DNA serves as a stable medium of genomic data but is also chemically reactive. These reactions may cause deleterious DNA damage undermining the integrity of …
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
Repair of damaged DNA plays a crucial role in maintaining genomic integrity and normal cell function. The base excision repair (BER) pathway is primarily responsible …
Genomic DNA is chemically reactive and is therefore susceptible to damage by many exogenous and endogenous sources. If left unrepaired, nucleobase modifications that occur as …
As a result of endogenous and exogenous sources of DNA damage, DNA is chemically labile, resulting in the modification of DNA nucleobases. If damage is …
