- Title Information
- Title
- High Frequency Viscoelasticity of Soft Materials at Low to Moderate
Strains with Implications for Vocal Fold Tissue Engineering
- Name:
Personal
- Name Part
- Teller, Sean S
- Role
- Role Term:
Text
- creator
- Origin Information
- Copyright Date
- 2013
- Physical Description
- Extent
- xiii, 122 p.
- digitalOrigin
- born digital
- Note
- Thesis (Ph.D. -- Brown University (2013)
- Name:
Personal
- Name Part
- Clifton, Rodney
- Role
- Role Term:
Text
- Director
- Name:
Personal
- Name Part
- Kim, Kyung-Suk
- Role
- Role Term:
Text
- Reader
- Name:
Personal
- Name Part
- Tripathi, Anubhav
- Role
- Role Term:
Text
- Reader
- Name:
Corporate
- Name Part
- Brown University. ENGINEERING: Solid Mechanics
- Role
- Role Term:
Text
- sponsor
- Genre (aat)
- theses
- Subject
- Topic
- vocal folds
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1167814")
- Topic
- Viscoelasticity
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1151484")
- Topic
- Tissue engineering
- Subject (FAST)
(authorityURI="http://id.worldcat.org/fast", valueURI="http://id.worldcat.org/fast/1168347")
- Topic
- Vocal cords
- Record Information
- Record Content Source (marcorg)
- RPB
- Record Creation Date
(encoding="iso8601")
- 20131217
- Language
- Language Term:
Code (ISO639-2B)
- eng
- Language Term:
Text
- English
- Abstract
- Vocal folds are driven in a shear-dominated, wave-like motion at high frequencies (100-1000 Hz) at strains up to 30% during phonation. Damage to the vocal folds may cause significantly stiffer scar tissue to form, impairing voice function. Due to the biomechanically active nature of the tissue, candidate tissue-engineered replacement materials must have mechanical properties (i.e. viscoelastic shear modulus) that are similar to those of native tissues. The torsional wave experiment (TWE), a stress-wave based resonance test, was used to determine the linear viscoelastic complex shear modulus of human and porcine vocal folds up to low audio frequencies, while histology investigated the structure-property relationship. Human tissues were harvested from adult males and females between 39 and 93 years of age, while porcine tissues were from fetal, newborn, adolescent, and adult pigs. Adult porcine tissues had an average storage modulus of 2207+1440 Pa with a loss tangent of 0.38+0.10, while human vocal folds had an average storage modulus and loss tangent of 824+479 Pa and 0.42+0.10, respectively. Viscoelastic moduli did not exhibit gender dependence in either human or porcine vocal folds, although age dependence was found in porcine tissues. Histology of porcine tissues similarly showed a dependence on age. <br/>
A finite strain torsional wave experiment was developed that superposes high-frequency, infinitesimal deformations on a low-frequency, finite-strain deformation. This experiment enables the determination of a complex viscoelastic tangent shear modulus at a known pre-strain. In addition to enabling measurements at finite strain, the new experiment increased the resonance frequency of the system― allowing for measurements at higher frequencies than those obtained in the TWE. Experiments were performed on 0.45% (w/v) agarose gels at pre-strains up to 80%; the storage modulus did not change with applied pre-strain while the loss tangent increased. Future work includes reducing the time to perform the experiments, extending the strain and frequency test ranges, and collecting data on natural tissues.
- Identifier:
DOI
- 10.7301/Z0KD1W7R
- Access Condition:
rights statement
(href="http://rightsstatements.org/vocab/InC/1.0/")
- In Copyright
- Access Condition:
restriction on access
- Collection is open for research.
- Type of Resource (primo)
- dissertations