Antibiotic resistance is an urgent threat to public health. For this reason, new antimicrobial therapies are constantly needed to treat ever-evolving pathogens. One such pathogen …
Liver transplantation remains the standard of care for liver failure but is constrained by a shortage of organs. Fetal hepatic cell transplantation (HCT) offers a …
OBJECTIVES: To derive and validate a 30-day mortality clinical prediction rule for heart failure based on admission data and prior healthcare usage. A secondary objective …
Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
The use of ultrasound (US) is a developing area of curricular growth in undergraduate medical education (UME). In the past several academic years, the Warren …
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Abstract of A Novel NearInfrared Diffuse Optical Spectroscopy System for Stroke Prediction and Diagnosis on the Neck, by Ning Zhang, Degree ScM, Brown University, May …
Sepsis is defined as a state of life-threatening organ dysfunction due to dysregulated host response to infection. Because of its complex pathogenesis, sepsis is difficult …
NAFLD and NASH have caught the attention of scientists to make an accurate diagnosis and find effective treatments. Studies have found that both hyperinsulinemia and …
The brain’s ability to attribute valence to sensory stimuli in our environment and modulate these associations to reflect its current state is essential for goal …
Introduction: The burden of diabetes mellitus is increasing in low- and middle- income countries (LMICs). Few studies have explored pathways to care among individuals with …
Purpose Success for diverse learners is a shared goal among medical educators. This can be challenging to achieve, particularly during certain transition points, such as …
Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome …
Dried blood spots technology has emerged as an attractive alternative to conventional venous blood sampling in both research and clinical settings due to its low …
BACKGROUND: Walking provides substantial physical and mental health benefits including reduced all-cause mortality, with the greatest impact seen in older adults. However, pedestrian injury and …
Head and neck squamous cell carcinomas form a heterogeneous group of cancers of the upper aerodigestive tract, arising from the surface epithelium of the oral …
Immunotherapies such as immune checkpoint inhibitors (ICI) show great promise as more efficacious treatments for various cancers compared to current methods like chemotherapy. However, preclinical …
Abstract of A STUDY OF PRG4 AS IT RELATES TO URIC ACID AND GOUT, by Talia D’Ambruoso, ScM, Brown University, DECEMBER, 2021. Objective: Proteoglycan-4 (PRG4) …
There is a high demand for developing a computational platform for global analysis of position- specific sequence variation within HIV-1 subtypes. Undesirable probe designs can …
The goal of this thesis was to use non-invasive quantifiable MR parameters of volume, signal intensity and T2* relaxation time to predict the biomechanical or …
