In this thesis we provide evidence that the FAIRE method can reveal interesting and relevant changes in genome-wide chromatin organization as cells undergo replicative senescence, …
Polycomb Group (PcG) epigenetic regulators are important but not well-understood components of cellular senescence. EZH2, a PcG histone H3 lysine-27 methyltransferase, is repressed in senescent …
Studying the biological mechanisms of the aging process in the fruit fly Drosophila melanogaster has been crucial to the advancement of the field. In particular, …