Increased oscillations and synchronized behavior in the Subthalamic Nucleus (STN) and nearby structures have been linked to the progression of Parkinson’s Disease (PD), and this …
Objective: Deep brain stimulation (DBS) has become a widely adopted treatment for the advanced progression of Parkinson’s disease (PD) and is thought to modulate the …
Parkinson’s disease (PD) is a debilitating, progressive neurological disease that involves the degeneration of dopaminergic neurons. Incidence and prevalence of the disease increases with age. …
The insulin (IR) and insulin-like growth factor receptors (IGF-IR) are critical mediators of growth, development and survival. Given their immense biological significance, a complex system …
Parkinson’s disease (PD) is a common neurodegenerative disease characterized by distinct motor symptoms such as tremor, bradykinesia, and rigidity. These symptoms present heterogeneously across patients …
Neurodegenerative diseases are a group of etiologically heterogeneous diseases characterized by the loss of a vulnerable subset of neurons. Despite this heterogeneity in etiology, TDP-43 …
Magnetic resonance (MR) has expanded over the past few decades into exciting new applications that have advanced the diagnosis, evaluation and treatment of many diseases. …
Abstract of Neural Biomarker Based Parameter Optimization Using Deep Brain Stimulation for Parkinson’s Disease, by Pranav Akella, ScM., Brown University, May 2022. Introduction: Parkinson’s Disease …
Deep brain stimulation (DBS) is an effective treatment for the mid/late stage Parkinson’s disease (PD), which significantly reduces the dopamine medication and improves motor symptoms. …
The phosphatidylinositol 3 kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway is essential for cell survival, growth, proliferation, and differentiation. It is highly conserved and …
Parkinson’s disease (PD) is a neurodegenerative movement disorder associated with the death of dopaminergic neurons in the substantia nigra. Mutations and deletions in the DJ-1 …
