The central nervous system (CNS) contains a complex assortment of cell types and extracellular matrix proteins, which are arranged into an intricate architecture and ultimately …
The etiology of schizophrenia (SCZ) remains elusive, though dopaminergic and genetic influences have been established as contributing factors to the disease’s pathophysiology. Current treatments for …
Pain, particularly chronic pain, is a debilitating condition that detracts from multiple facets of daily life in millions of people. Spinal cord stimulation (SCS) is …
The need to arrest ongoing or planned actions is a hallmark of adaptive control that is crucial for goal-directed behaviors and survival. When the brain …
An essential step in the development of a cortical auditory neural prothesis (ANP) is the development of a reliable method for reconstructing acoustic stimuli from …
Neuroprosthesis research aims to enable communication between the brain and external assistive devices while restoring lost functionality such as occurs from stroke, spinal cord injury …
Midbrain dopamine neurons are functionally heterogeneous as demonstrated by the wide variety of behaviors they support and brain circuits they participate in, including reward signaling, …
When a neurological disorder prevents proper communication between central and peripheral aspects of the nervous system, significant motor and sensory deficits often result. Understanding the …
Nervous system wiring is accomplished by individual axons sensing a multitude of attractive and repulsive chemical cues in their environment and growing in response to …
To construct a functional nervous system, billions of neurons must form trillions of connections during embryonic and postnatal stages. Errors in the complex processes that …
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease of motor neurons that affects at least 30,000 people in the United States at any one time …
Abstract Amyotrophic lateral sclerosis (ALS) is a lethal neurodegenerative disease characterized by the degeneration of both upper and lower motor neurons, which causes muscle wasting …
Neural circuits give direct insight into cognition, behavior, and various disease states. A circuit’s connectivity largely determines its role, highlighting the importance of circuit mapping. …
Fragile X syndrome, a leading cause of autism and the most common form of inherited intellectual disability, results from the loss of Fragile X mental …
Human pluripotent stem cells have the theoretical capacity to produce every cell type of the body in vitro. Such stem cell-derived tissue grants unprecedented access …
Why should an animal move? Given that actions have time, energy, and opportunity costs, all behavior should benefit an animal, maximizing its current or future …
Commissural neurons are a highly heterogenous neural subtype that have been extensively studied for their axon guidance properties in the developing spinal cord. During spinal …
Although Type I lissencephaly is one of the most severe cortical malformation disorders and is highly comorbid with epilepsy, the cellular and circuit mechanisms driving …
My graduate work examined the reaction of neuronal cells to the shape of their extra-cellular environment. Over the last century, many studies have confirmed that …