Brown Digital Repository | Theses and Dissertations

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Items (1-20) out of 639 results

"He can run away, life goes on;" Factors in Partner Disclosure among HIV Positive Adolescents in Cape Town, South Africa

Description:: Background: Home to around 7.7 million HIV positive individuals, South Africa holds 20% of the global HIV population. HIV presents many challenges, such as stigmatization, …
Year:: 2020
Contributor:: Belsky, Mikaela S. (creator); Harrison, Abigail (thesis advisor); Pellowski, Jennifer (reader); Brown University. Biology Undergraduate Education (sponsor)
Genre:: theses
Subject:: HIV-positive persons; Africa, Sub-Saharan; Teenagers--Sexual behavior
Collection:: Biology and Medicine; Theses and Dissertations

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A Biophysical Analysis of Neutrophil Force Generation in a Biochemical Environment

Description:: Neutrophils are the most abundant circulating white blood cell in the human body, and play a crucial role in the innate immune response to infection …
Year:: 2018
Contributor:: Andrews, Christina (creator); Franck, Christian (Advisor); Lefort, Craig (Reader); Reichner, Jonathan (Reader); Wong, Ian (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Immunology; Immune system; Septicemia; Cells--Mechanical properties; soft materials; traction force microscopy
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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A BMP-dependent feedback loop regulates dpp expression by direct and indirect mechanisms in the Drosophila wing imaginal disc

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Description:: Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
Year:: 2012
Contributor:: Aldrich, Maryanna M (creator); Wharton, Kristi (Director); McKeown, Michael (Reader); Freiman, Richard (Reader); Johnson, Mark (Reader); Raftery, Laurel (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: BMP signaling; dpp; negative regulation; Min jin dang (China); Transcription; Drosophila
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A Data Assimilating Model of the Microbial Ecosystem in the Open Ocean

Description:: Prokaryotic microbes, commonly termed bacteria, are essential components of the ecosystem in the open ocean. They are major primary producers, major diazotrophs that fix dinitrogen …
Year:: 2009
Contributor:: Luo, Yawei (creator); Ducklow, Hugh (director); Friedrichs, Marjorie (reader); Prell, Warren (reader); Vallino, Joseph (reader); Brown University. Division of Biology and Medicine. Ecological and Evolutionary Biology (sponsor)
Genre:: theses
Subject:: Data assimilation; Marine Ecosystem; Model; Dissolved organic matter; Primary production; Dinitrogen fixation; Heterotrophic bacteria; Water--Organic compound content; Nitrogen--Fixation
Collection:: Biology and Medicine; Theses and Dissertations; Biology and Medicine; Ecological and Evolutionary Biology; Theses and Dissertations

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A Data-Driven Approach for Characterizing Childhood and Adult Malnutrition at the National and Global Level

Description:: This thesis explores clinical and social factors to characterize underweight malnutrition on the national and global level using the UNICEF Childhood Malnutrition Datasets (survey-level data …
Year:: 2020
Contributor:: DeBare, Mariana L (creator); Schell, Jacquelyn (Reader); Chen, Elizabeth (Advisor); Gillani, Fizza (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Malnutrition in children; Malnutrition--Prevention; Malnutrition--Social aspects; Malnutrition; Malnutrition in the elderly; Malnutrition in the United States
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Feasibility Study of a Load Sensor to Measure Weight Bearing in Pediatric Standers

Description:: Persons afflicted with neuromuscular diseases, whether acute or congenital, frequently suffer from secondary musculoskeletal conditions. These conditions may be so severe that they prevent persons …
Year:: 2020
Contributor:: Daniel, Joshua Runako (creator); Crisco, Joseph (Advisor); Bull, Christopher (Reader); Schiller, Jonathan (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: non-ambulatory; weight bearing; skeletal health; mechanical loading; assisted standing; load sensor
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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A Fetal Testis Xenograft Bioassay to Assess Human Susceptibility to Phthalate-Induced Endocrine Disruption

Description:: Recent increases in the incidence of congenital (hypospadias, cryptorchidism) and adult-onset (testis germ cell cancer, lowered sperm counts) diseases of the male reproductive tract are …
Year:: 2012
Contributor:: Heger, Nicholas E (creator); Boekelheide, Kim (Director); Hixon, Mary (Reader); Freiman, Richard (Reader); DePaepe, Monique (Reader); Howdeshell, Kembra (Reader); Brown University. BIOMED: Pathobiology (sponsor)
Genre:: theses
Subject:: phthalate; endocrine disruption; Testis; Xenografts
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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A Matter of Life and Death: Novel Ligands Mediating Cytotoxic Function and Revealing Metabolically Stimulative Function of the Sigma-2 Receptor in Human Cancer

Description:: The sigma-2 receptor is a pharmacologically-defined protein receptor present in a variety of tissues, and interest in its role in a wide array of diseases …
Year:: 2016
Contributor:: Nicholson, Hilary E (creator); Bowen, Wayne (Director); Marshall, John (Reader); Matsumoto, Rae (Reader); Oancea, Elena (Reader); Zhitkovich, Anatoly (Reader); Brown University. BIOMED: Molecular Pharmacology, Physiology, and Biotechnology (sponsor)
Genre:: theses
Subject:: sigma-2 receptor; CM572; CM764; sigma receptor; cellular metabolism; triple negative breast cancer; Glycolysis; Neuroblastoma
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Multivariable Prediction Model for Mortality in Individuals Admitted for Heart Failure

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Description:: OBJECTIVES: To derive and validate a 30-day mortality clinical prediction rule for heart failure based on admission data and prior healthcare usage. A secondary objective …
Year:: 2020
Contributor:: Bowen, Garrett Scott (creator); Rudolph, James (Advisor); Brown University. Division of Biology and Medicine (sponsor)
Genre:: theses
Subject:: patient-centered outcomes research; Heart failure; palliative care; Prognostic prediction; Mortality
Collection:: Biology and Medicine; Theses and Dissertations

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A Mutagenic Screen Identifies Jim as a Regulator of Transposition, Heterochromatin, and Aging

Description:: Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Year:: 2020
Contributor:: Liu, Julianna J. (creator); Helfand, Stephen (thesis advisor); Lawrence, Charles (reader); Taylor, Jackson (reader); Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:: theses
Subject:: Drosophila melanogaster; Genetics; Aging; Transposons; Heterochromatin; Chromatin; Gene silencing; Zinc-finger proteins
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A New Model of Amyotrophic Lateral Sclerosis in Drosophila melanogaster: Precise Genetic Engineering, Characterization and Genetic Suppression

Description:: ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Year:: 2015
Contributor:: Sahin, Asli (creator); Reenan, Robert (Director); Fallon, Justin (Reader); Hart, Anne (Reader); Wharton, Kristi (Reader); Bonini, Nancy (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: ALS; Motor neuron; Disease; neurodegeneration; homologous recombination; ems; genetic screen; Drosophila; Genetic engineering
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A Novel Near Infrared Diffuse Optical Spectroscopy System for Stroke Prediction and Diagnosis on the Neck

Description:: Abstract of A Novel NearInfrared Diffuse Optical Spectroscopy System for Stroke Prediction and Diagnosis on the Neck, by Ning Zhang, Degree ScM, Brown University, May …
Year:: 2019
Contributor:: Zhang, Ning (creator); Nurmikko, Arto (Advisor); Xu, Jimmy (Reader); Marissa, Gray (Reader); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Biomedical engineering
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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A Novel Role for Programmed Cell Death Receptor Ligand 2 (PD-L2) in Sepsis-Induced Hepatic Dysfunction

Description:: Sepsis is defined as a state of life-threatening organ dysfunction due to dysregulated host response to infection. Because of its complex pathogenesis, sepsis is difficult …
Year:: 2017
Contributor:: Le, Marilyn C (creator); Zimmerman, Anita (Reader); Bowen, Wayne (Reader); Ayala, Alfred (Advisor); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Immunology; Septicemia
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A novel target for insulin resistance in Nonalcoholic Steatohepatitis

Description:: NAFLD and NASH have caught the attention of scientists to make an accurate diagnosis and find effective treatments. Studies have found that both hyperinsulinemia and …
Year:: 2019
Contributor:: Lin, Mengqi (creator); Wands, Jack (Advisor); Li, Jisu (Reader); Zhang, Songhua (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: Liver--Diseases
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Novel, Context Dependent Two Alternative Forced Choice Task for the Exploration of the Neural Correlates of Higher Order Cognition in Mice

Description:: The brain’s ability to attribute valence to sensory stimuli in our environment and modulate these associations to reflect its current state is essential for goal …
Year:: 2017
Contributor:: Gill, Jay Lathen (creator); Moore, Christopher (Advisor); Frank, Michael (Reader); Bath, Kevin (Reader); Brown University. Department of Molecular Pharmacology, Physiology and Biotechnology (sponsor)
Genre:: theses
Subject:: behavioral neuroscience
Collection:: Biology and Medicine; Molecular Pharmacology, Physiology, and Biotechnology; Theses and Dissertations

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A Quantitative Phosphoproteomic Analysis of the T-Cell Receptor Signaling Pathway Using Novel High-Throughput Approaches

Thumbnail for A Quantitative Phosphoproteomic …

Description:: Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome …
Year:: 2011
Contributor:: Nguyen, Vinh Hai (creator); Salomon, Arthur (Director); Brossay, Laurent (Reader); Wessel, Gary (Reader); Gruppuso, Philip (Reader); Sauer, Karsten (Reader); Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:: theses
Subject:: mass spectometry; TCR signaling; Jurkat T-cells; SILAC; label-free; hybrid quantitative approach; Zap-70; FYN regulation; method development; ERK positive feedback
Collection:: Biology and Medicine; Molecular Biology, Cell Biology, and Biochemistry; Theses and Dissertations

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A role for microRNAs in the etiology of head and neck squamous cell carcinoma

Description:: Head and neck squamous cell carcinomas form a heterogeneous group of cancers of the upper aerodigestive tract, arising from the surface epithelium of the oral …
Year:: 2009
Contributor:: Avissar-Whiting, Michele (creator); Marsit, Carmen (director); Kane, Agnes (reader); Kelsey, Karl (reader); Hixon, Mary (reader); Chen, Jia (reader); Brown University. Division of Biology and Medicine. Pathobiology (sponsor)
Genre:: theses
Subject:: microRNA; head and neck cancer; Epigenetics
Collection:: Biology and Medicine; Theses and Dissertations; Biology and Medicine; Pathobiology; Theses and Dissertations

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A Scalable 3D Printed Microfluidic Device for Rapid Preclinical Assays of Cancer Samples

Description:: Immunotherapies such as immune checkpoint inhibitors (ICI) show great promise as more efficacious treatments for various cancers compared to current methods like chemotherapy. However, preclinical …
Year:: 2020
Contributor:: Markoski, Alex (creator); Wong, Ian (Advisor); Morgan, Jeffrey (Reader); Reichner, Jonathan (Reader); Borenstein, Jeffrey (Advisor); Brown University. Biology and Medicine: Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Microfluidic devices; Cancer--Immunotherapy; tumor spheroids; 3D Printed; preclinical assay
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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A Thermodynamics-Based Algorithm for Optimizing HIV Drug Resistance Probe Designs

Thumbnail for A Thermodynamics-Based Algorithm …

Description:: There is a high demand for developing a computational platform for global analysis of position- specific sequence variation within HIV-1 subtypes. Undesirable probe designs can …
Year:: 2018
Contributor:: Lizbinski, Rico Leonardo (creator); Tripathi, Anubhav (Advisor); Brown University. Biology and Medicine: Pathobiology (sponsor)
Genre:: theses
Subject:: HIV/AIDS; Algorithms; Drug resistance; Thermodynamics; Probes
Collection:: Biology and Medicine; Pathobiology; Theses and Dissertations

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A Translational Method to Quantify Anterior Cruciate Ligament Healing Using Magnetic Resonance Imaging for Research and Clinical Applications

Description:: The goal of this thesis was to use non-invasive quantifiable MR parameters of volume, signal intensity and T2* relaxation time to predict the biomechanical or …
Year:: 2015
Contributor:: Biercevicz, Alison M (creator); Fleming, Braden (Director); Crisco, Joseph (Reader); Darling, Eric (Reader); Deoni, Sean (Reader); Thornton, Gail (Reader); Brown University. Biomedical Engineering (sponsor)
Genre:: theses
Subject:: Orthopaedics; MRI; Ligament mechanics; T2* relaxometry; Linear Regression Modeling; Reconstruction; Injury; Orthopedics; Anterior cruciate ligament; Knee; Magnetic resonance imaging; Surgery; Biomechanics
Collection:: Biology and Medicine; Biomedical Engineering; Theses and Dissertations

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Brown University Theses and Dissertations

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