There has been mounting concern over the health hazards of per- and polyfluoroalkyl substances (PFAS), which has spread beyond the scientific community to federal regulators, …
High Grade Serous Carcinoma (HGSC) is the deadliest form of ovarian cancer among women and causes the most deaths of gynaecological cancers overall (Tudrej, Patrycja …
Sigma receptors are a pharmacologically defined class of intracellular orphan receptors that bind a variety of psychotropic agents. The endogenous function of the sigma-2 receptor …
The GH18 gene family includes true chitinases (Cs) and chitinase-like proteins (CLPs). Chitinase 3-like-1 (CHI3L1) is a prototypic CLP and elevated CHI3L1 expression has been …
KMT2A-translocations are seen in 5-10% of patients with leukemia, but it is present in approximately 50% of pediatric AML diagnoses. Acute leukemias carrying chromosomal translocations …
Abstract of CHARACTERIZING SEEDING DENSITY AS A MECHANISM OF CHEMOTHERAPY RESISTANCE IN CANCER CELLS, by Ujwal Punyamurtula, ScM, Brown University, May, 2022. While the 50% …
This dissertation focuses on the development of new drug delivery platforms using carbon nanotubes. Two nanotube systems, namely single walled carbon nanotubes (SWNTs) and multi-walled …
Human glioblastomas develop within the brain parenchyma in which there is continuous interaction of glioma cells with axon fibers, glial cells and endothelial cells. This …
The experiences of cisgender sexual minority and gender minority patients with cancer are different. Previous research has demonstrated that gender minority people are less likely …
Breast cancer is the second most frequently diagnosed cancer and the second leading cause of cancer death in U.S. women. The studies presented in this …
Neuroblastoma accounts for 15% of all pediatric cancer-related deaths, with a 60% survival rate for high-risk patients. MYCN-amplified neuroblastoma tumors in particular progress more quickly …
Checkpoint blockade therapy, which targets conserved negative regulators of immune cell activation that act as “checkpoint molecules” that govern the balance between inhibition and hyperactivation …
Ovarian cancer is the most lethal gynecological cancer largely due to its late detection after metastasis has occurred. Stromal cells (SCs) promote cancer cell growth …
Hepatocellular carcinoma (HCC) is the fifth most common cancer in the world and the third leading cause of cancer death in the United States. Chronic …
Anxiety during radiation therapy (RT) can negatively impact the effectiveness of treatment and can lead to poorer health outcomes for cancer patients. Currently, the prevalent …
Cells are rich in a variety of diagnostic information, from morphology to nucleic acid, protein, and metabolite composition. Cells possess more data than any other …
Cellular immunotherapy is a rapidly developing field in cancer research that uses the immune system of both the recipients and the donors to attack tumor …
Abstract of Profiling Cancer Cell Invasion and Plasticity in Biomimetic Materials, by Amanda S. Khoo, Ph.D., Brown University, February 2022 Cancer metastasis is a major …
The tumor microenvironment is characterized by an acidic pH which confers the expression of more malignant phenotypes in cancer cells such as increased proliferation, migration, …
Chitinase 3-like-1 (CHI3L1), a pleiotropic secretory molecule, plays essential roles in the pathogenesis of a variety of malignancies by boosting tumor cell proliferation, migration, epithelial-to-mesenchymal …