The sense of taste provides animals with a means of discriminating nutritive from noxious compounds in potential food sources. Neural circuits are thought to represent …
Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Data for tables and figures from dissertation "Mitonuclear genotype, tissue type and sex modify the effects of rapamycin on transcription and metabolism" by John C. …
Alcohol use disorder (AUD), defined as prolonged alcohol consumption despite negative consequences, is fundamentally a disease of associative memory. Individuals with AUD form short-term aversive …
Biological systems must regulate complex gene transcriptional programs to mediate phenotypic response to diverse stimuli. Control of gene expression requires specific DNA sequence patterns called …
Neural circuits underlie all functions of the brain including perception, memory, and the execution of behavior. Neural circuits are composed of neurons, the basic structural …
Reciprocal recombinant F2 populations of the fruitfly were created and analyzed using a pooled whole-genome sequencing approach to investigate the effects of divergent mitochondrial DNA …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of motor neurons that affects at least 30,000 people in the United States at any one time …
Retrotransposable element (RTE) mobilization due to heterochromatin loss is among the molecular mechanisms associated with deleterious phenotypes that accompany biological aging. Here, we describe novel …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a progressive, rapid loss of motor function. Within 3-5 years, a loss of motor function …
In recent years, attempts at mapping neuronal circuitry have become more effective with the advent of new technologies that can label precise synapses and provide …
Mitochondria carry their own unique genome which must functionally coordinate with the nuclear genome in meeting cellular demands for energy and maintaining homeostatic conditions. This …
Studying the biological mechanisms of the aging process in the fruit fly Drosophila melanogaster has been crucial to the advancement of the field. In particular, …
The progression from embryo to reproductive adult to death describes the fundamental life history of an organism. From the perspective of evolutionary biology, life histories …
Ethanol is a naturally occurring organic compound that has had a profound impact on behavior and society. In the natural environment it directs an animal …
Amyotrophic Lateral Sclerosis (ALS) is a fatal multisystem neurodegenerative disease characterized by progressive loss of neuronal function. The disease has no cure and is fatal …
Neural circuits ensure the proper integration of various external sensory stimuli to generate the appropriate sets of behaviors for an animal’s survival. They are rendered …
An organism’s survival relies on its ability to navigate through the environment. To perform this task, animals must construct a map of space and translate …
Drugs of abuse such as alcohol disrupt the brain’s natural pathways for reward and can lead to addiction. In both mammals and Drosophila, dopamine mediates …
