Liver transplantation remains the standard of care for liver failure but is constrained by a shortage of organs. Fetal hepatic cell transplantation (HCT) offers a …
NAFLD affects more than one-quarter of adults worldwide with 60% in diabetic patients and 90% in obese people. Aspartate beta-hydroxylase (ASPH), an alpha-ketoglutarate dependent enzyme …
Carbon nanomaterials are under development for diverse commercial applications ranging from conductive films to oil dispersants. Either through intended use or accidental release, the potential …
Background and aims: Liver transplantation is the only effective treatment for patients with end-stage liver disease, but long waiting times and shortage of donor livers …
Ischemia –reperfusion (IR) injury is an unavoidable consequence of the interruption and reintroduction of blood to an organ. During liver transplantation, aged and steatotic donors …
This study aimed to evaluate the following (1) Rates and patterns of screening for HCV within a cohort born between1945-65 (“Baby-boomers”) seen at 7 primary …
The studies presented in this thesis investigated innate immune events in the liver during acute infection with murine cytomegalovirus (MCMV). While many responses that occur …
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer death in the United States. Chronic …
The transcription factor MYC is overexpressed in many human cancers and has a significant causal role in tumor incidence and progression. Remarkably, mice with decreased …
Liver disease is a term that encompasses many different etiologies, such as alcoholic liver disease, fatty liver disease, viral hepatitis, and autoimmune liver diseases. In …
Sepsis continues to affect millions of people around the world, and the incidences are increasing. Sepsis is difficult to treat given the multi-factorial complications associated …
Diabetes mellitus results from gradual decline in pancreatic beta cell mass and function. Cell-based therapies in diabetes research are mainly focused on using stem cells …