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This disruption has been shown to result in mitochondrial dysfunction associated with ROS dependent oxidative stress. Mitochondrial inheritance is entirely maternal, so mothers exposed to chemicals like Nitrogen Mustard face the risk of passing down damaged mitochondria in their oocytes to their children, as oocytes do not allow for the destruction of damaged oocytes through mitophagy.

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Visualizing Nanoparticles: Integration of Methods Used for Biological and Polymeric Interfaces Seeta Rajpara B.S., The University of California, Irvine, 2012 Thesis Submitted in partial fulfillment of the requirements for the Degree of Master of Science in the Department of Molecular Pharmacology, Physiology and Biotechnology at Brown University Providence, Rhode Island May 2016 AUTHORIZATION TO LEND AND REPRODUCE THIS THESIS As the sole author of this thesis, I authorize Brown University to lend it to other institutions or individuals for the purpose of scholarly research.

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