Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases …
Ten years ago, the first RNA-seq study was published. Since then over 200 thousand RNA-seq studies have been published, spanning many different organisms, tissue types, …
This study introduces Biologically Annotated Neural Networks (BANNs) for identifying causal Single Nucleotide Polymorphisms (SNPs) linked to complex traits. BANNs combine neural network flexibility with …
This dissertation focuses on biomechanistic and bioinformatic modeling of diabetes. Specifically, it is expanded on four fronts: 1) Quantification of fibrinogen-dependent red blood cells adhesion. …
Cellular heterogeneity is inherent in the brain, and resolving differential cell type-specific contributions to overall function is critical for understanding both normal and pathological neurobiology. …
How to effectively extract important information and conduct meaningful analyses from large collections of data is an essential problem we need to tackle in order …
Risk factor-based prediction is the cornerstone of guidelines for the primary prevention of atherosclerotic cardiovascular disease (ASCVD). Despite clear criteria for statin therapy, ASCVD remains …
Streptomycetes are a large group of Gram-positive, soil-dwelling bacteria that have evolved remarkable metabolic capabilities for survival in a nutrient-poor and a biodiverse ecological niche. …
Development is a complex process governed by coordinated gene regulation at a precise time and place. Uncovering how transcription factors (TFs) and their targets communicate …
Background: Single-cell RNA sequencing (scRNA-seq) quantifies the whole transcriptome on a cellular level which enables the exploration of tissue heterogeneity in biological samples. One common …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with symptom-onset occurring in adulthood. ALS is characterized by progressive degeneration of upper and lower motor …
The discipline of protein evolution aims to understand the principles and driving forces whereby new protein-coding genes, protein structures, and biological functions emerge due to …
For most eukaryotic organisms, protein coding sequences are only a small portion of the genome. Much of the genome is made up of transposable elements, …
The ability to detect and adapt to changing conditions and circumstances is a requirement of life at both the organismal and cellular levels. Inside the …
We present an intuitive strategy for predicting the effect of sequence variation on splicing. In contrast to transcriptional elements, splicing elements appear to be strongly …
Over time, more neurodegenerative disorder-linked mutations are being discovered, with more components of RNA/RNP granules containing disordered regions/domains and exhibiting the ability to undergo liquid-liquid …
