Transposable elements (TEs) are potentially harmful DNA sequences that can copy themselves and then insert elsewhere into the genome, causing damage and disrupting normal gene …
Aging is associated with an increased risk of arrhythmias and sudden cardiac death (SCD). Yet, much remains unknown about the mechanisms that underlie the age-related, …
Abstract of Aging Effects on Task-Evoked Pupillary Reponses, by Mingjian He, Degree ScM., Brown University, May 2018. Previous studies have found decreased cell counts and …
Background: Older adults are increasingly spending more of their income on housing, which is associated with reduced spending on health care. This study tests the …
Abstract of An Exploration of the Biology Underlying Epigenetic Clocks by Nicholas J. Skvir, Ph.D., Brown University, October 2022. Epigenetic clocks have gained popularity over …
Neurogenesis sharply declines with age in the subventricular zone (SVZ). The SVZ niche contains multipotent neural stem cells (NSCs) that can differentiate into neurons, astrocytes, …
One of the major consequences of aging is the loss of voluntary motor capacity, which reduces the self-sufficiency and overall health of individuals. Among the …
In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
Insulin and IGF signaling (IIS) is a complex system that controls diverse processes including development, metabolism, stress responses and aging. Drosophila melanogaster IIS is propagated …
Abstract of Comparative Effectiveness of EFA and MFA for Estimation of Alzheimer’s Disease Cognitive Biomarkers , by Joanna Walsh, Sc.M., Brown University, May 2022. Exploratory …
Despite many studies linking FOXO factors to longevity, how these factors directly regulate aging particularly in humans, is not completely understood. The focus of this …
Transposable elements (TEs) are genetic elements that can move around the genome, causing mutations and genomic instability. These "jumping" genes are ubiquitous in the genomes …
Senescent cells have many harmful effects to the tissue they surround by creating an inflammatory environment and increase DNA damage by inducing retrotransposable elements. With …
Retrotransposable element (RTE) mobilization due to heterochromatin loss is among the molecular mechanisms associated with deleterious phenotypes that accompany biological aging. Here, we describe novel …
Polycomb Group (PcG) epigenetic regulators are important but not well-understood components of cellular senescence. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent …
Cellular senescence and aging are associated with extensive chromatin and transcriptional changes. We examined cell-free DNA (cfDNA) in individuals of different age groups to elucidate …
Context – In the United States, institutional long term care facilities are used by many older adults who could otherwise benefit from home- and community-based …
The ability to learn task structure and perform well according to task rules and organization declines across healthy aging in humans, especially in cognitive tasks …
