Brown University Theses and Dissertations

Brown University Library archives dissertations in accordance with the Brown Graduate School policy.

For dissertations published prior to 2008, please consult the following Dissertation LibGuide

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Items (1-20) out of 95 results

A BMP-dependent feedback loop regulates dpp expression by direct and indirect mechanisms in the Drosophila wing imaginal disc

Description:
Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter ...
Copyright Date:
2012
Contributors:
Aldrich, Maryanna M (creator) Wharton, Kristi (Director) McKeown, Michael (Reader) Freiman, Richard (Reader) Johnson, Mark (Reader) Raftery, Laurel (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
BMP signaling dpp negative regulation Min jin dang (China) Transcription Drosophila
Full Record

A New Model of Amyotrophic Lateral Sclerosis in Drosophila melanogaster: Precise Genetic Engineering, Characterization and Genetic Suppression

Description:
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length ...
Copyright Date:
2015
Contributors:
Sahin, Asli (creator) Reenan, Robert (Director) Fallon, Justin (Reader) Hart, Anne (Reader) Wharton, Kristi (Reader) Bonini, Nancy (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
ALS Motor neuron Disease neurodegeneration homologous recombination ems genetic screen Drosophila Genetic engineering
Full Record

A Quantitative Phosphoproteomic Analysis of the T-Cell Receptor Signaling Pathway Using Novel High-Throughput Approaches

Description:
Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome ...
Copyright Date:
2011
Contributors:
Nguyen, Vinh Hai (creator) Salomon, Arthur (Director) Brossay, Laurent (Reader) Wessel, Gary (Reader) Gruppuso, Philip (Reader) Sauer, Karsten (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
mass spectometry TCR signaling Jurkat T-cells SILAC label-free hybrid quantitative approach Zap-70 FYN regulation method development ERK positive feedback
Full Record

A-to-I RNA Editing of Voltage-Gated Potassium Channels: Regulation and Functional Consequences in Drosophila melanogaster.

Description:
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This ...
Copyright Date:
2011
Contributors:
Maloney, Rachel A (creator) Reenan, Robert (Director) McKeown, Michael (Reader) Fairbrother, William (Reader) Lipscombe, Diane (Reader) Rogina, Blanka (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
RNA editing Potassium channels Drosophila
Full Record

An Investigation of miRNA Repertoires in Bdelloid Rotifers

Description:
An exceptional group of aquatic invertebrates makes up Class Bdelloidea. Bdelloid rotifers are the only group of ancient asexual animals known. A second distinction that ...
Copyright Date:
2013
Contributors:
Dutta, Anupriya (creator) Mark Welch, David (Director) Mckeown, Michael (Reader) Bennett, Richard (Reader) Arkhipova, Irina (Reader) Chen, Kevin (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
miRNAs microRNAs rotifers bdelloid rotifers let-7 miR-100 miRNA editing Evolution Rotifera RNA editing
Full Record

Analysis of Endoderm Patterning and Pancreatic Organogenesis in Xenopus laevis

Description:
The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the ...
Copyright Date:
2014
Contributors:
Bilogan, Cassandra K (creator) Horb, Marko (Director) Wessel, Gary (Reader) Mowry, Kimberly (Reader) Wharton, Kristi (Reader) He, Xi (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
Endoderm Staufen2 Ptf1a Development Xenopus Economic development Pancreas
Full Record

Biological Consequences of Specific and Promiscuous A-to-I RNA Editing Revealed Through Precise Genetic Engineering.

Description:
In eukaryotic cells, informational recoding and RNA interference (RNAi) proceed through structurally diverse double-stranded (ds) RNA molecules. Informational recoding of RNA by the catalytic deamination ...
Copyright Date:
2011
Contributors:
Savva, Yiannis A (creator) Reenan, Robert (Director) McKeown, Michael (Reader) Johnson, Mark (Reader) Bender, Judith (Reader) Carmichael, Gordon (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
RNA editing
Full Record

Cardiovascular response to peer rejection as a biomarker for adolescent depression risk

Description:
This study assessed how cardiovascular measures and cardiovascular reactivity differ between physically healthy adolescent girls diagnosed with major depressive disorder (MDD), those at high risk ...
Date Created:
2016-04-29
Contributors:
Speakman, Rachel (author) Stroud, Laura (advisor) Zielinski-Habershaw, Beth (reader)
Genre:
theses
Keywords:
Mental depression Cardiovascular system Heart beat Blood pressure
Full Record

Changes in Chromatin Conformation During Replicative Senescence of Normal Human Diploid Fibroblasts

Description:
In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence ...
Copyright Date:
2012
Contributors:
Peckham, Edward Joseph (creator) Sedivy, John (Director) Helfand, Stephen (Reader) Zervas, Mark (Reader) Brodsky, Alexander (Reader) Johnson, F (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
senescence LINE SINE Aging Chromatin
Full Record

Characterizing Distinct and Shared Functions of Drosophila Insulin-Like Peptides in Regulating Metabolism and Longevity

Description:
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including development, metabolism, stress responses and aging. Drosophila melanogaster IIS is propagated ...
Copyright Date:
2018
Contributors:
Post, Stephanie (creator) Tatar, Marc (Advisor) Gruppuso, Philip (Reader) Salomon, Arthur (Reader) Neretti, Nicola (Reader) Fridell, Yih-Woei (Reader) Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Keywords:
Metabolism Drosophila Insulin-like Peptides Aging Insulin Cell signaling
Full Record

Complex Tertiary Structure Governs RNA Editing of the Drosophila Paralytic Transcript

Description:
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here ...
Copyright Date:
2014
Contributors:
Rieder, Leila E (creator) Reenan, Robert (Director) Michael, McKeown (Reader) Erica, Larschan (Reader) Eric, Morrow (Reader) Ronald, Emeson (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
RNA structure tertiary structure splicing homologous recombination RNA RNA editing Adar RNA--Structure RNA splicing Drosophila
Full Record

Computational Phylogenetics Reveals Conserved Motifs in Ribosomal RNA that Link Ribosome Biogenesis with Cell Cycle and Autophagy in Eukaryotes

Description:
A detailed understanding of ribosomal RNA (rRNA) structure is essential to understanding its function in the cell. Here we present a new comparative phylogenetic analysis ...
Copyright Date:
2009
Contributors:
Doris, Stephen M. (creator) Gerbi, Susan (director) Dahlberg, Albert (reader) Mowry, Kimberly (reader) Serio, Tricia (reader) Woolford, John (reader) Brown University. Division of Biology and Medicine. Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
Phylogenetic analysis Ribosomal RNA Alignment Autophagy Cell cycle
Full Record

Coupling Gamete Fusion with Sperm Cell Delivery Maximizes Reproductive Success in Flowering Plants

Description:
In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite ...
Copyright Date:
2014
Contributors:
Beale, Kristin M (creator) Johnson, Mark (Director) Palanivelu, Ravi (Reader) Bender, Judith (Reader) Page, Rebecca (Reader) Wessel, Gary (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
Gamete fusion plant reproduction polyspermy polytubey Plants--Reproduction
Full Record

Development, Disease, and Regeneration: Using Zebrafish to Model Neurological Perturbations

Description:
As medical technologies advance, effective vertebrate models of human disease are vital to determine safety and efficacy of treatments. My research has further developed zebrafish ...
Copyright Date:
2018
Contributors:
Thorn, Robert Joseph (creator) Hart, Anne (Reader) Wessel, Gary (Reader) Creton, Robbert (Advisor) Mowry, Kimberly (Reader) DeLong, Alison (Reader) Aluru, Neel (Reader) Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Keywords:
Zebrafish Brain Development Brain--Diseases Zebrafish Behavior
Full Record

Differential Gene Expression in the Fungus Fly, Sciara coprophila: The Quest for Stable Reference Genes

Description:
Strict regulatory mechanisms ensure that the cell’s genome is perfectly duplicated. In eukaryotic cells, origins of replication fire once and only once per cell ...
Copyright Date:
2017
Contributors:
Lee, Audrey (creator) Gerbi, Susan (Advisor) Wharton, Kristi (Reader) Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Keywords:
Sex determination, Genetic DNA amplification Gene expression Sciara
Full Record

Differential regulation of gene expression in D. melanogaster is mediated by context-specific functions of the essential CLAMP transcription factor

Description:
Defining diverse roles of a single transcription factor on the cellular level is key to understanding its role in the context of an organism. However ...
Copyright Date:
2017
Contributors:
Urban, Jennifer Anne (creator) Larschan, Erica (Advisor) Wharton, Kristi (Reader) Kaun, Karla (Reader) Neretti, Nicola (Reader) Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Keywords:
Drosophila melanogaster--Genetics Genomics Transcription factors Chromatin Sex determination, Genetic dosage compensation
Full Record

Dissecting the role of dosage compensation in brain development in Drosophila melanogaster

Description:
Regulation of gene expression is an essential process in all cell types, from stem cells to neurons. A key aspect of gene expression that remains ...
Date Created:
2016-05-05
Contributors:
Xu, Lucy (author) Larschan, Erica (advisor) Kaun, Karla (reader)
Genre:
theses
Keywords:
Epigenetics Gene expression Brain development
Full Record

Diverse subtypes of fast-spiking inhibitory neurons in neocortex

Description:
Inhibitory interneurons are essential for normal cortical function. They prevent seizures, regulate temporal and spatial coding, and generate oscillations and synchrony in pyramidal cells. The ...
Copyright Date:
2015
Contributors:
Sugden, Arthur U (creator) Connors, Barry (Director) Cruikshank, Scott (Director) Barnea, Gilad (Reader) Berson, David (Reader) Jaworski, Alexander (Reader) Harwell, Corey (Reader) Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Keywords:
inhibitory gamma parvalbumin fast-spiking
Full Record

Diversification of Protein Phosphatase 2A Regulatory Subunits in Plants: Functional and Phylogenetic Analysis

Description:
Protein Phosphatase 2A (PP2A) is heterotrimeric enzyme that regulates key signaling pathways in eukaryotes by dephosphorylating target proteins. PP2A enzymes are composed of a structural ...
Copyright Date:
2017
Contributors:
Booker, Matthew A (creator) DeLong, Alison (Advisor) Johnson, Mark (Reader) Hart, Anne (Reader) Welch, David Mark (Reader) Shiu, Shin-Han (Reader) Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Keywords:
ethylene Protein Phosphatase 2A gene expansion ACS6
Available to Brown-affiliated users only
Full Record

Ecdysone-Regulated DNA Amplification in Sciara coprophila

Description:
Abstract of ‘Ecdysone-Regulated DNA Amplification in Sciara coprophila’, by Léo Kadota, Sc.M., Brown University, May 2017. The eukaryotic genome contains thousands of origins (ORIs ...
Copyright Date:
2017
Contributors:
Kadota, Léo (creator) Gerbi, Susan (Advisor) Helfand, Stephen (Reader) Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Keywords:
DNA replication sciara coprophila DNA amplification DNA puffs Sciara Ecdysone
Full Record

Items (1-20) out of 95 results