This recorded lecture introduces undergraduate students to the advantages of bioluminescence as an optical reporter of a chemical reaction and its use with optogenetics (BL-OG) …
This digital poster created for the 2021 BRAIN Initiative Investigators Meeting provides an overview of the advantages of bioluminescence for neuroscience research. Our BioLuminescent-OptoGenetics (BL-OG) …
In BioLuminescent OptoGenetics, a genetically encoded light source, a luciferase, activates a light-sensing optogenetic element, a channelrhodopsin or a pump. Here, we leveraged this coupling …
State-of-the-art imaging tools rely on a restrained preparation, limiting natural behavior while measuring cellular activity via fluorescence (FL). Recently, advances in wearable microscopy expanded the …
A wealth of new tools can directly control output of specific neurons on fast (e.g., optogenetic) or sustained (e.g., chemogenetic) time scales. In contrast, almost …
Coelenterazine (CTZ) is the substrate of many luciferases and photoproteins critical for native and applied bioluminescence. CTZ has a long track-record and is welltolerated across …