Serous epithelial ovarian cancer (EOC) is the most lethal gynecological malignancy and is associated with accumulation of ascites fluid, which is rich in cell-secreted exosomes. …
T cells recognize antigens via T cell receptors (TCR), initiating an intracellular signal transduction cascade. Tyrosine is one of the main amino acids that is …
T cell receptor (TCR) activation, driven by the phosphorylation of tyrosine kinases, is crucial in mounting proper adaptive immune responses. Although major kinases and phosphatases …
T cells are integral to the adaptive immune system and human physiology. A comprehensive understanding T cell signaling pathways can facilitate the utility of T …
T cells recognize antigens via T cell receptors (TCR), initiating an intracellular signal transduction cascade. Tyrosine is one of the main amino acids that is …
The ability to detect and adapt to changing conditions and circumstances is a requirement of life at both the organismal and cellular levels. Inside the …
The S-palmitoylated signal-transducing rat sarcoma GTPase (Ras), which plays important roles in cellular growth, division, and differentiation, is frequently mutated in various types of cancer. …
Reliable quantitation of protein abundance is fundamental in accurately determining differential protein expression associated with biological phenomena such as cell growth and differentiation, disease progression, …
The α7 nicotinic acetylcholine receptor (α7 nAChR), a ligand-gated ion channel whose involvement in numerous neurological and somatic pathologies makes it a target of considerable …
Mass spectrometry has been a long-standing analytical tool for chemists. Tandem mass spectrometry-based proteomics capitalizes on the sensitivity, accuracy, and efficiency of this classic technique …
Recent advances in the speed and sensitivity of mass spectrometers and analytical methods, the exponential acceleration of computer powers, and the availability of genomic databases …