Brown University Theses and Dissertations

Brown University Library archives dissertations in accordance with the Brown Graduate School policy.

For dissertations published prior to 2008, please consult the following Dissertation LibGuide

Refine Your Search

Selected Facets
DepartmentChemistry Cancel selected facet

Items

Items (1-20) out of 138 results

A Kinetic Perspective on DNA Base Excision Repair

Description:
The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol ...
Copyright Date:
2014
Contributors:
Schermerhorn, Kelly (creator) Delaney, Sarah (Director) Cane, David (Reader) Basu, Amit (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Base Excision Repair Enzyme kinetics Huntington's disease
Full Record

A Multidisciplinary Approach for the Development of Novel Therapeutic Agents for the Treatment of Bacterial Infections

Description:
Infections caused by antibiotic-resistant bacteria present an ever-growing challenge to physicians. The growing antibiotic resistance among pathogenic bacteria has caused the Centers for Disease Control ...
Copyright Date:
2015
Contributors:
Compton, Corey L (creator) Sello, Jason (Director) Sello, Jason (Reader) Cane, David (Reader) Seto, Christopher (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
ClpP ADEP proteasome Mycobacterium Proteolysis Streptomyces
Full Record

A Phosphoproteomic Study of Insulin Signaling Pathway Using A Novel High-Throughput Pipeline

Description:
Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases ...
Copyright Date:
2009
Contributors:
Yu, Kebing (creator) Salomon, Arthur (director) Sun, Shouheng (reader) Bazemore-Walker, Carthene (reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Signaling Pathway Database Proteomics Bioinformatics Phosphorylation
Full Record

AN ACTIVITY-BASED PROBE FOR THE ACYL PROTEIN THIOESTERASES

Description:
The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer ...
Copyright Date:
2016
Contributors:
Chen, Yiming (creator) Seto, Christopher (Director) Paul, Williard (Reader) Sello, Jason (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Activity-Based Probe Acyl Protein Thioesterases Organic Synthesis Kinetic Assay Organic compounds--Synthesis Mass spectrometry Proteomics
Full Record

An Investigation of Carbohydrate – Carbohydrate Interactions Using Glycopolymers and Supramolecular Glycoconjugates as Multivalent Model Systems

Description:
Carbohydrate-carbohydrate interactions (CCIs) between cell surface carbohydrates play an important role in cell adhesion and cell surface signaling. Glycopolymers, synthetic polymers functionalized with carbohydrate pendant ...
Copyright Date:
2018
Contributors:
Leeber, Blaise William (creator) Basu, Amit (Advisor) Delaney, Sarah (Reader) Sello, Jason (Reader) Brown University. Department of Chemistry (sponsor)
Genre:
theses
Keywords:
Polymers Carbohydrates Supramolecular chemistry Carbohydrate-carbohydrate interactions Self-assembly
Available to Brown-affiliated users only
Full Record

Analysis of the Human Microtubule Interactome Using Multidimensional Chromatography and Tandem Mass Spectrometry

Description:
Recent developments in mass spectrometer technology has increased the sensitivity and speed to an unprecedented level, along with the continuing improvements of high performance liquid ...
Copyright Date:
2013
Contributors:
GONG, CHAO (creator) Bazemore-Walker, Carthene (Director) Sun, Shouheng (Reader) Salomon, Arthur (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
microtubule associated protein MAP two dimensional reversed phase HPLC peptide separation peptide diethylation Microtubules Peptides--Separation
Full Record

Base Excision Repair: Kinetics in Context

Description:
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If ...
Copyright Date:
2017
Contributors:
Bilotti, Katharina (creator) Delaney, Sarah (Advisor) Salomon, Arthur (Reader) Cane, David (Reader) Brown University. Department of Chemistry (sponsor)
Genre:
theses
Keywords:
DNA Biochemistry Chemistry DNA repair
Available to Brown-affiliated users only
Full Record

Bioaccessibility and Environmental Transformations of Metal-Containing Nanomaterials and Consumer Products

Description:
The widespread use of nanomaterial-containing consumer products increases the potential for human and environmental exposure, and has raised concerns about the adverse impacts associated with ...
Copyright Date:
2013
Contributors:
Liu, Jingyu (creator) Hurt, Robert (Director) Sweigart, Dwight (Reader) Kim, Eunsuk (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
silver nanoparticles bioaccessibility environmental transformations ion release controlled release silver nanoparticles silver nanoparticle oxysulfidation quantum dots/polymer consumer product stability
Full Record

Biological and Environmental Transformations and Applications of Two-Dimensional Nanomaterials and Hybrids

Description:
The widespread use of nanomaterials in established and emerging technologies will inevitably lead to human and environmental exposures that must be characterized and managed to ...
Copyright Date:
2015
Contributors:
Wang, Zhongying (creator) Hurt, Robert (Director) Wang, Lai-Sheng (Reader) Sun, Shouheng (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
nanomaterials transformation toxicity human health environment Nanostructured materials Graphene Ecology
Full Record

Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics

Description:
Abstract of "Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of ...
Copyright Date:
2014
Contributors:
Sigdel, Aruna (creator) Sun, Shouheng (Director) Basu, Amit (Reader) Hurt, Robert (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Material Science Nanomaterials Bio-sensors Nanoparticle Characterization Drug-delivery Functionalization Theranostics Targeting Magnetic Nanoparticles Diagnostics Detection Materials science Surface chemistry Polymers Nanostructured materials Nanotechnology Biosensors Drug delivery systems
Full Record

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone

Description:
Streptomyces are Gram-positive, filamentous, soil-dwelling saprophytic bacteria that are the source of a vast array of bioactive secondary metabolites. The albaflavenone biosynthetic gene cluster in ...
Copyright Date:
2009
Contributors:
Lin, Xin (creator) Cane, David (director) Basu, Amit (reader) Sello, Jason (reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
albaflavenone epi-isozizaene sesquiterpene synthase Streptomyces
Full Record

Carbon Dioxide as a C1 Source: The Activation of Carbon Dioxide with Molybdenum and Iron Complexes

Description:
The current reliance on finite fossil fuels for the production of commodity chemicals has been recognized as unsustainable, and therefore has led to increasing pressure ...
Copyright Date:
2015
Contributors:
MacIntosh, Alex Dale (creator) Bernskoetter, Wesley (Director) Kim, Eunsuk (Reader) Williard, Paul (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Triphos Turnover Number Organometallo Ligand Quinone Methide Carbon dioxide Molybdenum Acrylic acid Iron Lewis acids Formic acid Catalysis
Full Record

Carbon Dioxide Functionalization to Acrylate and Formate by Homogenous Mo and Fe Complexes

Description:
CO2 functionalization to commodity chemicals and molecular energy provide an powerful mechanism to leverage one of the world most abundant alternative sustainable carbon resources. This ...
Copyright Date:
2015
Contributors:
Zhang, Yuanyuan (creator) Bernskoetter, Wesley (Director) Kim, Eunsuk (Reader) Sun, Shouheng (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
carbon dioxide functionalization formate Acrylates Iron Molybdenum
Full Record

Characterization of Reactive Intermediates by Multinuclear Diffusion-Ordered NMR Spectroscopy (DOSY)

Description:
Pulsed gradient spin-echo (PGSE) diffusion NMR spectroscopy was designed to measure diffusion coefficients and deduce the hydrodynamic radii of molecules in solution. By incorporation of ...
Copyright Date:
2008
Contributors:
Li, Deyu (creator) Williard, Paul (director) Cane, David (reader) Suggs, J. (reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Diffusion-Ordered NMR Spectroscopy DOSY Reactive Intermediates
Full Record

Chemical Dynamics in the Condensed Phase: Time-resolved X-ray Imaging and Ultrafast X-ray Absorption Spectroscopy

Description:
Understanding the "how" and "why" of chemical reactions requires rapid snapshots of a system's transient states. One approach is pulsing the probing radiation, namely ...
Copyright Date:
2011
Contributors:
Ahr, Brian C (creator) Rose-Petruck, Christoph (Director) Diebold, Gerald (Reader) Zimmt, Matthew (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
propagation-based phase-contrast x-ray imaging spatial harmonic imaging x-ray absorption spectroscopy iron pentacarbonyl
Full Record

Chemical Syntheses and Evaluations of Novel Anti-Infective Small Molecules

Description:
Infectious diseases are the 2nd leading cause of death worldwide and pose a global health problem that requires constant effort towards the discovery of new ...
Copyright Date:
2014
Contributors:
Carney, Daniel W (creator) Sello, Jason (Director) Seto, Chrisopher (Reader) Williard, Parul (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
ClpP ADEP antiviral retro-2 Antibiotics Peptides Antiviral agents
Full Record

Chemically Tunable 2D Layered Materials

Description:
2D layered materials reside in a class of crystals consisting of weakly bonded atomic layers. The thickness of a single layer ranges from one atom ...
Copyright Date:
2018
Contributors:
Wang, Mengjing (creator) Koski, Kristie (Advisor) Hurt, Robert (Reader) Rose-Petruck, Christoph (Reader) Brown University. Department of Chemistry (sponsor)
Genre:
theses
Keywords:
2D Materials Intercalation layered oxide Layered Chalcogenides
Available to Brown-affiliated users only
Full Record

Chemistry of Iron-Sulfur Clusters and Their Role in Crosstalk Between Nitric Oxide and Hydrogen Sulfide

Description:
Iron-sulfur [Fe-S] clusters are found at the active sites of various metalloenzymes and are one of the main targets of nitric oxide (NO). NO is ...
Copyright Date:
2015
Contributors:
Tran, Camly Thien (creator) Kim, Eunsuk (Director) Bernskoetter, Wesley (Reader) Williard, Paul (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
iron sulfur clusters degradation Nitric oxide Hydrogen sulfide Crosstalk
Full Record

Coherent Structural Dynamics of Rydberg-Excited Molecules

Description:
Structural dynamics of molecular systems, i.e. the change of the arrangement of atoms and functional groups over time, is the essence of many chemical ...
Copyright Date:
2016
Contributors:
Zhang, Yao (creator) Weber, Peter (Director) Jonsson, Hannes (Director) Stratt, Richard (Reader) Diebold, Gerald (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
Coherent structural dynamics Internal conversion Rydberg states Photoelectron spectroscopy
Full Record

Comprehensive Studies On the Outer Membrane Subproteome of Caulobacter crescentus Using Mass Spectrometry Based Shotgun Proteomics

Description:
Efforts to characterize proteins found in the outer membrane of gram-negative bacteria have been steadily increasing due to the promise of expanding our understanding of ...
Copyright Date:
2013
Contributors:
Cao, Yuan (creator) Bazemore-Walker, Carthene (Director) Suggs, William (Reader) Salomon, Arthur (Reader) Brown University. Chemistry (sponsor)
Genre:
theses
Keywords:
caulobacter crescentus outer membrane subcellular proteome LC-MS/MS shotgun proteomics Mass spectrometry
Full Record

Items (1-20) out of 138 results