In this thesis, the potential success of a novel drug delivery system (PDAL DDS) in the current antifungal DDS market was evaluated. Focus was placed …
Oral dosage forms are generally targeting the absorption in the gastrointestinal (GI) tract. For systemic drug delivery, bioavailability of administered drugs is determined by their …
Advancements in neurotechnology have helped people living with paralysis regain function through brain control of communication interfaces, prostheses, and even restored command of one’s own …
Abstract of "Biological Application of Magnetic Nanoparticles in Targeted Therapeutics and Diagnostics" by Aruna Sigdel, Ph.D., Brown University, May 2014 Theranostics, the combination of diagnosis …
There is a need for smart biomaterials for the improved treatment of fungal infections. With a limited antifungal drug repertoire and the spread of drug …
This dissertation focuses on the development of new drug delivery platforms using carbon nanotubes. Two nanotube systems, namely single walled carbon nanotubes (SWNTs) and multi-walled …
Polymeric nanoparticles loaded with insulin is a highly sought-after drug delivery system in the treatment of diabetes mellitus. The goal of this experiment is to …
This work aims to develop a method of using Fourier-Transform Infrared Spectroscopy (FT-IR) for quantification of polymer levels in biological samples, ex vivo. A method …
Inflammatory bowel disease (IBD) consists of a group of intestinal disorders that cause prolonged inflammation along the gastrointestinal (GI) tract, specifically within the intestines. Biologics …
Diabetics will typically take an insulin regimen with fast acting bolus insulin and long acting basal insulin. The most common methods of delivering this insulin …
Theranostics is the ability to diagnose with greater detail to disease properties and tailor specialized therapeutic regiments to a patient's unique case. Advancements in nanoparticle …
Oral absorption of many potential pharmaceuticals is limited due to problems of enzyme degradation, dissolution and permeation. Bioadhesive poly(fumaric-co-sebacic) anhydride microspheres have been investigated as …
Over the last decade, there has been increased interest in "nanomaterial", which describes materials with structure on one dimension between 1nm and 100nm. A variety …
The ability to encapsulate drugs in a polymer delivery vehicle can have significant practical benefits. Polymers may allow for greater apparent solubility, as well as …
The brain is a highly-privileged organ within the body. Evolution has ensured that access to brain tissue is tightly regulated against or completely impenetrable to …
Nowadays, based on nanotechnology, bio-inspired self-assembled nanomaterials emerged as a type of charming biomaterials for bone and cartilage repair. For example, rosette nanotubes (RNTs) are …
Active pharmaceutical ingredients (APIs) with poor physico-chemical properties such as low solubility or inappropriate lipophilicity often present significant challenges in formulation developments and preclinical investigations. …
