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Traumatic Brain Injury Accelerates Parkinson’s Disease Onset Without Altering Parkinson’s Neuropathology

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Overview

Year:
2020
Contributor:
Spiegel, Jonathan (Author)
Sone, Je Yeong (Author)
Butler, Tracy (Author)
Pirraglia, Elizabeth (Author)
de Leon, Mony (Author)
Brown University. Alpert Medical School. Scholarly Concentration Program. Non-Scholarly Concentrator (research program)
Subject:
Parkinson's disease
Neurology
Epidemiology
DOI
https://doi.org/10.26300/jyce-b094

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Description

Abstract:
Traumatic brain injury (TBI) is a well-established risk factor for Parkinson’s disease (PD), though it remains unclear how TBI impacts the time course and progression of PD. This study examines these questions using the National Alzheimer’s Coordinating Centers (NACC) dataset. 423 (53 TBI+) participants diagnosed clinically with PD and 1,133 (150 TBI+) participants assessed for substantia nigra neuropathology, selected without regard to antemortem diagnoses, are included. Among participants with clinical PD, TBI was associated with a 4.9 (1.5-8.2) year earlier age at onset (AAO) of PD and a 5.9 (3.0-8.8) year longer survival. In the postmortem cohort however, TBI was not associated with the severity of substantia nigra pathology. Cumulatively, these results suggest that TBI might lower the threshold required for substantia nigra pathology to present as symptomatic PD.
Notes:
Scholarly concentration: Non-Scholarly Concentrator

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Citation

Spiegel, Jonathan, Sone, Je Yeong, Butler, Tracy, et al., "Traumatic Brain Injury Accelerates Parkinson’s Disease Onset Without Altering Parkinson’s Neuropathology" (2020). Warren Alpert Medical School Academic Symposium. Brown Digital Repository. Brown University Library. https://doi.org/10.26300/jyce-b094

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    Warren Alpert Medical School Academic Symposium

    The Warren Alpert Medical School Academic Symposium is an annual event at Warren Alpert Medical School of Brown University that provides Year II medical students a venue to present their summer research in a poster format. Participation in the Symposium …
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