Infections caused by antibiotic-resistant bacteria present an ever-growing challenge to physicians. The growing antibiotic resistance among pathogenic bacteria has caused the Centers for Disease Control …
The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer. …
Carbohydrate-carbohydrate interactions (CCIs) between cell surface carbohydrates play an important role in cell adhesion and cell surface signaling. Glycopolymers, synthetic polymers functionalized with carbohydrate pendant …
Diffusion-ordered NMR spectroscopy (DOSY) has been established as an efficient means for the separation of the NMR resonances in mixtures of compounds in solution. Despite …
DNA stores the genetic information of almost all organisms and its integrity and stability are essential to life. Unfortunately, mutations can occur within the genome …
Recombinant NANS module 2, with DEBS TE appended to the C-terminus, was expressed in Escherichia coli BAP1. Incubation of NANS module 2+DEBS_TE with (2RS) 2 …
The surfaces of prokaryotic and eukaryotic cells are covered by glycocalyx which contains a complex network of glycans. Studies continue to reveal that these carbohydrates …
The activation of T-lymphocytes through antigen-mediated T-cell receptor (TCR) clustering is vital in the regulation of the adaptive-immune response and must be properly regulated to …
Reliable quantitation of protein abundance is fundamental in accurately determining differential protein expression associated with biological phenomena such as cell growth and differentiation, disease progression, …
Phosphorylation is the most commonly employed biological mechanism for regulating protein function. The opposing functions of kinases and phosphatases “tune” the activities of proteins. Serine …
Terpenoids are among the largest families of natural products comprising numerous organic compounds with a broad range of physiological properties and immense structural diversity. These …
An oxidized lesion of guanine that is detected following exposure of DNA to several oxidizing agents is 8-oxo-7,8-dihydro-guanine (8-oxoG). Studies done in vitro show that …
