Active pharmaceutical ingredients (APIs) with poor physico-chemical properties such as low solubility or inappropriate lipophilicity often present significant challenges in formulation developments and preclinical investigations. …
This dissertation is centered on two areas: (i) rational design and synthesis of robust porous metal-organic frameworks using well-defined building blocks and (ii) synthesis of …
The volatile metabolite geosmin is a degraded sesquiterpene that is responsible for the characteristic smell of moist soil. Geosmin is produced by a wide range …
Pulsed gradient spin-echo (PGSE) diffusion NMR spectroscopy was designed to measure diffusion coefficients and deduce the hydrodynamic radii of molecules in solution. By incorporation of …
By high temperature decomposition, magnetic nanoparticles (MFe2O4, Co, Fe, Au-Fe3O4, M=Fe, Mn, Co) were synthesized. The nanoparticles' size and composition can be well controlled through …
The investigations of single metal nickel, cadmium, and lead, and copper/nickel mixtures in the particulate spouted bed of conductive particles from acidic aqueous solution are …
Tetrahydroisoquinolines (THIQ) are an important structural motif in many alkaloids, and they display significant biological and pharmacological properties. A majority of these compounds possess a …
A series of 1,5-bis(alkoxymethyl) anthracene derivatives was designed and synthesized for development of structure - monolayer morphology relationships. The morphologies and unit cells of the …
Over the last decade, there has been increased interest in "nanomaterial", which describes materials with structure on one dimension between 1nm and 100nm. A variety …
Surfactants-Mediated Method is adapted in the chemical synthesis of FePt nanoparticles. The size and structure of FePt nanoparticles can be simply tuned by controlling the …
Monodisperse nanoparticles (NPs) below 20nm are of intense current interests, not only for the general miniaturization of the size, but also for their novel properties. …
There have been intensive studies on not only the structure of quinonoid metal complexes but also the metal-organometallic coordination polymers by the use of quinone …
Carbohydrate-carbohydrate interactions (CCIs) make up a separate genre of interactions that have been implicated in intercellular adhesion and signaling. As with most carbohydrate-binding interaction, CCIs …
Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases …
Cross-linked polymer shells are coated at the surface of gold nanoparticles through surface-initiated ring-opening metathesis polymerization followed by selective cross-linking. The stability of the cross-linked …
This dissertation work focuses on preparations and applications of robust, physisorbed SAMs on HOPG. The molecules contain an anthracene derivative core and two -CH2OC6H12OC22H45 side …
Streptomyces are Gram-positive, filamentous, soil-dwelling saprophytic bacteria that are the source of a vast array of bioactive secondary metabolites. The albaflavenone biosynthetic gene cluster in …
Rydberg Fingerprint Spectroscopy (RFS) has been deftly applied to small molecules and shown exquisitely sensitive to global molecular structure. This has stimulated interest in its …
Reversible protein phosphorylation plays a vital role in the regulation of cellular signaling pathways. With recent breakthrough developments in mass spectrometry-based proteomics technologies, including phosphopeptide …