Multicellular aggregate assembly, whereby individual cells coalesce into a single multicellular structure, is a phenomenon that can model both healthy tissue morphogenesis and cancer pathogenesis. …
The repair of damaged skeletal muscle may be enhanced by the injection of muscle stem cells and/or recombinant growth factors, but is currently limited by …
The method of phase inversion nanoencapsulation was utilized to develop an oral insulin microsphere delivery system fabricated from poly(fumaric-co-sebacic anhydride) (p(FASA)). As particle uptake in …
My graduate work examined the reaction of neuronal cells to the shape of their extra-cellular environment. Over the last century, many studies have confirmed that …
Oral absorption of many potential pharmaceuticals is limited due to problems of enzyme degradation, dissolution and permeation. Bioadhesive poly(fumaric-co-sebacic) anhydride microspheres have been investigated as …
Mucoadhesion is defined as the adhesion between a biomaterial and mucus. Mucoadhesion enhances drug delivery by increasing transit time and causing intimate contact with intestinal …
How to deliver the increasing number of therapeutics with poor oral bioavailability in pill form is one of the greatest challenges currently facing the field …
When exposed to pressures below and above their glass transition temperature (Tg) and melting temperatures (Tm) over time, both the amorphous and crystalline regions of …
Central nervous system (CNS) pathologies which are characterized by cell death and tissue loss currently lack effective treatment options. Cell therapies have emerged as a …
The work in this dissertation develops two different biomaterial approaches towards advancing our understanding of how neural cell behavior, specifically migration and proliferation, can respond …