ABSTRACT Amyotrophic Lateral Sclerosis (ALS), the most common adult-onset motor neuron disease in the world, can be caused by mutations scattered along the full length …
The mouse olfactory system mediates the sense of odorants and appropriate behavioral responses. The main olfactory epithelium (MOE) expresses the largest number of G-protein coupled …
The aim of this thesis research is to identify and model neuromuscular diseases. I focused on two particular congenital neuromuscular diseases. Among the many genes …
Aging is generally defined as the progressive and time-dependent loss of function accompanied by increasing vulnerability to diseases and mortality. In particular, aging is associated …
Skeletal muscle atrophy has been well characterized in various animal models, and while certain pathways that lead to disuse atrophy and its associated functional deficits …