- Title Information
- Title
- Active metal oxides and polymer hybrids as biomaterials
- Name:
Personal
- Name Part
- Jarrell, John D.
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
(keyDate="yes", encoding="w3cdtf")
- 2008
- Physical Description
- Extent
- xix, 212 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D.) -- Brown University (2008)
- Name:
Personal
- Name Part
- Morgan, Jeffrey
- Role
- Role Term:
Text
- director
- Name:
Personal
- Name Part
- Mathiowitz, Edith
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Tripathi, Anubhav
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Hoffman-Kim, Diane
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Lee, William
- Role
- Role Term:
Text
- reader
- Name:
Corporate
- Name Part
- Brown University. Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- Bone anchored prosthetic attachments, like other percutaneous devices, suffer from poor soft tissue integration, seen as chronic inflammation, infection, epithelial downgrowth and
regression. We looked at the use of metal oxides as bioactive agents that elicit different bioresponses, ranging from cell attachment, tissue integration and reduction of inflammation to
modulation of cell proliferation, morphology and microbe killing. This study presents a novel method for creating titanium oxide and polydimethylsiloxane (PDMS) hybrid coated microplates for
high throughput biological, bacterial and photocatalytic screening that overcomes several limitations of using bulk metal samples. Titanium oxide coatings were doped with silver, zinc, vanadium,
aluminum, calcium and phosphorous, while PDMS was doped with titanium, vanadium and silver and subjected to hydrothermal heat treatment to determine the influence of chemistry and crystallinity
on the viability, proliferation and adhesion of human fibroblasts, keratinocytes and Hela cells. Also explored was the influence of Ag and Zn doping on E. coli proliferation. We determined how
titanium concentration in hybrids and silver doping influenced the photocatalytic degradation of methylene blue by coatings. A combined sub/percutaneous, polyurethane device was developed and
implanted into the backs of CD hairless rats to investigate how optimized coatings influenced soft tissue integration in vivo. We demonstrate that the bioresponse of cells to coatings is
controlled by elemental doping (V & Ag) and that planktonic bacterial growth was greatly reduced or stopped by Ag, but not Zn doping. Hydrothermal heat treatments (65 °C and 121 °C) did
not greatly influence cellular bioresponse to coatings. We discovered a range of temperature resistant (up to 400 °C), solid state dispersions with enhanced ability to block full spectrum photon
transmission and degrade methylene using medical x-rays, UV, visible and infrared photons. We show that silver doping improved the photoactivity of oxide coatings, but hindered activity of a
specific hybrid. Doped titanium oxide and polymer hybrid coatings have potential for improving soft tissue integration of medical implants and wound healing by modulating cell proliferation,
attachment, inflammation and providing controlled delivery of bioactive and antimicrobial compounds and photon induced electro-chemical activity.
- Subject (Local)
- Topic
- Titanium oxide
- Subject (Local)
- Topic
- Hela
- Subject (Local)
- Topic
- Crystallinity
- Subject (Local)
- Topic
- Surface modification
- Subject (Local)
- Topic
- Cell viability
- Subject (Local)
- Topic
- Sol-gel techniques
- Subject (Local)
- Topic
- Metal ion release
- Subject (Local)
- Topic
- Bioactivity
- Subject (Local)
- Topic
- Phosphorous
- Subject (Local)
- Topic
- Percutaneous implants
- Subject (Local)
- Topic
- Bone anchored prosthetics
- Subject (Local)
- Topic
- Small animal models
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1151576")
- Topic
- Titanium dioxide
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/923669")
- Topic
- Fibroblasts
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/986853")
- Topic
- Keratinocytes
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/850224")
- Topic
- Cell proliferation
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/850164")
- Topic
- Cell adhesion
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1763742")
- Topic
- Polydimethylsiloxane
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1118837")
- Topic
- Silver
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1164010")
- Topic
- Vanadium
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/806262")
- Topic
- Aluminum
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/844035")
- Topic
- Calcium
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1061449")
- Topic
- Phosphorus
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1181480")
- Topic
- Wound healing
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20091218
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z08G8J01
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations