Antimicrobial resistance poses a global challenge to human health that is only expected to increase without significant treatment innovations. Novel therapeutic strategies are needed for …
Infectious diseases are the 2nd leading cause of death worldwide and pose a global health problem that requires constant effort towards the discovery of new …
The gut microbiome is essential for the maintenance of host health, and perturbations to the gut microbial community can lead to disease states. While antibiotics …
The human microbiome contributes to a number of physiological processes, including digestion, neurological development, and proper immune function. Due to its central role in human …
Biofilm formation and drug resistance complicate the treatment of bacterial infections. These infections are comprised of bacteria with low metabolic activity, limiting the effects of …
Chemical communication mediated by molecules called semiochemicals occurs in organisms from all taxonomic kingdoms. My doctoral work as focused on chemical communication in Streptomyces bacteria, …
Infectious disease is one of the most severe healthcare issues worldwide (Nathan, 2004; Nathan & Goldberg, 2005; WHO, 2002). Moreover, this healthcare issue is worsened …
This dissertation includes two essays that consider the importance of externalities in different public health contexts. The first chapter examines the link between community water …
Host-microbe interactions heavily influence both fitness and disease. Traditionally, research on host-microbe interactions focused on the concept that microbes only contribute to pathogenesis. However, recent …
The rise in antibiotic resistance and the importance of the mammalian microbiome necessitates new models that could expedite and streamline the study of host-microbiome interactions …
The gut microbiome is the assemblage of symbiotic microbes inhabiting distinct ecological niches within the host that participate in key physiological functions such as energy …
Antibiotic therapy alters bacterial abundance and metabolism in the gut microbiome, leading to adverse health outcomes such as dysbiosis and opportunistic infections. Additionally, antibiotic effectiveness …
Antibiotic-induced gut dysbiosis is currently a frequent and serious side effect of antibiotic use. Host diet can be a therapeutic target to modulate the structure …
