In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
In BioLuminescent driven OptoGenetics (BL-OG) a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. When light emitter …
This is a movie showing bioluminescence in left primary somatosensory cortex in a mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing bioluminescence in left primary somatosensory cortex in a mouse expressing the LMO3 molecule. Water-Soluble Coelenterazine (CTZ) by Nanolight was injected …
This is a movie showing Calcium Dependent Bioluminescence in a mouse expressing LMC4 in left primary somatosensory cortex. Water soluble Coelenterazine (CTZ) was injected in …
This is a movie showing Calcium Dependent Bioluminescence in a mouse expressing LMC4 in left primary somatosensory cortex. Water soluble Coelenterazine (CTZ) was injected in …
Despite ever improving treatment methods, there still is no way to effectively restore function after spinal cord injury. A promising approach is to re-engage spinal …
A non-invasive and highly specific approach to neuronal stimulation is bioluminescent-optogenetics, where genetically expressed light emitting luciferases are tethered to light sensitive channelrhodopsins (luminopsins, LMO); …
Coelenterazine (CTZ) is the substrate of many luciferases and photoproteins critical for native and applied bioluminescence. CTZ has a long track-record and is welltolerated across …
Biological light activation of optogenetic sensors across synaptic partners offers the potential to optogenetically dissect synaptic communication non-invasively. The genetically encoded light source, a luciferase, …
