Ischemic heart disease (IHD) is the single leading cause of death in the world and restorative treatment for IHD poses a global healthcare challenge. Myocardial …
Central nervous system disease pathologies are poorly understood in part due to the inability of animal and in vitro models to recapitulate their complexity. It …
While 2D in vitro cell culture models have been used over the decades, 3D cell culture technique is becoming increasingly important as it better replicates …
Tendon and ligament injuries display poor healing capacities from the formation of scar-like tissue resulting in decreased mechanical properties. The application of biomechanics, the study …
Meniscus tears are among the most frequent orthopaedic injuries that commonly affect active and young populations. These tears ultimately increase the risk of developing post-traumatic …
Cardiac patch therapies have become a promising treatment to lower the risk of heart failure after myocardial infarct to restore heart function. Engineered tissue scaffolds …
The thesis introduces a novel computational tool developed using graph theory and implemented in Wolfram Mathematica to analyze neuronal network integrity within three-dimensional cortical microtissues. …
Early tissue formation and regeneration is regulated by mechanical forces. However, few tools exist that can measure such forces in situ in cell-dense structures and …
Introduction: Osteoarthritis is a debilitating joint disease that affects over 27 million Americans. Tissue engineered cartilage could be a viable option for patients that have …
The need for tissues and organs presents a complex problem for our society that can be potentially resolved through bioengineering. Thus, there is an extensive …
Sorting methods are important tools that enable cellular subpopulation isolation for basic science investigations and clinical therapies. Each method can be characterized by a set …
The systemic shift in healthcare towards precision medicine has prompted the alignment of anticancer drug selection with a more individualized approach. Moreover, advancements in 3D …
Cardiovascular engineering using human pluripotent stem cell (hPSC)-derived cardiomyocytes holds incredible potential for disease modeling, therapeutic development and testing, and cardiac regeneration. The heterogeneity and …
Due to the global burden of cardiovascular disease, there exists a need for readily available blood vessel replacements that can integrate into the patient’s native …
Cells are rich in a variety of diagnostic information, from morphology to nucleic acid, protein, and metabolite composition. Cells possess more data than any other …
The advancement of three dimensional biological techniques, such as microtissues, allows for the more accurate representation of in vivo structures. Yet, the added dimension pushes …
