Alcohol use disorder (AUD), defined as prolonged alcohol consumption despite negative consequences, is fundamentally a disease of associative memory. Individuals with AUD form short-term aversive …
As the Earth’s climate is rapidly changing, it has become increasingly important to understand how to improve agricultural output, crop productivity, and crop viability. By …
This dissertation is motivated by complex data architectures—typical in genetics research—that break the assumptions of classical frequentist analyses. Predictors are not necessarily independent nor fewer …
In genetics, one fundamental goal is to understand which mutations in the human genome have significant effects on complex traits and diseases. Achieving this goal …
Retrotransposable element (RTE) mobilization due to heterochromatin loss is among the molecular mechanisms associated with deleterious phenotypes that accompany biological aging. Here, we describe novel …
Preterm birth disparately impacts different groups of women based on a number of risk factors. Nearly half of the risk is attributed to genetic factors. …
The aim of our study was to determine if the gene Stat92E influenced locomotion in response to alcohol exposure. Previous research suggested that Stat92E may …
KMT2A-translocations are seen in 5-10% of patients with leukemia, but it is present in approximately 50% of pediatric AML diagnoses. Acute leukemias carrying chromosomal translocations …
Single cell RNA sequencing (scRNA-seq) is a recently developed technology that enables the quantification of RNA transcripts at individual cell level, providing cellular level resolution …
In recent years, attempts at mapping neuronal circuitry have become more effective with the advent of new technologies that can label precise synapses and provide …
Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Over the past decade, genome-wide associations studies (GWAS) and other methods have used human genetic data to successfully identify thousands of genomic elements underpinning complex …
Abstract of Disruption of yfjD Gene in Francisella, by Japheth Omonira, ScM., Brown University, May 2018. Francisella tularensis is the causative agent of tularemia, a …
Psychostimulant drugs including amphetamines have been employed for a wide range of applications across diverse populations. These include prescription medications for conditions such as ADHD …
Prefrontal cortical dysfunction is well-established in schizophrenia and is thought to contribute to working memory (WM) impairment, which occurs early in development before the onset …
Motor neurons are a class of post-mitotic cells expected to survive for the duration of the human lifetime. While other cells routinely undergo programmed cell …
The growing interest in genealogy for African Americans is one expression of a longstanding desire to find answers to questions about ancestors, family, and heritage …
This dissertation examines the constitutive relation of gender and performance to knowledge production in the genetic sciences in twentieth and twenty-first century US. In recent …
Head and neck squamous cell carcinoma (HNSCC) afflicts over half a million new patients each year. The major risk factors for developing this disease include …