Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
In eukaryotic cells, informational recoding and RNA interference (RNAi) proceed through structurally diverse double-stranded (ds) RNA molecules. Informational recoding of RNA by the catalytic deamination …
The bone morphogenetic protein (BMP) signaling pathway is an essential regulator of developmental and cellular processes. Secreted ligands initiate BMP signaling by binding to a …
The regulation of gene expression in eukaryotic cells is controlled by both chromatin dynamics and the actions of myriad components of the transcriptional machinery. While …