Sepsis is defined as a state of life-threatening organ dysfunction due to dysregulated host response to infection. Because of its complex pathogenesis, sepsis is difficult …
The neutrophil is known as the first responder to bacterial infection, using oxidative and non-oxidative killing mechanisms to prevent pathogens from reproducing and causing further …
The research presented in this thesis aims to examine the role of varied cadherin expression on transformed cells and how this impacts disease severity and …
Natural killer (NK) cells are innate lymphocytes essential for host defense against viral infections and cancer. They recognize and eliminate cells termed ‘altered self’ based …
Abstract of Disruption of yfjD Gene in Francisella, by Japheth Omonira, ScM., Brown University, May 2018. Francisella tularensis is the causative agent of tularemia, a …
E-cigarettes are a variety of ENDS (or electronic nicotine delivery system). They are battery-powered devices that convey an aerosol to the user of propylene glycol, …
T cells are integral to the adaptive immune system and human physiology. A comprehensive understanding T cell signaling pathways can facilitate the utility of T …
Innate lymphoid cells (ILCs) are diverse innate lymphocytes that contribute to the immune response against pathogens and cancer cells, and play a variety of roles …
Helicobacter pylori infection is associated with severe chronic inflammation, however the host immune response is unable to clear the bacterium. Thymus derived lymphocyte populations such …
In the contest between the host immune system and the microbial world, the host has limited genetic material with which to respond to potentially limitless …
Checkpoint blockade therapy, which targets conserved negative regulators of immune cell activation that act as “checkpoint molecules” that govern the balance between inhibition and hyperactivation …
Abstract of “Modeling Innate Immune Triage: The Early Responses to Concurrent Dermal Wounds and Pulmonary Infections” by Yun Xu, Ph.D., Brown University, May 2018 Abstract …
The innate and adaptive immune systems are often considered independent. The innate arm is generalized as broad and non-specific, while the adaptive arm more slowly …
T cells recognize antigens via T cell receptors (TCR), initiating an intracellular signal transduction cascade. Tyrosine is one of the main amino acids that is …
T cells recognize antigens via T cell receptors (TCR), initiating an intracellular signal transduction cascade. Tyrosine is one of the main amino acids that is …
Chitinase 3-like-1 (CHI3L1), a pleiotropic secretory molecule, plays essential roles in the pathogenesis of a variety of malignancies by boosting tumor cell proliferation, migration, epithelial-to-mesenchymal …
Asthma pathogenesis is characterized by type 2 immune responses. Recent studies have established the importance of innate type 2 immune responses and specific cell types …
Schistosomiasis is a neglected tropical disease intimately associated with poverty, which afflicts over 250 million people world-wide and leads to significant morbidity in endemic regions. …
Abstract of SDC4 Identified as a Cell Surface Receptor for Murine Norovirus Nonstructural Protein 1, by Kathryn Bound, ScM., Brown University, May, 2022. Noroviruses are …
