Neurodegenerative disease is one of the greatest yet poorest understood medical challenges facing humanity today. A fundamental hurdle that continues to frustrate therapeutic development is …
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of the upper and lower motor neurons resulting in weakness, paralysis and death within two to five …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of motor neurons that affects at least 30,000 people in the United States at any one time …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a progressive, rapid loss of motor function. Within 3-5 years, a loss of motor function …
Mutations in Cu/Zn superoxide dismutase 1 (SOD1) and FUsed in Sarcoma (FUS) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that affects glutamatergic and …
Amyotrophic lateral sclerosis (ALS) is a progressive degenerative disease that results from the loss of glutamatergic and cholinergic motor neurons. Variations in many genes have …
RNA-binding proteins (RBPs) interact with a network of other proteins to form ribonucleoprotein (RNP) complexes, which are critical players throughout the lifecycle of RNA. Dysfunction …
Neurodegenerative diseases are a group of etiologically heterogeneous diseases characterized by the loss of a vulnerable subset of neurons. Despite this heterogeneity in etiology, TDP-43 …
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are related neurodegenerative diseases with overlapping genetic causes. A number of ALS/FTD- associated mutations have been identified …
Brain Computer Interfaces (BCIs) use neural information recorded from the brain for the voluntary control of external devices. Motor imagery can be decoded using intracortical …
Cellular homeostasis depends on proper spatiotemporal partitioning of biochemistry. In addition to the classical paradigm of subcellular division through membrane-bound organelles, cells utilize the phenomenon …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting the upper and lower motor neurons. While most ALS cases are sporadic, there have been …
Implantable brain-computer interface (BCI) systems may one day offer persons with locked-in syndrome a means of interacting and communicating with the outside world. These systems …
