The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β) …
Automation has been rapidly changing the research performed in the scientific community. With more high-throughput technologies available to both academic and industrial scientists, improvements to …
DNA serves as a stable medium of genomic data but is also chemically reactive. These reactions may cause deleterious DNA damage undermining the integrity of …
Infectious agents pose a significant threat to global health with profound health and economic implications. Particularly concerning is the emergence of epidemic-competent and life-threatening drug-resistant …
Abstract of "Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis …
Cellular redox homeostasis regulates metabolism, cell death, differentiation and development, immune responses, circadian rhythm, and overall cell health. This is achieved through a balance of …
Medicine can be divided into two central components: the diagnosis of a disease and its treatment. Both components of medicine are being transformed by the …
Three energy-related studies are described in this thesis (1) studies on the capability of conducting polymers (CP) to store electrochemical energy, (2) studies on the …
Fluorescent silica nanoparticles possess excellent fluorescence brightness, photo-stability, flexibility in surface functionalization and biocompatibility. Fluorescent silica nanoparticles as a novel and biocompatible fluorescent material have …
Towards the full understanding the physiology of human Sigma-1 receptor (Sig-1R), we developed a novel ligand-based enrichment strategy and mass spectrometry analysis of the receptor. …
Physisorbed, multi-component self-assembled monolayers (SAMs) that exhibit designed patterns of molecules on graphite surface have garnished attention in recent years. In principle, spatial arrangements of …
Self-assembled organic monolayers are widely used as a bottom-up approach in nanofabrication and find potential applications in organic electronic devices, e.g., as photovoltaic cells, memory …
Parasites have developed a variety of strategies for invading hosts and escaping their immune response. A common mechanism by which parasites escape nitric oxide (NO) …
Recent studies have demonstrated that any exposure to oxygen during the first hours of life can upregulate oxidative stress and put premature infants at an …
Recently mechanochemical synthesis has attracted our attention since it avoids the use of bulky organic solvents and simplifies reaction processes through grinding or milling. Mechanochemical …
Lithium enolates are used pervasively throughout organic synthesis as versatile carbon nucleophiles to introduce substituents alpha to the carbonyl group in ketones, esters, aldehydes, and …
Structural characterization of organolithium compounds in solution is an important but challenging task. Solution nuclear magnetic resonance (NMR) and X-ray crystallography are two of the …
Supramolecular self-assembly of molecules at the liquid-surface interface is a developing tool for bottom-up construction of ordered, nano-scale architectures. Significant research has been directed towards …
As a result of endogenous and exogenous sources of DNA damage, DNA is chemically labile, resulting in the modification of DNA nucleobases. If damage is …