- Title Information
- Title
- Towards Automated Additive Manufacturing of Bio-Tubes
- Name:
Personal
- Name Part
- Manning, Kali L
- Role
- Role Term:
Text
- creator
- Name:
Personal
- Name Part
- Morgan, Jeffrey
- Role
- Role Term:
Text
- Advisor
- Name:
Personal
- Name Part
- Schell, Jacquelyn
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Hoffman-Kim, Diane
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Tripathi, Anubhav
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Waller, Kimberly
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. Biology and Medicine: Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Origin Information
- Copyright Date
- 2020
- Physical Description
- Extent
- xv, 125 p.
- digitalOrigin
- born digital
- Note:
thesis
- Thesis (Ph. D.)--Brown University, 2020
- Genre (aat)
- theses
- Abstract
- While many strides have been made in the field of tissue engineering since its inception, the need for a physiologically relevant biological substitute remains unmet. One facet of tissue engineering that still needs to be developed is manufacturing schemes for human tissue products. Currently, a manufacturing gap exists that makes clinical translation of products challenging. Manufacturing is an essential component of any commercial product since it produces products faster, more reproducibly, and more uniformly of a higher quality than if manually constructed. Automation is a crucial aspect of manufacturing that greatly assists in producing products of a higher quality at a quicker speed while reducing human error. Automated biofabrication methods have only recently begun to be investigated, however, they are a critical step in the advancement of human tissue products and their eventual clinical translation. Specifically, there is a need for a simple self-aligning automated technique using standard components readily available and easily translatable into existing automated schemes. The work presented herein develops a novel method for the biofabrication of bio-tubes using automated additive manufacturing techniques. The thesis is presented in three sections which aim to (1) develop a new microtissue manipulation platform for the fabrication of bio-tubes, (2) automate the new method and develop a real-time quality control step using vision recognition, and (3) discuss the theory behind fabricating a vascular unit containing a blood vessel-like tube that branches into a perfusable capillary tissue bed, an application of the developed automated method. Completion of these aims is a step toward creating automated manufacturing schemes for human tissue products and their eventual translation into clinical settings.
- Subject
- Topic
- tissue engineering
- Subject
- Topic
- biofabrication
- Subject
- Topic
- Additive Manufacturing
- Subject
- Topic
- Microtissue Manipulation
- Language
- Language Term (ISO639-2B)
- English
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20200720
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations