- Title Information
- Title
- Nano-fabrication and Characterization of Novel Titanium Surfaces for Vascular Stent Application
- Name:
Personal
- Name Part
- Lu, Jing
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
- 2010
- Physical Description
- Extent
- xxxvi, 295 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D. -- Brown University (2010)
- Name:
Personal
- Name Part
- Webster, Thomas
- Role
- Role Term:
Text
- Director
- Name:
Personal
- Name Part
- Hurt, Robert
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Stein, Derek
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Franck, Christian
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Darling, Eric
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- The limit of current vascular stents lies in in-stent restenosis due to incomplete endothelialization, vascular smooth muscle cell hyperproliferation and immune responses. In this case, modifying vascular metal stent surface properties becomes important. Bio-inspired nano-structured stents might be promising alternative for current drug-eluting vascular stents. There are three important surface properties to be considered to fabricate such materials: topography, roughness and surface energy. The contribution of the present study to the field of vascular implantology centers on investigating effects of different surface features in vascular and immune cell functions and then developing bio-mimicking nano/sub-micron structured titanium surfaces with optimal surface properties to control cellular responses using nanotechnology. To achieve these goals, different titanium surface topographies (including patterned and non-patterned surface features), different surface roughness and surface energy, were created by plasma dry etching-based micromachining techniques (TIDE process), e-beam deposition and cold compaction in this study. These surfaces were investigated for their ability to control vascular cell and immune responses to find the optimal surface parameters for better bare-metal vascular stents. In addition, some of the more complicated cell culture models, including competitive co-culture systems and dynamic flow systems, were employed to better understand different cell behaviors in vitro. Finally, correlation of surface energy, adsorption of major extracellular matrix protein and cell responses was studied to determine the mechanism of different cell responses to different surface features. Results demonstrated bio-mimicking nanopatterned titanium surfaces significantly improve vascular endothelial cells. In terms of surface roughness and energy, it was concluded different surface roughness was correlated to surface energy and thus regulate different cell functions. For the first time, results demonstrated that e-beam deposition combined with masking techniques was able to control different optimal surface properties (nano to sub-micron patterned titanium) and thus has great potential for fabricating next generation bare-metal vascular stents.
- Subject
- Topic
- Vascular stents
- Subject
- Topic
- Surface properties
- Subject
- Topic
- Cell functions
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1151522")
- Topic
- Titanium
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1032639")
- Topic
- Nanotechnology
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20111003
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z0N8780P
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations