Abstract of An Exploration of the Biology Underlying Epigenetic Clocks by Nicholas J. Skvir, Ph.D., Brown University, October 2022. Epigenetic clocks have gained popularity over …
Candida albicans is an opportunistic human fungal pathogen that can adapt to fluctuating host environments by both genetic and epigenetic mechanisms. In this study, the …
Quiescent neural stem cells (NSCs) are the source of new neurons in the adult mammalian brain. Upon activation, NSCs proliferate and return to quiescence or …
Despite many studies linking FOXO factors to longevity, how these factors directly regulate aging particularly in humans, is not completely understood. The focus of this …
Background: Stem cell maturation is a fundamental, yet poorly understood aspect of human development. We devised a DNA methylation signature that represented embryonic stem cells …
Objective: To assess the association between prenatal methamphetamine exposure (PME) and methylation of the gene 11-Beta hydroxysteroid dehydrogenase type 2 (11B-HSD2) Methods: The Infant Development, …
Abstract of Inhibition of HDAC7 Using RNAi As an Epigenetic- Based Therapy in Targeting Malignancies, by Ola Hassan, Ph.D., Brown University, May 2024. Class IIa …
MicroRNAs (miRNAs) are conserved post-transcriptional regulators which epigenetically suppress mRNAs in precise, highly regulated yet convoluted manners. MiRNAs are essential for the development and maintenance …
Background: Periodontal disease and DNA methylation markers have separately been associated with lung cancer risk. Evaluating methylation levels at two relevant genomic regions that serve …
Preterm birth and low birth weight are associated with both short-term (e.g., cerebral palsy, developmental delays) and long-term (e.g., kidney disease, hypertension) adverse health outcomes. …
Abstract Background: Global prevalence of Type 2 diabetes (T2D), especially in Samoa, has risen significantly, leading to 66% premature deaths. Gender disparities in risk are …
Epigenetic mechanisms have been proposed to act as mediators for the pathway between the environment and the genome and evidence for the regulatory action of …
The mammalian olfactory cortex is central to the historical definition of paleocortex, a three-layered cortical trait that resembles the cortex of reptiles and amphibians, and …
Alzheimer’s Disease (AD) is a neurodegenerative disorder characterized by progressive impairment in cognitive ability and memory loss. On a pathological and molecular level, AD has …
Aging is the one thing that no person has survived. This complex phenotype is driven by many changes, including an increased prevalence of cellular senescence. …
