Within the field of microfluidics, scientists have discovered methods to manipulate flow at the micron scale, downsizing standard laboratory procedures. These techniques boast faster results …
Although breast cancer screening assays exist, many are inaccessible, uninformative, and have high turnaround times, leaving a significant need for better alternatives. Here, we propose …
The field of medical diagnostics is governed by two practical goals that drive the engineering and relevant innovation necessary to move the technology forward. Firstly, …
In recent years, there has been an exponential growth in biopharmaceutical development stemming from its ability to treat previously incurable diseases and to go from …
This dissertation reports the development of the PDMS-glass microfluidic chips that integrate nanostructured electrode arrays as the working electrodes in the three-electrode electrochemical cell configurations. …
Molecular diagnostic testing provides critical information to patients that can lead to earlier detection and disease prevention, specific treatment options, and personalized medicine. The workflow …
In fully-developed pressure-driven flow, the spreading of a dissolved solute is enhanced in the flow direction due to transverse velocity variations in a phenomenon now …
Microfluidic devices have the potential to transform diagnostic assays by reducing error, complexity, time, and cost. Furthermore, the miniaturization of multiple assay steps onto a …
"Smart'' hydrogels are 3D networks of crosslinked hydrophilic polymers that can dramatically and dynamically change in response to triggered stimuli such as temperature, pH, and …
This dissertation explores fluid and structure interactions in microfluidic environments using lubrication models to simplify the governing equations of low-Reynolds number flows. In addition, I …
The past quarter-century of biomedical research has seen the emergence of powerful and transformational methods such as quantitative polymerase chain reaction, next generation sequencing, and …
Microfluidic technology provides a means of precisely controlling fluid flow for molecular analytics and diagnostics, as well for the biological analysis of cells and small …
Microfluidics based diagnostic systems are believed to have great competency for the ever-demanding healthcare in resource limited settings. These miniaturized devices have promise for detecting …
This project aims to improve control and predictability in the liquid lithography process, which is a promising method for simplifying the fabrication of 3D microstructures …
Biomedical research is inherently multidisciplinary and multi-branched. Translational research, such as medical diagnostics often require the marriage of multiple fields of expertise. In this dissertation, …
Cells are rich in a variety of diagnostic information, from morphology to nucleic acid, protein, and metabolite composition. Cells possess more data than any other …
Many diagnostic tests are dependent on the effective capture and amplification of nucleic acids. However, the biological samples which contain the target molecules (blood, urine, …
Diffusiophoresis and diffusioosmosis are the motion of a particle and flow near a stationary boundary, respectively, in the presence of a solute concentration gradient. They …
Next generation sequencing (NGS) analysis, isolation and identification of rare cell events, analysis and characterization of extraction genetic material requires multiple use of manual steps …
