Brown University Theses and Dissertations

Brown University Library archives dissertations in accordance with the Brown Graduate School policy.

For dissertations published prior to 2008, please consult the following Dissertation LibGuide

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Items (1-20) out of 150 results

A Kinetic Perspective on DNA Base Excision Repair

Description:
The DNA base excision repair (BER) pathway is compromised of several enzymes, including DNA glycosylases, apurinic/apyrimidinic (AP) endonuclease 1 (APE1), DNA polymerase β (pol β) …
Year:
2014
Contributor:
Schermerhorn, Kelly (creator)
Delaney, Sarah (Director)
Cane, David (Reader)
Basu, Amit (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Base Excision Repair
Enzyme kinetics
Huntington's disease
Collection:
Chemistry
Theses and Dissertations
Full Record

A Multidisciplinary Approach for the Development of Novel Therapeutic Agents for the Treatment of Bacterial Infections

Description:
Infections caused by antibiotic-resistant bacteria present an ever-growing challenge to physicians. The growing antibiotic resistance among pathogenic bacteria has caused the Centers for Disease Control …
Year:
2015
Contributor:
Compton, Corey L (creator)
Sello, Jason (Director)
Sello, Jason (Reader)
Cane, David (Reader)
Seto, Christopher (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
ClpP
ADEP
proteasome
Mycobacterium
Proteolysis
Streptomyces
Collection:
Chemistry
Theses and Dissertations
Full Record

A Phosphoproteomic Study of Insulin Signaling Pathway Using A Novel High-Throughput Pipeline

Description:
Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases …
Year:
2009
Contributor:
Yu, Kebing (creator)
Salomon, Arthur (director)
Sun, Shouheng (reader)
Bazemore-Walker, Carthene (reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Signaling Pathway
Database
Proteomics
Bioinformatics
Phosphorylation
Collection:
Chemistry
Theses and Dissertations
Full Record

A Rational Design Strategy to Improve the Potency of Third Generation Diamide Inhibitors Against GH73 N-Acetylglucosaminidases and Interrogating Yariv Reagent Properties in Solution

Description:
N/A
Year:
2019
Contributor:
Saladino, Michael (creator)
Basu, Amit (Advisor)
Delaney, Sarah (Reader)
Sello, Jason (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
Carbohydrates
Antibacterial agents
Chemistry, Organic
Collection:
Chemistry
Theses and Dissertations
Full Record

AN ACTIVITY-BASED PROBE FOR THE ACYL PROTEIN THIOESTERASES

Description:
The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer. …
Year:
2016
Contributor:
Chen, Yiming (creator)
Seto, Christopher (Director)
Paul, Williard (Reader)
Sello, Jason (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Activity-Based Probe
Acyl Protein Thioesterases
Organic Synthesis
Kinetic Assay
Organic compounds--Synthesis
Mass spectrometry
Proteomics
Collection:
Chemistry
Theses and Dissertations
Full Record

An Investigation of Carbohydrate – Carbohydrate Interactions Using Glycopolymers and Supramolecular Glycoconjugates as Multivalent Model Systems

Description:
Carbohydrate-carbohydrate interactions (CCIs) between cell surface carbohydrates play an important role in cell adhesion and cell surface signaling. Glycopolymers, synthetic polymers functionalized with carbohydrate pendant …
Year:
2018
Contributor:
Leeber, Blaise William (creator)
Basu, Amit (Advisor)
Delaney, Sarah (Reader)
Sello, Jason (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
Polymers
Carbohydrates
Supramolecular chemistry
Carbohydrate-carbohydrate interactions
Self-assembly
Collection:
Chemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Analysis of the Human Microtubule Interactome Using Multidimensional Chromatography and Tandem Mass Spectrometry

Description:
Recent developments in mass spectrometer technology has increased the sensitivity and speed to an unprecedented level, along with the continuing improvements of high performance liquid …
Year:
2013
Contributor:
GONG, CHAO (creator)
Bazemore-Walker, Carthene (Director)
Sun, Shouheng (Reader)
Salomon, Arthur (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
microtubule associated protein
MAP
two dimensional reversed phase HPLC
peptide separation
peptide diethylation
Microtubules
Peptides--Separation
Collection:
Chemistry
Theses and Dissertations
Full Record

Base Excision Repair: Kinetics in Context

Description:
DNA damage is the primary molecular mechanism responsible for cancer and aging. DNA lesions can derive from oxidation, deamination, or alkylation of the nucleobases. If …
Year:
2017
Contributor:
Bilotti, Katharina (creator)
Delaney, Sarah (Advisor)
Salomon, Arthur (Reader)
Cane, David (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
DNA
Biochemistry
Chemistry
DNA repair
Collection:
Chemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Bioaccessibility and Environmental Transformations of Metal-Containing Nanomaterials and Consumer Products

Description:
The widespread use of nanomaterial-containing consumer products increases the potential for human and environmental exposure, and has raised concerns about the adverse impacts associated with …
Year:
2013
Contributor:
Liu, Jingyu (creator)
Hurt, Robert (Director)
Sweigart, Dwight (Reader)
Kim, Eunsuk (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
silver nanoparticles
bioaccessibility
environmental transformations
ion release
controlled release silver nanoparticles
silver nanoparticle oxysulfidation
quantum dots/polymer consumer product stability
Collection:
Chemistry
Theses and Dissertations
Full Record

Biological and Environmental Transformations and Applications of Two-Dimensional Nanomaterials and Hybrids

Description:
The widespread use of nanomaterials in established and emerging technologies will inevitably lead to human and environmental exposures that must be characterized and managed to …
Year:
2015
Contributor:
Wang, Zhongying (creator)
Hurt, Robert (Director)
Wang, Lai-Sheng (Reader)
Sun, Shouheng (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
nanomaterials
transformation
toxicity
human health
environment
Nanostructured materials
Graphene
Ecology
Collection:
Chemistry
Theses and Dissertations
Full Record

Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics

Description:
Abstract of "Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis …
Year:
2014
Contributor:
Sigdel, Aruna (creator)
Sun, Shouheng (Director)
Basu, Amit (Reader)
Hurt, Robert (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Material Science
Nanomaterials
Bio-sensors
Nanoparticle Characterization
Drug-delivery
Functionalization
Theranostics
Targeting
Magnetic Nanoparticles
Diagnostics
Detection
Materials science
Surface chemistry
Polymers
Nanostructured materials
Nanotechnology
Biosensors
Drug delivery systems
Collection:
Chemistry
Theses and Dissertations
Full Record

Biosynthesis of the Sesquiterpene Antibiotic Albaflavenone

Description:
Streptomyces are Gram-positive, filamentous, soil-dwelling saprophytic bacteria that are the source of a vast array of bioactive secondary metabolites. The albaflavenone biosynthetic gene cluster in …
Year:
2009
Contributor:
Lin, Xin (creator)
Cane, David (director)
Basu, Amit (reader)
Sello, Jason (reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
albaflavenone
epi-isozizaene
sesquiterpene synthase
Streptomyces
Collection:
Chemistry
Theses and Dissertations
Full Record

Carbon Dioxide as a C1 Source: The Activation of Carbon Dioxide with Molybdenum and Iron Complexes

Description:
The current reliance on finite fossil fuels for the production of commodity chemicals has been recognized as unsustainable, and therefore has led to increasing pressure …
Year:
2015
Contributor:
MacIntosh, Alex Dale (creator)
Bernskoetter, Wesley (Director)
Kim, Eunsuk (Reader)
Williard, Paul (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Triphos
Turnover Number
Organometallo Ligand
Quinone Methide
Carbon dioxide
Molybdenum
Acrylic acid
Iron
Lewis acids
Formic acid
Catalysis
Collection:
Chemistry
Theses and Dissertations
Full Record

Carbon Dioxide Functionalization to Acrylate and Formate by Homogenous Mo and Fe Complexes

Description:
CO2 functionalization to commodity chemicals and molecular energy provide an powerful mechanism to leverage one of the world most abundant alternative sustainable carbon resources. This …
Year:
2015
Contributor:
Zhang, Yuanyuan (creator)
Bernskoetter, Wesley (Director)
Kim, Eunsuk (Reader)
Sun, Shouheng (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
carbon dioxide functionalization
formate
Acrylates
Iron
Molybdenum
Collection:
Chemistry
Theses and Dissertations
Full Record

Characterization of Reactive Intermediates by Multinuclear Diffusion-Ordered NMR Spectroscopy (DOSY)

Description:
Pulsed gradient spin-echo (PGSE) diffusion NMR spectroscopy was designed to measure diffusion coefficients and deduce the hydrodynamic radii of molecules in solution. By incorporation of …
Year:
2008
Contributor:
Li, Deyu (creator)
Williard, Paul (director)
Cane, David (reader)
Suggs, J. (reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Diffusion-Ordered NMR Spectroscopy
DOSY
Reactive Intermediates
Collection:
Chemistry
Theses and Dissertations
Full Record

Chemical Dynamics in the Condensed Phase: Time-resolved X-ray Imaging and Ultrafast X-ray Absorption Spectroscopy

Description:
Understanding the "how" and "why" of chemical reactions requires rapid snapshots of a system's transient states. One approach is pulsing the probing radiation, namely x-radiation …
Year:
2011
Contributor:
Ahr, Brian C (creator)
Rose-Petruck, Christoph (Director)
Diebold, Gerald (Reader)
Zimmt, Matthew (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
propagation-based phase-contrast x-ray imaging
spatial harmonic imaging
x-ray absorption spectroscopy
iron pentacarbonyl
Collection:
Chemistry
Theses and Dissertations
Full Record

Chemical Syntheses and Evaluations of Novel Anti-Infective Small Molecules

Description:
Infectious diseases are the 2nd leading cause of death worldwide and pose a global health problem that requires constant effort towards the discovery of new …
Year:
2014
Contributor:
Carney, Daniel W (creator)
Sello, Jason (Director)
Seto, Chrisopher (Reader)
Williard, Parul (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
ClpP
ADEP
antiviral
retro-2
Antibiotics
Peptides
Antiviral agents
Collection:
Chemistry
Theses and Dissertations
Full Record

Chemically Tunable 2D Layered Materials

Description:
2D layered materials reside in a class of crystals consisting of weakly bonded atomic layers. The thickness of a single layer ranges from one atom …
Year:
2018
Contributor:
Wang, Mengjing (creator)
Koski, Kristie (Advisor)
Hurt, Robert (Reader)
Rose-Petruck, Christoph (Reader)
Brown University. Department of Chemistry (sponsor)
Genre:
theses
Subject:
2D Materials
Intercalation
layered oxide
Layered Chalcogenides
Collection:
Chemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Chemistry of Iron-Sulfur Clusters and Their Role in Crosstalk Between Nitric Oxide and Hydrogen Sulfide

Description:
Iron-sulfur [Fe-S] clusters are found at the active sites of various metalloenzymes and are one of the main targets of nitric oxide (NO). NO is …
Year:
2015
Contributor:
Tran, Camly Thien (creator)
Kim, Eunsuk (Director)
Bernskoetter, Wesley (Reader)
Williard, Paul (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
iron sulfur clusters
degradation
Nitric oxide
Hydrogen sulfide
Crosstalk
Collection:
Chemistry
Theses and Dissertations
Full Record

Coherent Structural Dynamics of Rydberg-Excited Molecules

Description:
Structural dynamics of molecular systems, i.e. the change of the arrangement of atoms and functional groups over time, is the essence of many chemical processes. …
Year:
2016
Contributor:
Zhang, Yao (creator)
Weber, Peter (Director)
Jonsson, Hannes (Director)
Stratt, Richard (Reader)
Diebold, Gerald (Reader)
Brown University. Chemistry (sponsor)
Genre:
theses
Subject:
Coherent structural dynamics
Internal conversion
Rydberg states
Photoelectron spectroscopy
Collection:
Chemistry
Theses and Dissertations
Full Record

Items (1-20) out of 150 results