holding different beliefs in their efforts to reach shared norms by looking to each other, appealing to shared beliefs, seeking agonistic compromise, and constructing beliefs. Taking into consideration a hard case like the Tea Party movement shows the importance of these principles under some of the most challenging circumstances we might face. Yet, I argue that we should not shy away from those circumstances if we care about justice. Rather, individuals with a commitment to equal rights and liberties who act in courageous and original ways have the capacity to manifest new bricolages of justice in the political economy. By drawing on and critiquing theorists including Connolly, White, Coles, and Levi-Strauss, I suggest that kind of commitment demonstrates the right ethos for justice in the political economy."], "mods_abstract_ssim": ["What are the implications of different emergent social movements for social justice in contemporary liberal democracies? I explore this question as it relates to issues regarding hypothetical and actual consent, and propose a new form of politics for our engagements with each other. Rawls attempts to ground his two principles as a freestanding political conception. I argue that he does not persuasively ground the difference principle once we take seriously the suggestion that other liberal conceptions might come to contend for the basis of a more or less wide overlapping consensus. Rawls runs into a motivation problem around those principles that threatens the reciprocity he hopes they would generate. Habermas challenges Rawls on this point and argues instead for a discourse ethics that would ground motivation around our shared terms directly in the \u2018embers of radical democracy.\u2019 I argue that Habermas assumes too much about the capacity for objective and noncoerced discourse. Yet, I suggest that we might redeem the role for reason-giving in politics by transfiguring the \u2018truthfulness\u2019 condition of validity to include a role for distorted reasons. To better resolve questions about consent and justice I examine the efforts of an environmental group in Kansas that makes gains against climate change by taking beliefs seriously as starting points in their politics. 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By drawing on and critiquing theorists including Connolly, White, Coles, and Levi-Strauss, I suggest that kind of commitment demonstrates the right ethos for justice in the political economy."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z07P8WQB", "mods_id": "etd1188", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["tallent, christopher p", "Krause, Sharon", "Blyth, Mark", "Morone, James", "Brown University. 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"_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["Athens in the fourth century BCE faced many economic and military pressures, to which the Athenians responded with a multitude of political experiments. This dissertation argues that praise became in this period a focal point of political thought, as the benefits of bestowing praise on individual citizens began to outweigh the risks of elevating individuals above the rest of the community. Athenian authors tested the waters of enshrining praise of individuals in literary texts, particularly in prose, and by the 340s the Athenians were regularly inscribing for public display decrees that honored their own citizens. Though praise poetry, prose encomia, historiography, Socratic dialogues, law-court speeches, and honorific inscriptions are often considered separately, this dissertation examines these cultural phenomena collectively to demonstrate not only that praise was important to the Athenians for ordering their social world, but that it was being promoted as a means of both mending ethical deficits and attaining practical goals. The first chapter distills from the works of Xenophon, particularly the Hieron and Poroi, that author\u2019s general theory of the role of praise in government. The second chapter then applies that theory to Xenophon\u2019s own practice of praise for contemporary figures, chief among them Agesilaus. In these works, Xenophon emphasizes the value of rhetorical display (epideixis) of praise, which enables the replication of the original praiseworthy deeds; this usage of epideixis predates and must be distinguished from Aristotle\u2019s delimiting of the epideictic genre, which has dominated previous analyses of oratory. The third chapter examines the Evagoras of Isocrates, which is exemplary of that author\u2019s thought on praise and, with Xenophon\u2019s Agesilaus, is one of only two standalone prose encomia surviving from the fourth century. Finally, the fourth chapter, contextualized by a brief review of civic honorific practices, demonstrates how the praise theories of Xenophon and Isocrates are reflected in five landmark speeches of the third quarter of the fourth century: Demosthenes\u2019 Against Leptines and On the Crown, Lycurgus\u2019 Against Leocrates, Aeschines\u2019 Against Ctesiphon, and Hypereides\u2019 funeral oration."], "mods_abstract_ssim": ["Athens in the fourth century BCE faced many economic and military pressures, to which the Athenians responded with a multitude of political experiments. This dissertation argues that praise became in this period a focal point of political thought, as the benefits of bestowing praise on individual citizens began to outweigh the risks of elevating individuals above the rest of the community. Athenian authors tested the waters of enshrining praise of individuals in literary texts, particularly in prose, and by the 340s the Athenians were regularly inscribing for public display decrees that honored their own citizens. Though praise poetry, prose encomia, historiography, Socratic dialogues, law-court speeches, and honorific inscriptions are often considered separately, this dissertation examines these cultural phenomena collectively to demonstrate not only that praise was important to the Athenians for ordering their social world, but that it was being promoted as a means of both mending ethical deficits and attaining practical goals. The first chapter distills from the works of Xenophon, particularly the Hieron and Poroi, that author\u2019s general theory of the role of praise in government. The second chapter then applies that theory to Xenophon\u2019s own practice of praise for contemporary figures, chief among them Agesilaus. In these works, Xenophon emphasizes the value of rhetorical display (epideixis) of praise, which enables the replication of the original praiseworthy deeds; this usage of epideixis predates and must be distinguished from Aristotle\u2019s delimiting of the epideictic genre, which has dominated previous analyses of oratory. The third chapter examines the Evagoras of Isocrates, which is exemplary of that author\u2019s thought on praise and, with Xenophon\u2019s Agesilaus, is one of only two standalone prose encomia surviving from the fourth century. Finally, the fourth chapter, contextualized by a brief review of civic honorific practices, demonstrates how the praise theories of Xenophon and Isocrates are reflected in five landmark speeches of the third quarter of the fourth century: Demosthenes\u2019 Against Leptines and On the Crown, Lycurgus\u2019 Against Leocrates, Aeschines\u2019 Against Ctesiphon, and Hypereides\u2019 funeral oration."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0X34VSN", "mods_id": "etd1243", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Parks, Mitchell H", "Scafuro, Adele", "Hanink, Johanna", "Reed, Joseph", "Brown University. 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One particularly persistent line of literary criticism has theorized the temporal mode of lyric as a kind of perpetual present that resists the passage of time and strives for access to the eternal. This line of thought has led to a larger assumption about the closed nature of lyric time: that is, that the \u201cnow\u201d that lyric insists upon makes it fundamentally less capable than other literary genres of incorporating other tenses, of positing relations between temporal actions or events, or of navigating between story and discourse. I argue that this assumption will not withstand a sustained examination of how time works in lyric and the thinking that it enables. Because the temporality of a poem is part of its non-paraphrasable content, it is difficult to use it to produce a \u201creading\u201d of a text. I argue that what the temporal qualities of lyric may reveal instead is how a poem thinks, how we think when we read a poem, and what poetic modes of thinking can offer\u2014ethically as well as aesthetically\u2014that other cognitive modes cannot."], "mods_abstract_ssim": ["My work examines the ways in which modernist lyric poems activate specific ways of thinking through their formal and thematic engagements with time. One particularly persistent line of literary criticism has theorized the temporal mode of lyric as a kind of perpetual present that resists the passage of time and strives for access to the eternal. This line of thought has led to a larger assumption about the closed nature of lyric time: that is, that the \u201cnow\u201d that lyric insists upon makes it fundamentally less capable than other literary genres of incorporating other tenses, of positing relations between temporal actions or events, or of navigating between story and discourse. I argue that this assumption will not withstand a sustained examination of how time works in lyric and the thinking that it enables. Because the temporality of a poem is part of its non-paraphrasable content, it is difficult to use it to produce a \u201creading\u201d of a text. I argue that what the temporal qualities of lyric may reveal instead is how a poem thinks, how we think when we read a poem, and what poetic modes of thinking can offer\u2014ethically as well as aesthetically\u2014that other cognitive modes cannot."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0SB4435", "mods_id": "etd1244", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Miller, Katherine M", "Blasing, Mutlu", "Armstrong, Paul", "Reichman, Ravit", "Brown University. 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Beginning by critiquing the treatment of purity \u201csystems\u201d in recent scholarship about the Hebrew Bible, this study highlights the idea that purity rhetoric was dynamic and could be applied in myriad ways for a variety of purposes. Examining concepts related to purity in Mesopotamia, Anatolia and Egypt, it is argued that there does not seem to be evidence of a categorization of purity along \u201cmoral/ritual\u201d lines among Israel\u2019s neighbors. Additionally, such a schematization does not seem to persist in biblical literature, as there is significant overlap between purity traditions. The study analyzes the convergence of land and purity issues by examining biblical texts that refer to \u201cmoral\u201d land impurity on the one hand, and the variety of ways in which foreign lands are addressed, on the other. It is argued that \u201cmoral\u201d land impurity was applied only to the land of Israel. 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Using a contextualist approach, I demonstrate how the iconic American photographer Walker Evans\u2019s images from the Great Depression were created in a period that forged aesthetic alliances between disparate international influences, including the work of the French photographer Eug\u00e8ne Atget, the poetry of Hart Crane and other American writers, the agrarianism of William Faulkner, and the radical politics of the Diego Rivera circle. Moreover, I examine how debates about immigrant policy and racial politics in the United States and cultural relations with Cuba informed the subjects of Evans\u2019s photographs. This project contributes to the discipline of visual studies by renegotiating the parameters and delineations of art history. 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The first is his photographic work for Carleton Beals\u2019s The Crime of Cuba (1933), a project for which he traveled to a politically unstable and violent Cuba during a period of strained cultural relations between that country and the United States. The second is his publication in 1938 of his well-known book, American Photographs."], "mods_abstract_ssim": ["This project foregrounds the connections between American, European, and Latin American influences in American art history as signaled by the use of \u201ctransnational\u201d in my dissertation title. 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TNR expansion, facilitated by formation of stable non-canonical secondary structures (e.g. hairpins), has been linked to several neurodegenerative diseases, such as Huntington\u2019s Disease (caused by expansion of CAG/CTG repeats) and Fragile X Syndrome (caused by expansion of CGG/CCG repeats). TNR structure and expansion has been studied in vitro using both oligonucleotides and TNRs incorporated into plasmids; however, genomic DNA is packaged into chromatin, and little is know about the effect of packaging on the ability of repetitive DNA to expand. Previous studies have shown that disease-length, expanded CAG/CTG repeats readily incorporate into the basic unit of chromatin packing, the nucleosome core particle (NCP), composed of 146 base pairs of DNA wrapped around a core of eight histone proteins. However, long CGG/CCG repeats exclude NCP formation. Here, we seek to investigate not only the properties associated with healthy-length repeats incorporated into NCPs, but also the effect of the flanking gene sequence. Additionally we investigate the behavior of a hairpin formed by CAG repeats when flanked by well-matched duplex, forming a three- way junction, and how hairpin formation can affect chromatin packaging. To assess the global forces regulating interaction between the TNRs and the histone core, we performed competitive nucleosome exchanges to determine the efficiency with which various TNR sequences incorporate into NCPs. We then used enzymatic and chemical probing to determine the effect of histone occupancy on the TNRs, including the formation of possible non-canonical structures. Understanding the intricacies underlying the interaction between unexpanded TNRs and the histone core is important to understanding how TNRs expand in the genome."], "mods_abstract_ssim": ["Trinucleotide repeats (TNRs) occur throughout the genome and their expansion can affect varied cellular processes such as gene expression, mRNA processing, and protein folding. TNR expansion, facilitated by formation of stable non-canonical secondary structures (e.g. hairpins), has been linked to several neurodegenerative diseases, such as Huntington\u2019s Disease (caused by expansion of CAG/CTG repeats) and Fragile X Syndrome (caused by expansion of CGG/CCG repeats). TNR structure and expansion has been studied in vitro using both oligonucleotides and TNRs incorporated into plasmids; however, genomic DNA is packaged into chromatin, and little is know about the effect of packaging on the ability of repetitive DNA to expand. Previous studies have shown that disease-length, expanded CAG/CTG repeats readily incorporate into the basic unit of chromatin packing, the nucleosome core particle (NCP), composed of 146 base pairs of DNA wrapped around a core of eight histone proteins. However, long CGG/CCG repeats exclude NCP formation. Here, we seek to investigate not only the properties associated with healthy-length repeats incorporated into NCPs, but also the effect of the flanking gene sequence. Additionally we investigate the behavior of a hairpin formed by CAG repeats when flanked by well-matched duplex, forming a three- way junction, and how hairpin formation can affect chromatin packaging. To assess the global forces regulating interaction between the TNRs and the histone core, we performed competitive nucleosome exchanges to determine the efficiency with which various TNR sequences incorporate into NCPs. We then used enzymatic and chemical probing to determine the effect of histone occupancy on the TNRs, including the formation of possible non-canonical structures. Understanding the intricacies underlying the interaction between unexpanded TNRs and the histone core is important to understanding how TNRs expand in the genome."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0K935W9", "mods_id": "etd1135", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Volle, Catherine B", "Delaney, Sarah", "Gerbi, Susan", "Freiman, Richard", "Zhitkovich, Anatoly", "Freudenreich, Catherine", "Brown University. 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BIOMED: Molecular Biology, Cell Biology, and Biochemistry"], "note": ["Thesis (Ph.D. -- Brown University (2014)"], "mods_physicalDescription_extent_ssim": ["xviii, 224 p."], "mods_physicalDescription_digitalOrigin_ssim": ["born digital"], "keyword": ["Nucleosome", "DNA Hairpin", "Trinucleotide repeats", "Chromatin"], "mods_subject_ssim": ["Nucleosome", "DNA Hairpin", "Trinucleotide repeats", "Chromatin"], "mods_subject_fast_ssim": ["Trinucleotide repeats", "Chromatin"], "mods_subject_joined_ssim": ["Nucleosome", "DNA Hairpin", "Trinucleotide repeats", "Chromatin"], "mods_subject_joined_fast_ssim": ["Trinucleotide repeats", "Chromatin"], "mods_type_of_resource": ["dissertations"], "mods_title_full_tsim": ["The Trouble with Triples:Elucidating the Behavior of Trinucleotide Repeats in Chromatin"], "mods_title_full_primary_tsi": "The Trouble with Triples:Elucidating the Behavior of Trinucleotide Repeats in Chromatin", "primary_title": "The Trouble with Triples:Elucidating the Behavior of 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Archaeology and the Ancient World", "Graduate Research", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": true, "_display_private_bsi": false, "abstract": ["This dissertation presents the first comprehensive study of the archaeological record of sacrifice and the site-specific character of the ritual in Republican Rome and Latium. The research focuses on the multiple altars at five sanctuaries, with dates spanning the Republican era \u2013 S.Omobono in Rome (6th-3rd century B.C.E.), the Thirteen Altars at Lavinium (6th-4th century), Area A at Fosso dell'Incastro at Ardea (4th-2nd century), the Sacred Area of the Republican Temples at Ostia (3rd-1st century), and Largo Argentina in Rome (3rd-1st century). The chief distinguishing characteristics at each of the five sites provide the organizational framework for five thematic chapters. Each chapter is informed by a different theoretical approach to the assembled data: memory (Lavinium); orientation (Ardea); negotiation of sacred space (Ostia); and economy of ritual (subdivided into two parts \u2013 votive deposits [Largo Argentina, with a particular focus on terracotta miniature altar votives] and faunal remains [S. Omobono]). In three main ways, the research presented in this dissertation reorients the study of sacrificial practice: by establishing the primacy of the sacred landscape in determining religious authority rather than assigning agency exclusively to individual action; by viewing religious activities as haptic manifestations of human behavior and as structured experiences in the material world, rather than as expressions of a doctrinal, belief-based mentality; and by considering Roman sacrifice as a local, site-specific ritual rather than a universal, unvarying practice."], "mods_abstract_ssim": ["This dissertation presents the first comprehensive study of the archaeological record of sacrifice and the site-specific character of the ritual in Republican Rome and Latium. The research focuses on the multiple altars at five sanctuaries, with dates spanning the Republican era \u2013 S.Omobono in Rome (6th-3rd century B.C.E.), the Thirteen Altars at Lavinium (6th-4th century), Area A at Fosso dell'Incastro at Ardea (4th-2nd century), the Sacred Area of the Republican Temples at Ostia (3rd-1st century), and Largo Argentina in Rome (3rd-1st century). The chief distinguishing characteristics at each of the five sites provide the organizational framework for five thematic chapters. Each chapter is informed by a different theoretical approach to the assembled data: memory (Lavinium); orientation (Ardea); negotiation of sacred space (Ostia); and economy of ritual (subdivided into two parts \u2013 votive deposits [Largo Argentina, with a particular focus on terracotta miniature altar votives] and faunal remains [S. Omobono]). In three main ways, the research presented in this dissertation reorients the study of sacrificial practice: by establishing the primacy of the sacred landscape in determining religious authority rather than assigning agency exclusively to individual action; by viewing religious activities as haptic manifestations of human behavior and as structured experiences in the material world, rather than as expressions of a doctrinal, belief-based mentality; and by considering Roman sacrifice as a local, site-specific ritual rather than a universal, unvarying practice."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z0HX1B2F", "mods_id": "etd1246", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Moser, Claudia H", "Alcock, Susan", "Bodel, John", "Smith, Christopher", "Stowers, Stanley", "Brown University. 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"rel_is_member_of_collection_ssim": ["bdr:2rdc7d9g"], "rel_type_facet_ssim": ["Doctoral Dissertation"], "deposit_date": "2014-10-16T00:00:00Z", "collection_date": "2014-10-16T00:00:00Z", "ir_collection_id": [315], "ir_collection_name": ["Biology and Medicine", "Pathobiology", "Theses and Dissertations"], "_display_public_bsi": true, "_display_brown_bsi": false, "_display_private_bsi": false, "abstract": ["Abstract of \u201cEndocrine Disruption of the Developing Human Fetal Prostate\u201d by Camelia M. Saffarini, Ph.D., Brown University, May 2014 Prostate cancer is a major concern among adult men, as it is the most frequently diagnosed non-skin cancer. However, little is known about how developmental exposures affect human fetal prostate tissue. One hypothesis is that exogenous exposure to endocrine disrupting chemicals during development can alter the epigenome, leading to alterations in cellular differentiation, and a subsequent earlier onset of disease. This thesis explored this hypothesis using human fetal prostate xenografts transplanted into immune-deficient rodent hosts and a dosing paradigm termed the \u201cone-hit\u201d versus \u201ctwo-hit\u201d that evaluates both early (\u201cone-hit\u201d), and a combination of early- and later-life estrogenic exposures (\u201ctwo-hit\u201d). The human fetal prostate xenografts were first characterized using a variety of immunohistochemical markers for epithelial and stromal maturation, which validated its utility as a model. Histopathological lesions, immunohistochemical markers, proliferation, and serum hormone levels were assessed at 7, 30, 90, 200, and 400-days post-implantation using the \u201cone-hit versus \u201ctwo-hit\u201d dosing paradigm. The expression of 40 key genes involved in normal prostate development and prostate tumorogenesis were evaluated. Additionally, DNA methylation was assessed in 200-day whole tissue and laser capture microdissected epithelial and stromal xenograft tissue. Histopathological changes in 7 and 30-day estrogen-treated xenografts showed the greatest changes affecting the stromal compartment. Combined early and later-life estrogen treatment (E/E) revealed hyperplastic ducts at 200 days concomitant with gene expression changes related to the PI3K-Akt pathway. These changes affected genes relating to cellular proliferation and apoptosis. Additionally, DNA methylation analysis showed no changes in the evaluation of whole-tissue, but revealed 89 differentially methylated CpG sites that were predominantly altered in the stromal compartment providing a focus for future studies. This model provides evidence supporting the use of a human fetal prostate xenograft model to examine both gene expression and epigenetic alterations resulting from developmental estrogen exposure. This study eliminates the need for species extrapolation, thereby providing novel insights into human fetal prostate development, and provides the foundation for its utility in the investigation of future studies of endocrine disrupting chemicals."], "mods_abstract_ssim": ["Abstract of \u201cEndocrine Disruption of the Developing Human Fetal Prostate\u201d by Camelia M. Saffarini, Ph.D., Brown University, May 2014 Prostate cancer is a major concern among adult men, as it is the most frequently diagnosed non-skin cancer. However, little is known about how developmental exposures affect human fetal prostate tissue. One hypothesis is that exogenous exposure to endocrine disrupting chemicals during development can alter the epigenome, leading to alterations in cellular differentiation, and a subsequent earlier onset of disease. This thesis explored this hypothesis using human fetal prostate xenografts transplanted into immune-deficient rodent hosts and a dosing paradigm termed the \u201cone-hit\u201d versus \u201ctwo-hit\u201d that evaluates both early (\u201cone-hit\u201d), and a combination of early- and later-life estrogenic exposures (\u201ctwo-hit\u201d). The human fetal prostate xenografts were first characterized using a variety of immunohistochemical markers for epithelial and stromal maturation, which validated its utility as a model. Histopathological lesions, immunohistochemical markers, proliferation, and serum hormone levels were assessed at 7, 30, 90, 200, and 400-days post-implantation using the \u201cone-hit versus \u201ctwo-hit\u201d dosing paradigm. The expression of 40 key genes involved in normal prostate development and prostate tumorogenesis were evaluated. Additionally, DNA methylation was assessed in 200-day whole tissue and laser capture microdissected epithelial and stromal xenograft tissue. Histopathological changes in 7 and 30-day estrogen-treated xenografts showed the greatest changes affecting the stromal compartment. Combined early and later-life estrogen treatment (E/E) revealed hyperplastic ducts at 200 days concomitant with gene expression changes related to the PI3K-Akt pathway. These changes affected genes relating to cellular proliferation and apoptosis. Additionally, DNA methylation analysis showed no changes in the evaluation of whole-tissue, but revealed 89 differentially methylated CpG sites that were predominantly altered in the stromal compartment providing a focus for future studies. This model provides evidence supporting the use of a human fetal prostate xenograft model to examine both gene expression and epigenetic alterations resulting from developmental estrogen exposure. This study eliminates the need for species extrapolation, thereby providing novel insights into human fetal prostate development, and provides the foundation for its utility in the investigation of future studies of endocrine disrupting chemicals."], "mods_access_condition_rights_text_tsim": ["In Copyright"], "mods_access_condition_rights_link_ssim": ["http://rightsstatements.org/vocab/InC/1.0/"], "mods_access_condition_restriction_text_tsim": ["Collection is open for research."], "mods_copyrightDate_ssim": ["2014"], "mods_dateAll_ssim": ["2014"], "copyrightDate_year_ssim": ["2014"], "copyrightDate_month_ssim": ["01"], "copyrightDate_month_text_ssim": ["January"], "mods_dateAll_year_ssim": ["2014"], "copyrightDate": "2014-01-01T00:00:00Z", "date_dsi": "2014-01-01T00:00:00Z", "mods_id_doi_ssi": "10.7301/Z00R9MST", "mods_id": "etd1286", "mods_language_ssim": ["eng", "English"], "mods_language_code_ssim": ["eng"], "mods_language_text_ssim": ["English"], "genre": ["theses"], "mods_genre_aat_ssim": ["theses"], "genre_aat": ["theses"], "name": ["Saffarini, Camelia M", "Boekelheide, Kim", "Freiman, Richard", "Sanders, Jennifer", "Mills, David", "Hayward, Simon", "Brown University. 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Lateness\u2014as in the \u201clate work\u201d or \u201clate capitalism\u201d\u2014simultaneously suggests something that has survived beyond its own era, a final stage in a telos of development, the most up-to-date instance in a continuing series, and a spectral, melancholy, or undead phenomenon. Late Cinema: Avantgarde, Medium, Capital theorizes this complex and contradictory notion of \u201clateness\u201d by interrogating attempts by the cinematic avantgardes of the twentieth and twenty-first centuries to produce and cultivate excess temporalities that are autonomous of the demands of historical progress. I argue that lateness is an excess of temporality produced in the historical contradictions of modernity; it is that which is left behind by history, and not subject to the force of progress. Working from the claim that cinema has a privileged relation to modernity, the chapters focus on central categories of modernity\u2014the avantgarde, the medium, and capital\u2014in order to develop a multidimensional model of cinema\u2019s lateness. Late cinema engages cinema\u2019s privileged relation to modernity through the medium\u2019s insistent attempt to produce excess time that is autonomous from the demands of historical development. In this way, late cinema produces a futural temporality that offers the possibility of imagining historical difference."], "mods_abstract_ssim": ["We are often told that ours is a \u201clate\u201d age. Lateness\u2014as in the \u201clate work\u201d or \u201clate capitalism\u201d\u2014simultaneously suggests something that has survived beyond its own era, a final stage in a telos of development, the most up-to-date instance in a continuing series, and a spectral, melancholy, or undead phenomenon. Late Cinema: Avantgarde, Medium, Capital theorizes this complex and contradictory notion of \u201clateness\u201d by interrogating attempts by the cinematic avantgardes of the twentieth and twenty-first centuries to produce and cultivate excess temporalities that are autonomous of the demands of historical progress. I argue that lateness is an excess of temporality produced in the historical contradictions of modernity; it is that which is left behind by history, and not subject to the force of progress. Working from the claim that cinema has a privileged relation to modernity, the chapters focus on central categories of modernity\u2014the avantgarde, the medium, and capital\u2014in order to develop a multidimensional model of cinema\u2019s lateness. Late cinema engages cinema\u2019s privileged relation to modernity through the medium\u2019s insistent attempt to produce excess time that is autonomous from the demands of historical development. 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\"thumbnail\": {\"mimeType\": \"application/octet-stream\", \"size\": 4704, \"checksum\": \"292349422cdd00560c092881ee742feed13033de9e2b64c935e5c17db95a2ecb48aec38e7cf6654d27e44112df88de97baa632bd0c0143133648891c519ee843\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2014-11-10T14:22:52.419000Z\"}, \"DWC\": {\"mimeType\": \"text/xml\", \"size\": 2061, \"checksum\": \"361bc081668bc32ffd0121d29fddec86342dc1787e5c16323a6b7c4faeffcd56bc23c9df79f486eef997a04a6f9ccc629942f934fe1fc8faad74e1afea4a2973\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2019-08-16T02:32:16.259000Z\"}, \"RELS-EXT\": {\"mimeType\": \"text/xml\", \"size\": 626, \"checksum\": \"62bc19fbb205a9f2bfff93aa46868ab87af60b7a052726015c77ed5cbf336f4dcafa195f87d30dd5b281ccdd09d8ea7140b60ee092979323864fae9f934e1ec0\", \"checksumType\": \"SHA-512\", \"lastModified\": \"2021-11-23T13:37:38.820669Z\"}, \"irMetadata\": {\"mimeType\": \"application/octet-stream\", \"size\": 525, \"checksum\": 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