The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer. …
Efforts to characterize proteins found in the outer membrane of gram-negative bacteria have been steadily increasing due to the promise of expanding our understanding of …
Alkenones are one of the best biomarkers for paleo-temperature reconstructions. Despite numerous successful applications of alkenones, there are a number of outstanding scientific problems. 1) …
Post-translational modifications (PTMs) of proteins can have significant effects on different biological processes in which the proteins are involved. Analysis of protein post-translational modifications (PTMs) …
Towards the full understanding the physiology of human Sigma-1 receptor (Sig-1R), we developed a novel ligand-based enrichment strategy and mass spectrometry analysis of the receptor. …
Physisorbed, multi-component self-assembled monolayers (SAMs) that exhibit designed patterns of molecules on graphite surface have garnished attention in recent years. In principle, spatial arrangements of …
Mass spectrometry has been a long-standing analytical tool for chemists. Tandem mass spectrometry-based proteomics capitalizes on the sensitivity, accuracy, and efficiency of this classic technique …
Reversible protein phosphorylation plays a vital role in the regulation of cellular signaling pathways. With recent breakthrough developments in mass spectrometry-based proteomics technologies, including phosphopeptide …
The activation of T-lymphocytes through antigen-mediated T-cell receptor (TCR) clustering is vital in the regulation of the adaptive-immune response and must be properly regulated to …
Parasites have developed a variety of strategies for invading hosts and escaping their immune response. A common mechanism by which parasites escape nitric oxide (NO) …
A longstanding goal in cluster science is to discover highly stable clusters and use them as model catalysts. Ligand-protected gold nanoclusters (AuNCs) have been investigated …
