Brown University Theses and Dissertations

Brown University Library archives dissertations in accordance with the Brown Graduate School policy.

For dissertations published prior to 2008, please consult the following Dissertation LibGuide

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Items (1-20) out of 116 results

A BMP-dependent feedback loop regulates dpp expression by direct and indirect mechanisms in the Drosophila wing imaginal disc

Description:
Morphogen activity gradients assign positional information within fields of cells in a concentration-dependent manner. As transcriptional changes respond to signaling activity thresholds, cells must encounter …
Year:
2012
Contributor:
Aldrich, Maryanna M (creator)
Wharton, Kristi (Director)
McKeown, Michael (Reader)
Freiman, Richard (Reader)
Johnson, Mark (Reader)
Raftery, Laurel (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
BMP signaling
dpp
negative regulation
Min jin dang (China)
Transcription
Drosophila
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

A Mutagenic Screen Identifies Jim as a Regulator of Transposition, Heterochromatin, and Aging

Description:
Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Year:
2020
Contributor:
Liu, Julianna J. (creator)
Helfand, Stephen (thesis advisor)
Lawrence, Charles (reader)
Taylor, Jackson (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Drosophila melanogaster
Genetics
Aging
Transposons
Heterochromatin
Chromatin
Gene silencing
Zinc-finger proteins
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

A New Model of Amyotrophic Lateral Sclerosis in Drosophila melanogaster: Precise Genetic Engineering, Characterization and Genetic Suppression

Description:
ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
Year:
2015
Contributor:
Sahin, Asli (creator)
Reenan, Robert (Director)
Fallon, Justin (Reader)
Hart, Anne (Reader)
Wharton, Kristi (Reader)
Bonini, Nancy (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
ALS
Motor neuron
Disease
neurodegeneration
homologous recombination
ems
genetic screen
Drosophila
Genetic engineering
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

A Quantitative Phosphoproteomic Analysis of the T-Cell Receptor Signaling Pathway Using Novel High-Throughput Approaches

Description:
Reversible protein phosphorylation plays a pivotal role in the regulation of cellular signaling pathways. Current approaches in phosphoproteomics focus on analysis of the global phosphoproteome …
Year:
2011
Contributor:
Nguyen, Vinh Hai (creator)
Salomon, Arthur (Director)
Brossay, Laurent (Reader)
Wessel, Gary (Reader)
Gruppuso, Philip (Reader)
Sauer, Karsten (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
mass spectometry
TCR signaling
Jurkat T-cells
SILAC
label-free
hybrid quantitative approach
Zap-70
FYN regulation
method development
ERK positive feedback
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

A-to-I RNA Editing of Voltage-Gated Potassium Channels: Regulation and Functional Consequences in Drosophila melanogaster.

Description:
A-to-I RNA editing is the post-transcriptional modification of pre-mRNA transcripts,where specific adenosine residues are converted to inosine by Adenosine DeaminasesActing on RNA (ADARs). This modification …
Year:
2011
Contributor:
Maloney, Rachel A (creator)
Reenan, Robert (Director)
McKeown, Michael (Reader)
Fairbrother, William (Reader)
Lipscombe, Diane (Reader)
Rogina, Blanka (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
RNA editing
Potassium channels
Drosophila
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

An Investigation of miRNA Repertoires in Bdelloid Rotifers

Description:
An exceptional group of aquatic invertebrates makes up Class Bdelloidea. Bdelloid rotifers are the only group of ancient asexual animals known. A second distinction that …
Year:
2013
Contributor:
Dutta, Anupriya (creator)
Mark Welch, David (Director)
Mckeown, Michael (Reader)
Bennett, Richard (Reader)
Arkhipova, Irina (Reader)
Chen, Kevin (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
miRNAs
microRNAs
rotifers
bdelloid rotifers
let-7
miR-100
miRNA editing
Evolution
Rotifera
RNA editing
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Analysis of Endoderm Patterning and Pancreatic Organogenesis in Xenopus laevis

Description:
The endoderm germ layer gives rise to the epithelial lining of the respiratory and digestive tracts and their associated organs. Gastrulation and formation of the …
Year:
2014
Contributor:
Bilogan, Cassandra K (creator)
Horb, Marko (Director)
Wessel, Gary (Reader)
Mowry, Kimberly (Reader)
Wharton, Kristi (Reader)
He, Xi (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Endoderm
Staufen2
Ptf1a
Development
Xenopus
Economic development
Pancreas
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Analysis of Secreted Enzymes, Metabolism and Virulence in the Bat Fungal Pathogen Pseudogymnoascus destructans

Description:
Pseudogymnoascus destructans is the invasive fungal pathogen responsible for White-Nose Syndrome (WNS), a devastating disease affecting North American bats. WNS has led to the loss …
Year:
2019
Contributor:
Beekman, Chapman (creator)
Bennett, Richard J. (Advisor)
DeLong, Alison (Reader)
Johnson, Mark (Reader)
Belenky, Peter (Reader)
Cramer, Robert A., Jr, (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Metabolism
Bats
Fungi
Virulence (Microbiology)
Peptidase
White-nose Syndrome
pathogenicity
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Behaviour of Ovarian Cancer Cells in 2D and 3D Under Adherent and Non-Adherent Conditions

Description:
High Grade Serous Carcinoma (HGSC) is the deadliest form of ovarian cancer among women and causes the most deaths of gynaecological cancers overall (Tudrej, Patrycja …
Year:
2019
Contributor:
Niewchas, Abbigail E. (creator)
Freiman, Richard (thesis advisor)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Cancer
Ovarian
BRCA genes
TAF
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Biological Consequences of Specific and Promiscuous A-to-I RNA Editing Revealed Through Precise Genetic Engineering.

Description:
In eukaryotic cells, informational recoding and RNA interference (RNAi) proceed through structurally diverse double-stranded (ds) RNA molecules. Informational recoding of RNA by the catalytic deamination …
Year:
2011
Contributor:
Savva, Yiannis A (creator)
Reenan, Robert (Director)
McKeown, Michael (Reader)
Johnson, Mark (Reader)
Bender, Judith (Reader)
Carmichael, Gordon (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
RNA editing
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Cardiovascular response to peer rejection as a biomarker for adolescent depression risk

Description:
This study assessed how cardiovascular measures and cardiovascular reactivity differ between physically healthy adolescent girls diagnosed with major depressive disorder (MDD), those at high risk …
Year:
2016
Contributor:
Speakman, Rachel (author)
Stroud, Laura (advisor)
Zielinski-Habershaw, Beth (reader)
Genre:
theses
Subject:
Mental depression
Cardiovascular system
Heart beat
Blood pressure
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Changes in Chromatin Conformation During Replicative Senescence of Normal Human Diploid Fibroblasts

Description:
In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
Year:
2012
Contributor:
Peckham, Edward Joseph (creator)
Sedivy, John (Director)
Helfand, Stephen (Reader)
Zervas, Mark (Reader)
Brodsky, Alexander (Reader)
Johnson, F (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
senescence
LINE
SINE
Aging
Chromatin
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Characterization of Vegetal RNP Transport Granules in Xenopus laevis Oocytes.

Description:
Subcellular mRNA localization is a conserved mechanism across eukaryotes, which is found in both somatic and germ cells. RNA localization in combination with local translation …
Year:
2018
Contributor:
Jeschonek, Samantha Page (creator)
Mowry, Kimberly (Advisor)
Creton, Robbert (Reader)
DeLong, Alison (Reader)
Wessel, Gary (Reader)
Blower, Michael (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Xenopus laevis
RNP granules
RNA localization
Ovum
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Characterizing Distinct and Shared Functions of Drosophila Insulin-Like Peptides in Regulating Metabolism and Longevity

Description:
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including development, metabolism, stress responses and aging. Drosophila melanogaster IIS is propagated …
Year:
2018
Contributor:
Post, Stephanie (creator)
Tatar, Marc (Advisor)
Gruppuso, Philip (Reader)
Salomon, Arthur (Reader)
Neretti, Nicola (Reader)
Fridell, Yih-Woei (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Metabolism
Drosophila Insulin-like Peptides
Aging
Insulin
Cell signaling
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Complex Tertiary Structure Governs RNA Editing of the Drosophila Paralytic Transcript

Description:
The specificity and extent of RNA editing by ADAR enzymes is determined largely by local primary sequence and secondary structural imperfections in duplex RNA. Here, …
Year:
2014
Contributor:
Rieder, Leila E (creator)
Reenan, Robert (Director)
Michael, McKeown (Reader)
Erica, Larschan (Reader)
Eric, Morrow (Reader)
Ronald, Emeson (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
RNA structure
tertiary structure
splicing
homologous recombination
RNA
RNA editing
Adar
RNA--Structure
RNA splicing
Drosophila
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Computational Phylogenetics Reveals Conserved Motifs in Ribosomal RNA that Link Ribosome Biogenesis with Cell Cycle and Autophagy in Eukaryotes

Description:
A detailed understanding of ribosomal RNA (rRNA) structure is essential to understanding its function in the cell. Here we present a new comparative phylogenetic analysis …
Year:
2009
Contributor:
Doris, Stephen M. (creator)
Gerbi, Susan (director)
Dahlberg, Albert (reader)
Mowry, Kimberly (reader)
Serio, Tricia (reader)
Woolford, John (reader)
Brown University. Division of Biology and Medicine. Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Phylogenetic analysis
Ribosomal RNA
Alignment
Autophagy
Cell cycle
Collection:
Biology and Medicine
Theses and Dissertations
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Constructing HIV-1 Transmission Networks in Rhode Island through Phylogenetic Analysis of HIV-1 Whole Genome Sequences

Description:
Human Immunodeficiency Virus (HIV) remains a global public health challenge, primarily due to its uncontrolled transmission. Analysis of HIV-1 sequence data can lead to phylogenetic …
Year:
2020
Contributor:
Won, Cindy Y. (creator)
Kantor, Rami (thesis advisor)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
HIV (Viruses)
Rhode Island
Phylogeny
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Coupling Gamete Fusion with Sperm Cell Delivery Maximizes Reproductive Success in Flowering Plants

Description:
In sexual reproduction, fusion of haploid sperm and egg cells (gametes) are required to produce a unique diploid individual that represents the next generation. Despite …
Year:
2014
Contributor:
Beale, Kristin M (creator)
Johnson, Mark (Director)
Palanivelu, Ravi (Reader)
Bender, Judith (Reader)
Page, Rebecca (Reader)
Wessel, Gary (Reader)
Brown University. BIOMED: Molecular Biology, Cell Biology, and Biochemistry (sponsor)
Genre:
theses
Subject:
Gamete fusion
plant reproduction
polyspermy
polytubey
Plants--Reproduction
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Development of a novel imaging system for automated high-throughput drug screening in zebrafish

Description:
Worldwide, 253 million people are afflicted with visual impairment. The development of novel therapies for the prevention and treatment of visual disorders is necessary 1. …
Year:
2019
Contributor:
Baek, Peter (creator)
Créton, Robbert (thesis advisor)
Hoffman-Kim, Diane (reader)
Brown University. Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Vision
Zebra danio
High throughput screening (Drug development)
Drugs
Fishes--Larvae
Imaging systems
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Available to Brown-affiliated users only
Full Record

Development, Disease, and Regeneration: Using Zebrafish to Model Neurological Perturbations

Description:
As medical technologies advance, effective vertebrate models of human disease are vital to determine safety and efficacy of treatments. My research has further developed zebrafish …
Year:
2018
Contributor:
Thorn, Robert Joseph (creator)
Hart, Anne (Reader)
Wessel, Gary (Reader)
Creton, Robbert (Advisor)
Mowry, Kimberly (Reader)
DeLong, Alison (Reader)
Aluru, Neel (Reader)
Brown University. Department of Molecular Biology, Cell Biology and Biochemistry (sponsor)
Genre:
theses
Subject:
Zebrafish
Brain Development
Brain--Diseases
Zebrafish Behavior
Collection:
Biology and Medicine
Molecular Biology, Cell Biology, and Biochemistry
Theses and Dissertations
Full Record

Items (1-20) out of 116 results