In this thesis, the potential success of a novel drug delivery system (PDAL DDS) in the current antifungal DDS market was evaluated. Focus was placed …
Advancements in neurotechnology have helped people living with paralysis regain function through brain control of communication interfaces, prostheses, and even restored command of one’s own …
This dissertation focuses on the development of new drug delivery platforms using carbon nanotubes. Two nanotube systems, namely single walled carbon nanotubes (SWNTs) and multi-walled …
Polymeric nanoparticles loaded with insulin is a highly sought-after drug delivery system in the treatment of diabetes mellitus. The goal of this experiment is to …
This work aims to develop a method of using Fourier-Transform Infrared Spectroscopy (FT-IR) for quantification of polymer levels in biological samples, ex vivo. A method …
Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics …
Diabetics will typically take an insulin regimen with fast acting bolus insulin and long acting basal insulin. The most common methods of delivering this insulin …
Oral absorption of many potential pharmaceuticals is limited due to problems of enzyme degradation, dissolution and permeation. Bioadhesive poly(fumaric-co-sebacic) anhydride microspheres have been investigated as …
The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
The brain is a highly-privileged organ within the body. Evolution has ensured that access to brain tissue is tightly regulated against or completely impenetrable to …
Microsphere drug delivery systems still face many hurdles specific to gastrointestinal uptake. Human physiological components are difficult to properly emulate and test without the usage …
Certain compounds have proven efficacious in treating prevalent pathologies such as cancer, neurodegenerative disorders, and obesity(1)(2). However, poor bioavailability of these therapeutic drugs limits their …
Abstract of β-Lactamase Responsive Delivery of Bacteriophages for the Treatment of Multidrug Resistant Pseudomonas aeruginosa, by Alison M Veintimilla, ScM, Brown University, May, 2022. Antibiotic …