<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-7.xsd">
  <mods:titleInfo>
    <mods:title>DCLK1 Inhibits Vesicular Trafficking in Non-Neuronal Cells</mods:title>
  </mods:titleInfo>
  <mods:abstract>Normal brain development, involving neuronal migration, polarity and differentiation, requires &#13;
synaptic trafficking of essential cargo. These cargo are primarily transported on microtubules &#13;
(MTs), which play a key role in neuronal morphology. Mutations in MT-related proteins were &#13;
previously found to be associated with epilepsy.&#13;
&#13;
Specifically, Dcx and Dclk1 (doublecortin family proteins) were found to regulate Kif1a (a kinesin &#13;
motor protein) mediated transport and localization in neurons (Liu et. al 2012). However, it is &#13;
unknown whether Dclk1 alone is sufficient for transport.Vamp2, a vesicle membrane protein &#13;
carried by Kif1a, has been found to be transported by other kinesins, including Kif53 and Kif23.6 &#13;
In particular, these kinesins are expressed significantly more in conventional non-neuronal HEK &#13;
and HeLa cells as opposed to Kif1a7. It is possible that Dclk1 plays a different role in trafficking &#13;
when Kif1a is not the primary transporter of Vamp2-containing vesicles. &#13;
&#13;
Our experiments show that Dclk1 inhibits mobile vesicle movement in two cell culture models &#13;
expressing low levels of Kif1a, indicating a potential role for Dclk1 in mediating other modes of &#13;
vesicle trafficking.</mods:abstract>
  <mods:name type="personal">
    <mods:namePart>Lee, Jenny</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">creator</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:name type="personal">
    <mods:namePart>McCarthy-Sinclair, Brendan</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">creator</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:name type="personal">
    <mods:namePart>Papendorf, Carin</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">creator</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:name type="personal">
    <mods:namePart>Liu, Judy S.</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">creator</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:name type="personal">
    <mods:namePart>Dr. Judy S. Liu</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">advisor</mods:roleTerm>
    </mods:role>
    <mods:affiliation>Brown University. Department of Molecular Biology, Cellular Biology, and Biochemistry</mods:affiliation>
  </mods:name>
  <mods:name type="corporate">
    <mods:namePart>Brown University. Karen T. Romer Undergraduate Teaching and Research Awards</mods:namePart>
    <mods:role>
      <mods:roleTerm type="text">research program</mods:roleTerm>
    </mods:role>
  </mods:name>
  <mods:subject authority="fast" authorityURI="http://id.worldcat.org/fast" valueURI="http://id.worldcat.org/fast/01024734">
    <mods:topic>Molecular biology</mods:topic>
  </mods:subject>
  <mods:subject authority="fast" authorityURI="http://id.worldcat.org/fast" valueURI="http://id.worldcat.org/fast/00914183">
    <mods:topic>Epilepsy</mods:topic>
  </mods:subject>
  <mods:language>
    <mods:languageTerm type="text" authority="iso639-2b">English</mods:languageTerm>
  </mods:language>
  <mods:typeOfResource>still image</mods:typeOfResource>
  <mods:genre authority="aat">posters</mods:genre>
  <mods:originInfo>
    <mods:place>
      <mods:placeTerm type="code" authority="marccountry">riu</mods:placeTerm>
    </mods:place>
    <mods:place>
      <mods:placeTerm type="text">Providence, RI</mods:placeTerm>
    </mods:place>
    <mods:publisher>Brown University</mods:publisher>
    <mods:dateCreated keyDate="yes" encoding="w3cdtf">2019
    </mods:dateCreated>
  </mods:originInfo>
  <mods:physicalDescription>
    <mods:extent>1 poster</mods:extent>
    <mods:digitalOrigin>born digital</mods:digitalOrigin>
  </mods:physicalDescription>
  <mods:identifier type="doi">10.26300/jf7r-d707</mods:identifier>
  <mods:accessCondition type="rights statement" xlink:href="http://rightsstatements.org/vocab/InC/1.0/">In Copyright</mods:accessCondition>

</mods:mods>