<mods:mods xmlns:mods="http://www.loc.gov/mods/v3" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-7.xsd"><mods:titleInfo><mods:title>Navigating the Normal Pressure Hydrocephalus Landscape: A Product Development Strategy for a Neurodegenerative Diagnostic Startup</mods:title></mods:titleInfo><mods:typeOfResource authority="primo">dissertations</mods:typeOfResource><mods:name type="personal"><mods:namePart>Modarres, John Eran</mods:namePart><mods:role><mods:roleTerm type="text">creator</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Huang, Eric</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Analoui, Mostafa</mods:namePart><mods:role><mods:roleTerm type="text">Reader</mods:roleTerm></mods:role></mods:name><mods:name type="personal"><mods:namePart>Ruocco, Maria</mods:namePart><mods:role><mods:roleTerm type="text">Advisor</mods:roleTerm></mods:role></mods:name><mods:name type="corporate"><mods:namePart>Brown University. Biology and Medicine: Biotechnology</mods:namePart><mods:role><mods:roleTerm type="text">sponsor</mods:roleTerm></mods:role></mods:name><mods:originInfo><mods:copyrightDate>2025</mods:copyrightDate></mods:originInfo><mods:physicalDescription><mods:extent>ix, 76 p.</mods:extent><mods:digitalOrigin>born digital</mods:digitalOrigin></mods:physicalDescription><mods:note type="thesis">Thesis (Sc. M.)--Brown University, 2025</mods:note><mods:genre authority="aat">theses</mods:genre><mods:abstract>This thesis investigates the optimal product development strategy for Adelle Diagnostics, a neurodiagnostic startup from Brown University developing the Shunt IQ test to predict the efficacy of Normal Pressure Hydrocephalus (NPH) shunt surgery. Amidst a competitive&#13;
neurodiagnostic landscape and challenging funding environment, the central research question&#13;
explores the characteristics required for a diagnostic tool to achieve financial success. The study&#13;
evaluates the hypothesis that focusing on the NPH shunt prediction application, enhancing&#13;
intellectual property (IP), and pursuing potential licensing offers is the most viable path for Adelle. A mixed-methods approach combined quantitative competitive analysis of 89 startups with qualitative analysis of high-performing outliers and 26 Key Opinion Leader (KOL)&#13;
interviews guided by I-Corps principles. Statistical analysis revealed patent quantity and employee count as strong predictors of startup valuation and capital raised, supporting the IP-centric hypothesis. Qualitative analysis highlighted higher valuations for companies with&#13;
diversified portfolios and the risks associated with single-asset pipelines. KOL interviews confirmed a significant unmet need to predict NPH shunt efficacy and a substantial, underdiagnosed NPH market. While enthusiasm exists for biomarker diagnostics, a&#13;
strong preference for less invasive methods over CSF was noted, though CSF analysis via&#13;
ShuntIQ may be justifiable pre-shunt. Key recommendations include rigorous clinical validation&#13;
and robust IP protection for ShuntIQ, prioritizing developing a blood-based assay if feasible,&#13;
maintaining strategic focus on the NPH indication given market conditions, and actively&#13;
exploring strategic partnerships. This strategy aims to optimize Adelle's clinical and financial&#13;
success potential by addressing a clear market need while navigating resource constraints.</mods:abstract><mods:subject><mods:topic>Alzheimer’s disease and related dementias</mods:topic></mods:subject><mods:subject><mods:topic>Normal Pressure Hydrocephalus</mods:topic></mods:subject><mods:subject authority="fast" authorityURI="http://id.worldcat.org/fast" valueURI="http://id.worldcat.org/fast/01010284"><mods:topic>Marketing research</mods:topic></mods:subject><mods:language><mods:languageTerm authority="iso639-2b">English</mods:languageTerm></mods:language><mods:recordInfo><mods:recordContentSource authority="marcorg">RPB</mods:recordContentSource><mods:recordCreationDate encoding="iso8601">20250707</mods:recordCreationDate></mods:recordInfo></mods:mods>