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Our research revealed that the bioprinting field has advanced rapidly in the past two decades and is close to creating tissue products with high commercial and therapeutic value. We found that the commercial adoption of bioprinted products will likely occur for in vitro tissue models first, within 5-10 years, for simple tissue grafts like skin and bone second, in 10- 15 years, followed by vascularized patches and functional organ regeneration implants third, in 20-25 years, and organ transplants last, 3-4 decades in the future.

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Life-course associations between access to green space and blood lipid levels By Anthony Mei April 29, 2018 Honors thesis submitted in partial fulfillment of the requirements for graduating with the degree of Bachelor of Arts with Honors in the Health and Human Biology concentration at Brown University 1 I INTRODUCTION The Centers for Disease Control and Prevention report that cardiovascular disease (CVD) is the primary cause of death among American adults [1].

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Microbiome analysis of Brassica fermentation Michelle A. Zabat Department of Molecular Microbiology & Immunology Dr. Peter Belenky, Thesis Advisor Dr.

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The results show a stable level of dSirt6 expression in the brain over the fly lifespan. A long-term decrease in dSirt6 expression in the AD model flies was also shown. However, the effect on dSirt6 expression in the AD models is dynamic over the lifespan and sex-specific.

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The Role of Type 2 Polyaxonal Amacrine Cells (PAC2) in mediating light adaptation Work conducted under advisor: Dr. David M. Berson Marjo Beltoja, Biophysics, Class of 2018 A thesis presented for the Honors in Biophysics Bachelors of Science Degree Department of Biophysics Brown University USA April, 2018 Contents 1 Abstract 4 2 Introduction 6 2.1 Anatomy of the Retina . . . . . . . . . . . . . . . . . . . . . . . . . . 6 2.2 Amacrine Cells . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 2.3 The Intrinsically Photosensitive Retinal Ganglion Cell . . . . . . . . . 11 3 Methods 14 3.1 Animal Model Used . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 3.2 Retinal Tissue Preparation . . . . . . . . . . . . . . . . . . . . . . . . 14 3.3 Imaging via SBEM . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 3.4 Tracing Software . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 4 Results 17 4.1 The Polyaxonal Amacrine Cell (PAC 2) Circuitry . . . . . . . . . . . 17 5 Discussion 25 5.1 Summary of results . . . . . . . . . . . . . . . . . . . . . . . . . . . . 25 5.2 Further directions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 26 5.3 Limitations of Knossos Tracing . . . . . . . . . . . . . . . . . . . . . 26 5.4 Advantages of Knossos Tracing . . . . . . . . . . . . . . . . . . . . . 28 6 Acknowledgments 29 6.1 Appreciations . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 29 6.2 Contributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 30 2 List of Figures 2.1 General overview of the retina’s location in the eye. . . . . . . . . . . 7 2.2 The different layers constituting the retina. . . . . . . . . . . . . . . . 8 2.3 A likely model of how PAC2s modulate RGCs. . . . . . . . . . . . . . 10 2.4 The M1-M3 ipRGCs displayed in numerical order starting with the M1 on the far left. . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 4.1 Electron micrograph of an output synapse from the PAC2. . . . . . . 18 4.2 Output synapses of the PAC 2. . . . . . . . . . . . . . . . . . . . . . 19 4.3 A.

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This disruption has been shown to result in mitochondrial dysfunction associated with ROS dependent oxidative stress. Mitochondrial inheritance is entirely maternal, so mothers exposed to chemicals like Nitrogen Mustard face the risk of passing down damaged mitochondria in their oocytes to their children, as oocytes do not allow for the destruction of damaged oocytes through mitophagy.

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Visualizing Nanoparticles: Integration of Methods Used for Biological and Polymeric Interfaces Seeta Rajpara B.S., The University of California, Irvine, 2012 Thesis Submitted in partial fulfillment of the requirements for the Degree of Master of Science in the Department of Molecular Pharmacology, Physiology and Biotechnology at Brown University Providence, Rhode Island May 2016 AUTHORIZATION TO LEND AND REPRODUCE THIS THESIS As the sole author of this thesis, I authorize Brown University to lend it to other institutions or individuals for the purpose of scholarly research.

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We Don’t Need Your Pity, We Need Our Rights:” Understanding the Experiences of Sex Workers within the HIV Continuum of Care in the United States Julianna Brown April 20, 2018 Health and Human Biology Forward This project serves as an undergraduate honors thesis within the Health and Human Biology Department at Brown University.

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