Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
Atherosclerotic plaque calcification is associated increased risk of cardiovascular events. Inflammation plays a key role in the development of atherosclerosis and is thought to potentially …
Cytokinesis is an essential process for the proliferation of eukaryotic species. However, our knowledge of how a eukaryotic cell accomplishes cytokinesis is relegated to a …
Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome …
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
Sex determination is an essential, and highly variable process, of organismal development. Looking for common threads used in evolution to determine sex is difficult simply …
An exceptional group of aquatic invertebrates makes up Class Bdelloidea. Bdelloid rotifers are the only group of ancient asexual animals known. A second distinction that …
Neurogenesis sharply declines with age in the subventricular zone (SVZ). The SVZ niche contains multipotent neural stem cells (NSCs) that can differentiate into neurons, astrocytes, …
The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the …
Pseudogymnoascus destructans is the invasive fungal pathogen responsible for White-Nose Syndrome (WNS), a devastating disease affecting North American bats. WNS has led to the loss …
Eukaryotic organisms undergo changes in morphology in order to survive and proliferate within a variety of different environments and conditions. The human fungal pathogen Candida …
High Grade Serous Carcinoma (HGSC) is the deadliest form of ovarian cancer among women and causes the most deaths of gynaecological cancers overall (Tudrej, Patrycja …
In eukaryotic cells, informational recoding and RNA interference (RNAi) proceed through structurally diverse double-stranded (ds) RNA molecules. Informational recoding of RNA by the catalytic deamination …
This study assessed how cardiovascular measures and cardiovascular reactivity differ between physically healthy adolescent girls diagnosed with major depressive disorder (MDD), those at high risk …
In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
This thesis is divided into two parts. The first part of this thesis, including chapters 1-3, examines the role of the protein Muscle specific kinase …
Subcellular mRNA localization is a conserved mechanism across eukaryotes, which is found in both somatic and germ cells. RNA localization in combination with local translation …
