<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-7.xsd"><mods:titleInfo><mods:title>Delivering Functionalized Gold Nanorods to the Rodent Cerebral Cortex for Near-Infrared Neural Stimulation</mods:title></mods:titleInfo><mods:typeOfResource>text</mods:typeOfResource><mods:name type="personal"><mods:namePart>Hussein, Kareem R.</mods:namePart><mods:role><mods:roleTerm type="text">creator</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Lee, Jonghwan</mods:namePart><mods:role><mods:roleTerm type="text">Advisor</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Borton, David</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Gray, Marissa</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="corporate"><mods:namePart>Brown University. Biology and Medicine: Biomedical Engineering</mods:namePart><mods:role><mods:roleTerm type="text">sponsor</mods:roleTerm></mods:role></mods:name><mods:originInfo><mods:copyrightDate>2020</mods:copyrightDate></mods:originInfo><mods:physicalDescription><mods:extent>ix, 25 p.</mods:extent><mods:digitalOrigin>born digital</mods:digitalOrigin></mods:physicalDescription><mods:note type="thesis">Thesis (Sc. M.)--Brown University, 2020</mods:note><mods:genre authority="aat">theses</mods:genre><mods:abstract>Introduction: Near-infrared neural stimulation has potential advantages such as non-invasiveness and no need for genetic manipulation. But it has not been well demonstrated in the cortex in vivo, mainly due to the difficulty in delivering nanoparticles to the tissue. The purpose of this thesis is to optimize the delivery efficiency of functionalized gold nanorods to the mouse cortex and identify how long the particles remain in the tissue as the physiological washout occurs in vivo. This aids in feasibility for future research in near-infrared stimulation of cortical neurons. Methods: Intracortical nanorod injections during craniotomies were performed. Fixed &amp; live coronal tissue slices were imaged 1 or 2 days later via two-photon luminescence microscopy to detect nanorod luminescence. Results: Abundant green spots were detected from the nanorod-injected and opposite hemispheres while almost no green spots were seen in live control cortices.</mods:abstract><mods:subject><mods:topic>AuNRs</mods:topic></mods:subject><mods:subject><mods:topic>gold nanorods</mods:topic></mods:subject><mods:subject><mods:topic>intracortical injection</mods:topic></mods:subject><mods:subject><mods:topic>streptavidin</mods:topic></mods:subject><mods:subject><mods:topic>intracortical nanorod injection</mods:topic></mods:subject><mods:subject><mods:topic>NINS</mods:topic></mods:subject><mods:subject><mods:topic>near infrared neural stimulation</mods:topic></mods:subject><mods:subject><mods:topic>two-photon luminescence imaging</mods:topic></mods:subject><mods:subject><mods:topic>TPL imaging</mods:topic></mods:subject><mods:language><mods:languageTerm authority="iso639-2b">English</mods:languageTerm></mods:language><mods:recordInfo><mods:recordContentSource authority="marcorg">RPB</mods:recordContentSource><mods:recordCreationDate encoding="iso8601">20200720</mods:recordCreationDate></mods:recordInfo><mods:identifier type="doi">10.26300/hynx-gy96</mods:identifier><mods:accessCondition type="rights statement" xlink:href="http://rightsstatements.org/vocab/InC/1.0/">In Copyright</mods:accessCondition><mods:accessCondition type="restriction on access">Collection is open for research.</mods:accessCondition></mods:mods>