BioLuminescent-OptoGenetic molecules for driving and imaging neural activity have a number of advantages in vivo. In this approach, genetically expressed luciferases bind with injected luciferins …
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
This recorded lecture introduces undergraduate students to the advantages of bioluminescence as an optical reporter of a chemical reaction and its use with optogenetics (BL-OG) …
Fluorescence-based optogenetic tools are powerful methods for dissecting cell-type specific circuit dynamics in the nervous system. These tools, however, rely on external, generic modification of …
Using optogenetics, we can manipulate neuronal activity using light. Due to the young age of the animals used in this study, a non-invasive light source …
This is a movie showing bioluminescence of the Choroid Plexus in a transgenic mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing bioluminescence in left primary somatosensory cortex in a mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing bioluminescence in left primary somatosensory cortex in a mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing Calcium Dependent Bioluminescence in a mouse expressing LMC4 in left primary somatosensory cortex. Water soluble Coelenterazine (CTZ) was injected in …
Despite ever improving treatment methods, there still is no way to effectively restore function after spinal cord injury. A promising approach is to re-engage spinal …
The amount and pattern of neuronal activity present during the early developmental period is believed to guide structural and functional properties of neural circuit assembly. …
The amount and pattern of neuronal activity present during the early developmental period is believed to guide structural and functional properties of neural circuit assembly. …
Bioluminescent optogenetics (BL-OG) can be utilized for trans-synaptic neuronal communication by expressing the light emitting luciferase in the presynaptic and the light sensing opsin in …
Biological light activation of optogenetic sensors across synaptic partners offers the potential to optogenetically dissect synaptic communication non-invasively. The genetically encoded light source, a luciferase, …
Bioluminescent optogenetics (BL-OG) can be utilized for trans-synaptic neuronal communication by expressing the light emitting luciferase in the presynaptic and the light sensing opsin in …
