Abstract of An Exploration of the Biology Underlying Epigenetic Clocks by Nicholas J. Skvir, Ph.D., Brown University, October 2022. Epigenetic clocks have gained popularity over …
Ten years ago, the first RNA-seq study was published. Since then over 200 thousand RNA-seq studies have been published, spanning many different organisms, tissue types, …
Anesthesia, in particular opioids, may have significant clinical implications in cancer. This effect cannot be generalized across different cancer types, and this likely holds true …
Risk factor-based prediction is the cornerstone of guidelines for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Despite clear criteria for statin therapy, ASCVD remains …
Cancer is characterized by heterogeneity at multiple scales, with implications for diagnosis, prognosis, and treatment. Major advances in genomics have led to a proliferation of …
In genetics, one fundamental goal is to understand which mutations in the human genome have significant effects on complex traits and diseases. Achieving this goal …
Development is a complex process governed by coordinated gene regulation at a precise time and place. Uncovering how transcription factors (TFs) and their targets communicate …
Advances in sequencing technologies in the last decade have enabled us to profile various genomic features at the single-cell resolution, such as gene expression and …
Over the past 20 years, a vast amount of human genetic variation has been discovered through next-generation sequencing. However, our ability to make sense of …
Preeclampsia is a complex pregnancy-specific disorder characterized by the onset of maternal hypertension and proteinuria. This multifactorial disorder complicates 2-8% of US deliveries and is …
In the past ten years, the amount of genetic data available to researchers has increased exponentially. This wealth of data has enabled researchers to identify …
Cell developmental processes – both healthy and aberrant – are controlled by complex gene expression programs. While much work has been done to unravel the …
