There is great interest in exploiting van der Waals gaps in layered materials. Two-dimensional (2D) nanosheets of graphene oxide (GO) films are of great potential …
The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β) …
Carbohydrate-carbohydrate interactions (CCIs) mediate cell-cell adhesion and are involved in processes that include embryo development, metastasis, and myelin compaction. The main focus of this thesis …
Infections caused by antibiotic-resistant bacteria present an ever-growing challenge to physicians. The growing antibiotic resistance among pathogenic bacteria has caused the Centers for Disease Control …
Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases …
DNA serves as a stable medium of genomic data but is also chemically reactive. These reactions may cause deleterious DNA damage undermining the integrity of …
The accurate evaluation of quantum mechanical properties of molecules and materials becomes more challenging when highly accurate descriptions of electron correlation are required. Different flavors …
The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer. …
Carbohydrate-carbohydrate interactions (CCIs) between cell surface carbohydrates play an important role in cell adhesion and cell surface signaling. Glycopolymers, synthetic polymers functionalized with carbohydrate pendant …
Recent developments in mass spectrometer technology has increased the sensitivity and speed to an unprecedented level, along with the continuing improvements of high performance liquid …
Abstract of "Antioxidant and Antimicrobial Nanoparticles: The Role of Shape, Size and Surface Chemistry" by Yue Hu, Ph.D., Brown University, May 2021 There are many …
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
Reactive sulfur species (RSS) belong to a class of biologically relevant molecules that play a crucial role in redox homeostasis. Abnormalities in the regulation of …
The widespread use of nanomaterial-containing consumer products increases the potential for human and environmental exposure, and has raised concerns about the adverse impacts associated with …
The widespread use of nanomaterials in established and emerging technologies will inevitably lead to human and environmental exposures that must be characterized and managed to …
Abstract of "Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis …
Streptomyces are Gram-positive, filamentous, soil-dwelling saprophytic bacteria that are the source of a vast array of bioactive secondary metabolites. The albaflavenone biosynthetic gene cluster in …
The current reliance on finite fossil fuels for the production of commodity chemicals has been recognized as unsustainable, and therefore has led to increasing pressure …
CO2 functionalization to commodity chemicals and molecular energy provide an powerful mechanism to leverage one of the world most abundant alternative sustainable carbon resources. This …
