- Title Information
- Title
- Designing novel orthopedic implants based on an anodization platform
- Name:
Personal
- Name Part
- Yao, Chang
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
(keyDate="yes", encoding="w3cdtf")
- 2008
- Physical Description
- Extent
- xxvi, 192 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D.) -- Brown University (2009)
- Name:
Personal
- Name Part
- Webster, Thomas
- Role
- Role Term:
Text
- director
- Name:
Personal
- Name Part
- Mathiowitz, Edith
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Sheldon, Brian
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Thripathi, Anubhav
- Role
- Role Term:
Text
- reader
- Name:
Personal
- Name Part
- Meyer, Donna
- Role
- Role Term:
Text
- reader
- Name:
Corporate
- Name Part
- Brown University. Biomedical Engineering
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Abstract
- Titanium, titanium alloys, and cobalt-chromium alloys are widely used in orthopedic applications. To promote the osseointegration of implants into juxtaposed bone, an
electrochemical surface modification method, anodization, was utilized in the present study to create biologically-inspired titania nanotubular structures on currently-used titanium implant
surfaces. This anodization technique was also applied to Ti6Al4V and a CoCr alloy. Characterizations of such anodized Ti, Ti6Al4V and CoCr demonstrated increased nano-roughness, increased
surface wettability, and increased surface energy compared to their non-anodized equivalents. Cytocompatibility tests with osteoblasts and chondrocytes showed enhanced short term and long term
cellular responses on anodized Ti, Ti6Al4V and CoCr compared to their non-anodized counterparts for the first time. Importantly, the underlying mechanisms of this observed increased cellular
responses were elucidated in this study by greater amounts of vitronectin and fibronectin (proteins that mediate osteoblast and chondrocyte adhesion) preadsorption on anodized compared to
unanodized surfaces. The anodized titanium possessing nanotubular structures was also studied for novel metallic drug delivery applications. For this, anodized titanium was functionalized with
hydroxyl, amine, or methyl groups to possess varied surface energy properties. Antibiotics (such as penicillin/streptomycin and penicillin G sodium salt) were loaded into such anodized titania
nanotubes via a physical adsorption method. Characterization of drug release behavior showed that the most hydrophilic anodized titanium with hydroxyl groups released the most amounts of
antibiotics after two days. Antibiotics were loaded onto anodized titania nanotubes via a co-precipitation method that combined antibiotics with calcium phosphates. Drugs loaded onto anodized
titanium implants using this method exhibited a prolonged release of up to 3 weeks. Antibiotic-loaded anodized titanium further inhibited S. epidermidis (the primary bacteria which causes
orthopedic implant infection) attachment but did not inhibit osteoblast adhesion. In summary, these results indicated that anodization can be used as a quick, inexpensive platform to modify
numerous orthopedic implants to possess nanofeatures and, thus, increase the responses of bone and cartilage cells. Further, anodizing titanium to possess nanotubular structures can be an
innovative metal-based drug delivery system to further ensure the efficacy of orthopedic implants.
- Subject (Local)
- Topic
- anodization,titanium,drug delivery,orthopedics
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20091218
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Identifier:
DOI
- 10.7301/Z0VT1QC3
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations