Neutrophil-mediated host defense against pathogens includes the extrusion of a lattice of DNA and microbicidal enzymes known as Neutrophil Extracellular Traps (NETs). The receptor:ligand interactions …
The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the …
Understanding the fundamental mechanisms, and forces, underlying cell migration holds the promise of effective approaches for treating diseases and promoting cellular transplantation. One such disease …
Aspartyl-asparaginyl-β-hydroxylase (AAH) is a ~86 kD protein abundantly expressed in hepatocellular carcinoma (HCC) and downregulated by chronic ethanol exposure, contributing to alcoholic liver disease (ALD). …
Echolocating mammals such as bats, dolphins, and toothed whales perceive images of objects with hyper-resolution and navigate seamlessly through obstacles in complex acoustic environments. The …
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here, …
Background: Chronic alcoholic liver disease is associated with hepatic insulin resistance, inflammation, oxidative and ER stress, mitochondrial dysfunction, and DNA damage. Peroxisome proliferator activated receptor …
In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite …
Over the past few decades, remarkable progress has been made in the development of analytical biosensors for use in medical diagnostics. This dissertation focuses on …
Abstract of “Endocrine Disruption of the Developing Human Fetal Prostate” by Camelia M. Saffarini, Ph.D., Brown University, May 2014 Prostate cancer is a major concern …
The fate of nitrate (NO3-) in marine sediments depends on a balance of microbially mediated processes that remove or recycle available nitrogen (N), i.e. denitrification …
Future brain-computer interfaces will require technologies that enable efficient, reliable and high-speed transmission of broadband multichannel neural data out of the brain with minimal number …
In our approach to understanding the biomechanics of concussions, we have defined head impact exposure as a multifactorial term that includes the frequency, magnitude, and …
Studying the biological mechanisms of the aging process in the fruit fly Drosophila melanogaster has been crucial to the advancement of the field. In particular, …
Gliomas are a family of extremely aggressive brain cancers, which, despite current treatment options, have poor prognoses. There are distinct subtypes of gliomas, and accurately …
In the spinal cord dorsal horn, persistent changes in synaptic strength may contribute to nociceptive information processing and to pathological pain states. These changes overlap …
Microfluidic technology provides a means of precisely controlling fluid flow for molecular analytics and diagnostics, as well for the biological analysis of cells and small …
Microfluidics based diagnostic systems are believed to have great competency for the ever-demanding healthcare in resource limited settings. These miniaturized devices have promise for detecting …
Communication between the mitochondrial and nuclear genomes is vital for cellular function. The assembly of mitochondrial enzyme complexes that produce the majority of cellular energy …