Abstract Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons, which causes muscle wasting …
Abstract of “Exosome detection of brain abnormalities and responses to treatment in an alcohol related brain disease”, by Camilla Macy Homans, Biotechnology ScM., Brown University, …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by a progressive, rapid loss of motor function. Within 3-5 years, a loss of motor function …
The insulin (IR) and insulin-like growth factor receptors (IGF-IR) are critical mediators of growth, development and survival. Given their immense biological significance, a complex system …
Resistance to starvation is a classical complex trait, where varying genetic and environmental landscapes can greatly modify an animal’s ability to cope. In this study, …
Amyotrophic Lateral Sclerosis (ALS) is a fatal multisystem neurodegenerative disease characterized by progressive loss of neuronal function. The disease has no cure and is fatal …
The motor system is vital for an organism’s survival. Information to control motor function flows from the brain and spinal cord, through peripheral nerves and …
Christianson syndrome (CS) is a monogenic, X-linked neurological disorder caused by loss-of-function mutations in the gene encoding endosomal Na+/H+ exchanger 6 (NHE6) (also known as …
Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease with symptom-onset occurring in adulthood. ALS is characterized by progressive degeneration of upper and lower motor …
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive impairment in cognitive ability and memory loss. On a pathological and molecular level, AD has …
Recessive loss-of-function mutations in the mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) in humans cause reduced postnatal brain growth, and cognitive and motor disability. GPT2 …
The human brain's intricate machinery relies on the seamless function of its neurons throughout the organism’s lifetime. However, when faced with genetic mutations or environmental …
Over time, more neurodegenerative disorder-linked mutations are being discovered, with more components of RNA/RNP granules containing disordered regions/domains and exhibiting the ability to undergo liquid-liquid …
