In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
This dissertation examines two cytochrome P450 monooxygenases, namely CYP27B1 and CYP24A1, for their potential applications in biosensors and drug metabolism, respectively. First, the feasibility of …
Historically, the TFIID complex has been viewed as part of the general transcriptional apparatus; however, recent studies demonstrate that it is flexible in its constituents …
The conversion of epithelial cells to mesenchymal cells, or the epithelial-mesenchymal transition (EMT), is a phenotypic program critical to embryonic development and wound healing, however, …
We present an intuitive strategy for predicting the effect of sequence variation on splicing. In contrast to transcriptional elements, splicing elements appear to be strongly …
Fluorescence in situ hybridization (FISH) is a molecular labeling technique that can be used to visualize and taxonomically identify microbial cells. In this study, spectral …
The epithelial-mesenchymal transition (EMT) is a process in which epithelial cells undergo biochemical and morphological transition to acquire a mesenchymal phenotype. It has been shown …