Head and neck squamous cell carcinomas form a heterogeneous group of cancers of the upper aerodigestive tract, arising from the surface epithelium of the oral …
Malignant mesothelioma is an aggressive cancer of the mesothelial lining causally linked to asbestos exposure and is highly resistant to current therapies. We hypothesize a …
The mammalian Target of Rapamycin (mTOR) is a Ser/Thr kinase that regulates cell growth through its control of cell cycle progression, translation, ribosome biogenesis and …
Immunity to Toxoplasma gondii infection is principally mediated by the activation of CD8+ T cells producing the protective cytokine IFN-?. To characterize primary CTL activation, …
Xeroderma pigmentosum Group A protein (XPA) is essential in the nucleotide excision repair (NER) pathway. Patients without functional XPA have extreme sensitivity to ultraviolet (UV) …
Maintenance of an intricate balance between positive and negative regulators of the cell cycle is vital, as altered cell cycle regulation results in the uncontrolled …
Early and late term pregnancy maladies may correlate with infection and inflammation at the maternal-fetal interface. Infectious agents may manifest systemically or through intrauterine routes, …
Schistosomiasis is a chronic debilitating disease caused by helminths of the genus Schistosoma, and currently affecting millions in the developing world. Treatment with Praziquantel has …